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Q9STL5

- CEP3_ARATH

UniProt

Q9STL5 - CEP3_ARATH

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Protein

KDEL-tailed cysteine endopeptidase CEP3

Gene
CEP3, At3g48350, T29H11.130
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Involved in the final stage of developmental programmed cell death and in intercalation of new cells. Cleaves extensins, thus probably supporing the final cell collapse By similarity.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei150 – 1501 By similarity
Active sitei287 – 2871 By similarity
Active sitei308 – 3081 By similarity

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Enzyme and pathway databases

BioCyciARA:AT3G48350-MONOMER.

Protein family/group databases

MEROPSiC01.A02.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL-tailed cysteine endopeptidase CEP3 (EC:3.4.22.-)
Gene namesi
Name:CEP3
Ordered Locus Names:At3g48350
ORF Names:T29H11.130
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G48350.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 364344KDEL-tailed cysteine endopeptidase CEP3PRO_0000403791Add
BLAST

Proteomic databases

PaxDbiQ9STL5.
PRIDEiQ9STL5.

Expressioni

Tissue specificityi

Expressed in roots, stems, flowers, buds, green siliques, trichomes and near the stomata of cotyledons but not of true leaves. Found at the hypocotyl-root transition zone, in the vascular tissue, along primary and lateral roots, but not in root tips. Never found in the abscission zone of flower organs.1 Publication

Developmental stagei

Expressed during silique development, but limited to the carpels and the pedicel.1 Publication

Gene expression databases

GenevestigatoriQ9STL5.

Interactioni

Protein-protein interaction databases

BioGridi9312. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ9STL5.
SMRiQ9STL5. Positions 38-347.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi361 – 3644Prevents secretion from ER Reviewed prediction

Sequence similaritiesi

Belongs to the peptidase C1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG4870.
HOGENOMiHOG000230773.
InParanoidiQ9STL5.
KOiK16292.
OMAiFADITHH.
PhylomeDBiQ9STL5.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9STL5-1 [UniParc]FASTAAdd to Basket

« Hide

MKLFFIVLIS FLSLLQASKG FDFDEKELET EENVWKLYER WRGHHSVSRA    50
SHEAIKRFNV FRHNVLHVHR TNKKNKPYKL KINRFADITH HEFRSSYAGS 100
NVKHHRMLRG PKRGSGGFMY ENVTRVPSSV DWREKGAVTE VKNQQDCGSC 150
WAFSTVAAVE GINKIRTNKL VSLSEQELVD CDTEENQGCA GGLMEPAFEF 200
IKNNGGIKTE ETYPYDSSDV QFCRANSIGG ETVTIDGHEH VPENDEEELL 250
KAVAHQPVSV AIDAGSSDFQ LYSEGVFIGE CGTQLNHGVV IVGYGETKNG 300
TKYWIVRNSW GPEWGEGGYV RIERGISENE GRCGIAMEAS YPTKLSSTPS 350
THESVVRDDV KDEL 364
Length:364
Mass (Da):40,971
Last modified:May 1, 2000 - v1
Checksum:i81C725D07DCE2E78
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK119026 mRNA. Translation: BAC43602.1.
AL049659 Genomic DNA. Translation: CAB41163.1.
CP002686 Genomic DNA. Translation: AEE78406.1.
PIRiT06707.
RefSeqiNP_566901.1. NM_114696.3.
UniGeneiAt.3162.

Genome annotation databases

EnsemblPlantsiAT3G48350.1; AT3G48350.1; AT3G48350.
GeneIDi823993.
KEGGiath:AT3G48350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK119026 mRNA. Translation: BAC43602.1 .
AL049659 Genomic DNA. Translation: CAB41163.1 .
CP002686 Genomic DNA. Translation: AEE78406.1 .
PIRi T06707.
RefSeqi NP_566901.1. NM_114696.3.
UniGenei At.3162.

3D structure databases

ProteinModelPortali Q9STL5.
SMRi Q9STL5. Positions 38-347.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 9312. 1 interaction.

Protein family/group databases

MEROPSi C01.A02.

Proteomic databases

PaxDbi Q9STL5.
PRIDEi Q9STL5.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G48350.1 ; AT3G48350.1 ; AT3G48350 .
GeneIDi 823993.
KEGGi ath:AT3G48350.

Organism-specific databases

TAIRi AT3G48350.

Phylogenomic databases

eggNOGi COG4870.
HOGENOMi HOG000230773.
InParanoidi Q9STL5.
KOi K16292.
OMAi FADITHH.
PhylomeDBi Q9STL5.

Enzyme and pathway databases

BioCyci ARA:AT3G48350-MONOMER.

Miscellaneous databases

PROi Q9STL5.

Gene expression databases

Genevestigatori Q9STL5.

Family and domain databases

InterProi IPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view ]
PANTHERi PTHR12411. PTHR12411. 1 hit.
Pfami PF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view ]
PRINTSi PR00705. PAPAIN.
SMARTi SM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view ]
PROSITEi PS00014. ER_TARGET. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "KDEL-tailed cysteine endopeptidases involved in programmed cell death, intercalation of new cells, and dismantling of extensin scaffolds."
    Helm M., Schmid M., Hierl G., Terneus K., Tan L., Lottspeich F., Kieliszewski M.J., Gietl C.
    Am. J. Bot. 95:1049-1062(2008)
    Cited for: FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCEP3_ARATH
AccessioniPrimary (citable) accession number: Q9STL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi