ID DWRF8_MAIZE Reviewed; 630 AA. AC Q9ST48; Q93V57; Q93VT0; Q93VT1; Q93VT2; Q93WG1; Q93WI7; Q945I5; Q945I6; AC Q945I7; Q945I8; Q945I9; Q945J0; Q945J1; Q945J2; Q945J3; Q945J4; Q945J5; AC Q945J6; DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 27-MAR-2024, entry version 109. DE RecName: Full=DELLA protein DWARF8; DE Short=Protein dwarf-8; GN Name=D8; OS Zea mays (Maize). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; PACMAD clade; OC Panicoideae; Andropogonodae; Andropogoneae; Tripsacinae; Zea. OX NCBI_TaxID=4577; RN [1] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS 55-ASP--LYS-59 DELINS GLY RP AND 87-LEU--ASP-98 DEL. RX PubMed=10421366; DOI=10.1038/22307; RA Peng J., Richards D.E., Hartley N.M., Murphy G.P., Devos K.M., RA Flintham J.E., Beales J., Fish L.J., Worland A.J., Pelica F., Sudhakar D., RA Christou P., Snape J.W., Gale M.D., Harberd N.P.; RT "'Green revolution' genes encode mutant gibberellin response modulators."; RL Nature 400:256-261(1999). RN [2] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-581, AND VARIANTS ASP-12; GLY-13 RP INS; VAL-28; VAL-231 DEL; HIS-255; ARG-304; ILE-390; CYS-413; THR-475; RP LYS-480; SER-484; ASP-486; HIS-500; SER-505; 510-GLY-ALA-511 DEL; ALA-519; RP LYS-533 AND SER-578. RC STRAIN=cv. 38-11, cv. A272, cv. A619, cv. A632, cv. B103, cv. B104, RC cv. B37, cv. B68, cv. B73, cv. C103, cv. CM105, cv. CM174, cv. CML258, RC cv. CML281, cv. CML5, cv. CMV3, cv. EP1, cv. F2, cv. F2834T, cv. F7, RC cv. GT112, cv. H99, cv. I137TN, cv. I29, cv. KUI21, cv. KUI3, cv. RC KUI43, cv. M162W, cv. M37W, cv. Missouri 17, cv. Missouri 24W, cv. RC MS153, cv. N192, cv. ND246, cv. North Carolina 250, cv. North Carolina RC 260, cv. North Carolina 304, cv. North Carolina 320, cv. North RC Carolina 348, cv. North Carolina 350, cv. North Carolina 352, cv. RC North Carolina 354, cv. Ohio 43, cv. Ohio 7B, cv. P39, cv. PA91, cv. RC Q6199, cv. SA24, cv. SC213, cv. SG18, cv. Tennessee 232, cv. Texas RC 601, cv. Tzi10, cv. Tzi18, cv. U267Y, cv. WF9, cv. Wisconsin 117HT, RC cv. Wisconsin 182B, and cv. Wisconsin 64A; RX PubMed=11562485; DOI=10.1073/pnas.201394398; RA Remington D.L., Thornsberry J.M., Matsuoka Y., Wilson L.M., Whitt S.R., RA Doebley J., Kresovich S., Goodman M.M., Buckler E.S. IV; RT "Structure of linkage disequilibrium and phenotypic associations in the RT maize genome."; RL Proc. Natl. Acad. Sci. U.S.A. 98:11479-11484(2001). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 169-434. RX PubMed=11470895; DOI=10.1073/pnas.151244298; RA Tenaillon M.I., Sawkins M.C., Long A.D., Gaut R.L., Doebley J.F., RA Gaut B.S.; RT "Patterns of DNA sequence polymorphism along chromosome 1 of maize (Zea RT mays ssp. mays L.)."; RL Proc. Natl. Acad. Sci. U.S.A. 98:9161-9166(2001). RN [4] RP NUCLEOTIDE SEQUENCE [MRNA] OF 477-630. RA Kim H., Collura K., Wissotski M., Smart D., Kudrna D., Muller C., Rao K., RA Haller K., Wing R., Soderlund C., Walbot V., Yu Y.; RT "Maize full-length cDNA project."; RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. RN [5] RP POLYMORPHISM. RX PubMed=11431702; DOI=10.1038/90135; RA Thornsberry J.M., Goodman M.M., Doebley J., Kresovich S., Nielsen D., RA Buckler E.S. IV; RT "Dwarf8 polymorphisms associate with variation in flowering time."; RL Nat. Genet. 