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Protein

F-box protein CPR1

Gene

CPR1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Component of SCF(ASK-cullin-F-box) E3 ubiquitin ligase complexes, which may mediate the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates negatively both salicylic acid (SA)-dependent and SA-independent defense signaling.By similarity1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

  • negative regulation of defense response Source: TAIR
  • negative regulation of protein catabolic process Source: TAIR
  • plant-type hypersensitive response Source: UniProtKB-KW
  • SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: GO_Central

Keywordsi

Biological processHypersensitive response, Plant defense, Ubl conjugation pathway

Enzyme and pathway databases

UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
F-box protein CPR1
Alternative name(s):
Protein CONSTITUTIVE EXPRESSER OF PR GENES 1
Protein CONSTITUTIVE EXPRESSER OF PR GENES 301 Publication
Gene namesi
Name:CPR1
Synonyms:CPR301 Publication
Ordered Locus Names:At4g12560
ORF Names:T1P17.150
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G12560.
TAIRilocus:2135615. AT4G12560.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Disruption phenotypei

Temperature dependent; normal at high temperature (above 28 degrees Celsius), but in colder temperature, dwarf morphology, constitutive resistance to the bacterial pathogen Pseudomonas syringae, and induction of defense-response gene expression such as PR-30.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002835021 – 413F-box protein CPR1Add BLAST413

Proteomic databases

PaxDbiQ9SU30.

Expressioni

Tissue specificityi

Expressed in seedling, root, stem, leaves, inflorescence and silique, especially in veins and trichomes.1 Publication

Gene expression databases

ExpressionAtlasiQ9SU30. baseline and differential.

Interactioni

Subunit structurei

Part of a SCF (ASK-cullin-F-box) protein ligase complex (By similarity). Interacts with SKP1A/ASK1, SPK1B/ASK2, ASK9, ASK10, ASK11, ASK13, ASK14, ASK16, ASK17, ASK18 and ASK19. Interacts with TRAF1B (PubMed:26867179).By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
SNC1O235302EBI-15941797,EBI-15866586

Protein-protein interaction databases

BioGridi12167. 16 interactors.
DIPiDIP-59704N.
IntActiQ9SU30. 2 interactors.
STRINGi3702.AT4G12560.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SU30.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 48F-boxPROSITE-ProRule annotationAdd BLAST48

Domaini

The F-box is necessary for the interaction with ASK proteins.By similarity

Phylogenomic databases

eggNOGiENOG410J96M. Eukaryota.
ENOG4111BET. LUCA.
HOGENOMiHOG000090389.
InParanoidiQ9SU30.
OMAiCPSSYSA.
OrthoDBiEOG09360EFF.
PhylomeDBiQ9SU30.

Family and domain databases

InterProiView protein in InterPro
IPR006527. F-box-assoc_dom_typ1.
IPR017451. F-box-assoc_interact_dom.
IPR036047. F-box-like_dom_sf.
IPR001810. F-box_dom.
PfamiView protein in Pfam
PF00646. F-box. 1 hit.
PF07734. FBA_1. 1 hit.
SMARTiView protein in SMART
SM00256. FBOX. 1 hit.
SUPFAMiSSF81383. SSF81383. 1 hit.
TIGRFAMsiTIGR01640. F_box_assoc_1. 1 hit.
PROSITEiView protein in PROSITE
PS50181. FBOX. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9SU30-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATIPMDIVN DIFLRLPAKT LVRCRALSKP CYHLINDPDF IESHLHRVLQ
60 70 80 90 100
TGDHLMILLR GALRLYSVDL DSLDSVSDVE HPMKRGGPTE VFGSSNGLIG
110 120 130 140 150
LSNSPTDLAV FNPSTRQIHR LPPSSIDLPD GSSTRGYVFY GLGYDSVSDD
160 170 180 190 200
YKVVRMVQFK IDSEDELGCS FPYEVKVFSL KKNSWKRIES VASSIQLLFY
210 220 230 240 250
FYYHLLYRRG YGVLAGNSLH WVLPRRPGLI AFNLIVRFDL ALEEFEIVRF
260 270 280 290 300
PEAVANGNVD IQMDIGVLDG CLCLMCNYDQ SYVDVWMMKE YNVRDSWTKV
310 320 330 340 350
FTVQKPKSVK SFSYMRPLVY SKDKKKVLLE LNNTKLVWFD LESKKMSTLR
360 370 380 390 400
IKDCPSSYSA ELVVSSLVLG CKGDLNNIKY RKEQQAKEAR EAKIMQNTKR
410
RDDFLSKGFK LVL
Length:413
Mass (Da):47,259
Last modified:April 3, 2007 - v2
Checksum:iFFE6E60966C780E4
GO

Sequence cautioni

The sequence CAB41726 differs from that shown. Reason: Erroneous gene model prediction.Curated
The sequence CAB78299 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti402D → G in BAF01202 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049730 Genomic DNA. Translation: CAB41726.1. Sequence problems.
AL161534 Genomic DNA. Translation: CAB78299.1. Sequence problems.
CP002687 Genomic DNA. Translation: AEE83147.1.
CP002687 Genomic DNA. Translation: AEE83148.1.
CP002687 Genomic DNA. Translation: ANM66283.1.
AK229339 mRNA. Translation: BAF01202.1.
PIRiT07648.
RefSeqiNP_001078377.1. NM_001084908.2.
NP_001328191.1. NM_001340790.1.
NP_192993.2. NM_117326.4.
UniGeneiAt.33465.

Genome annotation databases

EnsemblPlantsiAT4G12560.1; AT4G12560.1; AT4G12560.
AT4G12560.2; AT4G12560.2; AT4G12560.
AT4G12560.3; AT4G12560.3; AT4G12560.
GeneIDi826869.
GrameneiAT4G12560.1; AT4G12560.1; AT4G12560.
AT4G12560.2; AT4G12560.2; AT4G12560.
AT4G12560.3; AT4G12560.3; AT4G12560.
KEGGiath:AT4G12560.

Similar proteinsi

Entry informationi

Entry nameiCPR1_ARATH
AccessioniPrimary (citable) accession number: Q9SU30
Secondary accession number(s): Q0WNU7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: April 3, 2007
Last modified: November 22, 2017
This is version 103 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways