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Protein

KDEL-tailed cysteine endopeptidase CEP2

Gene

CEP2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the final stage of developmental programmed cell death and in intercalation of new cells. Cleaves extensins, thus probably supporting the final cell collapse.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei152PROSITE-ProRule annotation1
Active sitei288PROSITE-ProRule annotation1
Active sitei308PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease

Protein family/group databases

MEROPSiI29.003

Names & Taxonomyi

Protein namesi
Recommended name:
KDEL-tailed cysteine endopeptidase CEP2 (EC:3.4.22.-)
Gene namesi
Name:CEP21 Publication
Ordered Locus Names:At3g48340Imported
ORF Names:T29H11.140Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G48340
TAIRilocus:504955641 AT3G48340

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
PropeptideiPRO_000043632221 – 127Activation peptideCuratedAdd BLAST107
ChainiPRO_0000403790128 – 361KDEL-tailed cysteine endopeptidase CEP2Add BLAST234

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi75N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi124N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Disulfide bondi149 ↔ 191By similarity
Disulfide bondi183 ↔ 224By similarity
Disulfide bondi282 ↔ 333By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ9STL4
PRIDEiQ9STL4

Expressioni

Tissue specificityi

Expressed in roots, stems, rosette and cauline leaves, flowers, buds and green siliques. Found in the tip of young primary leaves, in very young root tips and at later stages in all tissues of lateral root, including the vascular bundle. Not expressed in lateral root primordia, while directly emerging through the epidermis.1 Publication

Gene expression databases

ExpressionAtlasiQ9STL4 baseline and differential

Interactioni

Protein-protein interaction databases

BioGridi9311, 1 interactor
IntActiQ9STL4, 1 interactor
STRINGi3702.AT3G48340.1

Structurei

3D structure databases

ProteinModelPortaliQ9STL4
SMRiQ9STL4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi358 – 361Prevents secretion from ERPROSITE-ProRule annotation4

Sequence similaritiesi

Belongs to the peptidase C1 family.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG1543 Eukaryota
COG4870 LUCA
HOGENOMiHOG000230773
InParanoidiQ9STL4
KOiK16292
OMAiYHDNELE
OrthoDBiEOG09360FGY
PhylomeDBiQ9STL4

Family and domain databases

InterProiView protein in InterPro
IPR038765 Papain_like_cys_pep_sf
IPR025661 Pept_asp_AS
IPR000169 Pept_cys_AS
IPR025660 Pept_his_AS
IPR013128 Peptidase_C1A
IPR000668 Peptidase_C1A_C
IPR013201 Prot_inhib_I29
PANTHERiPTHR12411 PTHR12411, 1 hit
PfamiView protein in Pfam
PF08246 Inhibitor_I29, 1 hit
PF00112 Peptidase_C1, 1 hit
PRINTSiPR00705 PAPAIN
SMARTiView protein in SMART
SM00848 Inhibitor_I29, 1 hit
SM00645 Pept_C1, 1 hit
SUPFAMiSSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS00014 ER_TARGET, 1 hit
PS00640 THIOL_PROTEASE_ASN, 1 hit
PS00139 THIOL_PROTEASE_CYS, 1 hit
PS00639 THIOL_PROTEASE_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9STL4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKLLLIFLF SLVILQTACG FDYDDKEIES EEGLSTLYDR WRSHHSVPRS
60 70 80 90 100
LNEREKRFNV FRHNVMHVHN TNKKNRSYKL KLNKFADLTI NEFKNAYTGS
110 120 130 140 150
NIKHHRMLQG PKRGSKQFMY DHENLSKLPS SVDWRKKGAV TEIKNQGKCG
160 170 180 190 200
SCWAFSTVAA VEGINKIKTN KLVSLSEQEL VDCDTKQNEG CNGGLMEIAF
210 220 230 240 250
EFIKKNGGIT TEDSYPYEGI DGKCDASKDN GVLVTIDGHE DVPENDENAL
260 270 280 290 300
LKAVANQPVS VAIDAGSSDF QFYSEGVFTG SCGTELNHGV AAVGYGSERG
310 320 330 340 350
KKYWIVRNSW GAEWGEGGYI KIEREIDEPE GRCGIAMEAS YPIKLSSSNP
360
TPKDGDVKDE L
Length:361
Mass (Da):40,371
Last modified:May 1, 2000 - v1
Checksum:iFEF1381FFE780C6E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL049659 Genomic DNA Translation: CAB41164.1
CP002686 Genomic DNA Translation: AEE78403.1
PIRiT06708
RefSeqiNP_680113.3, NM_148860.5
UniGeneiAt.46818

Genome annotation databases

EnsemblPlantsiAT3G48340.1; AT3G48340.1; AT3G48340
GeneIDi823992
GrameneiAT3G48340.1; AT3G48340.1; AT3G48340
KEGGiath:AT3G48340

Similar proteinsi

Entry informationi

Entry nameiCEP2_ARATH
AccessioniPrimary (citable) accession number: Q9STL4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: May 1, 2000
Last modified: June 20, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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