ID   RHT1_WHEAT              Reviewed;         623 AA.
AC   Q9ST59;
DT   22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   27-MAR-2024, entry version 94.
DE   RecName: Full=DELLA protein RHT-1;
DE   AltName: Full=Protein Rht-B1/Rht-D1;
DE   AltName: Full=Reduced height protein 1;
GN   Name=RHT1;
OS   Triticum aestivum (Wheat).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4565;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS 61-GLN--GLU-64 DEL AND
RP   62-GLN--GLU-64 DEL.
RC   STRAIN=cv. Rht-B1b, and cv. Rht-D1b;
RX   PubMed=10421366; DOI=10.1038/22307;
RA   Peng J., Richards D.E., Hartley N.M., Murphy G.P., Devos K.M.,
RA   Flintham J.E., Beales J., Fish L.J., Worland A.J., Pelica F., Sudhakar D.,
RA   Christou P., Snape J.W., Gale M.D., Harberd N.P.;
RT   "'Green revolution' genes encode mutant gibberellin response modulators.";
RL   Nature 400:256-261(1999).
CC   -!- FUNCTION: Probable transcriptional regulator that acts as a repressor
CC       of the gibberellin (GA) signaling pathway. Probably acts by
CC       participating in large multiprotein complexes that repress
CC       transcription of GA-inducible genes. Upon GA application, it is
CC       degraded by the proteasome, allowing the GA signaling pathway.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- DOMAIN: The DELLA motif is required for its GA-induced degradation.
CC       {ECO:0000305}.
CC   -!- PTM: Phosphorylated. {ECO:0000250}.
CC   -!- PTM: Ubiquitinated. Upon GA application it is ubiquitinated, leading to
CC       its subsequent degradation (Probable). {ECO:0000305}.
CC   -!- BIOTECHNOLOGY: This gene, also known as the 'green revolution gene' has
CC       been introduced by conventional breeding procedures into several
CC       cultivars. It produces shorter plants, increase grain yield at the
CC       expense of straw biomass, and are more resistant to damage by wind and
CC       rain. These wheats are short because they respond abnormally to GA.
CC   -!- SIMILARITY: Belongs to the GRAS family. DELLA subfamily. {ECO:0000305}.
CC   -!- WEB RESOURCE: Name=Protein Spotlight; Note=All things dwarfed and
CC       beautiful - Issue 70 of May 2006;
CC       URL="https://web.expasy.org/spotlight/back_issues/070";
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DR   EMBL; AJ242531; CAB51555.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9ST59; -.
DR   SMR; Q9ST59; -.
DR   STRING; 4565.Q9ST59; -.
DR   PaxDb; 4565-Traes_4BS_2EE4988CD-1; -.
DR   EnsemblPlants; TraesCAD_scaffold_027774_01G000100.1; TraesCAD_scaffold_027774_01G000100.1; TraesCAD_scaffold_027774_01G000100.
DR   EnsemblPlants; TraesCS4D02G040400.1; TraesCS4D02G040400.1.cds1; TraesCS4D02G040400.
DR   EnsemblPlants; TraesCS4D03G0067100.1; TraesCS4D03G0067100.1.CDS1; TraesCS4D03G0067100.
DR   EnsemblPlants; TraesKAR4D01G0014970.1; cds.TraesKAR4D01G0014970.1; TraesKAR4D01G0014970.
DR   EnsemblPlants; TraesPAR_scaffold_021593_01G000100.1; TraesPAR_scaffold_021593_01G000100.1; TraesPAR_scaffold_021593_01G000100.
DR   EnsemblPlants; TraesROB_scaffold_023654_01G000100.1; TraesROB_scaffold_023654_01G000100.1; TraesROB_scaffold_023654_01G000100.
DR   EnsemblPlants; TraesWEE_scaffold_064278_01G000100.1; TraesWEE_scaffold_064278_01G000100.1; TraesWEE_scaffold_064278_01G000100.
DR   Gramene; TraesCAD_scaffold_027774_01G000100.1; TraesCAD_scaffold_027774_01G000100.1; TraesCAD_scaffold_027774_01G000100.
DR   Gramene; TraesCS4D02G040400.1; TraesCS4D02G040400.1.cds1; TraesCS4D02G040400.
DR   Gramene; TraesCS4D03G0067100.1; TraesCS4D03G0067100.1.CDS1; TraesCS4D03G0067100.
DR   Gramene; TraesKAR4D01G0014970.1; cds.TraesKAR4D01G0014970.1; TraesKAR4D01G0014970.
