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Q9SS48

- SDP6_ARATH

UniProt

Q9SS48 - SDP6_ARATH

Protein

Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial

Gene

SDP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 81 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Required for glycerol catabolism and involved in NADH/NAD+ homeostasis. Essential for postgerminative growth and seedling establishment.2 Publications

    Catalytic activityi

    sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

    Cofactori

    FAD.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi75 – 10329FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase activity Source: TAIR
    2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: TAIR
    3. glycerophosphate shuttle Source: TAIR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciARA:AT3G10370-MONOMER.
    MetaCyc:AT3G10370-MONOMER.
    UniPathwayiUPA00618; UER00673.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial (EC:1.1.5.3)
    Alternative name(s):
    Protein SUGAR-DEPENDENT 6
    Gene namesi
    Name:SDP6
    Ordered Locus Names:At3g10370
    ORF Names:F14P13.3
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G10370.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. mitochondrion Source: TAIR

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi86 – 861S → F in spd6-2; loss of 90% of activity.
    Mutagenesisi546 – 5461E → G in spd6-1; loss of 90% of activity.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 629Glycerol-3-phosphate dehydrogenase SDP6, mitochondrialPRO_0000355965
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    PaxDbiQ9SS48.
    PRIDEiQ9SS48.

    Expressioni

    Tissue specificityi

    Expressed in germinating seedlings. Also detected in roots, leaves, flowers, developing siliques and germinating seeds.1 Publication

    Gene expression databases

    GenevestigatoriQ9SS48.

    Interactioni

    Protein-protein interaction databases

    BioGridi5533. 1 interaction.
    STRINGi3702.AT3G10370.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SS48.
    SMRiQ9SS48. Positions 66-606.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0578.
    HOGENOMiHOG000004813.
    InParanoidiQ9SS48.
    KOiK00111.
    OMAiKHLTESY.
    PhylomeDBiQ9SS48.

    Family and domain databases

    InterProiIPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    [Graphical view]
    PRINTSiPR01001. FADG3PDH.
    PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9SS48-1 [UniParc]FASTAAdd to Basket

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    MSLASIRRLA AGAAVIAAAS GGAVYLSPSV ASSDKGGGPI LDSLRRRLGD    50
    PTASVPSRSA QESALIAATA SDPLDVLVIG GGATGSGVAL DAVTRGLRVG 100
    LVEREDFSSG TSSRSTKLIH GGVRYLEKAV FNLDYGQLKL VFHALEERKQ 150
    LIENAPHLCH ALPCMTPCFD WFEVIYFWMG LKMYDLVAGP RLLHLSRYYS 200
    AKESIELFPT LARKGKDKNL RGTVVYYDGQ MNDSRLNVGL ACTAALAGAA 250
    VLNHAEVVSL ITDDATKRII GARIRNNLTG QEFNSYAKVV VNAAGPFCDS 300
    IRKMIDEDTK PMICPSSGVH IVLPDYYSPE GMGLIVPKTK DGRVVFMLPW 350
    LGRTVAGTTD SNTSITSLPE PHEDEIQFIL DAISDYLNIK VRRTDVLSAW 400
    SGIRPLAMDP TAKSTESISR DHVVFEENPG LVTITGGKWT TYRSMAEDAV 450
    DAAIKSGQLK PTNECVTQKL QLLGSYGWEP SSFTTLAQQY VRMKKTYGGK 500
    VVPGAMDTAA AKHLSHAYGS MADRVATIAQ EEGLGKRLAH GHPFLEAEVA 550
    YCARHEYCES AVDFIARRCR IAFLDTDAAA RALQRVVEIL ASEHKWDKSR 600
    QKQELQKAKE FLETFKSSKN AQFNDGKHN 629
    Length:629
    Mass (Da):68,451
    Last modified:May 1, 2000 - v1
    Checksum:iCBEA821F268B7DE9
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009400 Genomic DNA. Translation: AAF02807.1.
    CP002686 Genomic DNA. Translation: AEE74897.1.
    AY063863 mRNA. Translation: AAL36219.1.
    AY096363 mRNA. Translation: AAM20004.1.
    RefSeqiNP_187648.1. NM_111872.5.
    UniGeneiAt.18427.

    Genome annotation databases

    EnsemblPlantsiAT3G10370.1; AT3G10370.1; AT3G10370.
    GeneIDi820199.
    KEGGiath:AT3G10370.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009400 Genomic DNA. Translation: AAF02807.1 .
    CP002686 Genomic DNA. Translation: AEE74897.1 .
    AY063863 mRNA. Translation: AAL36219.1 .
    AY096363 mRNA. Translation: AAM20004.1 .
    RefSeqi NP_187648.1. NM_111872.5.
    UniGenei At.18427.

    3D structure databases

    ProteinModelPortali Q9SS48.
    SMRi Q9SS48. Positions 66-606.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 5533. 1 interaction.
    STRINGi 3702.AT3G10370.1-P.

    Proteomic databases

    PaxDbi Q9SS48.
    PRIDEi Q9SS48.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G10370.1 ; AT3G10370.1 ; AT3G10370 .
    GeneIDi 820199.
    KEGGi ath:AT3G10370.

    Organism-specific databases

    TAIRi AT3G10370.

    Phylogenomic databases

    eggNOGi COG0578.
    HOGENOMi HOG000004813.
    InParanoidi Q9SS48.
    KOi K00111.
    OMAi KHLTESY.
    PhylomeDBi Q9SS48.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00673 .
    BioCyci ARA:AT3G10370-MONOMER.
    MetaCyc:AT3G10370-MONOMER.

    Miscellaneous databases

    PROi Q9SS48.

    Gene expression databases

    Genevestigatori Q9SS48.

    Family and domain databases

    InterProi IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    [Graphical view ]
    PRINTSi PR01001. FADG3PDH.
    PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Identification of a mitochondrial glycerol-3-phosphate dehydrogenase from Arabidopsis thaliana: evidence for a mitochondrial glycerol-3-phosphate shuttle in plants."
      Shen W., Wei Y., Dauk M., Zheng Z., Zou J.
      FEBS Lett. 536:92-96(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    5. "SUGAR-DEPENDENT6 encodes a mitochondrial flavin adenine dinucleotide-dependent glycerol-3-p dehydrogenase, which is required for glycerol catabolism and post germinative seedling growth in Arabidopsis."
      Quettier A.-L., Shaw E., Eastmond P.J.
      Plant Physiol. 148:519-528(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, MUTANTS SPD6-1 AND SPD6-2.

    Entry informationi

    Entry nameiSDP6_ARATH
    AccessioniPrimary (citable) accession number: Q9SS48
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 16, 2008
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 81 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Plants lacking SDP6 are impaired in gluconeogenesis during postgerminative growth.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3