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Protein

Aldehyde dehydrogenase family 2 member B4, mitochondrial

Gene

ALDH2B4

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Possesses activity on acetaldehyde and glycolaldehyde in vitro.1 Publication

Catalytic activityi

An aldehyde + NAD+ + H2O = a carboxylate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei206Transition state stabilizerBy similarity1
Active sitei305Proton acceptorPROSITE-ProRule annotation1
Active sitei339NucleophilePROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi282 – 287NADBy similarity6

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: TAIR
  • ATP binding Source: TAIR

GO - Biological processi

  • response to cadmium ion Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BioCyciARA:AT3G48000-MONOMER.
ReactomeiR-ATH-380612. Metabolism of serotonin.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-70350. Fructose catabolism.
R-ATH-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 2 member B4, mitochondrial (EC:1.2.1.3)
Short name:
ALDH2a
Gene namesi
Name:ALDH2B4
Synonyms:ALDH2
Ordered Locus Names:At3g48000
ORF Names:T17F15.130
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G48000.
TAIRilocus:2097845. AT3G48000.

Subcellular locationi

  • Mitochondrion matrix 1 Publication

GO - Cellular componenti

  • chloroplast Source: TAIR
  • mitochondrial matrix Source: UniProtKB-SubCell
  • mitochondrion Source: TAIR

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 38Mitochondrion1 PublicationAdd BLAST38
ChainiPRO_000025605639 – 538Aldehyde dehydrogenase family 2 member B4, mitochondrialAdd BLAST500

Proteomic databases

PaxDbiQ9SU63.
PRIDEiQ9SU63.

Expressioni

Gene expression databases

GenevisibleiQ9SU63. AT.

Interactioni

Subunit structurei

Homotetramer.By similarity

Protein-protein interaction databases

BioGridi9274. 2 interactors.
STRINGi3702.AT3G48000.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SU63.
SMRiQ9SU63.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2450. Eukaryota.
COG1012. LUCA.
HOGENOMiHOG000271505.
InParanoidiQ9SU63.
KOiK00128.
OMAiPLSMATW.
OrthoDBiEOG0936062U.
PhylomeDBiQ9SU63.

Family and domain databases

Gene3Di3.40.605.10. 1 hit.
InterProiView protein in InterPro
IPR016161. Ald_DH/histidinol_DH.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
PfamiView protein in Pfam
PF00171. Aldedh. 1 hit.
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiView protein in PROSITE
PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SU63-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAARRVSSLL SRSFSASSPL LFRSQGRNCY NGGILRRFGT SSAAAEEIIN
60 70 80 90 100
PSVQVSHTQL LINGNFVDSA SGKTFPTLDP RTGEVIAHVA EGDAEDINRA
110 120 130 140 150
VKAARTAFDE GPWPKMSAYE RSRVLLRFAD LVEKHSEELA SLETWDNGKP
160 170 180 190 200
YQQSLTAEIP MFARLFRYYA GWADKIHGLT IPADGNYQVH TLHEPIGVAG
210 220 230 240 250
QIIPWNFPLL MFAWKVGPAL ACGNTIVLKT AEQTPLTAFY AGKLFLEAGL
260 270 280 290 300
PPGVLNIVSG FGATAGAALA SHMDVDKLAF TGSTDTGKVI LGLAANSNLK
310 320 330 340 350
PVTLELGGKS PFIVFEDADI DKAVELAHFA LFFNQGQCCC AGSRTFVHEK
360 370 380 390 400
VYDEFVEKSK ARALKRVVGD PFRKGIEQGP QIDLKQFEKV MKYIKSGIES
410 420 430 440 450
NATLECGGDQ IGDKGYFIQP TVFSNVKDDM LIAQDEIFGP VQSILKFSDV
460 470 480 490 500
DEVIKRANET KYGLAAGVFT KNLDTANRVS RALKAGTVWV NCFDVFDAAI
510 520 530
PFGGYKMSGN GREKGIYSLN NYLQIKAVVT ALNKPAWI
Length:538
Mass (Da):58,589
Last modified:May 1, 2000 - v1
Checksum:iB7C054157659391C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti125L → C in CAA81249 (Ref. 6) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030820 mRNA. Translation: BAA96792.1.
AF349447 mRNA. Translation: AAM27003.1.
AL049658 Genomic DNA. Translation: CAB41139.1.
CP002686 Genomic DNA. Translation: AEE78355.1.
AF327426 mRNA. Translation: AAG42016.1.
AF349522 mRNA. Translation: AAK15569.1.
AF372911 mRNA. Translation: AAK49627.1.
AY090443 mRNA. Translation: AAL91287.1.
BT000752 mRNA. Translation: AAN31892.1.
BT006371 mRNA. Translation: AAP21179.1.
Z26417 mRNA. Translation: CAA81249.1.
PIRiT06683.
RefSeqiNP_190383.1. NM_114669.4.
UniGeneiAt.22890.

Genome annotation databases

EnsemblPlantsiAT3G48000.1; AT3G48000.1; AT3G48000.
GeneIDi823955.
GrameneiAT3G48000.1; AT3G48000.1; AT3G48000.
KEGGiath:AT3G48000.

Similar proteinsi

Entry informationi

Entry nameiAL2B4_ARATH
AccessioniPrimary (citable) accession number: Q9SU63
Secondary accession number(s): Q42090
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families