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Protein

UDP-glucuronate 4-epimerase 5

Gene

GAE5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components.

Catalytic activityi

UDP-glucuronate = UDP-D-galacturonate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei247Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 128NADBy similarityAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi5.1.3.6. 399.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronate 4-epimerase 5 (EC:5.1.3.6)
Alternative name(s):
UDP-glucuronic acid epimerase 5
Gene namesi
Name:GAE5
Ordered Locus Names:At4g12250
ORF Names:T4C9.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

TAIRiAT4G12250.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • endosome Source: TAIR
  • Golgi apparatus Source: TAIR
  • Golgi cisterna membrane Source: UniProtKB-SubCell
  • integral component of membrane Source: UniProtKB-KW
  • trans-Golgi network Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002926001 – 436UDP-glucuronate 4-epimerase 5Add BLAST436

Proteomic databases

PaxDbiQ9STI6.

Expressioni

Tissue specificityi

In leaves, pollen and siliques, but not in roots or flowers.2 Publications

Gene expression databases

GenevisibleiQ9STI6. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi12131. 14 interactors.
STRINGi3702.AT4G12250.1.

Structurei

3D structure databases

ProteinModelPortaliQ9STI6.
SMRiQ9STI6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 224Poly-Ser4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IU3F. Eukaryota.
COG0451. LUCA.
HOGENOMiHOG000168000.
InParanoidiQ9STI6.
KOiK08679.
OMAiIMPLPRN.
OrthoDBiEOG09360AZR.
PhylomeDBiQ9STI6.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR008089. Nuc_sugar_epim.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
PRINTSiPR01713. NUCEPIMERASE.
SUPFAMiSSF51735. SSF51735. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9STI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLDDLPST PGKYKTDKVP PYGILHHHRY LRLSKLTLWA SLFLALFLFY
60 70 80 90 100
LVLSPPPSPS RRNLNDSSSI SAAKYGGSHW EKQVRKSARP RSHGGLTVLV
110 120 130 140 150
TGASGFVGTH VSIALRRRGD GVLGLDNFNR YYDPKLKRAR QGLLERSGVF
160 170 180 190 200
VVEGDINDAV LLRKLFDVVL FTHVMHLAAQ AGVRYAMQNP GSYVNSNIAG
210 220 230 240 250
FVNLLEVSKS ANPQPAIVWA SSSSVYGLNS KVPFSEKDRT DQPASLYAAT
260 270 280 290 300
KKAGEGIAHT YNHIYGLSLT GLRFFTVYGP WGRPDMAYFF FTKDILKGKT
310 320 330 340 350
ITVFESPDKG SVARDFTYID DIVKGCLGAL DTAEKSTGSG GKKKGPAMFR
360 370 380 390 400
IYNLGNTSPV PVTKLVTILE KLLKMKAKKK IMPLPRNGDV EFTHANITLA
410 420 430
QAELGYKPAV DLETGLKKFV KWYMGFYTGS KKKSSW
Length:436
Mass (Da):48,165
Last modified:May 1, 2000 - v1
Checksum:i2D9B645D80735C14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116R → Q in AAK93670 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080318 Genomic DNA. Translation: CAB45972.1.
AL161533 Genomic DNA. Translation: CAB78268.1.
CP002687 Genomic DNA. Translation: AEE83108.1.
AY050993 mRNA. Translation: AAK93670.1.
AY150403 mRNA. Translation: AAN12948.1.
PIRiT48135.
RefSeqiNP_192962.1. NM_117295.4.
UniGeneiAt.48849.
At.66589.

Genome annotation databases

EnsemblPlantsiAT4G12250.1; AT4G12250.1; AT4G12250.
GeneIDi826833.
GrameneiAT4G12250.1; AT4G12250.1; AT4G12250.
KEGGiath:AT4G12250.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080318 Genomic DNA. Translation: CAB45972.1.
AL161533 Genomic DNA. Translation: CAB78268.1.
CP002687 Genomic DNA. Translation: AEE83108.1.
AY050993 mRNA. Translation: AAK93670.1.
AY150403 mRNA. Translation: AAN12948.1.
PIRiT48135.
RefSeqiNP_192962.1. NM_117295.4.
UniGeneiAt.48849.
At.66589.

3D structure databases

ProteinModelPortaliQ9STI6.
SMRiQ9STI6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi12131. 14 interactors.
STRINGi3702.AT4G12250.1.

Proteomic databases

PaxDbiQ9STI6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT4G12250.1; AT4G12250.1; AT4G12250.
GeneIDi826833.
GrameneiAT4G12250.1; AT4G12250.1; AT4G12250.
KEGGiath:AT4G12250.

Organism-specific databases

TAIRiAT4G12250.

Phylogenomic databases

eggNOGiENOG410IU3F. Eukaryota.
COG0451. LUCA.
HOGENOMiHOG000168000.
InParanoidiQ9STI6.
KOiK08679.
OMAiIMPLPRN.
OrthoDBiEOG09360AZR.
PhylomeDBiQ9STI6.

Enzyme and pathway databases

BRENDAi5.1.3.6. 399.

Miscellaneous databases

PROiQ9STI6.

Gene expression databases

GenevisibleiQ9STI6. AT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
IPR008089. Nuc_sugar_epim.
[Graphical view]
PfamiPF01370. Epimerase. 1 hit.
[Graphical view]
PRINTSiPR01713. NUCEPIMERASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGAE5_ARATH
AccessioniPrimary (citable) accession number: Q9STI6
Secondary accession number(s): Q949N3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.