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Protein

Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial

Gene

At4g20930

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalytic activityi

3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH.

Pathwayi: L-valine degradation

This protein is involved in the pathway L-valine degradation, which is part of Amino-acid degradation.
View all proteins of this organism that are known to be involved in the pathway L-valine degradation and in Amino-acid degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei134NAD; via amide nitrogenBy similarity1
Active sitei219By similarity1
Binding sitei294NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi38 – 67NADBy similarityAdd BLAST30
Nucleotide bindingi101 – 102NADBy similarity2

GO - Molecular functioni

  • 3-hydroxyisobutyrate dehydrogenase activity Source: TAIR
  • NAD binding Source: InterPro
  • phosphogluconate dehydrogenase (decarboxylating) activity Source: InterPro
  • protein self-association Source: TAIR

GO - Biological processi

  • leucine metabolic process Source: TAIR
  • valine catabolic process Source: UniProtKB-UniPathway
  • valine metabolic process Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processBranched-chain amino acid catabolism
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT4G20930-MONOMER
ReactomeiR-ATH-70895 Branched-chain amino acid catabolism
UniPathwayiUPA00362

Names & Taxonomyi

Protein namesi
Recommended name:
Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrial (EC:1.1.1.31)
Short name:
HIBADH
Gene namesi
Ordered Locus Names:At4g20930
ORF Names:T13K14.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G20930
TAIRilocus:2133134 AT4G20930

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionBy similarityAdd BLAST34
ChainiPRO_000000716235 – 347Probable 3-hydroxyisobutyrate dehydrogenase, mitochondrialAdd BLAST313

Proteomic databases

PaxDbiQ9SUC0

PTM databases

iPTMnetiQ9SUC0

Expressioni

Gene expression databases

ExpressionAtlasiQ9SUC0 baseline and differential
GenevisibleiQ9SUC0 AT

Interactioni

GO - Molecular functioni

  • protein self-association Source: TAIR

Protein-protein interaction databases

BioGridi13132, 1 interactor
STRINGi3702.AT4G20930.1

Structurei

3D structure databases

ProteinModelPortaliQ9SUC0
SMRiQ9SUC0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0409 Eukaryota
COG2084 LUCA
HOGENOMiHOG000219610
InParanoidiQ9SUC0
KOiK00020
OMAiWPSEVNN
OrthoDBiEOG09360H9O
PhylomeDBiQ9SUC0

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR002204 3-OH-isobutyrate_DH-rel_CS
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006115 6PGDH_NADP-bd
IPR011548 HIBADH
IPR015815 HIBADH-related
IPR036291 NAD(P)-bd_dom_sf
IPR029154 NADP-bd
PfamiView protein in Pfam
PF14833 NAD_binding_11, 1 hit
PF03446 NAD_binding_2, 1 hit
PIRSFiPIRSF000103 HIBADH, 1 hit
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR01692 HIBADH, 1 hit
PROSITEiView protein in PROSITE
PS00895 3_HYDROXYISOBUT_DH, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SUC0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRRAQTLL CLSKFKTNFV SGSLHRFSSS SQNSNQFQNV GFIGLGNMGF
60 70 80 90 100
RMVNNLIRAG YKVTVHDINR DVMKMFTEMG VSSRETPYEV AQDSEVVITM
110 120 130 140 150
LPSSSHVMDV YTGTNGLLLG ENDIRPALFI DSSTIDPQTT RKISLAVSNC
160 170 180 190 200
NLKEKRDNWE KPVMLDAPVS GGVLAAEAGT LTFMVGGPED AYLAARPILQ
210 220 230 240 250
SMGRTSIYCG GSGNGSAAKI CNNLAMAVSM LGTSEALALG QSLGISASTL
260 270 280 290 300
TEVLNTSSGR CWSSDAYNPV PGVMKGVPSS RDYNGGFASK LMAKDLNLAA
310 320 330 340
ASAEEVGHKS PLISKAQEIY KKMCEEGHET KDFSCVFRHF YNGKDEV
Length:347
Mass (Da):37,365
Last modified:April 30, 2003 - v3
Checksum:i6ED2E87CC3DE191C
GO

Sequence cautioni

The sequence CAB45888 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB79093 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21S → F in AAM63893 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080282 Genomic DNA Translation: CAB45888.1 Sequence problems.
AL161554 Genomic DNA Translation: CAB79093.1 Sequence problems.
CP002687 Genomic DNA Translation: AEE84377.1
BT025657 mRNA Translation: ABF74718.1
AK228571 mRNA Translation: BAF00489.1
AY086845 mRNA Translation: AAM63893.1
RefSeqiNP_567617.1, NM_118211.5
UniGeneiAt.32684

Genome annotation databases

EnsemblPlantsiAT4G20930.1; AT4G20930.1; AT4G20930
GeneIDi827841
GrameneiAT4G20930.1; AT4G20930.1; AT4G20930
KEGGiath:AT4G20930

Similar proteinsi

Entry informationi

Entry namei3HIDH_ARATH
AccessioniPrimary (citable) accession number: Q9SUC0
Secondary accession number(s): Q1ECP8, Q8LC25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: April 30, 2003
Last modified: May 23, 2018
This is version 136 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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