Reviewed, UniProtKB/Swiss-Prot Q9SU94 (ANM11_ARATH)

Names and origin

Protein names

Recommended name:
    Probable protein arginine N-methyltransferase 1.1
    EC=2.1.1.-
Alternative name(s):
    Arginine methyltransferase pam1

Gene names

Name:	PRMT1.1
Synonyms:	PAM1
Ordered Locus Names:	At4g29510
ORF Names:	T16L4.20

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	390 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in a glycine and arginine-rich domain (can methylate histones) By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the protein arginine N-methyltransferase family.

Ontologies

Keywords
Cellular component	Nucleus
Molecular function	Methyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	nucleus Inferred from direct assay. Source: TAIR
Molecular function	identical protein binding Inferred from physical interaction. Source: IntAct protein-arginine N-methyltransferase activity Inferred from direct assay. Source: TAIR
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-1382731,EBI-1382731
FIB2	Q94AH9	1	EBI-1382731,EBI-1382666
HIST1H4A	P62805	1	EBI-1382731,EBI-302023	From a different organism.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 390	390	Probable protein arginine N-methyltransferase 1.1		PRO_0000293986
Experimental info
	Sequence conflict	260	1	D → G in AAL36326. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q9SU94-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 9BE43387CD7AE0B2	FASTA	390	43,894
	10 20 30 40 50 60 MTKNSNHDEN EFISFEPNQN TKIRFEDADE DEVAEGSGVA GEETPQDESM FDAGESADTA 70 80 90 100 110 120 EVTDDTTSAD YYFDSYSHFG IHEEMLKDVV RTKTYQNVIY QNKFLIKDKI VLDVGAGTGI 130 140 150 160 170 180 LSLFCAKAGA AHVYAVECSQ MADMAKEIVK ANGFSDVITV LKGKIEEIEL PTPKVDVIIS 190 200 210 220 230 240 EWMGYFLLFE NMLDSVLYAR DKWLVEGGVV LPDKASLHLT AIEDSEYKED KIEFWNSVYG 250 260 270 280 290 300 FDMSCIKKKA MMEPLVDTVD QNQIVTDSRL LKTMDISKMS SGDASFTAPF KLVAQRNDYI 310 320 330 340 350 360 HALVAYFDVS FTMCHKLLGF STGPKSRATH WKQTVLYLED VLTICEGETI TGTMSVSPNK 370 380 390 KNPRDIDIKL SYSLNGQHCK ISRTQHYKMR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana." Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B. , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R. Nature 402:769-777(1999) [PubMed: 10617198] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R. Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia.
[3]	"Full-length cDNA from Arabidopsis thaliana." Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A. Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Identification and isolation of the first protein arginine methyltransferase from Arabidopsis thaliana." Salchert K., Breuer F., Koncz C. Submitted (JUL-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-376. Strain: cv. Columbia.
[5]	"Protein arginine methyltransferases: evolution and assessment of their pharmacological and therapeutic potential." Krause C.D., Yang Z.H., Kim Y.S., Lee J.H., Cook J.R., Pestka S. Pharmacol. Ther. 113:50-87(2007) [PubMed: 17005254] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL079344 Genomic DNA. Translation: CAB45311.1. AL161575 Genomic DNA. Translation: CAB79709.1. AY150407 mRNA. Translation: AAN12952.1. AY063970 mRNA. Translation: AAL36326.1. AY087817 mRNA. Translation: AAM65371.1. AJ007582 mRNA. Translation: CAA07570.1.
IPI	IPI00522360.
PIR	T09914. T52248.
RefSeq	NP_194680.1.
UniGene	At.27463
3D structure databases
HSSP	HSSP built from PDB template 1ORH based on UniProtKB Q63009.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9SU94. 3 interactions.
Proteomic databases
PRIDE	Q9SU94.
Genome annotation databases
GeneID	829072.
GenomeReviews	Gene locus AT4G29510 in contig CT486007_GR.
KEGG	ath:AT4G29510.
NMPDR	fig|3702.1.peg.20921.
Organism-specific databases
TAIR	At4g29510.
Phylogenomic databases
OMA	Q9SU94. LIFPDKC.
Family and domain databases
InterPro	IPR013217. Methyltransf_12. [Graphical view]
Pfam	PF08242. Methyltransf_12. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ANM11_ARATH

Accession

Primary (citable) accession number: Q9SU94
Secondary accession number(s): O81813, Q8VZP0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 10, 2007
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)