28:286-289(2001). RN [6] RP POLYMORPHISM. RX PubMed=15933874; DOI=10.1007/s00122-005-1996-6; RA Andersen J.R., Schrag T., Melchinger A.E., Zein I., Luebberstedt T.; RT "Validation of Dwarf8 polymorphisms associated with flowering time in elite RT European inbred lines of maize (Zea mays L.)."; RL Theor. Appl. Genet. 111:206-217(2005). CC -!- FUNCTION: Probable transcriptional regulator that acts as a repressor CC of the gibberellin (GA) signaling pathway. Probably acts by CC participating in large multiprotein complexes that repress CC transcription of GA-inducible genes. Upon GA application, it is CC degraded by the proteasome, allowing the GA signaling pathway. CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. CC -!- DOMAIN: The DELLA motif is required for its GA-induced degradation. CC {ECO:0000305}. CC -!- PTM: Phosphorylated. {ECO:0000250}. CC -!- PTM: Ubiquitinated. Upon GA application it is ubiquitinated, leading to CC its subsequent degradation (Probable). {ECO:0000305}. CC -!- POLYMORPHISM: Variations between cultivars affect flowering time and CC plant height. CC -!- BIOTECHNOLOGY: This gene, also known as the 'green revolution gene' has CC been introduced by conventional breeding procedures into several CC cultivars. It produces shorter plants, increase grain yield at the CC expense of straw biomass, and are more resistant to damage by wind and CC rain. CC -!- SIMILARITY: Belongs to the GRAS family. DELLA subfamily. {ECO:0000305}. CC -!- WEB RESOURCE: Name=Protein Spotlight; Note=All things dwarfed and CC beautiful - Issue 70 of May 2006; CC URL="https://web.expasy.org/spotlight/back_issues/070"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AJ242530; CAB51557.1; -; Genomic_DNA. DR EMBL; AF413112; AAL10302.1; -; Genomic_DNA. DR EMBL; AF413113; AAL10303.1; -; Genomic_DNA. DR EMBL; AF413114; AAL10304.1; -; Genomic_DNA. DR EMBL; AF413115; AAL10305.1; -; Genomic_DNA. DR EMBL; AF413116; AAL10306.1; -; Genomic_DNA. DR EMBL; AF413117; AAL10307.1; -; Genomic_DNA. DR EMBL; AF413118; AAL10308.1; -; Genomic_DNA. DR EMBL; AF413119; AAL10309.1; -; Genomic_DNA. DR EMBL; AF413120; AAL10310.1; -; Genomic_DNA. DR EMBL; AF413121; AAL10311.1; -; Genomic_DNA. DR EMBL; AF413122; AAL10312.1; -; Genomic_DNA. DR EMBL; AF413123; AAL10313.1; -; Genomic_DNA. DR EMBL; AF413124; AAL10314.1; -; Genomic_DNA. DR EMBL; AF413125; AAL10315.1; -; Genomic_DNA. DR EMBL; AF413126; AAL10316.1; -; Genomic_DNA. DR EMBL; AF413127; AAL10317.1; -; Genomic_DNA. DR EMBL; AF413128; AAL10318.1; -; Genomic_DNA. DR EMBL; AF413129; AAL10319.1; -; Genomic_DNA. DR EMBL; AF413130; AAL10320.1; -; Genomic_DNA. DR EMBL; AF413131; AAL10321.1; -; Genomic_DNA. DR EMBL; AF413132; AAL10322.1; -; Genomic_DNA. DR EMBL; AF413133; AAL10323.1; -; Genomic_DNA. DR EMBL; AF413134; AAL10324.1; -; Genomic_DNA. DR EMBL; AF413135; AAL10325.1; -; Genomic_DNA. DR EMBL; AF413136; AAL10326.1; -; Genomic_DNA. DR EMBL; AF413137; AAL10327.1; -; Genomic_DNA. DR EMBL; AF413138; AAL10328.1; -; Genomic_DNA. DR EMBL; AF413139; AAL10329.1; -; Genomic_DNA. DR EMBL; AF413140; AAL10330.1; -; Genomic_DNA. DR EMBL; AF413141; AAL10331.1; -; Genomic_DNA. DR EMBL; AF413142; AAL10332.1; -; Genomic_DNA. DR