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Protein

UDP-glucuronate 4-epimerase 5

Gene

GAE5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Involved in the synthesis of the negatively charged monosaccharide that forms the backbone of pectic cell wall components.

Catalytic activityi

UDP-glucuronate = UDP-D-galacturonate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei247Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi97 – 128NADBy similarityAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomerase
Biological processCarbohydrate metabolism
LigandNAD

Enzyme and pathway databases

BRENDAi5.1.3.6 399

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-glucuronate 4-epimerase 5 (EC:5.1.3.6)
Alternative name(s):
UDP-glucuronic acid epimerase 5
Gene namesi
Name:GAE5
Ordered Locus Names:At4g12250
ORF Names:T4C9.90
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi

Organism-specific databases

AraportiAT4G12250
TAIRilocus:2139134 AT4G12250

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002926001 – 436UDP-glucuronate 4-epimerase 5Add BLAST436

Proteomic databases

PaxDbiQ9STI6

Expressioni

Tissue specificityi

In leaves, pollen and siliques, but not in roots or flowers.2 Publications

Gene expression databases

ExpressionAtlasiQ9STI6 baseline and differential
GenevisibleiQ9STI6 AT

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi12131, 14 interactors
STRINGi3702.AT4G12250.1

Structurei

3D structure databases

ProteinModelPortaliQ9STI6
SMRiQ9STI6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi221 – 224Poly-Ser4

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IU3F Eukaryota
COG0451 LUCA
HOGENOMiHOG000168000
InParanoidiQ9STI6
KOiK08679
OMAiPYAITKY
OrthoDBiEOG09360AZR
PhylomeDBiQ9STI6

Family and domain databases

InterProiView protein in InterPro
IPR001509 Epimerase_deHydtase
IPR036291 NAD(P)-bd_dom_sf
IPR008089 Nuc_sugar_epim
PfamiView protein in Pfam
PF01370 Epimerase, 1 hit
PRINTSiPR01713 NUCEPIMERASE
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

Q9STI6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHLDDLPST PGKYKTDKVP PYGILHHHRY LRLSKLTLWA SLFLALFLFY
60 70 80 90 100
LVLSPPPSPS RRNLNDSSSI SAAKYGGSHW EKQVRKSARP RSHGGLTVLV
110 120 130 140 150
TGASGFVGTH VSIALRRRGD GVLGLDNFNR YYDPKLKRAR QGLLERSGVF
160 170 180 190 200
VVEGDINDAV LLRKLFDVVL FTHVMHLAAQ AGVRYAMQNP GSYVNSNIAG
210 220 230 240 250
FVNLLEVSKS ANPQPAIVWA SSSSVYGLNS KVPFSEKDRT DQPASLYAAT
260 270 280 290 300
KKAGEGIAHT YNHIYGLSLT GLRFFTVYGP WGRPDMAYFF FTKDILKGKT
310 320 330 340 350
ITVFESPDKG SVARDFTYID DIVKGCLGAL DTAEKSTGSG GKKKGPAMFR
360 370 380 390 400
IYNLGNTSPV PVTKLVTILE KLLKMKAKKK IMPLPRNGDV EFTHANITLA
410 420 430
QAELGYKPAV DLETGLKKFV KWYMGFYTGS KKKSSW
Length:436
Mass (Da):48,165
Last modified:May 1, 2000 - v1
Checksum:i2D9B645D80735C14
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti116R → Q in AAK93670 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL080318 Genomic DNA Translation: CAB45972.1
AL161533 Genomic DNA Translation: CAB78268.1
CP002687 Genomic DNA Translation: AEE83108.1
AY050993 mRNA Translation: AAK93670.1
AY150403 mRNA Translation: AAN12948.1
PIRiT48135
RefSeqiNP_192962.1, NM_117295.4
UniGeneiAt.48849
At.66589

Genome annotation databases

EnsemblPlantsiAT4G12250.1; AT4G12250.1; AT4G12250
GeneIDi826833
GrameneiAT4G12250.1; AT4G12250.1; AT4G12250
KEGGiath:AT4G12250

Entry informationi

Entry nameiGAE5_ARATH
AccessioniPrimary (citable) accession number: Q9STI6
Secondary accession number(s): Q949N3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 26, 2007
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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