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Protein

Toll/interleukin-1 receptor-like protein

Gene

TIR

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Disease resistance protein. Resistance proteins guard the plant against pathogens that contain an appropriate avirulence protein via a direct or indirect interaction with this avirulence protein. That triggers a defense system including the hypersensitive response, which restricts the pathogen growth (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Plant defense

Names & Taxonomyi

Protein namesi
Recommended name:
Toll/interleukin-1 receptor-like protein
Short name:
AtTIR
Gene namesi
Name:TIR
Ordered Locus Names:At1g72930
ORF Names:F3N23.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRiAT1G72930.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB-SubCell
  • plasmodesma Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 176176Toll/interleukin-1 receptor-like proteinPRO_0000422275Add
BLAST

Proteomic databases

PaxDbiQ9SSN3.
PRIDEiQ9SSN3.

PTM databases

iPTMnetiQ9SSN3.

Expressioni

Tissue specificityi

Mostly present in shoots.1 Publication

Gene expression databases

GenevisibleiQ9SSN3. AT.

Interactioni

Subunit structurei

Interacts with MED37E.1 Publication

Protein-protein interaction databases

BioGridi28843. 2 interactions.
STRINGi3702.AT1G72930.1.

Structurei

Secondary structure

1
176
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi9 – 157Combined sources
Helixi17 – 204Combined sources
Turni21 – 233Combined sources
Helixi24 – 3411Combined sources
Beta strandi63 – 708Combined sources
Turni72 – 765Combined sources
Helixi78 – 9215Combined sources
Beta strandi97 – 1026Combined sources
Helixi107 – 1126Combined sources
Helixi117 – 1259Combined sources
Helixi130 – 14314Combined sources
Helixi155 – 16713Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JRNX-ray2.00A1-176[»]
ProteinModelPortaliQ9SSN3.
SMRiQ9SSN3. Positions 7-171.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9SSN3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 146140TIRPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 TIR domain.PROSITE-ProRule annotation

Phylogenomic databases

HOGENOMiHOG000015175.
InParanoidiQ9SSN3.
OMAiHEQRIME.
PhylomeDBiQ9SSN3.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000157. TIR_dom.
[Graphical view]
PfamiPF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SSN3-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSSHTATKYD VFLSFRGHDT RHNFISFLYK ELVRRSIRTF KDDKELENGQ
60 70 80 90 100
RFSPELKSPI EVSRFAVVVV SENYAASSWC LDELVTIMDF EKKGSITVMP
110 120 130 140 150
IFYGVEPNHV RWQTGVLAEQ FKKHASREDP EKVLKWRQAL TNFAQLSGDC
160 170
SGDDDSKLVD KIANEISNKK TIYATI
Length:176
Mass (Da):20,245
Last modified:May 1, 2000 - v1
Checksum:iA77AD072BF381216
GO
Isoform 2 (identifier: Q9SSN3-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     153-176: Missing.

Note: Derived from EST data. No experimental confirmation available.
Show »
Length:152
Mass (Da):17,568
Checksum:i0660586B5817D9A7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1272SR → RV in AAF01328 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei153 – 17624Missing in isoform 2. CuratedVSP_046493Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188334 mRNA. Translation: AAF01328.1.
AC008017 Genomic DNA. Translation: AAD55640.1.
CP002684 Genomic DNA. Translation: AEE35392.1.
CP002684 Genomic DNA. Translation: AEE35393.1.
AY044312 mRNA. Translation: AAK73253.1.
AY065114 mRNA. Translation: AAL38290.1.
AY081663 mRNA. Translation: AAM10225.1.
AK317547 mRNA. Translation: BAH20211.1.
AK317731 mRNA. Translation: BAH20388.1.
AY086809 mRNA. Translation: AAM63858.1.
PIRiE96754.
RefSeqiNP_001077816.1. NM_001084347.1. [Q9SSN3-2]
NP_177436.1. NM_105951.2. [Q9SSN3-1]
UniGeneiAt.24622.
At.48366.

Genome annotation databases

EnsemblPlantsiAT1G72930.1; AT1G72930.1; AT1G72930. [Q9SSN3-1]
GeneIDi843624.
KEGGiath:AT1G72930.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF188334 mRNA. Translation: AAF01328.1.
AC008017 Genomic DNA. Translation: AAD55640.1.
CP002684 Genomic DNA. Translation: AEE35392.1.
CP002684 Genomic DNA. Translation: AEE35393.1.
AY044312 mRNA. Translation: AAK73253.1.
AY065114 mRNA. Translation: AAL38290.1.
AY081663 mRNA. Translation: AAM10225.1.
AK317547 mRNA. Translation: BAH20211.1.
AK317731 mRNA. Translation: BAH20388.1.
AY086809 mRNA. Translation: AAM63858.1.
PIRiE96754.
RefSeqiNP_001077816.1. NM_001084347.1. [Q9SSN3-2]
NP_177436.1. NM_105951.2. [Q9SSN3-1]
UniGeneiAt.24622.
At.48366.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3JRNX-ray2.00A1-176[»]
ProteinModelPortaliQ9SSN3.
SMRiQ9SSN3. Positions 7-171.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi28843. 2 interactions.
STRINGi3702.AT1G72930.1.

PTM databases

iPTMnetiQ9SSN3.

Proteomic databases

PaxDbiQ9SSN3.
PRIDEiQ9SSN3.

Protocols and materials databases

DNASUi843624.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G72930.1; AT1G72930.1; AT1G72930. [Q9SSN3-1]
GeneIDi843624.
KEGGiath:AT1G72930.

Organism-specific databases

TAIRiAT1G72930.

Phylogenomic databases

HOGENOMiHOG000015175.
InParanoidiQ9SSN3.
OMAiHEQRIME.
PhylomeDBiQ9SSN3.

Miscellaneous databases

EvolutionaryTraceiQ9SSN3.
PROiQ9SSN3.

Gene expression databases

GenevisibleiQ9SSN3. AT.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000157. TIR_dom.
[Graphical view]
PfamiPF01582. TIR. 1 hit.
[Graphical view]
SMARTiSM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTIR_ARATH
AccessioniPrimary (citable) accession number: Q9SSN3
Secondary accession number(s): A8MRJ7, B9DHJ4, Q9SE46
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 1, 2013
Last sequence update: May 1, 2000
Last modified: January 20, 2016
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.