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Protein

Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial

Gene

SDP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Required for glycerol catabolism and involved in NADH/NAD+ homeostasis. Essential for postgerminative growth and seedling establishment.2 Publications

Miscellaneous

Plants lacking SDP6 are impaired in gluconeogenesis during postgerminative growth.

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial (SDP6)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 103FADSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • glycerol catabolic process Source: TAIR
  • glycerophosphate shuttle Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciARA:AT3G10370-MONOMER.
MetaCyc:AT3G10370-MONOMER.
ReactomeiR-ATH-163560. Triglyceride catabolism.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial (EC:1.1.5.3)
Alternative name(s):
Protein SUGAR-DEPENDENT 6
Gene namesi
Name:SDP6
Ordered Locus Names:At3g10370
ORF Names:F14P13.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G10370.
TAIRilocus:2076314. AT3G10370.

Subcellular locationi

  • Mitochondrion inner membrane 1 Publication

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi86S → F in spd6-2; loss of 90% of activity. 1
Mutagenesisi546E → G in spd6-1; loss of 90% of activity. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000355965? – 629Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ9SS48.
PRIDEiQ9SS48.

Expressioni

Tissue specificityi

Expressed in germinating seedlings. Also detected in roots, leaves, flowers, developing siliques and germinating seeds.1 Publication

Gene expression databases

ExpressionAtlasiQ9SS48. baseline and differential.
GenevisibleiQ9SS48. AT.

Interactioni

Protein-protein interaction databases

BioGridi5533. 1 interactor.
STRINGi3702.AT3G10370.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SS48.
SMRiQ9SS48.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0042. Eukaryota.
COG0578. LUCA.
HOGENOMiHOG000004813.
InParanoidiQ9SS48.
KOiK00111.
OMAiVPYYWVG.
OrthoDBiEOG093605OU.
PhylomeDBiQ9SS48.

Family and domain databases

Gene3Di3.50.50.60. 1 hit.
InterProiView protein in InterPro
IPR031656. DAO_C.
IPR006076. FAD-dep_OxRdtase.
IPR023753. FAD/NAD-binding_dom.
IPR000447. G3P_DH_FAD-dep.
PANTHERiPTHR11985. PTHR11985. 1 hit.
PfamiView protein in Pfam
PF01266. DAO. 1 hit.
PF16901. DAO_C. 1 hit.
PRINTSiPR01001. FADG3PDH.
SUPFAMiSSF51905. SSF51905. 2 hits.
PROSITEiView protein in PROSITE
PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SS48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLASIRRLA AGAAVIAAAS GGAVYLSPSV ASSDKGGGPI LDSLRRRLGD
60 70 80 90 100
PTASVPSRSA QESALIAATA SDPLDVLVIG GGATGSGVAL DAVTRGLRVG
110 120 130 140 150
LVEREDFSSG TSSRSTKLIH GGVRYLEKAV FNLDYGQLKL VFHALEERKQ
160 170 180 190 200
LIENAPHLCH ALPCMTPCFD WFEVIYFWMG LKMYDLVAGP RLLHLSRYYS
210 220 230 240 250
AKESIELFPT LARKGKDKNL RGTVVYYDGQ MNDSRLNVGL ACTAALAGAA
260 270 280 290 300
VLNHAEVVSL ITDDATKRII GARIRNNLTG QEFNSYAKVV VNAAGPFCDS
310 320 330 340 350
IRKMIDEDTK PMICPSSGVH IVLPDYYSPE GMGLIVPKTK DGRVVFMLPW
360 370 380 390 400
LGRTVAGTTD SNTSITSLPE PHEDEIQFIL DAISDYLNIK VRRTDVLSAW
410 420 430 440 450
SGIRPLAMDP TAKSTESISR DHVVFEENPG LVTITGGKWT TYRSMAEDAV
460 470 480 490 500
DAAIKSGQLK PTNECVTQKL QLLGSYGWEP SSFTTLAQQY VRMKKTYGGK
510 520 530 540 550
VVPGAMDTAA AKHLSHAYGS MADRVATIAQ EEGLGKRLAH GHPFLEAEVA
560 570 580 590 600
YCARHEYCES AVDFIARRCR IAFLDTDAAA RALQRVVEIL ASEHKWDKSR
610 620
QKQELQKAKE FLETFKSSKN AQFNDGKHN
Length:629
Mass (Da):68,451
Last modified:May 1, 2000 - v1
Checksum:iCBEA821F268B7DE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009400 Genomic DNA. Translation: AAF02807.1.
CP002686 Genomic DNA. Translation: AEE74897.1.
AY063863 mRNA. Translation: AAL36219.1.
AY096363 mRNA. Translation: AAM20004.1.
RefSeqiNP_187648.1. NM_111872.6.
UniGeneiAt.18427.

Genome annotation databases

EnsemblPlantsiAT3G10370.1; AT3G10370.1; AT3G10370.
GeneIDi820199.
GrameneiAT3G10370.1; AT3G10370.1; AT3G10370.
KEGGiath:AT3G10370.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiSDP6_ARATH
AccessioniPrimary (citable) accession number: Q9SS48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families