Reviewed,
UniProtKB/Swiss-Prot Q9SU63 (AL2B4_ARATH)
Last modified
February 9, 2010.
Version 65.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Aldehyde dehydrogenase family 2 member B4, mitochondrial Short name=ALDH2a EC=1.2.1.3 | ||||||||
| Gene names |
| ||||||||
| Organism | Arabidopsis thaliana (Mouse-ear cress) [Complete proteome] | ||||||||
| Taxonomic identifier | 3702 [NCBI] | ||||||||
| Taxonomic lineage | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis |
Protein attributes
| Sequence length | 538 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Possesses activity on acetaldehyde and glycolaldehyde in vitro. Ref.2 |
| Catalytic activity | An aldehyde + NAD+ + H2O = an acid + NADH. |
| Subunit structure | Homotetramer By similarity. |
| Subcellular location | Mitochondrion matrix Potential. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Mitochondrion |
| Domain | Transit peptide |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW response to cadmium ionInferred from expression pattern. Source: TAIR |
| Cellular component | chloroplast Inferred from direct assay. Source: TAIR mitochondrial matrixInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from direct assay. Source: TAIR aldehyde dehydrogenase (NAD) activityInferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Transit peptide | 1 – 21 | 21 | Mitochondrion Potential | ||||||
| Chain | 22 – 538 | 517 | Aldehyde dehydrogenase family 2 member B4, mitochondrial | PRO_0000256056 | |||||
Regions | |||||||||
| Nucleotide binding | 282 – 287 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 305 | 1 | Proton acceptor By similarity | ||||||
| Active site | 339 | 1 | Nucleophile By similarity | ||||||
| Site | 206 | 1 | Transition state stabilizer By similarity | ||||||
Experimental info | |||||||||
| Sequence conflict | 125 | 1 | L → C in CAA81249. Ref.5 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Molecular and cellular characterizations of a cDNA clone encoding a novel isozyme of aldehyde dehydrogenase from rice." Li Y., Nakazono M., Tsutsumi N., Hirai A. Gene 249:67-74(2000) [PubMed: 10831839] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis." Skibbe D.S., Liu F., Wen T.-J., Yandeau M.D., Cui X., Cao J., Simmons C.R., Schnable P.S. Plant Mol. Biol. 48:751-764(2002) [PubMed: 11999848] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION. |
| [3] | "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana." Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. Tabata S.Nature 408:820-822(2000) [PubMed: 11130713] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia. |
| [4] | "Empirical analysis of transcriptional activity in the Arabidopsis genome." Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. Ecker J.R.Science 302:842-846(2003) [PubMed: 14593172] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: cv. Columbia. |
| [5] | "The Arabidopsis thaliana transcribed genome: the GDR cDNA program." Philipps G., Gigot C. Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-125. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB030820 mRNA. Translation: BAA96792.1. AF349447 mRNA. Translation: AAM27003.1. AL049658 Genomic DNA. Translation: CAB41139.1. AF327426 mRNA. Translation: AAG42016.1. AF349522 mRNA. Translation: AAK15569.1. AF372911 mRNA. Translation: AAK49627.1. AY090443 mRNA. Translation: AAL91287.1. BT000752 mRNA. Translation: AAN31892.1. BT006371 mRNA. Translation: AAP21179.1. Z26417 mRNA. Translation: CAA81249.1. |
| IPI | IPI00548267. |
| PIR | T06683. |
| RefSeq | NP_190383.1. |
| UniGene | At.22890 Rra.22900 Rra.5935 Rsa.20009 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1ZUM based on UniProtKB P05091. |
| SMR | Q9SU63. Positions 50-528. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q9SU63. |
Proteomic databases | |
| PRIDE | Q9SU63. |
| ProMEX | Q9SU63. |
Genome annotation databases | |
| GeneID | 823955. |
| GenomeReviews | Gene locus AT3G48000 in contig BA000014_GR. |
| KEGG | ath:AT3G48000. |
| NMPDR | fig|3702.1.peg.16033. |
Organism-specific databases | |
| GeneFarm | 4339. |
| TAIR | At3g48000. |
Phylogenomic databases | |
| eggNOG | KOG2450. |
| HOGENOM | HBG752218. |
| InParanoid | Q9SU63. |
| OMA | LIAKDEI. |
| PhylomeDB | Q9SU63. |
Enzyme and pathway databases | |
| BRENDA | 1.2.1.3. 302. |
Gene expression databases | |
| ArrayExpress | Q9SU63. |
| Genevestigator | Q9SU63. |
| GermOnline | AT3G48000. Arabidopsis thaliana. |
Family and domain databases | |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AL2B4_ARATH | ||||||||
| Accession | Primary (citable) accession number: Q9SU63 Secondary accession number(s): Q42090 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | PPAP (Plant Proteome Annotation Project) | ||||||||
Relevant documents
| Arabidopsis thaliana Arabidopsis thaliana: entries and gene names |
| SIMILARITY comments Index of protein domains and families |

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