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Q9STL5

- CEP3_ARATH

UniProt

Q9STL5 - CEP3_ARATH

Protein

KDEL-tailed cysteine endopeptidase CEP3

Gene

CEP3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 82 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in the final stage of developmental programmed cell death and in intercalation of new cells. Cleaves extensins, thus probably supporing the final cell collapse By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei150 – 1501By similarity
    Active sitei287 – 2871By similarity
    Active sitei308 – 3081By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciARA:AT3G48350-MONOMER.

    Protein family/group databases

    MEROPSiC01.A02.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KDEL-tailed cysteine endopeptidase CEP3 (EC:3.4.22.-)
    Gene namesi
    Name:CEP3
    Ordered Locus Names:At3g48350
    ORF Names:T29H11.130
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G48350.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 364344KDEL-tailed cysteine endopeptidase CEP3PRO_0000403791Add
    BLAST

    Proteomic databases

    PaxDbiQ9STL5.
    PRIDEiQ9STL5.

    Expressioni

    Tissue specificityi

    Expressed in roots, stems, flowers, buds, green siliques, trichomes and near the stomata of cotyledons but not of true leaves. Found at the hypocotyl-root transition zone, in the vascular tissue, along primary and lateral roots, but not in root tips. Never found in the abscission zone of flower organs.1 Publication

    Developmental stagei

    Expressed during silique development, but limited to the carpels and the pedicel.1 Publication

    Gene expression databases

    GenevestigatoriQ9STL5.

    Interactioni

    Protein-protein interaction databases

    BioGridi9312. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9STL5.
    SMRiQ9STL5. Positions 38-347.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi361 – 3644Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    HOGENOMiHOG000230773.
    InParanoidiQ9STL5.
    KOiK16292.
    OMAiFADITHH.
    PhylomeDBiQ9STL5.

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9STL5-1 [UniParc]FASTAAdd to Basket

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    MKLFFIVLIS FLSLLQASKG FDFDEKELET EENVWKLYER WRGHHSVSRA    50
    SHEAIKRFNV FRHNVLHVHR TNKKNKPYKL KINRFADITH HEFRSSYAGS 100
    NVKHHRMLRG PKRGSGGFMY ENVTRVPSSV DWREKGAVTE VKNQQDCGSC 150
    WAFSTVAAVE GINKIRTNKL VSLSEQELVD CDTEENQGCA GGLMEPAFEF 200
    IKNNGGIKTE ETYPYDSSDV QFCRANSIGG ETVTIDGHEH VPENDEEELL 250
    KAVAHQPVSV AIDAGSSDFQ LYSEGVFIGE CGTQLNHGVV IVGYGETKNG 300
    TKYWIVRNSW GPEWGEGGYV RIERGISENE GRCGIAMEAS YPTKLSSTPS 350
    THESVVRDDV KDEL 364
    Length:364
    Mass (Da):40,971
    Last modified:May 1, 2000 - v1
    Checksum:i81C725D07DCE2E78
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK119026 mRNA. Translation: BAC43602.1.
    AL049659 Genomic DNA. Translation: CAB41163.1.
    CP002686 Genomic DNA. Translation: AEE78406.1.
    PIRiT06707.
    RefSeqiNP_566901.1. NM_114696.3.
    UniGeneiAt.3162.

    Genome annotation databases

    EnsemblPlantsiAT3G48350.1; AT3G48350.1; AT3G48350.
    GeneIDi823993.
    KEGGiath:AT3G48350.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK119026 mRNA. Translation: BAC43602.1 .
    AL049659 Genomic DNA. Translation: CAB41163.1 .
    CP002686 Genomic DNA. Translation: AEE78406.1 .
    PIRi T06707.
    RefSeqi NP_566901.1. NM_114696.3.
    UniGenei At.3162.

    3D structure databases

    ProteinModelPortali Q9STL5.
    SMRi Q9STL5. Positions 38-347.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 9312. 1 interaction.

    Protein family/group databases

    MEROPSi C01.A02.

    Proteomic databases

    PaxDbi Q9STL5.
    PRIDEi Q9STL5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G48350.1 ; AT3G48350.1 ; AT3G48350 .
    GeneIDi 823993.
    KEGGi ath:AT3G48350.

    Organism-specific databases

    TAIRi AT3G48350.

    Phylogenomic databases

    eggNOGi COG4870.
    HOGENOMi HOG000230773.
    InParanoidi Q9STL5.
    KOi K16292.
    OMAi FADITHH.
    PhylomeDBi Q9STL5.

    Enzyme and pathway databases

    BioCyci ARA:AT3G48350-MONOMER.

    Miscellaneous databases

    PROi Q9STL5.

    Gene expression databases

    Genevestigatori Q9STL5.

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "KDEL-tailed cysteine endopeptidases involved in programmed cell death, intercalation of new cells, and dismantling of extensin scaffolds."
      Helm M., Schmid M., Hierl G., Terneus K., Tan L., Lottspeich F., Kieliszewski M.J., Gietl C.
      Am. J. Bot. 95:1049-1062(2008)
      Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

    Entry informationi

    Entry nameiCEP3_ARATH
    AccessioniPrimary (citable) accession number: Q9STL5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 82 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3