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Protein

Toll/interleukin-1 receptor-like protein

Gene

TIR

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (By similarity).By similarity

GO - Biological processi

Keywordsi

Molecular functionReceptor
Biological processPlant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Toll/interleukin-1 receptor-like protein
Short name:
AtTIR
Gene namesi
Name:TIR
Ordered Locus Names:At1g72930
ORF Names:F3N23.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G72930
TAIRilocus:2032733 AT1G72930

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004222751 – 176Toll/interleukin-1 receptor-like proteinAdd BLAST176

Proteomic databases

PaxDbiQ9SSN3

PTM databases

iPTMnetiQ9SSN3

Expressioni

Tissue specificityi

Mostly present in shoots.1 Publication

Gene expression databases

ExpressionAtlasiQ9SSN3 baseline and differential
GenevisibleiQ9SSN3 AT

Interactioni

Subunit structurei

Interacts with MED37E.1 Publication

Protein-protein interaction databases

BioGridi28843, 2 interactors
STRINGi3702.AT1G72930.1

Structurei

Secondary structure

1176
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 15Combined sources7
Helixi17 – 20Combined sources4
Turni21 – 23Combined sources3
Helixi24 – 34Combined sources11
Beta strandi63 – 70Combined sources8
Turni72 – 76Combined sources5
Helixi78 – 92Combined sources15
Beta strandi97 – 102Combined sources6
Helixi107 – 112Combined sources6
Helixi117 – 125Combined sources9
Helixi130 – 143Combined sources14
Helixi155 – 167Combined sources13

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3JRNX-ray2.00A1-176[»]
ProteinModelPortaliQ9SSN3
SMRiQ9SSN3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9SSN3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 146TIRPROSITE-ProRule annotationAdd BLAST140

Phylogenomic databases

HOGENOMiHOG000015175
InParanoidiQ9SSN3
OMAiHEQRIME
PhylomeDBiQ9SSN3

Family and domain databases

Gene3Di3.40.50.10140, 1 hit
InterProiView protein in InterPro
IPR000157 TIR_dom
IPR035897 Toll_tir_struct_dom_sf
PfamiView protein in Pfam
PF01582 TIR, 1 hit
SMARTiView protein in SMART
SM00255 TIR, 1 hit
SUPFAMiSSF52200 SSF52200, 1 hit
PROSITEiView protein in PROSITE
PS50104 TIR, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SSN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSHTATKYD VFLSFRGHDT RHNFISFLYK ELVRRSIRTF KDDKELENGQ
60 70 80 90 100
RFSPELKSPI EVSRFAVVVV SENYAASSWC LDELVTIMDF EKKGSITVMP
110 120 130 140 150
IFYGVEPNHV RWQTGVLAEQ FKKHASREDP EKVLKWRQAL TNFAQLSGDC
160 170
SGDDDSKLVD KIANEISNKK TIYATI
Length:176
Mass (Da):20,245
Last modified:May 1, 2000 - v1
Checksum:iA77AD072BF381216
GO
Isoform 2 (identifier: Q9SSN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-176: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:152
Mass (Da):17,568
Checksum:i0660586B5817D9A7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti126 – 127SR → RV in AAF01328 (Ref. 1) Curated2

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046493153 – 176Missing in isoform 2. CuratedAdd BLAST24

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188334 mRNA Translation: AAF01328.1
AC008017 Genomic DNA Translation: AAD55640.1
CP002684 Genomic DNA Translation: AEE35392.1
CP002684 Genomic DNA Translation: AEE35393.1
AY044312 mRNA Translation: AAK73253.1
AY065114 mRNA Translation: AAL38290.1
AY081663 mRNA Translation: AAM10225.1
AK317547 mRNA Translation: BAH20211.1
AK317731 mRNA Translation: BAH20388.1
AY086809 mRNA Translation: AAM63858.1
PIRiE96754
RefSeqiNP_001077816.1, NM_001084347.1 [Q9SSN3-2]
NP_177436.1, NM_105951.3 [Q9SSN3-1]
UniGeneiAt.24622
At.48366

Genome annotation databases

EnsemblPlantsiAT1G72930.1; AT1G72930.1; AT1G72930 [Q9SSN3-1]
AT1G72930.2; AT1G72930.2; AT1G72930 [Q9SSN3-2]
GeneIDi843624
GrameneiAT1G72930.1; AT1G72930.1; AT1G72930 [Q9SSN3-1]
AT1G72930.2; AT1G72930.2; AT1G72930 [Q9SSN3-2]
KEGGiath:AT1G72930

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiTIR_ARATH
AccessioniPrimary (citable) accession number: Q9SSN3
Secondary accession number(s): A8MRJ7, B9DHJ4, Q9SE46
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 110 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health