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Protein

Ethylene-responsive transcription factor CRF4

Gene

CRF4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of the cytokinin signaling pathway involved in cotyledons, leaves, and embryos development. Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi117 – 174AP2/ERFPROSITE-ProRule annotationAdd BLAST58

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • transcription factor activity, sequence-specific DNA binding Source: TAIR

GO - Biological processi

  • cytokinin-activated signaling pathway Source: UniProtKB-KW
  • ethylene-activated signaling pathway Source: UniProtKB-KW
  • leaf development Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW
  • transcription factor import into nucleus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Cytokinin signaling pathway, Ethylene signaling pathway, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Ethylene-responsive transcription factor CRF4
Alternative name(s):
Protein CYTOKININ RESPONSE FACTOR 4
Gene namesi
Name:CRF4
Synonyms:ERF066
Ordered Locus Names:At4g27950
ORF Names:T13J8.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G27950.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002979191 – 335Ethylene-responsive transcription factor CRF4Add BLAST335

Proteomic databases

PaxDbiQ9SUE3.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CRF1O825034EBI-5567027,EBI-5567050
CRF2Q9SUQ24EBI-5567027,EBI-5567273
CRF3Q9FK124EBI-5567027,EBI-5567993
CRF5O823394EBI-5567027,EBI-5567180
CRF6Q9M3744EBI-5567027,EBI-5568101
ERF069Q8W4I53EBI-5567027,EBI-5568301
ERF070Q9C9953EBI-5567027,EBI-5568333

Protein-protein interaction databases

BioGridi14195. 13 interactors.
IntActiQ9SUE3. 13 interactors.
STRINGi3702.AT4G27950.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SUE3.
SMRiQ9SUE3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 AP2/ERF DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410JBVY. Eukaryota.
ENOG410YM3E. LUCA.
HOGENOMiHOG000237664.
InParanoidiQ9SUE3.
OMAiDSFPLDI.
OrthoDBiEOG09360H71.

Family and domain databases

CDDicd00018. AP2. 1 hit.
Gene3Di3.30.730.10. 1 hit.
InterProiIPR017392. AP2/ERF-transcript_factor.
IPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PANTHERiPTHR31194. PTHR31194. 1 hit.
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SUE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMMDEFMDLR PVKYTEHKTV IRKYTKKSSM ERKTSVRDSA RLVRVSMTDR
60 70 80 90 100
DATDSSSDEE EFLFPRRRVK RLINEIRVEP SSSSTGDVSA SPTKDRKRIN
110 120 130 140 150
VDSTVQKPSV SGQNQKKYRG VRQRPWGKWA AEIRDPEQRR RIWLGTFATA
160 170 180 190 200
EEAAIVYDNA AIKLRGPDAL TNFTVQPEPE PVQEQEQEPE SNMSVSISES
210 220 230 240 250
MDDSQHLSSP TSVLNYQTYV SEEPIDSLIK PVKQEFLEPE QEPISWHLGE
260 270 280 290 300
GNTNTNDDSF PLDITFLDNY FNESLPDISI FDQPMSPIQP TENDFFNDLM
310 320 330
LFDSNAEEYY SSEIKEIGSS FNDLDDSLIS DLLLV
Length:335
Mass (Da):38,448
Last modified:May 31, 2011 - v2
Checksum:iCA487909D2D1E318
GO

Sequence cautioni

The sequence CAB36764 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAB79597 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035524 Genomic DNA. Translation: CAB36764.1. Different initiation.
AL161572 Genomic DNA. Translation: CAB79597.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE85412.1.
BT033088 mRNA. Translation: ACF04811.1.
AY560872 mRNA. Translation: AAT44939.1.
PIRiT02896.
RefSeqiNP_194524.2. NM_118933.3.
UniGeneiAt.49716.

Genome annotation databases

EnsemblPlantsiAT4G27950.1; AT4G27950.1; AT4G27950.
GeneIDi828908.
GrameneiAT4G27950.1; AT4G27950.1; AT4G27950.
KEGGiath:AT4G27950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035524 Genomic DNA. Translation: CAB36764.1. Different initiation.
AL161572 Genomic DNA. Translation: CAB79597.1. Different initiation.
CP002687 Genomic DNA. Translation: AEE85412.1.
BT033088 mRNA. Translation: ACF04811.1.
AY560872 mRNA. Translation: AAT44939.1.
PIRiT02896.
RefSeqiNP_194524.2. NM_118933.3.
UniGeneiAt.49716.

3D structure databases

ProteinModelPortaliQ9SUE3.
SMRiQ9SUE3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14195. 13 interactors.
IntActiQ9SUE3. 13 interactors.
STRINGi3702.AT4G27950.1.

Proteomic databases

PaxDbiQ9SUE3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G27950.1; AT4G27950.1; AT4G27950.
GeneIDi828908.
GrameneiAT4G27950.1; AT4G27950.1; AT4G27950.
KEGGiath:AT4G27950.

Organism-specific databases

TAIRiAT4G27950.

Phylogenomic databases

eggNOGiENOG410JBVY. Eukaryota.
ENOG410YM3E. LUCA.
HOGENOMiHOG000237664.
InParanoidiQ9SUE3.
OMAiDSFPLDI.
OrthoDBiEOG09360H71.

Miscellaneous databases

PROiQ9SUE3.

Family and domain databases

CDDicd00018. AP2. 1 hit.
Gene3Di3.30.730.10. 1 hit.
InterProiIPR017392. AP2/ERF-transcript_factor.
IPR001471. AP2/ERF_dom.
IPR016177. DNA-bd_dom.
[Graphical view]
PANTHERiPTHR31194. PTHR31194. 1 hit.
PfamiPF00847. AP2. 1 hit.
[Graphical view]
PRINTSiPR00367. ETHRSPELEMNT.
SMARTiSM00380. AP2. 1 hit.
[Graphical view]
SUPFAMiSSF54171. SSF54171. 1 hit.
PROSITEiPS51032. AP2_ERF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRF4_ARATH
AccessioniPrimary (citable) accession number: Q9SUE3
Secondary accession number(s): B3LFA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 21, 2007
Last sequence update: May 31, 2011
Last modified: November 30, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.