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Q9SS48 (SDP6_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial

EC=1.1.5.3
Alternative name(s):
Protein SUGAR-DEPENDENT 6
Gene names
Name:SDP6
Ordered Locus Names:At3g10370
ORF Names:F14P13.3
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length629 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Required for glycerol catabolism and involved in NADH/NAD+ homeostasis. Essential for postgerminative growth and seedling establishment. Ref.4 Ref.5

Catalytic activity

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactor

FAD.

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route): step 1/1.

Subcellular location

Mitochondrion inner membrane Ref.4.

Tissue specificity

Expressed in germinating seedlings. Also detected in roots, leaves, flowers, developing siliques and germinating seeds. Ref.4

Miscellaneous

Plants lacking SDP6 are impaired in gluconeogenesis during postgerminative growth.

Sequence similarities

Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Transit peptide1 – ?Mitochondrion Potential
Chain? – 629Glycerol-3-phosphate dehydrogenase SDP6, mitochondrialPRO_0000355965

Regions

Nucleotide binding75 – 10329FAD Potential

Experimental info

Mutagenesis861S → F in spd6-2; loss of 90% of activity.
Mutagenesis5461E → G in spd6-1; loss of 90% of activity.

Sequences

Sequence LengthMass (Da)Tools
Q9SS48 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: CBEA821F268B7DE9

FASTA62968,451
        10         20         30         40         50         60 
MSLASIRRLA AGAAVIAAAS GGAVYLSPSV ASSDKGGGPI LDSLRRRLGD PTASVPSRSA 

        70         80         90        100        110        120 
QESALIAATA SDPLDVLVIG GGATGSGVAL DAVTRGLRVG LVEREDFSSG TSSRSTKLIH 

       130        140        150        160        170        180 
GGVRYLEKAV FNLDYGQLKL VFHALEERKQ LIENAPHLCH ALPCMTPCFD WFEVIYFWMG 

       190        200        210        220        230        240 
LKMYDLVAGP RLLHLSRYYS AKESIELFPT LARKGKDKNL RGTVVYYDGQ MNDSRLNVGL 

       250        260        270        280        290        300 
ACTAALAGAA VLNHAEVVSL ITDDATKRII GARIRNNLTG QEFNSYAKVV VNAAGPFCDS 

       310        320        330        340        350        360 
IRKMIDEDTK PMICPSSGVH IVLPDYYSPE GMGLIVPKTK DGRVVFMLPW LGRTVAGTTD 

       370        380        390        400        410        420 
SNTSITSLPE PHEDEIQFIL DAISDYLNIK VRRTDVLSAW SGIRPLAMDP TAKSTESISR 

       430        440        450        460        470        480 
DHVVFEENPG LVTITGGKWT TYRSMAEDAV DAAIKSGQLK PTNECVTQKL QLLGSYGWEP 

       490        500        510        520        530        540 
SSFTTLAQQY VRMKKTYGGK VVPGAMDTAA AKHLSHAYGS MADRVATIAQ EEGLGKRLAH 

       550        560        570        580        590        600 
GHPFLEAEVA YCARHEYCES AVDFIARRCR IAFLDTDAAA RALQRVVEIL ASEHKWDKSR 

       610        620 
QKQELQKAKE FLETFKSSKN AQFNDGKHN 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"Identification of a mitochondrial glycerol-3-phosphate dehydrogenase from Arabidopsis thaliana: evidence for a mitochondrial glycerol-3-phosphate shuttle in plants."
Shen W., Wei Y., Dauk M., Zheng Z., Zou J.
FEBS Lett. 536:92-96(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
[5]"SUGAR-DEPENDENT6 encodes a mitochondrial flavin adenine dinucleotide-dependent glycerol-3-p dehydrogenase, which is required for glycerol catabolism and post germinative seedling growth in Arabidopsis."
Quettier A.-L., Shaw E., Eastmond P.J.
Plant Physiol. 148:519-528(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, MUTANTS SPD6-1 AND SPD6-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC009400 Genomic DNA. Translation: AAF02807.1.
CP002686 Genomic DNA. Translation: AEE74897.1.
AY063863 mRNA. Translation: AAL36219.1.
AY096363 mRNA. Translation: AAM20004.1.
RefSeqNP_187648.1. NM_111872.5.
UniGeneAt.18427.

3D structure databases

ProteinModelPortalQ9SS48.
SMRQ9SS48. Positions 66-606.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid5533. 1 interaction.
STRING3702.AT3G10370.1-P.

Proteomic databases

PaxDbQ9SS48.
PRIDEQ9SS48.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G10370.1; AT3G10370.1; AT3G10370.
GeneID820199.
KEGGath:AT3G10370.

Organism-specific databases

TAIRAT3G10370.

Phylogenomic databases

eggNOGCOG0578.
HOGENOMHOG000004813.
InParanoidQ9SS48.
KOK00111.
OMASYFLTKS.
PhylomeDBQ9SS48.
ProtClustDBPLN02464.

Enzyme and pathway databases

BioCycARA:AT3G10370-MONOMER.
MetaCyc:AT3G10370-MONOMER.
UniPathwayUPA00618; UER00673.

Gene expression databases

GenevestigatorQ9SS48.

Family and domain databases

InterProIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamPF01266. DAO. 1 hit.
[Graphical view]
PRINTSPR01001. FADG3PDH.
PROSITEPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ9SS48.

Entry information

Entry nameSDP6_ARATH
AccessionPrimary (citable) accession number: Q9SS48
Entry history
Integrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: May 1, 2000
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names