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Q9SU63 (AL2B4_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 99. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Aldehyde dehydrogenase family 2 member B4, mitochondrial

Short name=ALDH2a
EC=1.2.1.3
Gene names
Name:ALDH2B4
Synonyms:ALDH2
Ordered Locus Names:At3g48000
ORF Names:T17F15.130
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length538 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Possesses activity on acetaldehyde and glycolaldehyde in vitro. Ref.2

Catalytic activity

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Subunit structure

Homotetramer By similarity.

Subcellular location

Mitochondrion matrix Potential.

Sequence similarities

Belongs to the aldehyde dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – 2121Mitochondrion Potential
Chain22 – 538517Aldehyde dehydrogenase family 2 member B4, mitochondrial
PRO_0000256056

Regions

Nucleotide binding282 – 2876NAD By similarity

Sites

Active site3051Proton acceptor By similarity
Active site3391Nucleophile By similarity
Site2061Transition state stabilizer By similarity

Experimental info

Sequence conflict1251L → C in CAA81249. Ref.6

Sequences

Sequence LengthMass (Da)Tools
Q9SU63 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: B7C054157659391C

FASTA53858,589
        10         20         30         40         50         60 
MAARRVSSLL SRSFSASSPL LFRSQGRNCY NGGILRRFGT SSAAAEEIIN PSVQVSHTQL 

        70         80         90        100        110        120 
LINGNFVDSA SGKTFPTLDP RTGEVIAHVA EGDAEDINRA VKAARTAFDE GPWPKMSAYE 

       130        140        150        160        170        180 
RSRVLLRFAD LVEKHSEELA SLETWDNGKP YQQSLTAEIP MFARLFRYYA GWADKIHGLT 

       190        200        210        220        230        240 
IPADGNYQVH TLHEPIGVAG QIIPWNFPLL MFAWKVGPAL ACGNTIVLKT AEQTPLTAFY 

       250        260        270        280        290        300 
AGKLFLEAGL PPGVLNIVSG FGATAGAALA SHMDVDKLAF TGSTDTGKVI LGLAANSNLK 

       310        320        330        340        350        360 
PVTLELGGKS PFIVFEDADI DKAVELAHFA LFFNQGQCCC AGSRTFVHEK VYDEFVEKSK 

       370        380        390        400        410        420 
ARALKRVVGD PFRKGIEQGP QIDLKQFEKV MKYIKSGIES NATLECGGDQ IGDKGYFIQP 

       430        440        450        460        470        480 
TVFSNVKDDM LIAQDEIFGP VQSILKFSDV DEVIKRANET KYGLAAGVFT KNLDTANRVS 

       490        500        510        520        530 
RALKAGTVWV NCFDVFDAAI PFGGYKMSGN GREKGIYSLN NYLQIKAVVT ALNKPAWI 

« Hide

References

« Hide 'large scale' references
[1]"Molecular and cellular characterizations of a cDNA clone encoding a novel isozyme of aldehyde dehydrogenase from rice."
Li Y., Nakazono M., Tsutsumi N., Hirai A.
Gene 249:67-74(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Characterization of the aldehyde dehydrogenase gene families of Zea mays and Arabidopsis."
Skibbe D.S., Liu F., Wen T.-J., Yandeau M.D., Cui X., Cao J., Simmons C.R., Schnable P.S.
Plant Mol. Biol. 48:751-764(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
[3]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[4]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[5]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[6]"The Arabidopsis thaliana transcribed genome: the GDR cDNA program."
Philipps G., Gigot C.
Submitted (SEP-1993) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 9-125.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB030820 mRNA. Translation: BAA96792.1.
AF349447 mRNA. Translation: AAM27003.1.
AL049658 Genomic DNA. Translation: CAB41139.1.
CP002686 Genomic DNA. Translation: AEE78355.1.
AF327426 mRNA. Translation: AAG42016.1.
AF349522 mRNA. Translation: AAK15569.1.
AF372911 mRNA. Translation: AAK49627.1.
AY090443 mRNA. Translation: AAL91287.1.
BT000752 mRNA. Translation: AAN31892.1.
BT006371 mRNA. Translation: AAP21179.1.
Z26417 mRNA. Translation: CAA81249.1.
PIRT06683.
RefSeqNP_190383.1. NM_114669.3.
UniGeneAt.22890.

3D structure databases

ProteinModelPortalQ9SU63.
SMRQ9SU63. Positions 54-528.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid9274. 2 interactions.

Proteomic databases

PaxDbQ9SU63.
PRIDEQ9SU63.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G48000.1; AT3G48000.1; AT3G48000.
GeneID823955.
KEGGath:AT3G48000.

Organism-specific databases

GeneFarm4339.
TAIRAT3G48000.

Phylogenomic databases

eggNOGCOG1012.
HOGENOMHOG000271505.
InParanoidQ9SU63.
KOK00128.
OMAMACWKMA.
PhylomeDBQ9SU63.

Enzyme and pathway databases

BioCycARA:AT3G48000-MONOMER.

Gene expression databases

GenevestigatorQ9SU63.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR015657. Aminobutyraldehyde_DH.
[Graphical view]
PANTHERPTHR11699:SF46. PTHR11699:SF46. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. SSF53720. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAL2B4_ARATH
AccessionPrimary (citable) accession number: Q9SU63
Secondary accession number(s): Q42090
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names