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Protein

Zinc finger protein AZF2

Gene

AZF2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Transcriptional repressor involved in the inhibition of plant growth under abiotic stress conditions. Can repress the expression of various genes, including osmotic stress and abscisic acid-repressive genes and auxin-inducible genes, by binding to their promoter regions in a DNA sequence-specific manner. Acts as a negative regulator of abscisic acid (ABA) signaling during seed germination. Probably involved in jasmonate (JA) early signaling response. May regulate the expression of the JA biosynthesis gene LOX3 and control the expression of TIFY10A/JAZ1, a key repressor in the JA signaling cascade. May act as a positive regulator of leaf senescence. Has been identified as a suppressor of the deficiency of yeast snf4 mutant to grow on non-fermentable carbon source.6 Publications

Miscellaneous

Plants overexpressing AZF2 have increased sensitivity to salt stress and barely survive under high salt conditons.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri106 – 128C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

  • DNA binding Source: TAIR
  • DNA binding transcription factor activity Source: TAIR
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: TAIR
  • transcription regulatory region DNA binding Source: TAIR

GO - Biological processi

  • abscisic acid-activated signaling pathway Source: UniProtKB-KW
  • embryo development ending in seed dormancy Source: TAIR
  • hyperosmotic salinity response Source: TAIR
  • negative regulation of transcription, DNA-templated Source: TAIR
  • response to abscisic acid Source: UniProtKB
  • response to chitin Source: TAIR
  • response to water deprivation Source: TAIR
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionDNA-binding, Repressor
Biological processAbscisic acid signaling pathway, Jasmonic acid signaling pathway, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein AZF2
Alternative name(s):
Zinc-finger protein 2
Gene namesi
Name:AZF2
Synonyms:ZF2
Ordered Locus Names:At3g19580
ORF Names:MMB12.27, MMB12.4
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G19580
TAIRilocus:2091201 AT3G19580

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Disruption phenotypei

Delayed senescence and hypersensitivity to ABA during seed germination.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004218271 – 273Zinc finger protein AZF2Add BLAST273

Proteomic databases

PaxDbiQ9SSW2

Expressioni

Tissue specificityi

Expressed in roots, radicles, cotyledons, hypocotyls, leaf veins, stems, sepals, petals, stamens, placenta, funiculi and maturated seeds.3 Publications

Inductioni

By abscisic acid (ABA), ethylene, salt, cold, dehydration and the monovalent and divalent cations Li+, Na+, K+, Cs+, Ca2+ and Mg2+.4 Publications

Gene expression databases

ExpressionAtlasiQ9SSW2 baseline and differential
GenevisibleiQ9SSW2 AT

Interactioni

Protein-protein interaction databases

BioGridi68281 interactor.
STRINGi3702.AT3G19580.1

Structurei

3D structure databases

ProteinModelPortaliQ9SSW2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi43 – 52Poly-Ser10
Compositional biasi193 – 199Poly-Gly7

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri106 – 128C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri165 – 187C2H2-type 2PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
HOGENOMiHOG000240166
OMAiVSEERSH
OrthoDBiEOG09360U2L
PhylomeDBiQ9SSW2

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 2 hits
SUPFAMiSSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 2 hits
PS50157 ZINC_FINGER_C2H2_2, 2 hits

Sequencei

Sequence statusi: Complete.

Q9SSW2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALEAMNTPT SSFTRIETKE DLMNDAVFIE PWLKRKRSKR QRSHSPSSSS
60 70 80 90 100
SSPPRSRPKS QNQDLTEEEY LALCLLMLAK DQPSQTRFHQ QSQSLTPPPE
110 120 130 140 150
SKNLPYKCNV CEKAFPSYQA LGGHKASHRI KPPTVISTTA DDSTAPTISI
160 170 180 190 200
VAGEKHPIAA SGKIHECSIC HKVFPTGQAL GGHKRCHYEG NLGGGGGGGS
210 220 230 240 250
KSISHSGSVS STVSEERSHR GFIDLNLPAL PELSLHHNPI VDEEILSPLT
260 270
GKKPLLLTDH DQVIKKEDLS LKI
Length:273
Mass (Da):29,796
Last modified:May 1, 2000 - v1
Checksum:i010930062AAE70C9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB030730 Genomic DNA Translation: BAA85107.1
AF250337 mRNA Translation: AAG10143.1
AP000417 Genomic DNA Translation: BAB02542.1
CP002686 Genomic DNA Translation: AEE76261.1
CP002686 Genomic DNA Translation: AEE76262.1
BT003816 mRNA Translation: AAO41869.1
PIRiT52385
RefSeqiNP_001118663.1, NM_001125191.1
NP_188592.1, NM_112848.2
UniGeneiAt.23023

Genome annotation databases

EnsemblPlantsiAT3G19580.1; AT3G19580.1; AT3G19580
AT3G19580.2; AT3G19580.2; AT3G19580
GeneIDi821495
GrameneiAT3G19580.1; AT3G19580.1; AT3G19580
AT3G19580.2; AT3G19580.2; AT3G19580
KEGGiath:AT3G19580

Similar proteinsi

Entry informationi

Entry nameiAZF2_ARATH
AccessioniPrimary (citable) accession number: Q9SSW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 6, 2013
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome