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Q9STL4

- CEP2_ARATH

UniProt

Q9STL4 - CEP2_ARATH

Protein

KDEL-tailed cysteine endopeptidase CEP2

Gene

CEP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 78 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Involved in the final stage of developmental programmed cell death and in intercalation of new cells. Cleaves extensins, thus probably supporing the final cell collapse By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei152 – 1521By similarity
    Active sitei288 – 2881By similarity
    Active sitei308 – 3081By similarity

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Enzyme and pathway databases

    BioCyciARA:GQT-212-MONOMER.

    Protein family/group databases

    MEROPSiC01.A01.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    KDEL-tailed cysteine endopeptidase CEP2 (EC:3.4.22.-)
    Gene namesi
    Name:CEP2
    Ordered Locus Names:At3g48340
    ORF Names:T29H11.140
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G48340.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Chaini21 – 361341KDEL-tailed cysteine endopeptidase CEP2PRO_0000403790Add
    BLAST

    Proteomic databases

    PaxDbiQ9STL4.
    PRIDEiQ9STL4.

    Expressioni

    Tissue specificityi

    Expressed in roots, stems, rosette and cauline leaves, flowers, buds and green siliques. Found in the tip of young primary leaves, in very young root tips and at later stages in all tissues of lateral root, including the vascular bundle. Not expressed in lateral root primordia, while directly emerging through the epidermis.1 Publication

    Gene expression databases

    GenevestigatoriQ9STL4.

    Interactioni

    Protein-protein interaction databases

    IntActiQ9STL4. 1 interaction.
    STRINGi3702.AT3G48340.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9STL4.
    SMRiQ9STL4. Positions 28-351.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi358 – 3614Prevents secretion from ERPROSITE-ProRule annotation

    Sequence similaritiesi

    Belongs to the peptidase C1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG4870.
    HOGENOMiHOG000230773.
    InParanoidiQ9STL4.
    KOiK16292.
    OMAiGTDDQPC.
    PhylomeDBiQ9STL4.

    Family and domain databases

    InterProiIPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view]
    PANTHERiPTHR12411. PTHR12411. 1 hit.
    PfamiPF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view]
    PRINTSiPR00705. PAPAIN.
    SMARTiSM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view]
    PROSITEiPS00014. ER_TARGET. 1 hit.
    PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9STL4-1 [UniParc]FASTAAdd to Basket

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    MKKLLLIFLF SLVILQTACG FDYDDKEIES EEGLSTLYDR WRSHHSVPRS    50
    LNEREKRFNV FRHNVMHVHN TNKKNRSYKL KLNKFADLTI NEFKNAYTGS 100
    NIKHHRMLQG PKRGSKQFMY DHENLSKLPS SVDWRKKGAV TEIKNQGKCG 150
    SCWAFSTVAA VEGINKIKTN KLVSLSEQEL VDCDTKQNEG CNGGLMEIAF 200
    EFIKKNGGIT TEDSYPYEGI DGKCDASKDN GVLVTIDGHE DVPENDENAL 250
    LKAVANQPVS VAIDAGSSDF QFYSEGVFTG SCGTELNHGV AAVGYGSERG 300
    KKYWIVRNSW GAEWGEGGYI KIEREIDEPE GRCGIAMEAS YPIKLSSSNP 350
    TPKDGDVKDE L 361
    Length:361
    Mass (Da):40,371
    Last modified:May 1, 2000 - v1
    Checksum:iFEF1381FFE780C6E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049659 Genomic DNA. Translation: CAB41164.1.
    CP002686 Genomic DNA. Translation: AEE78403.1.
    PIRiT06708.
    RefSeqiNP_680113.3. NM_148860.4.
    UniGeneiAt.46818.

    Genome annotation databases

    EnsemblPlantsiAT3G48340.1; AT3G48340.1; AT3G48340.
    GeneIDi823992.
    KEGGiath:AT3G48340.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AL049659 Genomic DNA. Translation: CAB41164.1 .
    CP002686 Genomic DNA. Translation: AEE78403.1 .
    PIRi T06708.
    RefSeqi NP_680113.3. NM_148860.4.
    UniGenei At.46818.

    3D structure databases

    ProteinModelPortali Q9STL4.
    SMRi Q9STL4. Positions 28-351.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q9STL4. 1 interaction.
    STRINGi 3702.AT3G48340.1-P.

    Protein family/group databases

    MEROPSi C01.A01.

    Proteomic databases

    PaxDbi Q9STL4.
    PRIDEi Q9STL4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G48340.1 ; AT3G48340.1 ; AT3G48340 .
    GeneIDi 823992.
    KEGGi ath:AT3G48340.

    Organism-specific databases

    TAIRi AT3G48340.

    Phylogenomic databases

    eggNOGi COG4870.
    HOGENOMi HOG000230773.
    InParanoidi Q9STL4.
    KOi K16292.
    OMAi GTDDQPC.
    PhylomeDBi Q9STL4.

    Enzyme and pathway databases

    BioCyci ARA:GQT-212-MONOMER.

    Gene expression databases

    Genevestigatori Q9STL4.

    Family and domain databases

    InterProi IPR025661. Pept_asp_AS.
    IPR000169. Pept_cys_AS.
    IPR025660. Pept_his_AS.
    IPR013128. Peptidase_C1A.
    IPR000668. Peptidase_C1A_C.
    IPR013201. Prot_inhib_I29.
    [Graphical view ]
    PANTHERi PTHR12411. PTHR12411. 1 hit.
    Pfami PF08246. Inhibitor_I29. 1 hit.
    PF00112. Peptidase_C1. 1 hit.
    [Graphical view ]
    PRINTSi PR00705. PAPAIN.
    SMARTi SM00848. Inhibitor_I29. 1 hit.
    SM00645. Pept_C1. 1 hit.
    [Graphical view ]
    PROSITEi PS00014. ER_TARGET. 1 hit.
    PS00640. THIOL_PROTEASE_ASN. 1 hit.
    PS00139. THIOL_PROTEASE_CYS. 1 hit.
    PS00639. THIOL_PROTEASE_HIS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "KDEL-tailed cysteine endopeptidases involved in programmed cell death, intercalation of new cells, and dismantling of extensin scaffolds."
      Helm M., Schmid M., Hierl G., Terneus K., Tan L., Lottspeich F., Kieliszewski M.J., Gietl C.
      Am. J. Bot. 95:1049-1062(2008)
      Cited for: FUNCTION, TISSUE SPECIFICITY.

    Entry informationi

    Entry nameiCEP2_ARATH
    AccessioniPrimary (citable) accession number: Q9STL4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2011
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 78 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3