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Protein

Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic

Gene

CYP38

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the assembly and stabilization of PSII, but has no PPIases activity.2 Publications

Caution

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: TAIR

Keywordsi

Molecular functionIsomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic (EC:5.2.1.8)
Short name:
PPIase CYP38
Alternative name(s):
Rotamase CYP38
Thylakoid lumen PPIase
Gene namesi
Name:CYP38
Ordered Locus Names:At3g01480
ORF Names:F4P13.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G01480
TAIRilocus:2084138 AT3G01480

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid, Thylakoid

Pathology & Biotechi

Disruption phenotypei

Stunted growth and hypersensitivity to high light.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 36ChloroplastSequence analysisAdd BLAST36
Transit peptidei37 – 92Thylakoid2 PublicationsAdd BLAST56
ChainiPRO_000034209593 – 437Peptidyl-prolyl cis-trans isomerase CYP38, chloroplasticAdd BLAST345

Proteomic databases

PaxDbiQ9SSA5
PRIDEiQ9SSA5
ProMEXiQ9SSA5

PTM databases

iPTMnetiQ9SSA5

Expressioni

Tissue specificityi

Ubiquitous. Lower levels of expression in roots.2 Publications

Inductioni

Up-regulated by light. Down-regulated by dark.1 Publication

Gene expression databases

ExpressionAtlasiQ9SSA5 baseline and differential
GenevisibleiQ9SSA5 AT

Interactioni

Protein-protein interaction databases

IntActiQ9SSA5 1 interactor.
STRINGi3702.AT3G01480.1

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi93 – 97Combined sources5
Helixi103 – 110Combined sources8
Helixi116 – 126Combined sources11
Helixi128 – 131Combined sources4
Turni137 – 139Combined sources3
Helixi140 – 154Combined sources15
Helixi157 – 161Combined sources5
Turni162 – 164Combined sources3
Helixi167 – 169Combined sources3
Helixi170 – 188Combined sources19
Beta strandi197 – 199Combined sources3
Helixi200 – 202Combined sources3
Helixi203 – 216Combined sources14
Beta strandi237 – 246Combined sources10
Beta strandi254 – 263Combined sources10
Turni264 – 266Combined sources3
Helixi268 – 279Combined sources12
Turni280 – 285Combined sources6
Beta strandi289 – 296Combined sources8
Beta strandi318 – 323Combined sources6
Beta strandi325 – 328Combined sources4
Helixi338 – 340Combined sources3
Beta strandi342 – 349Combined sources8
Beta strandi378 – 382Combined sources5
Beta strandi388 – 390Combined sources3
Beta strandi394 – 403Combined sources10
Helixi406 – 409Combined sources4
Beta strandi415 – 423Combined sources9
Helixi425 – 427Combined sources3
Beta strandi428 – 430Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RFYX-ray2.39A83-437[»]
ProteinModelPortaliQ9SSA5
SMRiQ9SSA5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini245 – 437PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST193

Domaini

The N-teminal helical domain blocks the interaction with the potential target PSII subunit chlorophyll protein 47 (CP47).1 Publication

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IEEW Eukaryota
COG0652 LUCA
HOGENOMiHOG000065979
InParanoidiQ9SSA5
OMAiRNAAFGY
OrthoDBiEOG09360ADD
PhylomeDBiQ9SSA5

Family and domain databases

Gene3Di2.40.100.102 hits
InterProiView protein in InterPro
IPR029000 Cyclophilin-like_dom_sf
IPR002130 Cyclophilin-type_PPIase_dom
IPR023222 PsbQ-like_dom_sf
PfamiView protein in Pfam
PF00160 Pro_isomerase, 1 hit
SUPFAMiSSF101112 SSF101112, 1 hit
SSF50891 SSF50891, 2 hits
PROSITEiView protein in PROSITE
PS50072 CSA_PPIASE_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SSA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAFASLPT FSVVNSSRFP RRRIGFSCSK KPLEVRCSSG NTRYTKQRGA
60 70 80 90 100
FTSLKECAIS LALSVGLMVS VPSIALPPNA HAVANPVIPD VSVLISGPPI
110 120 130 140 150
KDPEALLRYA LPIDNKAIRE VQKPLEDITD SLKIAGVKAL DSVERNVRQA
160 170 180 190 200
SRTLQQGKSI IVAGFAESKK DHGNEMIEKL EAGMQDMLKI VEDRKRDAVA
210 220 230 240 250
PKQKEILKYV GGIEEDMVDG FPYEVPEEYR NMPLLKGRAS VDMKVKIKDN
260 270 280 290 300
PNIEDCVFRI VLDGYNAPVT AGNFVDLVER HFYDGMEIQR SDGFVVQTGD
310 320 330 340 350
PEGPAEGFID PSTEKTRTVP LEIMVTGEKT PFYGSTLEEL GLYKAQVVIP
360 370 380 390 400
FNAFGTMAMA REEFENDSGS SQVFWLLKES ELTPSNSNIL DGRYAVFGYV
410 420 430
TDNEDFLADL KVGDVIESIQ VVSGLENLAN PSYKIAG
Length:437
Mass (Da):47,982
Last modified:May 1, 2000 - v1
Checksum:i7239C7ADE83953E0
GO
Isoform 2 (identifier: Q9SSA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-355: EELGLYKAQVVIPFNAFG → EVSLSKSLLVRDLYYIVF
     356-437: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:355
Mass (Da):39,141
Checksum:i460A33063125B06E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055391338 – 355EELGL…FNAFG → EVSLSKSLLVRDLYYIVF in isoform 2. CuratedAdd BLAST18
Alternative sequenceiVSP_055392356 – 437Missing in isoform 2. CuratedAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY568524 mRNA Translation: AAS75307.1
AC009325 Genomic DNA Translation: AAF01533.1
CP002686 Genomic DNA Translation: AEE73672.1
CP002686 Genomic DNA Translation: AEE73673.1
AY039843 mRNA Translation: AAK63947.1
AY113168 mRNA Translation: AAM47471.1
AY087781 mRNA Translation: AAM65317.1
AK317631 mRNA Translation: BAH20293.1
RefSeqiNP_001118550.1, NM_001125078.1 [Q9SSA5-2]
NP_186797.1, NM_111014.4 [Q9SSA5-1]
UniGeneiAt.20535

Genome annotation databases

EnsemblPlantsiAT3G01480.1; AT3G01480.1; AT3G01480 [Q9SSA5-1]
AT3G01480.2; AT3G01480.2; AT3G01480 [Q9SSA5-2]
GeneIDi821137
GrameneiAT3G01480.1; AT3G01480.1; AT3G01480 [Q9SSA5-1]
AT3G01480.2; AT3G01480.2; AT3G01480 [Q9SSA5-2]
KEGGiath:AT3G01480

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCYP38_ARATH
AccessioniPrimary (citable) accession number: Q9SSA5
Secondary accession number(s): B3H5B8, B9DHS6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome