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Protein

Trehalase

Gene

TRE1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the regulation of trehalose content by hydrolyzing trehalose to glucose.3 Publications

Catalytic activityi

Alpha,alpha-trehalose + H2O = beta-D-glucose + alpha-D-glucose.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei224SubstrateBy similarity1
Binding sitei268SubstrateBy similarity1
Binding sitei378Substrate; via carbonyl oxygenBy similarity1
Active sitei380Proton donor/acceptorBy similarity1
Active sitei580Proton donor/acceptorBy similarity1
Binding sitei595SubstrateBy similarity1

GO - Molecular functioni

  • alpha,alpha-trehalase activity Source: TAIR

GO - Biological processi

  • trehalose catabolic process Source: TAIR

Keywordsi

Molecular functionGlycosidase, Hydrolase
Biological processStress response

Protein family/group databases

CAZyiGH37 Glycoside Hydrolase Family 37

Names & Taxonomyi

Protein namesi
Recommended name:
Trehalase (EC:3.2.1.28)
Alternative name(s):
Alpha,alpha-trehalase
Alpha,alpha-trehalose glucohydrolase
Trehalase 1
Short name:
AtTRE1
Gene namesi
Name:TRE1
Ordered Locus Names:At4g24040
ORF Names:T19F6.15, T19F6.30
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G24040
TAIRilocus:2134961 AT4G24040

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 40HelicalSequence analysisAdd BLAST21
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

No visible phenotype under normal growth conditions, but plants accumulate high levels of trehalose and starch.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004176631 – 626TrehalaseAdd BLAST626

Proteomic databases

PaxDbiQ9SU50
PRIDEiQ9SU50

Expressioni

Tissue specificityi

Highly expressed in flowers. Expressed at low levels in leaves and stems.2 Publications

Gene expression databases

ExpressionAtlasiQ9SU50 baseline and differential
GenevisibleiQ9SU50 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT4G24040.1

Structurei

3D structure databases

ProteinModelPortaliQ9SU50
SMRiQ9SU50
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni231 – 232Substrate bindingBy similarity2
Regioni277 – 279Substrate bindingBy similarity3
Regioni344 – 346Substrate bindingBy similarity3

Sequence similaritiesi

Belongs to the glycosyl hydrolase 37 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0602 Eukaryota
COG1626 LUCA
HOGENOMiHOG000215465
InParanoidiQ9SU50
KOiK01194
OMAiKYDISNG
OrthoDBiEOG093608UZ
PhylomeDBiQ9SU50

Family and domain databases

Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR001661 Glyco_hydro_37
IPR018232 Glyco_hydro_37_CS
PANTHERiPTHR23403 PTHR23403, 1 hit
PfamiView protein in Pfam
PF01204 Trehalase, 1 hit
PRINTSiPR00744 GLHYDRLASE37
SUPFAMiSSF48208 SSF48208, 1 hit
PROSITEiView protein in PROSITE
PS00213 LIPOCALIN, 1 hit
PS00928 TREHALASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SU50-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKSYKLNNPN LLISTHTHNK LFLSSSPFNL LFSFPSFIYL KQQRSLFFFF
60 70 80 90 100
FFFLCFSFTT SMLDSDTDTD SGPVVATTKL VTFLQRVQHT ALRSYPKKQT
110 120 130 140 150
PDPKSYIDLS LKRPYSLSTI ESAFDDLTSE SHDQPVPVET LEKFVKEYFD
160 170 180 190 200
GAGEDLLHHE PVDFVSDPSG FLSNVENEEV REWAREVHGL WRNLSCRVSD
210 220 230 240 250
SVRESADRHT LLPLPEPVII PGSRFREVYY WDSYWVIKGL MTSQMFTTAK
260 270 280 290 300
GLVTNLMSLV ETYGYALNGA RAYYTNRSQP PLLSSMVYEI YNVTKDEELV
310 320 330 340 350
RKAIPLLLKE YEFWNSGKHK VVIRDANGYD HVLSRYYAMW NKPRPESSVF
360 370 380 390 400
DEESASGFST MLEKQRFHRD IATAAESGCD FSTRWMRDPP NFTTMATTSV
410 420 430 440 450
VPVDLNVFLL KMELDIAFMM KVSGDQNGSD RFVKASKARE KAFQTVFWNE
460 470 480 490 500
KAGQWLDYWL SSSGEESETW KAENQNTNVF ASNFAPIWIN SINSDENLVK
510 520 530 540 550
KVVTALKNSG LIAPAGILTS LTNSGQQWDS PNGWAPQQEM IVTGLGRSSV
560 570 580 590 600
KEAKEMAEDI ARRWIKSNYL VYKKSGTIHE KLKVTELGEY GGGGEYMPQT
610 620
GFGWSNGVIL AFLEEYGWPS HLSIEA
Length:626
Mass (Da):71,355
Last modified:May 1, 2000 - v1
Checksum:iA23D8E2C9C2D048F
GO

Sequence cautioni

The sequence AAB63620 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC002343 Genomic DNA Translation: AAB63620.1 Sequence problems.
AL109619 Genomic DNA Translation: CAB51647.1
AL161560 Genomic DNA Translation: CAB81322.1
CP002687 Genomic DNA Translation: AEE84844.1
AK118407 mRNA Translation: BAC43016.1
BT010732 mRNA Translation: AAR23702.1
PIRiT13444
RefSeqiNP_194135.1, NM_118536.4
UniGeneiAt.28685

Genome annotation databases

EnsemblPlantsiAT4G24040.1; AT4G24040.1; AT4G24040
GeneIDi828504
GrameneiAT4G24040.1; AT4G24040.1; AT4G24040
KEGGiath:AT4G24040

Similar proteinsi

Entry informationi

Entry nameiTRE1_ARATH
AccessioniPrimary (citable) accession number: Q9SU50
Secondary accession number(s): O22986
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 13, 2012
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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