Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Betaine aldehyde dehydrogenase 2, mitochondrial

Gene

ALDH10A9

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

Betaine aldehyde + NAD+ + H2O = betaine + NADH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei162 – 1621Transition state stabilizerBy similarity
Active sitei260 – 2601Proton acceptorPROSITE-ProRule annotation
Active sitei294 – 2941NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi238 – 2436NADBy similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase (NAD) activity Source: TAIR
  2. betaine-aldehyde dehydrogenase activity Source: TAIR

GO - Biological processi

  1. oxidation-reduction process Source: TAIR
  2. response to abscisic acid Source: TAIR
  3. response to water deprivation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciARA:AT3G48170-MONOMER.
MetaCyc:AT3G48170-MONOMER.
ReactomeiREACT_230585. Carnitine synthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Betaine aldehyde dehydrogenase 2, mitochondrial (EC:1.2.1.8)
Short name:
BADH
Alternative name(s):
Aldehyde dehydrogenase family 10 member A9
Gene namesi
Name:ALDH10A9
Ordered Locus Names:At3g48170
ORF Names:T24C20.50
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G48170.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-SubCell
  2. peroxisome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 6565MitochondrionSequence AnalysisAdd
BLAST
Chaini66 – 503438Betaine aldehyde dehydrogenase 2, mitochondrialPRO_0000256063Add
BLAST

Proteomic databases

PaxDbiQ9STS1.
PRIDEiQ9STS1.

Expressioni

Gene expression databases

ExpressionAtlasiQ9STS1. baseline and differential.
GenevestigatoriQ9STS1.

Interactioni

Subunit structurei

Homodimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ9STS1.
SMRiQ9STS1. Positions 5-503.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ9STS1.
KOiK00130.
OMAiNRLQFYI.
PhylomeDBiQ9STS1.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9STS1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAITVPRRQL FIGGQWTEPV LRKTLPVVNP ATEDIIGYIP AATSEDVELA
60 70 80 90 100
VEAARKAFTR NNGKDWARAT GAVRAKYLRA IAAKVIERKS ELANLEAIDC
110 120 130 140 150
GKPLDEAAWD MDDVAGCFEY YADLAEGLDA KQKTPLSLPM DTFKGYILKE
160 170 180 190 200
PIGVVGMITP WNYPLLMAVW KVAPSLAAGC TAILKPSELA SLTCLELADI
210 220 230 240 250
CREVGLPPGV LNILTGLGTE AGAPLASHPH VDKIVFTGST TTGSSIMTSA
260 270 280 290 300
AKLVKPVSLE LGGKSPIIVF DDVDIDKAVE WTMFGCFWTN GQICSATSRL
310 320 330 340 350
LVHERIADEF LDKLVKWTKN IKISDPFEEG CRLGPVVSKG QYERVLKFVS
360 370 380 390 400
NARNEGATVL CGGVRPEHLK KGYFVEPAIV SNVTTSMEIW REEVFGPALC
410 420 430 440 450
VKTFSTEDEA IQLANDSQYG LAGAVLSNDL ERCDRVSKAF QAGIVWVNCS
460 470 480 490 500
QPCFCQAPWG GTKRSGFGRE LGEWGLENYL SVKQVTQYIS DEPWGWYKPP

SKL
Length:503
Mass (Da):54,918
Last modified:May 1, 2000 - v1
Checksum:i7E17AE86E9F2784C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096856 Genomic DNA. Translation: CAB51064.1.
CP002686 Genomic DNA. Translation: AEE78376.1.
AF370333 mRNA. Translation: AAK44148.1.
AY062987 mRNA. Translation: AAL34161.1.
Z29888 mRNA. Translation: CAA82832.1.
PIRiT13006.
RefSeqiNP_190400.1. NM_114686.3.
UniGeneiAt.1613.

Genome annotation databases

EnsemblPlantsiAT3G48170.1; AT3G48170.1; AT3G48170.
GeneIDi823972.
KEGGiath:AT3G48170.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096856 Genomic DNA. Translation: CAB51064.1.
CP002686 Genomic DNA. Translation: AEE78376.1.
AF370333 mRNA. Translation: AAK44148.1.
AY062987 mRNA. Translation: AAL34161.1.
Z29888 mRNA. Translation: CAA82832.1.
PIRiT13006.
RefSeqiNP_190400.1. NM_114686.3.
UniGeneiAt.1613.

3D structure databases

ProteinModelPortaliQ9STS1.
SMRiQ9STS1. Positions 5-503.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ9STS1.
PRIDEiQ9STS1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G48170.1; AT3G48170.1; AT3G48170.
GeneIDi823972.
KEGGiath:AT3G48170.

Organism-specific databases

TAIRiAT3G48170.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
InParanoidiQ9STS1.
KOiK00130.
OMAiNRLQFYI.
PhylomeDBiQ9STS1.

Enzyme and pathway databases

BioCyciARA:AT3G48170-MONOMER.
MetaCyc:AT3G48170-MONOMER.
ReactomeiREACT_230585. Carnitine synthesis.

Gene expression databases

ExpressionAtlasiQ9STS1. baseline and differential.
GenevestigatoriQ9STS1.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR029510. Ald_DH_CS_GLU.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "The Arabidopsis thaliana transcribed genome: the GDR cDNA program."
    Raynal M., Grellet F., Laudie M., Meyer Y., Cooke R., Delseny M.
    Submitted (FEB-1994) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 417-503.
    Strain: cv. Columbia.
    Tissue: Seed.
  5. Cited for: NOMENCLATURE.

Entry informationi

Entry nameiBADH2_ARATH
AccessioniPrimary (citable) accession number: Q9STS1
Secondary accession number(s): Q42237
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: May 1, 2000
Last modified: January 7, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.