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Q9STL5 (CEP3_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
KDEL-tailed cysteine endopeptidase CEP3
EC=3.4.22.-
Gene names
Name:CEP3
Ordered Locus Names:At3g48350
ORF Names:T29H11.130
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length364 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Involved in the final stage of developmental programmed cell death and in intercalation of new cells. Cleaves extensins, thus probably supporing the final cell collapse By similarity. Ref.4

Subcellular location

Endoplasmic reticulum Probable.

Tissue specificity

Expressed in roots, stems, flowers, buds, green siliques, trichomes and near the stomata of cotyledons but not of true leaves. Found at the hypocotyl-root transition zone, in the vascular tissue, along primary and lateral roots, but not in root tips. Never found in the abscission zone of flower organs. Ref.4

Developmental stage

Expressed during silique development, but limited to the carpels and the pedicel. Ref.4

Sequence similarities

Belongs to the peptidase C1 family.

Ontologies

Keywords
   Cellular componentEndoplasmic reticulum
   DomainSignal
   Molecular functionHydrolase
Protease
Thiol protease
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processproteolysis

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentendoplasmic reticulum

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncysteine-type peptidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2020 Potential
Chain21 – 364344KDEL-tailed cysteine endopeptidase CEP3
PRO_0000403791

Regions

Motif361 – 3644Prevents secretion from ER Potential

Sites

Active site1501 By similarity
Active site2871 By similarity
Active site3081 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9STL5 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 81C725D07DCE2E78

FASTA36440,971
        10         20         30         40         50         60 
MKLFFIVLIS FLSLLQASKG FDFDEKELET EENVWKLYER WRGHHSVSRA SHEAIKRFNV 

        70         80         90        100        110        120 
FRHNVLHVHR TNKKNKPYKL KINRFADITH HEFRSSYAGS NVKHHRMLRG PKRGSGGFMY 

       130        140        150        160        170        180 
ENVTRVPSSV DWREKGAVTE VKNQQDCGSC WAFSTVAAVE GINKIRTNKL VSLSEQELVD 

       190        200        210        220        230        240 
CDTEENQGCA GGLMEPAFEF IKNNGGIKTE ETYPYDSSDV QFCRANSIGG ETVTIDGHEH 

       250        260        270        280        290        300 
VPENDEEELL KAVAHQPVSV AIDAGSSDFQ LYSEGVFIGE CGTQLNHGVV IVGYGETKNG 

       310        320        330        340        350        360 
TKYWIVRNSW GPEWGEGGYV RIERGISENE GRCGIAMEAS YPTKLSSTPS THESVVRDDV 


KDEL

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Functional annotation of a full-length Arabidopsis cDNA collection."
Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T., Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y., Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K., Shinagawa A., Shinozaki K.
Science 296:141-145(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"KDEL-tailed cysteine endopeptidases involved in programmed cell death, intercalation of new cells, and dismantling of extensin scaffolds."
Helm M., Schmid M., Hierl G., Terneus K., Tan L., Lottspeich F., Kieliszewski M.J., Gietl C.
Am. J. Bot. 95:1049-1062(2008)
Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK119026 mRNA. Translation: BAC43602.1.
AL049659 Genomic DNA. Translation: CAB41163.1.
CP002686 Genomic DNA. Translation: AEE78406.1.
IPIIPI00525150.
PIRT06707.
RefSeqNP_566901.1. NM_114696.3.
UniGeneAt.3162.

3D structure databases

HSSPHSSP built from PDB template 1S4V based on UniProtKB O65039.
ProteinModelPortalQ9STL5.
SMRQ9STL5. Positions 38-347.
ModBaseSearch...

Protein family/group databases

MEROPSC01.A02.

Proteomic databases

PaxDbQ9STL5.
PRIDEQ9STL5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G48350.1; AT3G48350.1; AT3G48350.
GeneID823993.
KEGGath:AT3G48350.

Organism-specific databases

TAIRAt3g48350.

Phylogenomic databases

eggNOGCOG4870.
HOGENOMHOG000230773.
InParanoidQ9STL5.
KOK16292.
OMADITHHEF.
PhylomeDBQ9STL5.
ProtClustDBCLSN2917387.

Gene expression databases

GenevestigatorQ9STL5.

Family and domain databases

InterProIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERPTHR12411. PTHR12411. 1 hit.
PfamPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSPR00705. PAPAIN.
SMARTSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEPS00014. ER_TARGET. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameCEP3_ARATH
AccessionPrimary (citable) accession number: Q9STL5
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: May 1, 2000
Last modified: May 1, 2013
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Peptidase families

Classification of peptidase families and list of entries

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents