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Reviewed, UniProtKB/Swiss-Prot Q9SU63 (AL2B4_ARATH)

Last modified February 9, 2010. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Aldehyde dehydrogenase family 2 member B4, mitochondrial
      Short name=ALDH2a
    EC=1.2.1.3
Gene names
Name: ALDH2B4
Synonyms: ALDH2
Ordered Locus Names: At3g48000
ORF Names: T17F15.130
OrganismArabidopsis thaliana (Mouse-ear cress) [Complete proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Possesses activity on acetaldehyde and glycolaldehyde in vitro. Ref.2

Catalytic activity

An aldehyde + NAD+ + H2O = an acid + NADH.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion matrix Potential.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

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Ontologies

Keywords
   Cellular componentMitochondrion
   DomainTransit peptide
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

response to cadmium ion

Inferred from expression pattern. Source: TAIR

   Cellular componentchloroplast

Inferred from direct assay. Source: TAIR

mitochondrial matrix

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionATP binding

Inferred from direct assay. Source: TAIR

aldehyde dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2121Mitochondrion Potential
Chain22 – 538517Aldehyde dehydrogenase family 2 member B4, mitochondrial
PRO_0000256056

Regions

Nucleotide binding282 – 2876NAD By similarity

Sites

Active site3051Proton acceptor By similarity
Active site3391Nucleophile By similarity
Site2061Transition state stabilizer By similarity

Experimental info

Sequence conflict1251L → C in CAA81249. Ref.5

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Sequences

Sequence LengthMass (Da)Tools
Q9SU63-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: B7C054157659391C

FASTA53858,589
        10         20         30         40         50         60 
MAARRVSSLL SRSFSASSPL LFRSQGRNCY NGGILRRFGT SSAAAEEIIN PSVQVSHTQL 

        70         80         90        100        110        120 
LINGNFVDSA SGKTFPTLDP RTGEVIAHVA EGDAEDINRA VKAARTAFDE GPWPKMSAYE 

       130        140        150        160        170        180 
RSRVLLRFAD LVEKHSEELA SLETWDNGKP YQQSLTAEIP MFARLFRYYA GWADKIHGLT 

       190        200        210        220        230        240 
IPADGNYQVH TLHEPIGVAG QIIPWNFPLL MFAWKVGPAL ACGNTIVLKT AEQTPLTAFY 

       250        260        270        280        290        300 
AGKLFLEAGL PPGVLNIVSG FGATAGAALA SHMDVDKLAF TGSTDTGKVI LGLAANSNLK 

       310        320        330        340        350        360 
PVTLELGGKS PFIVFEDADI DKAVELAHFA LFFNQGQCCC AGSRTFVHEK VYDEFVEKSK 

       370        380        390        400        410        420 
ARALKRVVGD PFRKGIEQGP QIDLKQFEKV MKYIKSGIES NATLECGGDQ IGDKGYFIQP 

       430        440        450        460        470        480 
TVFSNVKDDM LIAQDEIFGP VQSILKFSDV DEVIKRANET KYGLAAGVFT KNLDTANRVS 

       490        500        510        520        530 
RALKAGTVWV NCFDVFDAAI PFGGYKMSGN GREKGIYSLN NYLQIKAVVT ALNKPAWI

« Hide

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References

« Hide 'large scale' references
[1]"Molecular and cellular characterizations of a cDNA clone encoding a novel isozyme of aldehyde dehydrogenase from rice."
Li Y., Nakazono M., Tsutsumi N., Hirai A.
Gene 249:67-74(2000) [PubMed: 10831839] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis."
Skibbe D.S., Liu F., Wen T.-J., Yandeau M.D., Cui X., Cao J., Simmons C.R., Schnable P.S.
Plant Mol. Biol. 48:751-764(2002) [PubMed: 11999848] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[3]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed: 11130713] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[4]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed: 14593172] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[5]"The Arabidopsis thaliana transcribed genome: the GDR cDNA program."
Philipps G., Gigot C.
Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-125.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB030820 mRNA. Translation: BAA96792.1.
AF349447 mRNA. Translation: AAM27003.1.
AL049658 Genomic DNA. Translation: CAB41139.1.
AF327426 mRNA. Translation: AAG42016.1.
AF349522 mRNA. Translation: AAK15569.1.
AF372911 mRNA. Translation: AAK49627.1.
AY090443 mRNA. Translation: AAL91287.1.
BT000752 mRNA. Translation: AAN31892.1.
BT006371 mRNA. Translation: AAP21179.1.
Z26417 mRNA. Translation: CAA81249.1.
IPIIPI00548267.
PIRT06683.
RefSeqNP_190383.1.
UniGeneAt.22890
Rra.22900
Rra.5935
Rsa.20009

3D structure databases

HSSPHSSP built from PDB template 1ZUM based on UniProtKB P05091.
SMRQ9SU63. Positions 50-528.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9SU63.

Proteomic databases

PRIDEQ9SU63.
ProMEXQ9SU63.

Genome annotation databases

GeneID823955.
GenomeReviewsGene locus AT3G48000 in contig BA000014_GR.
KEGGath:AT3G48000.
NMPDRfig|3702.1.peg.16033.

Organism-specific databases

GeneFarm4339.
TAIRAt3g48000.

Phylogenomic databases

eggNOGKOG2450.
HOGENOMHBG752218.
InParanoidQ9SU63.
OMALIAKDEI.
PhylomeDBQ9SU63.

Enzyme and pathway databases

BRENDA1.2.1.3. 302.

Gene expression databases

ArrayExpressQ9SU63.
GenevestigatorQ9SU63.
GermOnlineAT3G48000. Arabidopsis thaliana.

Family and domain databases

InterProIPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH.
[Graphical view]
Gene3DG3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
PANTHERPTHR11699. Aldehyde_dehyd. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameAL2B4_ARATH
AccessionPrimary (citable) accession number: Q9SU63
Secondary accession number(s): Q42090
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: February 9, 2010
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectPPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents