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Protein

Acyl-CoA-binding domain-containing protein 2

Gene

ACBP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity. Can interact in vitro with palmitoyl-CoA, but not with oleoyl-CoA. Binds to lead ions (Pb). May function as an intracellular carrier of acyl-CoA esters. Required for proper phospholipid and, to a lower extent, galactolipid composition.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei162Acyl-CoA1
Binding sitei181Acyl-CoA1

GO - Molecular functioni

  • fatty-acyl-CoA binding Source: UniProtKB
  • lead ion binding Source: TAIR
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

  • lipid transport Source: TAIR
  • response to hypoxia Source: TAIR
  • response to lead ion Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

Lead, Lipid-binding, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-75105. Fatty Acyl-CoA Biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 2
Short name:
Acyl-CoA binding protein 2
Gene namesi
Name:ACBP2
Ordered Locus Names:At4g27780
ORF Names:T27E11.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G27780.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31Helical; Signal-anchorSequence analysisAdd BLAST21

GO - Cellular componenti

  • endoplasmic reticulum Source: TAIR
  • endoplasmic reticulum membrane Source: UniProtKB-SubCell
  • glyoxysome Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • peroxisomal membrane Source: UniProtKB-SubCell
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi136Y → A: Loss of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi140K → A: Loss of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi142A → D: Slight increase of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi145G → A: Normal palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi152P → A: Slight increase of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi162K → A: Loss of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi163W → A: Normal palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi166W → A: Slight increase of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi177A → S: Slight increase of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi181Y → A: Loss of palmitoyl-CoA-binding activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003799011 – 354Acyl-CoA-binding domain-containing protein 2Add BLAST354

Proteomic databases

PaxDbiQ9STP8.

PTM databases

iPTMnetiQ9STP8.

Expressioni

Tissue specificityi

Mostly expressed in roots and flowers, and, to a lower extent, in stems, pods and leaves (at protein level).2 Publications

Inductioni

In roots by lead.1 Publication

Gene expression databases

GenevisibleiQ9STP8. AT.

Interactioni

Subunit structurei

Interacts (via ankyrin repeats) with HIPP26 and the ethylene-responsive element-binding proteins RAP2-3/EBP and RAP2-12. Interacts with CSE.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
HIPP26Q9SZN75EBI-368234,EBI-2008207
RAP2-3P427363EBI-368234,EBI-368243

Protein-protein interaction databases

BioGridi14178. 5 interactors.
DIPiDIP-32848N.
IntActiQ9STP8. 3 interactors.
STRINGi3702.AT4G27780.1.

Structurei

3D structure databases

ProteinModelPortaliQ9STP8.
SMRiQ9STP8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 194ACBPROSITE-ProRule annotationAdd BLAST91
Repeati265 – 294ANK 1Add BLAST30
Repeati298 – 327ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni136 – 140Acyl-CoA binding5

Sequence similaritiesi

Belongs to the ACBP family.Curated
Contains 1 ACB (acyl-CoA-binding) domain.PROSITE-ProRule annotation
Contains 2 ANK repeats.PROSITE-ProRule annotation

Keywords - Domaini

ANK repeat, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000241133.
InParanoidiQ9STP8.
OMAiCESDWPW.
OrthoDBiEOG09360HG4.
PhylomeDBiQ9STP8.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR000582. Acyl-CoA-binding_protein.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
PR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF47027. SSF47027. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS51228. ACB_2. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9STP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWAQLAQS VILGLIFSYL LAKLISIVVT FKEDNLSLTR HPEESQLEIK
60 70 80 90 100
PEGVDSRRLD SSCGGFGGEA DSLVAEQGSS RSDSVAGDDS EEDDDWEGVE
110 120 130 140 150
STELDEAFSA ATLFVTTAAA DRLSQKVPSD VQQQLYGLYK IATEGPCTAP
160 170 180 190 200
QPSALKMTAR AKWQAWQKLG AMPPEEAMEK YIEIVTQLYP TWLDGGVKAG
210 220 230 240 250
SRGGDDAASN SRGTMGPVFS SLVYDEESEN ELKIDAIHGF AREGEVENLL
260 270 280 290 300
KSIESGIPVN ARDSEGRTPL HWAIDRGHLN IAKVLVDKNA DVNAKDNEGQ
310 320 330 340 350
TPLHYAVVCD REAIAEFLVK QNANTAAKDE DGNSPLDLCE SDWPWIRDSA