EMBL; AF413143; AAL10333.1; -; Genomic_DNA. DR EMBL; AF413144; AAL10334.1; -; Genomic_DNA. DR EMBL; AF413145; AAL10335.1; -; Genomic_DNA. DR EMBL; AF413146; AAL10336.1; -; Genomic_DNA. DR EMBL; AF413147; AAL10337.1; -; Genomic_DNA. DR EMBL; AF413148; AAL10338.1; -; Genomic_DNA. DR EMBL; AF413149; AAL10339.1; -; Genomic_DNA. DR EMBL; AF413150; AAL10340.1; -; Genomic_DNA. DR EMBL; AF413151; AAL10341.1; -; Genomic_DNA. DR EMBL; AF413152; AAL10342.1; -; Genomic_DNA. DR EMBL; AF413153; AAL10343.1; -; Genomic_DNA. DR EMBL; AF413154; AAL10344.1; -; Genomic_DNA. DR EMBL; AF413155; AAL10345.1; -; Genomic_DNA. DR EMBL; AF413156; AAL10346.1; -; Genomic_DNA. DR EMBL; AF413157; AAL10347.1; -; Genomic_DNA. DR EMBL; AF413158; AAL10348.1; -; Genomic_DNA. DR EMBL; AF413159; AAL10349.1; -; Genomic_DNA. DR EMBL; AF413160; AAL10350.1; -; Genomic_DNA. DR EMBL; AF413161; AAL10351.1; -; Genomic_DNA. DR EMBL; AF413162; AAL10352.1; -; Genomic_DNA. DR EMBL; AF413163; AAL10353.1; -; Genomic_DNA. DR EMBL; AF413164; AAL10354.1; -; Genomic_DNA. DR EMBL; AF413165; AAL10355.1; -; Genomic_DNA. DR EMBL; AF413166; AAL10356.1; -; Genomic_DNA. DR EMBL; AF413167; AAL10357.1; -; Genomic_DNA. DR EMBL; AF413168; AAL10358.1; -; Genomic_DNA. DR EMBL; AF413169; AAL10359.1; -; Genomic_DNA. DR EMBL; AF413170; AAL10360.1; -; Genomic_DNA. DR EMBL; AF413171; AAL10361.1; -; Genomic_DNA. DR EMBL; AF413172; AAL10362.1; -; Genomic_DNA. DR EMBL; AF413173; AAL10363.1; -; Genomic_DNA. DR EMBL; AF413174; AAL10364.1; -; Genomic_DNA. DR EMBL; AF413175; AAL10365.1; -; Genomic_DNA. DR EMBL; AF413176; AAL10366.1; -; Genomic_DNA. DR EMBL; AF413177; AAL10367.1; -; Genomic_DNA. DR EMBL; AF413178; AAL10368.1; -; Genomic_DNA. DR EMBL; AF413179; AAL10369.1; -; Genomic_DNA. DR EMBL; AF413180; AAL10370.1; -; Genomic_DNA. DR EMBL; AF413181; AAL10371.1; -; Genomic_DNA. DR EMBL; AF413182; AAL10372.1; -; Genomic_DNA. DR EMBL; AF413183; AAL10373.1; -; Genomic_DNA. DR EMBL; AF413184; AAL10374.1; -; Genomic_DNA. DR EMBL; AF413185; AAL10375.1; -; Genomic_DNA. DR EMBL; AF413186; AAL10376.1; -; Genomic_DNA. DR EMBL; AF413187; AAL10377.1; -; Genomic_DNA. DR EMBL; AF413188; AAL10378.1; -; Genomic_DNA. DR EMBL; AF413189; AAL10379.1; -; Genomic_DNA. DR EMBL; AF413190; AAL10380.1; -; Genomic_DNA. DR EMBL; AF413191; AAL10381.1; -; Genomic_DNA. DR EMBL; AF413192; AAL10382.1; -; Genomic_DNA. DR EMBL; AF413193; AAL10383.1; -; Genomic_DNA. DR EMBL; AF413194; AAL10384.1; -; Genomic_DNA. DR EMBL; AF413195; AAL10385.1; -; Genomic_DNA. DR EMBL; AF413196; AAL10386.1; -; Genomic_DNA. DR EMBL; AF413197; AAL10387.1; -; Genomic_DNA. DR EMBL; AF413198; AAL10388.1; -; Genomic_DNA. DR EMBL; AF413199; AAL10389.1; -; Genomic_DNA. DR EMBL; AF413200; AAL10390.1; -; Genomic_DNA. DR EMBL; AF413201; AAL10391.1; -; Genomic_DNA. DR EMBL; AF413202; AAL10392.1; -; Genomic_DNA. DR EMBL; AF413203; AAL10393.1; -; Genomic_DNA. DR EMBL; AF377621; AAK59901.1; -; Genomic_DNA. DR EMBL; AF377622; AAK59902.1; -; Genomic_DNA. DR EMBL; AF377623; AAK59903.1; -; Genomic_DNA. DR EMBL; AF377624; AAK59904.1; -; Genomic_DNA. DR EMBL; AF377625; AAK59905.1; -; Genomic_DNA. DR EMBL; AF377626; AAK59906.1; -; Genomic_DNA. DR EMBL; AF377627; AAK59907.1; -; Genomic_DNA. DR EMBL; AF377628; AAK59908.1; -; Genomic_DNA. DR