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Protein

1-aminocyclopropane-1-carboxylate synthase 7

Gene

ACS7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

1-aminocyclopropane-1-carboxylate synthase (ACS) enzymes catalyze the conversion of S-adenosyl-L-methionine (SAM) into 1-aminocyclopropane-1-carboxylate (ACC), a direct precursor of ethylene.

Miscellaneous

The stability of ACS proteins, and the regulation of such stability, play a central role in ethylene biosynthesis.

Catalytic activityi

S-adenosyl-L-methionine = 1-aminocyclopropane-1-carboxylate + methylthioadenosine.1 Publication

Cofactori

Kineticsi

  1. KM=8.3 µM for AdoMet
  1. Vmax=13.5 µM/h/mg enzyme

pH dependencei

Optimum pH is 8.

Pathwayi: ethylene biosynthesis via S-adenosyl-L-methionine

This protein is involved in step 1 of the subpathway that synthesizes ethylene from S-adenosyl-L-methionine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 1-aminocyclopropane-1-carboxylate synthase 4 (ACS4), 1-aminocyclopropane-1-carboxylate synthase 8 (ACS8), 1-aminocyclopropane-1-carboxylate synthase 2 (ACS2), 1-aminocyclopropane-1-carboxylate synthase 7 (ACS7), 1-aminocyclopropane-1-carboxylate synthase 11 (ACS11), 1-aminocyclopropane-1-carboxylate synthase 9 (ACS9), 1-aminocyclopropane-1-carboxylate synthase 6 (ACS6), 1-aminocyclopropane-1-carboxylate synthase 5 (ACS5)
  2. 1-aminocyclopropane-1-carboxylate oxidase 2 (ACO2), 1-aminocyclopropane-1-carboxylate oxidase 3 (At1g12010), 1-aminocyclopropane-1-carboxylate oxidase 4 (ACO4), 1-aminocyclopropane-1-carboxylate oxidase 1 (ACO1), 1-aminocyclopropane-1-carboxylate oxidase 5 (At1g77330)
This subpathway is part of the pathway ethylene biosynthesis via S-adenosyl-L-methionine, which is itself part of Alkene biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes ethylene from S-adenosyl-L-methionine, the pathway ethylene biosynthesis via S-adenosyl-L-methionine and in Alkene biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei61SubstrateBy similarity1
Binding sitei100SubstrateBy similarity1

GO - Molecular functioni

  • 1-aminocyclopropane-1-carboxylate synthase activity Source: TAIR
  • identical protein binding Source: IntAct
  • pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  • ethylene biosynthetic process Source: TAIR
  • fruit ripening Source: UniProtKB-KW

Keywordsi

Molecular functionLyase
Biological processEthylene biosynthesis, Fruit ripening
LigandPyridoxal phosphate, S-adenosyl-L-methionine

Enzyme and pathway databases

SABIO-RKiQ9STR4
UniPathwayiUPA00384; UER00562

Names & Taxonomyi

Protein namesi
Recommended name:
1-aminocyclopropane-1-carboxylate synthase 7 (EC:4.4.1.14)
Short name:
ACC synthase 7
Alternative name(s):
S-adenosyl-L-methionine methylthioadenosine-lyase 7
Gene namesi
Name:ACS7
Ordered Locus Names:At4g26200
ORF Names:T25K17.10
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G26200
TAIRilocus:2136779 AT4G26200

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001239011 – 4471-aminocyclopropane-1-carboxylate synthase 7Add BLAST447

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei285N6-(pyridoxal phosphate)lysineBy similarity1

Post-translational modificationi

Ubiquitinated by XBAT32. Ubiquitination probably leads to its subsequent degradation, thus controlling ethylene production.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

PaxDbiQ9STR4
PRIDEiQ9STR4

PTM databases

iPTMnetiQ9STR4

Expressioni

Tissue specificityi

Expressed in roots.1 Publication

Inductioni

By cycloheximide (CHX).1 Publication

Gene expression databases

ExpressionAtlasiQ9STR4 baseline and differential
GenevisibleiQ9STR4 AT

Interactioni

Subunit structurei

Homodimer and heterodimer. In vivo, the relevance of heterodimerization with other ACS enzymes is however unsure (By similarity). Interacts with XBAT32.By similarity1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi14013, 4 interactors
IntActiQ9STR4, 2 interactors
STRINGi3702.AT4G26200.1

Structurei

3D structure databases

ProteinModelPortaliQ9STR4
SMRiQ9STR4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0256 Eukaryota
COG0436 LUCA
HOGENOMiHOG000011234
InParanoidiQ9STR4
KOiK01762
OMAiHVPLDCE
OrthoDBiEOG09360ARA
PhylomeDBiQ9STR4

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR004838 NHTrfase_class1_PyrdxlP-BS
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit
PROSITEiView protein in PROSITE
PS00105 AA_TRANSFER_CLASS_1, 1 hit

Sequencei

Sequence statusi: Complete.

Q9STR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGLPLMMERS SNNNNVELSR VAVSDTHGED SPYFAGWKAY DENPYDESHN
60 70 80 90 100
PSGVIQMGLA ENQVSFDLLE TYLEKKNPEG SMWGSKGAPG FRENALFQDY
110 120 130 140 150
HGLKTFRQAM ASFMEQIRGG KARFDPDRIV LTAGATAANE LLTFILADPN
160 170 180 190 200
DALLVPTPYY PGFDRDLRWR TGVKIVPIHC DSSNHFQITP EALESAYQTA
210 220 230 240 250
RDANIRVRGV LITNPSNPLG ATVQKKVLED LLDFCVRKNI HLVSDEIYSG
260 270 280 290 300
SVFHASEFTS VAEIVENIDD VSVKERVHIV YSLSKDLGLP GFRVGTIYSY
310 320 330 340 350
NDNVVRTARR MSSFTLVSSQ TQHMLASMLS DEEFTEKYIR INRERLRRRY
360 370 380 390 400
DTIVEGLKKA GIECLKGNAG LFCWMNLGFL LEKKTKDGEL QLWDVILKEL
410 420 430 440
NLNISPGSSC HCSEVGWFRV CFANMSENTL EIALKRIHEF MDRRRRF
Length:447
Mass (Da):50,666
Last modified:May 1, 2000 - v1
Checksum:iE78CC1FC834FD4A9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049171 Genomic DNA Translation: CAB38949.1
AL161564 Genomic DNA Translation: CAB79475.1
CP002687 Genomic DNA Translation: AEE85169.1
AF332390 mRNA Translation: AAG48754.1
PIRiT06004
RefSeqiNP_194350.1, NM_118753.3
UniGeneiAt.20362

Genome annotation databases

EnsemblPlantsiAT4G26200.1; AT4G26200.1; AT4G26200
GeneIDi828726
GrameneiAT4G26200.1; AT4G26200.1; AT4G26200
KEGGiath:AT4G26200

Similar proteinsi

Entry informationi

Entry namei1A17_ARATH
AccessioniPrimary (citable) accession number: Q9STR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 118 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families
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