Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein arginine N-methyltransferase 1.1

Gene

PRMT11

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain. Type I arginine methyltransferase active on both histones and non-histone proteins. Required for leaves and flowers development. Mediates the methylation of MBD7 and MED36A.2 Publications

Catalytic activityi

2 S-adenosyl-L-methionine + [protein]-L-arginine = 2 S-adenosyl-L-homocysteine + [protein]-N(omega),N(omega)-dimethyl-L-arginine.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei181 – 1811By similarity
Active sitei190 – 1901By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciARA:AT4G29510-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein arginine N-methyltransferase 1.1 (EC:2.1.1.319)
Short name:
AtPRMT11
Alternative name(s):
Arginine methyltransferase pam1
Histone-arginine N-methyltransferase PRMT11
Gene namesi
Name:PRMT11
Synonyms:PAM1, PRMT1.1, PRMT1B
Ordered Locus Names:At4g29510
ORF Names:T16L4.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G29510.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • cytosol Source: TAIR
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Reduced levels of proteins with asymmetrically dimethylated arginines. Altered leaf morphology and development (curled leaves), multiple rosettes with an increased number of leaves, delayed flowering, disturbed inflorescence morphology, increased sterility.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 390390Protein arginine N-methyltransferase 1.1PRO_0000293986Add
BLAST

Proteomic databases

PaxDbiQ9SU94.
PRIDEiQ9SU94.

PTM databases

iPTMnetiQ9SU94.

Expressioni

Gene expression databases

GenevisibleiQ9SU94. AT.

Interactioni

Subunit structurei

Interacts with PRMT12, MBD7 and MED36A.2 Publications

Protein-protein interaction databases

BioGridi14359. 9 interactions.
IntActiQ9SU94. 4 interactions.
STRINGi3702.AT4G29510.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SU94.
SMRiQ9SU94. Positions 75-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini69 – 390322SAM-dependent MTase PRMT-typePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family.PROSITE-ProRule annotation
Contains 1 SAM-dependent MTase PRMT-type domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1499. Eukaryota.
ENOG410XQYH. LUCA.
HOGENOMiHOG000198521.
InParanoidiQ9SU94.
KOiK11434.
OMAiFVIDINF.
OrthoDBiEOG09360D5O.
PhylomeDBiQ9SU94.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025799. Arg_MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11006. PTHR11006. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51678. SAM_MT_PRMT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SU94-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKNSNHDEN EFISFEPNQN TKIRFEDADE DEVAEGSGVA GEETPQDESM
60 70 80 90 100
FDAGESADTA EVTDDTTSAD YYFDSYSHFG IHEEMLKDVV RTKTYQNVIY
110 120 130 140 150
QNKFLIKDKI VLDVGAGTGI LSLFCAKAGA AHVYAVECSQ MADMAKEIVK
160 170 180 190 200
ANGFSDVITV LKGKIEEIEL PTPKVDVIIS EWMGYFLLFE NMLDSVLYAR
210 220 230 240 250
DKWLVEGGVV LPDKASLHLT AIEDSEYKED KIEFWNSVYG FDMSCIKKKA
260 270 280 290 300
MMEPLVDTVD QNQIVTDSRL LKTMDISKMS SGDASFTAPF KLVAQRNDYI
310 320 330 340 350
HALVAYFDVS FTMCHKLLGF STGPKSRATH WKQTVLYLED VLTICEGETI
360 370 380 390
TGTMSVSPNK KNPRDIDIKL SYSLNGQHCK ISRTQHYKMR
Length:390
Mass (Da):43,894
Last modified:May 1, 2000 - v1
Checksum:i9BE43387CD7AE0B2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti260 – 2601D → G in AAL36326 (PubMed:14593172).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL079344 Genomic DNA. Translation: CAB45311.1.
AL161575 Genomic DNA. Translation: CAB79709.1.
CP002687 Genomic DNA. Translation: AEE85638.1.
AY150407 mRNA. Translation: AAN12952.1.
AY063970 mRNA. Translation: AAL36326.1.
AY087817 mRNA. Translation: AAM65371.1.
AJ007582 mRNA. Translation: CAA07570.1.
PIRiT09914.
T52248.
RefSeqiNP_194680.1. NM_119096.2.
UniGeneiAt.27463.
At.31913.

Genome annotation databases

EnsemblPlantsiAT4G29510.1; AT4G29510.1; AT4G29510.
GeneIDi829072.
GrameneiAT4G29510.1; AT4G29510.1; AT4G29510.
KEGGiath:AT4G29510.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL079344 Genomic DNA. Translation: CAB45311.1.
AL161575 Genomic DNA. Translation: CAB79709.1.
CP002687 Genomic DNA. Translation: AEE85638.1.
AY150407 mRNA. Translation: AAN12952.1.
AY063970 mRNA. Translation: AAL36326.1.
AY087817 mRNA. Translation: AAM65371.1.
AJ007582 mRNA. Translation: CAA07570.1.
PIRiT09914.
T52248.
RefSeqiNP_194680.1. NM_119096.2.
UniGeneiAt.27463.
At.31913.

3D structure databases

ProteinModelPortaliQ9SU94.
SMRiQ9SU94. Positions 75-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14359. 9 interactions.
IntActiQ9SU94. 4 interactions.
STRINGi3702.AT4G29510.1.

PTM databases

iPTMnetiQ9SU94.

Proteomic databases

PaxDbiQ9SU94.
PRIDEiQ9SU94.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G29510.1; AT4G29510.1; AT4G29510.
GeneIDi829072.
GrameneiAT4G29510.1; AT4G29510.1; AT4G29510.
KEGGiath:AT4G29510.

Organism-specific databases

TAIRiAT4G29510.

Phylogenomic databases

eggNOGiKOG1499. Eukaryota.
ENOG410XQYH. LUCA.
HOGENOMiHOG000198521.
InParanoidiQ9SU94.
KOiK11434.
OMAiFVIDINF.
OrthoDBiEOG09360D5O.
PhylomeDBiQ9SU94.

Enzyme and pathway databases

BioCyciARA:AT4G29510-MONOMER.

Miscellaneous databases

PROiQ9SU94.

Gene expression databases

GenevisibleiQ9SU94. AT.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
InterProiIPR025799. Arg_MeTrfase.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PANTHERiPTHR11006. PTHR11006. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
PROSITEiPS51678. SAM_MT_PRMT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANM11_ARATH
AccessioniPrimary (citable) accession number: Q9SU94
Secondary accession number(s): O81813, Q8VZP0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 107 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.