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Protein

Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic

Gene

CYP38

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for the assembly and stabilization of PSII, but has no PPIases activity.2 Publications

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

  • defense response to bacterium Source: TAIR
  • protein folding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase CYP38, chloroplastic (EC:5.2.1.8)
Short name:
PPIase CYP38
Alternative name(s):
Rotamase CYP38
Thylakoid lumen PPIase
Gene namesi
Name:CYP38
Ordered Locus Names:At3g01480
ORF Names:F4P13.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G01480.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast stroma Source: TAIR
  • chloroplast thylakoid Source: TAIR
  • chloroplast thylakoid lumen Source: UniProtKB-SubCell
  • chloroplast thylakoid membrane Source: TAIR
  • thylakoid Source: TAIR
  • thylakoid lumen Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Chloroplast, Plastid, Thylakoid

Pathology & Biotechi

Disruption phenotypei

Stunted growth and hypersensitivity to high light.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 36ChloroplastSequence analysisAdd BLAST36
Transit peptidei37 – 92Thylakoid2 PublicationsAdd BLAST56
ChainiPRO_000034209593 – 437Peptidyl-prolyl cis-trans isomerase CYP38, chloroplasticAdd BLAST345

Proteomic databases

PaxDbiQ9SSA5.
PRIDEiQ9SSA5.
ProMEXiQ9SSA5.

PTM databases

iPTMnetiQ9SSA5.

Expressioni

Tissue specificityi

Ubiquitous. Lower levels of expression in roots.2 Publications

Inductioni

Up-regulated by light. Down-regulated by dark.1 Publication

Gene expression databases

ExpressionAtlasiQ9SSA5. baseline and differential.
GenevisibleiQ9SSA5. AT.

Interactioni

Protein-protein interaction databases

IntActiQ9SSA5. 1 interactor.
STRINGi3702.AT3G01480.1.

Structurei

Secondary structure

1437
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi93 – 97Combined sources5
Helixi103 – 110Combined sources8
Helixi116 – 126Combined sources11
Helixi128 – 131Combined sources4
Turni137 – 139Combined sources3
Helixi140 – 154Combined sources15
Helixi157 – 161Combined sources5
Turni162 – 164Combined sources3
Helixi167 – 169Combined sources3
Helixi170 – 188Combined sources19
Beta strandi197 – 199Combined sources3
Helixi200 – 202Combined sources3
Helixi203 – 216Combined sources14
Beta strandi237 – 246Combined sources10
Beta strandi254 – 263Combined sources10
Turni264 – 266Combined sources3
Helixi268 – 279Combined sources12
Turni280 – 285Combined sources6
Beta strandi289 – 296Combined sources8
Beta strandi318 – 323Combined sources6
Beta strandi325 – 328Combined sources4
Helixi338 – 340Combined sources3
Beta strandi342 – 349Combined sources8
Beta strandi378 – 382Combined sources5
Beta strandi388 – 390Combined sources3
Beta strandi394 – 403Combined sources10
Helixi406 – 409Combined sources4
Beta strandi415 – 423Combined sources9
Helixi425 – 427Combined sources3
Beta strandi428 – 430Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RFYX-ray2.39A83-437[»]
ProteinModelPortaliQ9SSA5.
SMRiQ9SSA5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini245 – 437PPIase cyclophilin-typePROSITE-ProRule annotationAdd BLAST193

Domaini

The N-teminal helical domain blocks the interaction with the potential target PSII subunit chlorophyll protein 47 (CP47).1 Publication

Sequence similaritiesi

Contains 1 PPIase cyclophilin-type domain.PROSITE-ProRule annotation

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiENOG410IEEW. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065979.
InParanoidiQ9SSA5.
OMAiRNAAFGY.
OrthoDBiEOG09360ADD.
PhylomeDBiQ9SSA5.

Family and domain databases

Gene3Di1.20.120.290. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR023222. PsbQ-like_domain.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 2 hits.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
SUPFAMiSSF101112. SSF101112. 1 hit.
SSF50891. SSF50891. 2 hits.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SSA5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAFASLPT FSVVNSSRFP RRRIGFSCSK KPLEVRCSSG NTRYTKQRGA
60 70 80 90 100
FTSLKECAIS LALSVGLMVS VPSIALPPNA HAVANPVIPD VSVLISGPPI
110 120 130 140 150
KDPEALLRYA LPIDNKAIRE VQKPLEDITD SLKIAGVKAL DSVERNVRQA
160 170 180 190 200
SRTLQQGKSI IVAGFAESKK DHGNEMIEKL EAGMQDMLKI VEDRKRDAVA
210 220 230 240 250
PKQKEILKYV GGIEEDMVDG FPYEVPEEYR NMPLLKGRAS VDMKVKIKDN
260 270 280 290 300
PNIEDCVFRI VLDGYNAPVT AGNFVDLVER HFYDGMEIQR SDGFVVQTGD
310 320 330 340 350
PEGPAEGFID PSTEKTRTVP LEIMVTGEKT PFYGSTLEEL GLYKAQVVIP
360 370 380 390 400
FNAFGTMAMA REEFENDSGS SQVFWLLKES ELTPSNSNIL DGRYAVFGYV
410 420 430
TDNEDFLADL KVGDVIESIQ VVSGLENLAN PSYKIAG
Length:437
Mass (Da):47,982
Last modified:May 1, 2000 - v1
Checksum:i7239C7ADE83953E0
GO
Isoform 2 (identifier: Q9SSA5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     338-355: EELGLYKAQVVIPFNAFG → EVSLSKSLLVRDLYYIVF
     356-437: Missing.

