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Protein

KDEL-tailed cysteine endopeptidase CEP3

Gene

CEP3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the final stage of developmental programmed cell death and in intercalation of new cells. Cleaves extensins, thus probably supporting the final cell collapse.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei150PROSITE-ProRule annotation1
Active sitei287PROSITE-ProRule annotation1
Active sitei308PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiC01.A02.

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL-tailed cysteine endopeptidase CEP3 (EC:3.4.22.-)
Gene namesi
Name:CEP31 Publication
Ordered Locus Names:At3g48350Imported
ORF Names:T29H11.130Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G48350.

Subcellular locationi

  • Endoplasmic reticulum PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000043632321 – 125Activation peptideCuratedAdd BLAST105
ChainiPRO_0000403791126 – 364KDEL-tailed cysteine endopeptidase CEP3Add BLAST239

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi122N-linked (GlcNAc...)PROSITE-ProRule annotation1
Disulfide bondi147 ↔ 189By similarity
Disulfide bondi181 ↔ 223By similarity
Disulfide bondi281 ↔ 333By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9STL5.
PRIDEiQ9STL5.

Expressioni

Tissue specificityi

Expressed in roots, stems, flowers, buds, green siliques, trichomes and near the stomata of cotyledons but not of true leaves. Found at the hypocotyl-root transition zone, in the vascular tissue, along primary and lateral roots, but not in root tips. Never found in the abscission zone of flower organs.1 Publication

Developmental stagei

Expressed during silique development, but limited to the carpels and the pedicel.1 Publication

Gene expression databases

GenevisibleiQ9STL5. AT.

Interactioni

Protein-protein interaction databases

BioGridi9312. 1 interactor.
STRINGi3702.AT3G48350.1.

Structurei

3D structure databases

ProteinModelPortaliQ9STL5.
SMRiQ9STL5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi361 – 364Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230773.
InParanoidiQ9STL5.
KOiK16292.
OMAiFADITHH.
OrthoDBiEOG09360FGY.
PhylomeDBiQ9STL5.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9STL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLFFIVLIS FLSLLQASKG FDFDEKELET EENVWKLYER WRGHHSVSRA
60 70 80 90 100
SHEAIKRFNV FRHNVLHVHR TNKKNKPYKL KINRFADITH HEFRSSYAGS
110 120 130 140 150
NVKHHRMLRG PKRGSGGFMY ENVTRVPSSV DWREKGAVTE VKNQQDCGSC
160 170 180 190 200
WAFSTVAAVE GINKIRTNKL VSLSEQELVD CDTEENQGCA GGLMEPAFEF
210 220 230 240 250
IKNNGGIKTE ETYPYDSSDV QFCRANSIGG ETVTIDGHEH VPENDEEELL
260 270 280 290 300
KAVAHQPVSV AIDAGSSDFQ LYSEGVFIGE CGTQLNHGVV IVGYGETKNG
310 320 330 340 350
TKYWIVRNSW GPEWGEGGYV RIERGISENE GRCGIAMEAS YPTKLSSTPS
360
THESVVRDDV KDEL
Length:364
Mass (Da):40,971
Last modified:May 1, 2000 - v1
Checksum:i81C725D07DCE2E78
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049659 Genomic DNA. Translation: CAB41163.1.
CP002686 Genomic DNA. Translation: AEE78406.1.
AK119026 mRNA. Translation: BAC43602.1.
PIRiT06707.
RefSeqiNP_566901.1. NM_114696.4.
UniGeneiAt.3162.

Genome annotation databases

EnsemblPlantsiAT3G48350.1; AT3G48350.1; AT3G48350.
GeneIDi823993.
GrameneiAT3G48350.1; AT3G48350.1; AT3G48350.
KEGGiath:AT3G48350.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049659 Genomic DNA. Translation: CAB41163.1.
CP002686 Genomic DNA. Translation: AEE78406.1.
AK119026 mRNA. Translation: BAC43602.1.
PIRiT06707.
RefSeqiNP_566901.1. NM_114696.4.
UniGeneiAt.3162.

3D structure databases

ProteinModelPortaliQ9STL5.
SMRiQ9STL5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9312. 1 interactor.
STRINGi3702.AT3G48350.1.

Protein family/group databases

MEROPSiC01.A02.

Proteomic databases

PaxDbiQ9STL5.
PRIDEiQ9STL5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G48350.1; AT3G48350.1; AT3G48350.
GeneIDi823993.
GrameneiAT3G48350.1; AT3G48350.1; AT3G48350.
KEGGiath:AT3G48350.

Organism-specific databases

TAIRiAT3G48350.

Phylogenomic databases

eggNOGiKOG1543. Eukaryota.
COG4870. LUCA.
HOGENOMiHOG000230773.
InParanoidiQ9STL5.
KOiK16292.
OMAiFADITHH.
OrthoDBiEOG09360FGY.
PhylomeDBiQ9STL5.

Miscellaneous databases

PROiQ9STL5.

Gene expression databases

GenevisibleiQ9STL5. AT.

Family and domain databases

InterProiIPR025661. Pept_asp_AS.
IPR000169. Pept_cys_AS.
IPR025660. Pept_his_AS.
IPR013128. Peptidase_C1A.
IPR000668. Peptidase_C1A_C.
IPR013201. Prot_inhib_I29.
[Graphical view]
PANTHERiPTHR12411. PTHR12411. 1 hit.
PfamiPF08246. Inhibitor_I29. 1 hit.
PF00112. Peptidase_C1. 1 hit.
[Graphical view]
PRINTSiPR00705. PAPAIN.
SMARTiSM00848. Inhibitor_I29. 1 hit.
SM00645. Pept_C1. 1 hit.
[Graphical view]
PROSITEiPS00014. ER_TARGET. 1 hit.
PS00640. THIOL_PROTEASE_ASN. 1 hit.
PS00139. THIOL_PROTEASE_CYS. 1 hit.
PS00639. THIOL_PROTEASE_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEP3_ARATH
AccessioniPrimary (citable) accession number: Q9STL5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.