EMBL; AF377629; AAK59909.1; -; Genomic_DNA. DR EMBL; AF377630; AAK59910.1; -; Genomic_DNA. DR EMBL; AF377631; AAK59911.1; -; Genomic_DNA. DR EMBL; AF377632; AAK59912.1; -; Genomic_DNA. DR EMBL; AF377633; AAK59913.1; -; Genomic_DNA. DR EMBL; AF377634; AAK59914.1; -; Genomic_DNA. DR EMBL; AF377635; AAK59915.1; -; Genomic_DNA. DR EMBL; AF377636; AAK59916.1; -; Genomic_DNA. DR EMBL; AF377637; AAK59917.1; -; Genomic_DNA. DR EMBL; AF377638; AAK59918.1; -; Genomic_DNA. DR EMBL; AF377639; AAK59919.1; -; Genomic_DNA. DR EMBL; AF377640; AAK59920.1; -; Genomic_DNA. DR EMBL; AF377641; AAK59921.1; -; Genomic_DNA. DR EMBL; AF377642; AAK59922.1; -; Genomic_DNA. DR EMBL; AF377643; AAK59923.1; -; Genomic_DNA. DR EMBL; AF377644; AAK59924.1; -; Genomic_DNA. DR EMBL; AF377645; AAK59925.1; -; Genomic_DNA. DR EMBL; DR799058; -; NOT_ANNOTATED_CDS; mRNA. DR AlphaFoldDB; Q9ST48; -. DR SMR; Q9ST48; -. DR STRING; 4577.Q9ST48; -. DR PaxDb; 4577-GRMZM2G144744_P01; -. DR EnsemblPlants; Zm00001eb054480_T001; Zm00001eb054480_P001; Zm00001eb054480. DR Gramene; Zm00001eb054480_T001; Zm00001eb054480_P001; Zm00001eb054480. DR MaizeGDB; 12143; -. DR eggNOG; ENOG502QPMG; Eukaryota. DR InParanoid; Q9ST48; -. DR OMA; HNGAVFF; -. DR OrthoDB; 455942at2759; -. DR Proteomes; UP000007305; Chromosome 1. DR ExpressionAtlas; Q9ST48; baseline and differential. DR GO; GO:0005634; C:nucleus; IBA:GO_Central. DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central. DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central. DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IEA:UniProtKB-KW. DR GO; GO:0006355; P:regulation of DNA-templated transcription; IBA:GO_Central. DR Gene3D; 1.10.10.1290; Transcriptional regulator DELLA, N-terminal domain; 1. DR InterPro; IPR038088; DELLA_N_sf. DR InterPro; IPR021914; TF_DELLA_N. DR InterPro; IPR005202; TF_GRAS. DR PANTHER; PTHR31636:SF47; DELLA PROTEIN RGL1; 1. DR PANTHER; PTHR31636; OSJNBA0084A10.13 PROTEIN-RELATED; 1. DR Pfam; PF12041; DELLA; 1. DR Pfam; PF03514; GRAS; 1. DR SMART; SM01129; DELLA; 1. DR PROSITE; PS50985; GRAS; 1. DR Genevisible; Q9ST48; ZM. PE 1: Evidence at protein level; KW Gibberellin signaling pathway; Nucleus; Phosphoprotein; Reference proteome; KW Repressor; Transcription; Transcription regulation; Ubl conjugation. FT CHAIN 1..630 FT /note="DELLA protein DWARF8" FT /id="PRO_0000132246" FT DOMAIN 234..623 FT /note="GRAS" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191" FT REGION 1..35 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 161..222 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 241..297 FT /note="Leucine repeat I (LRI)" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191" FT REGION 316..381 FT /note="VHIID" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191" FT REGION 395..427 FT /note="Leucine repeat II (LRII)" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191" FT REGION 443..544 FT /note="PFYRE" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191" FT REGION 547..623 FT /note="SAW" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191" FT MOTIF 38..42 FT /note="DELLA motif" FT MOTIF 248..252 FT /note="LxCxE motif" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191" FT MOTIF 347..351 FT /note="VHIID" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191" FT MOTIF 451..455 FT /note="LXXLL motif" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01191" FT COMPBIAS 186..206 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT VARIANT 12 FT /note="G -> D (in strain: cv. CMV3)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 13 FT /note="G -> GG (in strain: cv. CML258, cv. CML5, cv. NC354 FT and cv. Q6199)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 28 FT /note="G -> V (in strain: cv. H99, cv. NC260, cv. PA91, cv. FT U267Y, cv. W64A and cv. WF9)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 55..59 FT /note="DVAQK -> G (in D8-d1; induces a dwarf phenotype)" FT /evidence="ECO:0000269|PubMed:10421366" FT VARIANT 87..98 FT /note="Missing (in D8-2023; induces a dwarf phenotype)" FT /evidence="ECO:0000269|PubMed:10421366" FT VARIANT 231 FT /note="Missing (in strain: cv. CM7)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 255 FT /note="Q -> H (in strain: cv. MO24W)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 304 FT /note="S -> R (in strain: cv. B103)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 390 FT /note="T -> I (in strain: cv. EP1)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 413 FT /note="Y -> C (in strain: cv. CMV3)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 475 FT /note="I -> T (in strain: cv. GT112)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 480 FT /note="E -> K (in strain: cv. H99)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 484 FT /note="N -> S (in strain: cv. NC260)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 486 FT /note="N -> D (in strain: cv. KUI43)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 500 FT /note="Y -> H (in strain: cv. NC320)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 505 FT /note="F -> S (in strain: cv. NC250)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 510..511 FT /note="Missing (in strain: cv. A619, cv. CM105, cv. CM174, FT cv. CMV3, cv. F7, cv. F2834T, cv. N192, cv. Ohio 43 and cv. FT P39)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 519 FT /note="T -> A (in strain: cv. A619, cv. CM105, cv. CM7, cv. FT CM174, cv. CMV3, cv. F2834T, cv. F7, cv. N192, cv. Ohio 43 FT and cv. P39)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 533 FT /note="M -> K (in strain: cv. F2)" FT /evidence="ECO:0000269|PubMed:11562485" FT VARIANT 578 FT /note="G -> S (in strain: cv. M37W and cv. Tzi10)" FT /evidence="ECO:0000269|PubMed:11562485" SQ SEQUENCE 630 AA; 66029 MW; 3D56851726C51042 CRC64; MKREYQDAGG SGGDMGSSKD KMMAAAAGAG EQEEEDVDEL LAALGYKVRS SDMADVAQKL EQLEMAMGMG GVGGAGATAD DGFVSHLATD TVHYNPSDLS SWVESMLSEL NAPPAPLPPA TPAPRLASTS STVTSGAAAG AGYFDLPPAV DSSSSTYALK PIPSPVAAPS ADPSTDSARE PKRMRTGGGS TSSSSSSSSS MDGGRTRSSV VEAAPPATQA SAAANGPAVP VVVVDTQEAG IRLVHALLAC AEAVQQENFS AAEALVKQIP MLASSQGGAM RKVAAYFGEA LARRVYRFRP PPDSSLLDAA FADLLHAHFY ESCPYLKFAH FTANQAILEA FAGCRRVHVV DFGIKQGMQW PALLQALALR PGGPPSFRLT GVGPPQPDET DALQQVGWKL AQFAHTIRVD FQYRGLVAAT LADLEPFMLQ PEGDDTDDEP EVIAVNSVFE LHRLLAQPGA LEKVLGTVRA VRPRIVTVVE QEANHNSGTF LDRFTESLHY YSTMFDSLEG AGAGSGQSTD ASPAAAGGTD QVMSEVYLGR QICNVVACEG AERTERHETL GQWRSRLGGS GFAPVHLGSN AYKQASTLLA LFAGGDGYRV EEKDGCLTLG WHTRPLIATS AWRVAAAAAP //