Note: No experimental confirmation available. Derived from EST data.
Show »
Length:355
Mass (Da):39,141
Checksum:i460A33063125B06E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055391338 – 355EELGL…FNAFG → EVSLSKSLLVRDLYYIVF in isoform 2. CuratedAdd BLAST18
Alternative sequenceiVSP_055392356 – 437Missing in isoform 2. CuratedAdd BLAST82

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY568524 mRNA. Translation: AAS75307.1.
AC009325 Genomic DNA. Translation: AAF01533.1.
CP002686 Genomic DNA. Translation: AEE73672.1.
CP002686 Genomic DNA. Translation: AEE73673.1.
AY039843 mRNA. Translation: AAK63947.1.
AY113168 mRNA. Translation: AAM47471.1.
AY087781 mRNA. Translation: AAM65317.1.
AK317631 mRNA. Translation: BAH20293.1.
RefSeqiNP_001118550.1. NM_001125078.1. [Q9SSA5-2]
NP_186797.1. NM_111014.4. [Q9SSA5-1]
UniGeneiAt.20535.

Genome annotation databases

EnsemblPlantsiAT3G01480.1; AT3G01480.1; AT3G01480. [Q9SSA5-1]
AT3G01480.2; AT3G01480.2; AT3G01480. [Q9SSA5-2]
GeneIDi821137.
GrameneiAT3G01480.1; AT3G01480.1; AT3G01480.
AT3G01480.2; AT3G01480.2; AT3G01480.
KEGGiath:AT3G01480.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY568524 mRNA. Translation: AAS75307.1.
AC009325 Genomic DNA. Translation: AAF01533.1.
CP002686 Genomic DNA. Translation: AEE73672.1.
CP002686 Genomic DNA. Translation: AEE73673.1.
AY039843 mRNA. Translation: AAK63947.1.
AY113168 mRNA. Translation: AAM47471.1.
AY087781 mRNA. Translation: AAM65317.1.
AK317631 mRNA. Translation: BAH20293.1.
RefSeqiNP_001118550.1. NM_001125078.1. [Q9SSA5-2]
NP_186797.1. NM_111014.4. [Q9SSA5-1]
UniGeneiAt.20535.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3RFYX-ray2.39A83-437[»]
ProteinModelPortaliQ9SSA5.
SMRiQ9SSA5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9SSA5. 1 interactor.
STRINGi3702.AT3G01480.1.

PTM databases

iPTMnetiQ9SSA5.

Proteomic databases

PaxDbiQ9SSA5.
PRIDEiQ9SSA5.
ProMEXiQ9SSA5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G01480.1; AT3G01480.1; AT3G01480. [Q9SSA5-1]
AT3G01480.2; AT3G01480.2; AT3G01480. [Q9SSA5-2]
GeneIDi821137.
GrameneiAT3G01480.1; AT3G01480.1; AT3G01480.
AT3G01480.2; AT3G01480.2; AT3G01480.
KEGGiath:AT3G01480.

Organism-specific databases

TAIRiAT3G01480.

Phylogenomic databases

eggNOGiENOG410IEEW. Eukaryota.
COG0652. LUCA.
HOGENOMiHOG000065979.
InParanoidiQ9SSA5.
OMAiRNAAFGY.
OrthoDBiEOG09360ADD.
PhylomeDBiQ9SSA5.

Miscellaneous databases

PROiQ9SSA5.

Gene expression databases

ExpressionAtlasiQ9SSA5. baseline and differential.
GenevisibleiQ9SSA5. AT.

Family and domain databases

Gene3Di1.20.120.290. 1 hit.
2.40.100.10. 1 hit.
InterProiIPR029000. Cyclophilin-like_dom.
IPR024936. Cyclophilin-type_PPIase.
IPR002130. Cyclophilin-type_PPIase_dom.
IPR023222. PsbQ-like_domain.
[Graphical view]
PANTHERiPTHR11071. PTHR11071. 2 hits.
PfamiPF00160. Pro_isomerase. 1 hit.
[Graphical view]
SUPFAMiSSF101112. SSF101112. 1 hit.
SSF50891. SSF50891. 2 hits.
PROSITEiPS50072. CSA_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCYP38_ARATH
AccessioniPrimary (citable) accession number: Q9SSA5
Secondary accession number(s): B3H5B8, B9DHS6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 116 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.