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Q9SS48

- SDP6_ARATH

UniProt

Q9SS48 - SDP6_ARATH

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Protein
Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
Gene
SDP6, At3g10370, F14P13.3
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Required for glycerol catabolism and involved in NADH/NAD+ homeostasis. Essential for postgerminative growth and seedling establishment.2 Publications

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FAD.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi75 – 10329FAD Reviewed prediction
Add
BLAST

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase activity Source: TAIR
  2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycerol catabolic process Source: TAIR
  2. glycerol-3-phosphate metabolic process Source: InterPro
  3. glycerophosphate shuttle Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciARA:AT3G10370-MONOMER.
MetaCyc:AT3G10370-MONOMER.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial (EC:1.1.5.3)
Alternative name(s):
Protein SUGAR-DEPENDENT 6
Gene namesi
Name:SDP6
Ordered Locus Names:At3g10370
ORF Names:F14P13.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G10370.

Subcellular locationi

Mitochondrion inner membrane 1 Publication

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. mitochondrion Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi86 – 861S → F in spd6-2; loss of 90% of activity.
Mutagenesisi546 – 5461E → G in spd6-1; loss of 90% of activity.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 629Glycerol-3-phosphate dehydrogenase SDP6, mitochondrialPRO_0000355965
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

PaxDbiQ9SS48.
PRIDEiQ9SS48.

Expressioni

Tissue specificityi

Expressed in germinating seedlings. Also detected in roots, leaves, flowers, developing siliques and germinating seeds.1 Publication

Gene expression databases

GenevestigatoriQ9SS48.

Interactioni

Protein-protein interaction databases

BioGridi5533. 1 interaction.
STRINGi3702.AT3G10370.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9SS48.
SMRiQ9SS48. Positions 66-606.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0578.
HOGENOMiHOG000004813.
InParanoidiQ9SS48.
KOiK00111.
OMAiKHLTESY.
PhylomeDBiQ9SS48.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SS48-1 [UniParc]FASTAAdd to Basket

« Hide

MSLASIRRLA AGAAVIAAAS GGAVYLSPSV ASSDKGGGPI LDSLRRRLGD    50
PTASVPSRSA QESALIAATA SDPLDVLVIG GGATGSGVAL DAVTRGLRVG 100
LVEREDFSSG TSSRSTKLIH GGVRYLEKAV FNLDYGQLKL VFHALEERKQ 150
LIENAPHLCH ALPCMTPCFD WFEVIYFWMG LKMYDLVAGP RLLHLSRYYS 200
AKESIELFPT LARKGKDKNL RGTVVYYDGQ MNDSRLNVGL ACTAALAGAA 250
VLNHAEVVSL ITDDATKRII GARIRNNLTG QEFNSYAKVV VNAAGPFCDS 300
IRKMIDEDTK PMICPSSGVH IVLPDYYSPE GMGLIVPKTK DGRVVFMLPW 350
LGRTVAGTTD SNTSITSLPE PHEDEIQFIL DAISDYLNIK VRRTDVLSAW 400
SGIRPLAMDP TAKSTESISR DHVVFEENPG LVTITGGKWT TYRSMAEDAV 450
DAAIKSGQLK PTNECVTQKL QLLGSYGWEP SSFTTLAQQY VRMKKTYGGK 500
VVPGAMDTAA AKHLSHAYGS MADRVATIAQ EEGLGKRLAH GHPFLEAEVA 550
YCARHEYCES AVDFIARRCR IAFLDTDAAA RALQRVVEIL ASEHKWDKSR 600
QKQELQKAKE FLETFKSSKN AQFNDGKHN 629
Length:629
Mass (Da):68,451
Last modified:May 1, 2000 - v1
Checksum:iCBEA821F268B7DE9
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009400 Genomic DNA. Translation: AAF02807.1.
CP002686 Genomic DNA. Translation: AEE74897.1.
AY063863 mRNA. Translation: AAL36219.1.
AY096363 mRNA. Translation: AAM20004.1.
RefSeqiNP_187648.1. NM_111872.5.
UniGeneiAt.18427.

Genome annotation databases

EnsemblPlantsiAT3G10370.1; AT3G10370.1; AT3G10370.
GeneIDi820199.
KEGGiath:AT3G10370.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009400 Genomic DNA. Translation: AAF02807.1 .
CP002686 Genomic DNA. Translation: AEE74897.1 .
AY063863 mRNA. Translation: AAL36219.1 .
AY096363 mRNA. Translation: AAM20004.1 .
RefSeqi NP_187648.1. NM_111872.5.
UniGenei At.18427.

3D structure databases

ProteinModelPortali Q9SS48.
SMRi Q9SS48. Positions 66-606.
ModBasei Search...

Protein-protein interaction databases

BioGridi 5533. 1 interaction.
STRINGi 3702.AT3G10370.1-P.

Proteomic databases

PaxDbi Q9SS48.
PRIDEi Q9SS48.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G10370.1 ; AT3G10370.1 ; AT3G10370 .
GeneIDi 820199.
KEGGi ath:AT3G10370.

Organism-specific databases

TAIRi AT3G10370.

Phylogenomic databases

eggNOGi COG0578.
HOGENOMi HOG000004813.
InParanoidi Q9SS48.
KOi K00111.
OMAi KHLTESY.
PhylomeDBi Q9SS48.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00673 .
BioCyci ARA:AT3G10370-MONOMER.
MetaCyc:AT3G10370-MONOMER.

Miscellaneous databases

PROi Q9SS48.

Gene expression databases

Genevestigatori Q9SS48.

Family and domain databases

InterProi IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Identification of a mitochondrial glycerol-3-phosphate dehydrogenase from Arabidopsis thaliana: evidence for a mitochondrial glycerol-3-phosphate shuttle in plants."
    Shen W., Wei Y., Dauk M., Zheng Z., Zou J.
    FEBS Lett. 536:92-96(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. "SUGAR-DEPENDENT6 encodes a mitochondrial flavin adenine dinucleotide-dependent glycerol-3-p dehydrogenase, which is required for glycerol catabolism and post germinative seedling growth in Arabidopsis."
    Quettier A.-L., Shaw E., Eastmond P.J.
    Plant Physiol. 148:519-528(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, MUTANTS SPD6-1 AND SPD6-2.

Entry informationi

Entry nameiSDP6_ARATH
AccessioniPrimary (citable) accession number: Q9SS48
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Plants lacking SDP6 are impaired in gluconeogenesis during postgerminative growth.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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