DR   Gramene; TraesPAR_scaffold_021593_01G000100.1; TraesPAR_scaffold_021593_01G000100.1; TraesPAR_scaffold_021593_01G000100.
DR   Gramene; TraesROB_scaffold_023654_01G000100.1; TraesROB_scaffold_023654_01G000100.1; TraesROB_scaffold_023654_01G000100.
DR   Gramene; TraesWEE_scaffold_064278_01G000100.1; TraesWEE_scaffold_064278_01G000100.1; TraesWEE_scaffold_064278_01G000100.
DR   eggNOG; ENOG502QPMG; Eukaryota.
DR   OMA; HNGAVFF; -.
DR   OrthoDB; 455942at2759; -.
DR   Proteomes; UP000019116; Chromosome 4D.
DR   ExpressionAtlas; Q9ST59; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW.
DR   GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central.
DR   Gene3D; 1.10.10.1290; Transcriptional regulator DELLA, N-terminal domain; 1.
DR   InterPro; IPR038088; DELLA_N_sf.
DR   InterPro; IPR021914; TF_DELLA_N.
DR   InterPro; IPR005202; TF_GRAS.
DR   PANTHER; PTHR31636:SF47; DELLA PROTEIN RGL1; 1.
DR   PANTHER; PTHR31636; OSJNBA0084A10.13 PROTEIN-RELATED; 1.
DR   Pfam; PF12041; DELLA; 1.
DR   Pfam; PF03514; GRAS; 1.
DR   SMART; SM01129; DELLA; 1.
DR   PROSITE; PS50985; GRAS; 1.
PE   1: Evidence at protein level;
KW   Gibberellin signaling pathway; Nucleus; Phosphoprotein; Reference proteome;
KW   Repressor; Transcription; Transcription regulation; Ubl conjugation.
FT   CHAIN           1..623
FT                   /note="DELLA protein RHT-1"
FT                   /id="PRO_0000132249"
FT   DOMAIN          225..619
FT                   /note="GRAS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          109..138
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          159..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..288
FT                   /note="Leucine repeat I (LRI)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT   REGION          307..372
FT                   /note="VHIID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT   REGION          386..425
FT                   /note="Leucine repeat II (LRII)"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT   REGION          435..540
FT                   /note="PFYRE"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT   REGION          543..619
FT                   /note="SAW"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT   MOTIF           38..42
FT                   /note="DELLA motif"
FT   MOTIF           239..243
FT                   /note="LxCxE motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT   MOTIF           338..342
FT                   /note="VHIID"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01191"
FT   COMPBIAS        122..138
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        178..199
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VARIANT         61..64
FT                   /note="Missing (in strain: cv. Rht-D1b; induces a dwarf
FT                   phenotype)"
FT   VARIANT         62..64
FT                   /note="Missing (in strain: cv. Rht-B1b; induces a dwarf
FT                   phenotype)"
SQ   SEQUENCE   623 AA;  65337 MW;  F2BAC34996D0A84F CRC64;
     MKREYQDAGG SGGGGGGMGS SEDKMMVSAA AGEGEEVDEL LAALGYKVRA SDMADVAQKL
     EQLEMAMGMG GVGAGAAPDD SFATHLATDT VHYNPTDLSS WVESMLSELN APPPPLPPAP
     QLNASTSSTV TGSGGYFDLP PSVDSSSSIY ALRPIPSPAG ATAPADLSAD SVRDPKRMRT
     GGSSTSSSSS SSSSLGGGAR SSVVEAAPPV AAAANATPAL PVVVVDTQEA GIRLVHALLA
     CAEAVQQENL SAAEALVKQI PLLAASQGGA MRKVAAYFGE ALARRVFRFR PQPDSSLLDA
     AFADLLHAHF YESCPYLKFA HFTANQAILE AFAGCRRVHV VDFGIKQGMQ WPALLQALAL
     RPGGPPSFRL TGVGPPQPDE TDALQQVGWK LAQFAHTIRV DFQYRGLVAA TLADLEPFML
     QPEGEEDPNE EPEVIAVNSV FEMHRLLAQP GALEKVLGTV RAVRPRIVTV VEQEANHNSG
     TFLDRFTESL HYYSTMFDSL EGGSSGGGPS EVSSGAAAAP AAAGTDQVMS EVYLGRQICN
     VVACEGAERT ERHETLGQWR NRLGNAGFET VHLGSNAYKQ ASTLLALFAG GDGYKVEEKE
     GCLTLGWHTR PLIATSAWRL AGP
//