KQAD
Length:354
Mass (Da):38,480
Last modified:May 1, 2000 - v1
Checksum:i84DF085DB5FBD05B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178947 mRNA. Translation: AAG46056.1.
AF192307 Genomic DNA. Translation: AAG46057.1.
AF320561 mRNA. Translation: AAK38078.1.
AL078579 Genomic DNA. Translation: CAB43966.1.
AL161571 Genomic DNA. Translation: CAB81427.1.
CP002687 Genomic DNA. Translation: AEE85391.1.
AY090256 mRNA. Translation: AAL90917.1.
AY122892 mRNA. Translation: AAM67425.1.
AY088510 mRNA. Translation: AAM66045.1.
PIRiT09017.
RefSeqiNP_194507.1. NM_118916.3.
UniGeneiAt.25382.

Genome annotation databases

EnsemblPlantsiAT4G27780.1; AT4G27780.1; AT4G27780.
GeneIDi828891.
GrameneiAT4G27780.1; AT4G27780.1; AT4G27780.
KEGGiath:AT4G27780.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178947 mRNA. Translation: AAG46056.1.
AF192307 Genomic DNA. Translation: AAG46057.1.
AF320561 mRNA. Translation: AAK38078.1.
AL078579 Genomic DNA. Translation: CAB43966.1.
AL161571 Genomic DNA. Translation: CAB81427.1.
CP002687 Genomic DNA. Translation: AEE85391.1.
AY090256 mRNA. Translation: AAL90917.1.
AY122892 mRNA. Translation: AAM67425.1.
AY088510 mRNA. Translation: AAM66045.1.
PIRiT09017.
RefSeqiNP_194507.1. NM_118916.3.
UniGeneiAt.25382.

3D structure databases

ProteinModelPortaliQ9STP8.
SMRiQ9STP8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi14178. 5 interactors.
DIPiDIP-32848N.
IntActiQ9STP8. 3 interactors.
STRINGi3702.AT4G27780.1.

PTM databases

iPTMnetiQ9STP8.

Proteomic databases

PaxDbiQ9STP8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G27780.1; AT4G27780.1; AT4G27780.
GeneIDi828891.
GrameneiAT4G27780.1; AT4G27780.1; AT4G27780.
KEGGiath:AT4G27780.

Organism-specific databases

TAIRiAT4G27780.

Phylogenomic databases

eggNOGiKOG0817. Eukaryota.
COG4281. LUCA.
HOGENOMiHOG000241133.
InParanoidiQ9STP8.
OMAiCESDWPW.
OrthoDBiEOG09360HG4.
PhylomeDBiQ9STP8.

Enzyme and pathway databases

ReactomeiR-ATH-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

PROiQ9STP8.

Gene expression databases

GenevisibleiQ9STP8. AT.

Family and domain databases

Gene3Di1.20.80.10. 1 hit.
1.25.40.20. 1 hit.
InterProiIPR000582. Acyl-CoA-binding_protein.
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR014352. FERM/acyl-CoA-bd_prot_3-hlx.
[Graphical view]
PfamiPF00887. ACBP. 1 hit.
[Graphical view]
PRINTSiPR00689. ACOABINDINGP.
PR01415. ANKYRIN.
SMARTiSM00248. ANK. 2 hits.
[Graphical view]
SUPFAMiSSF47027. SSF47027. 1 hit.
SSF48403. SSF48403. 1 hit.
PROSITEiPS51228. ACB_2. 1 hit.
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiACBP2_ARATH
AccessioniPrimary (citable) accession number: Q9STP8
Secondary accession number(s): Q9FR48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.