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Protein

Acyl-CoA-binding domain-containing protein 2

Gene

ACBP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds medium- and long-chain acyl-CoA esters with very high affinity. Can interact in vitro with palmitoyl-CoA, but not with oleoyl-CoA. Binds to lead ions (Pb). May function as an intracellular carrier of acyl-CoA esters. Required for proper phospholipid and, to a lower extent, galactolipid composition.4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei162Acyl-CoA1 Publication1
Binding sitei181Acyl-CoA1 Publication1

GO - Molecular functioni

  • fatty-acyl-CoA binding Source: UniProtKB
  • lead ion binding Source: TAIR
  • lipid binding Source: UniProtKB-KW

GO - Biological processi

  • lipid transport Source: TAIR
  • response to hypoxia Source: TAIR
  • response to lead ion Source: UniProtKB

Keywordsi

Biological processTransport
LigandLead, Lipid-binding, Metal-binding

Enzyme and pathway databases

ReactomeiR-ATH-77289 Mitochondrial Fatty Acid Beta-Oxidation

Names & Taxonomyi

Protein namesi
Recommended name:
Acyl-CoA-binding domain-containing protein 2
Short name:
Acyl-CoA binding protein 2
Gene namesi
Name:ACBP2
Ordered Locus Names:At4g27780
ORF Names:T27E11.20
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G27780
TAIRilocus:2137380 AT4G27780

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei11 – 31Helical; Signal-anchorSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Endoplasmic reticulum, Membrane, Peroxisome

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi136Y → A: Loss of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi140K → A: Loss of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi142A → D: Slight increase of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi145G → A: Normal palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi152P → A: Slight increase of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi162K → A: Loss of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi163W → A: Normal palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi166W → A: Slight increase of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi177A → S: Slight increase of palmitoyl-CoA-binding activity. 1 Publication1
Mutagenesisi181Y → A: Loss of palmitoyl-CoA-binding activity. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003799011 – 354Acyl-CoA-binding domain-containing protein 2Add BLAST354

Proteomic databases

PaxDbiQ9STP8

PTM databases

iPTMnetiQ9STP8

Expressioni

Tissue specificityi

Mostly expressed in roots and flowers, and, to a lower extent, in stems, pods and leaves (at protein level).2 Publications

Inductioni

In roots by lead.1 Publication

Gene expression databases

ExpressionAtlasiQ9STP8 baseline and differential
GenevisibleiQ9STP8 AT

Interactioni

Subunit structurei

Interacts (via ankyrin repeats) with HIPP26 and the ethylene-responsive element-binding proteins RAP2-3/EBP and RAP2-12. Interacts with CSE.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi14178, 5 interactors
DIPiDIP-32848N
IntActiQ9STP8, 4 interactors
STRINGi3702.AT4G27780.1

Structurei

3D structure databases

ProteinModelPortaliQ9STP8
SMRiQ9STP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini104 – 194ACBPROSITE-ProRule annotationAdd BLAST91
Repeati265 – 294ANK 1Add BLAST30
Repeati298 – 327ANK 2Add BLAST30

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni136 – 140Acyl-CoA binding1 Publication5

Sequence similaritiesi

Belongs to the ACBP family.Curated

Keywords - Domaini

ANK repeat, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0817 Eukaryota
COG4281 LUCA
HOGENOMiHOG000241133
InParanoidiQ9STP8
OMAiKEEMQAI
OrthoDBiEOG09360HG4
PhylomeDBiQ9STP8

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.20.80.10, 1 hit
1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR000582 Acyl-CoA-binding_protein
IPR035984 Acyl-CoA-binding_sf
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR014352 FERM/acyl-CoA-bd_prot_sf
PfamiView protein in Pfam
PF00887 ACBP, 1 hit
PF12796 Ank_2, 1 hit
PRINTSiPR00689 ACOABINDINGP
PR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF47027 SSF47027, 1 hit
SSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS51228 ACB_2, 1 hit
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 2 hits

Sequencei

Sequence statusi: Complete.

Q9STP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWAQLAQS VILGLIFSYL LAKLISIVVT FKEDNLSLTR HPEESQLEIK
60 70 80 90 100
PEGVDSRRLD SSCGGFGGEA DSLVAEQGSS RSDSVAGDDS EEDDDWEGVE
110 120 130 140 150
STELDEAFSA ATLFVTTAAA DRLSQKVPSD VQQQLYGLYK IATEGPCTAP
160 170 180 190 200
QPSALKMTAR AKWQAWQKLG AMPPEEAMEK YIEIVTQLYP TWLDGGVKAG
210 220 230 240 250
SRGGDDAASN SRGTMGPVFS SLVYDEESEN ELKIDAIHGF AREGEVENLL
260 270 280 290 300
KSIESGIPVN ARDSEGRTPL HWAIDRGHLN IAKVLVDKNA DVNAKDNEGQ
310 320 330 340 350
TPLHYAVVCD REAIAEFLVK QNANTAAKDE DGNSPLDLCE SDWPWIRDSA

KQAD
Length:354
Mass (Da):38,480
Last modified:May 1, 2000 - v1
Checksum:i84DF085DB5FBD05B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF178947 mRNA Translation: AAG46056.1
AF192307 Genomic DNA Translation: AAG46057.1
AF320561 mRNA Translation: AAK38078.1
AL078579 Genomic DNA Translation: CAB43966.1
AL161571 Genomic DNA Translation: CAB81427.1
CP002687 Genomic DNA Translation: AEE85391.1
AY090256 mRNA Translation: AAL90917.1
AY122892 mRNA Translation: AAM67425.1
AY088510 mRNA Translation: AAM66045.1
PIRiT09017
RefSeqiNP_194507.1, NM_118916.3
UniGeneiAt.25382

Genome annotation databases

EnsemblPlantsiAT4G27780.1; AT4G27780.1; AT4G27780
GeneIDi828891
GrameneiAT4G27780.1; AT4G27780.1; AT4G27780
KEGGiath:AT4G27780

Similar proteinsi

Entry informationi

Entry nameiACBP2_ARATH
AccessioniPrimary (citable) accession number: Q9STP8
Secondary accession number(s): Q9FR48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health