Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial

Gene

SDP6

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for glycerol catabolism and involved in NADH/NAD+ homeostasis. Essential for postgerminative growth and seedling establishment.2 Publications

Miscellaneous

Plants lacking SDP6 are impaired in gluconeogenesis during postgerminative growth.

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route).
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial (SDP6)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes glycerone phosphate from sn-glycerol 3-phosphate (anaerobic route), the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi75 – 103FADSequence analysisAdd BLAST29

GO - Molecular functioni

GO - Biological processi

  • glycerol catabolic process Source: TAIR
  • glycerophosphate shuttle Source: TAIR

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein

Enzyme and pathway databases

BioCyciARA:AT3G10370-MONOMER
MetaCyc:AT3G10370-MONOMER
ReactomeiR-ATH-1483166 Synthesis of PA
R-ATH-163560 Triglyceride catabolism
UniPathwayiUPA00618; UER00673

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial (EC:1.1.5.3)
Alternative name(s):
Protein SUGAR-DEPENDENT 6
Gene namesi
Name:SDP6
Ordered Locus Names:At3g10370
ORF Names:F14P13.3
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G10370
TAIRilocus:2076314 AT3G10370

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi86S → F in spd6-2; loss of 90% of activity. 1
Mutagenesisi546E → G in spd6-1; loss of 90% of activity. 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000355965? – 629Glycerol-3-phosphate dehydrogenase SDP6, mitochondrial
Transit peptidei1 – ?MitochondrionSequence analysis

Proteomic databases

PaxDbiQ9SS48
PRIDEiQ9SS48

Expressioni

Tissue specificityi

Expressed in germinating seedlings. Also detected in roots, leaves, flowers, developing siliques and germinating seeds.1 Publication

Gene expression databases

ExpressionAtlasiQ9SS48 baseline and differential
GenevisibleiQ9SS48 AT

Interactioni

Protein-protein interaction databases

BioGridi55331 interactor.
STRINGi3702.AT3G10370.1

Structurei

3D structure databases

ProteinModelPortaliQ9SS48
SMRiQ9SS48
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0042 Eukaryota
COG0578 LUCA
HOGENOMiHOG000004813
InParanoidiQ9SS48
KOiK00111
OMAiVPYYWVG
OrthoDBiEOG093605OU
PhylomeDBiQ9SS48

Family and domain databases

Gene3Di1.10.8.8701 hit
3.50.50.603 hits
InterProiView protein in InterPro
IPR031656 DAO_C
IPR038299 DAO_C_sf
IPR006076 FAD-dep_OxRdtase
IPR036188 FAD/NAD-bd_sf
IPR000447 G3P_DH_FAD-dep
PANTHERiPTHR11985 PTHR11985, 1 hit
PfamiView protein in Pfam
PF01266 DAO, 1 hit
PF16901 DAO_C, 1 hit
PRINTSiPR01001 FADG3PDH
SUPFAMiSSF51905 SSF51905, 2 hits
PROSITEiView protein in PROSITE
PS00977 FAD_G3PDH_1, 1 hit
PS00978 FAD_G3PDH_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SS48-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLASIRRLA AGAAVIAAAS GGAVYLSPSV ASSDKGGGPI LDSLRRRLGD
60 70 80 90 100
PTASVPSRSA QESALIAATA SDPLDVLVIG GGATGSGVAL DAVTRGLRVG
110 120 130 140 150
LVEREDFSSG TSSRSTKLIH GGVRYLEKAV FNLDYGQLKL VFHALEERKQ
160 170 180 190 200
LIENAPHLCH ALPCMTPCFD WFEVIYFWMG LKMYDLVAGP RLLHLSRYYS
210 220 230 240 250
AKESIELFPT LARKGKDKNL RGTVVYYDGQ MNDSRLNVGL ACTAALAGAA
260 270 280 290 300
VLNHAEVVSL ITDDATKRII GARIRNNLTG QEFNSYAKVV VNAAGPFCDS
310 320 330 340 350
IRKMIDEDTK PMICPSSGVH IVLPDYYSPE GMGLIVPKTK DGRVVFMLPW
360 370 380 390 400
LGRTVAGTTD SNTSITSLPE PHEDEIQFIL DAISDYLNIK VRRTDVLSAW
410 420 430 440 450
SGIRPLAMDP TAKSTESISR DHVVFEENPG LVTITGGKWT TYRSMAEDAV
460 470 480 490 500
DAAIKSGQLK PTNECVTQKL QLLGSYGWEP SSFTTLAQQY VRMKKTYGGK
510 520 530 540 550
VVPGAMDTAA AKHLSHAYGS MADRVATIAQ EEGLGKRLAH GHPFLEAEVA
560 570 580 590 600
YCARHEYCES AVDFIARRCR IAFLDTDAAA RALQRVVEIL ASEHKWDKSR
610 620
QKQELQKAKE FLETFKSSKN AQFNDGKHN
Length:629
Mass (Da):68,451
Last modified:May 1, 2000 - v1
Checksum:iCBEA821F268B7DE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009400 Genomic DNA Translation: AAF02807.1
CP002686 Genomic DNA Translation: AEE74897.1
AY063863 mRNA Translation: AAL36219.1
AY096363 mRNA Translation: AAM20004.1
RefSeqiNP_187648.1, NM_111872.6
UniGeneiAt.18427

Genome annotation databases

EnsemblPlantsiAT3G10370.1; AT3G10370.1; AT3G10370
GeneIDi820199
GrameneiAT3G10370.1; AT3G10370.1; AT3G10370
KEGGiath:AT3G10370

Similar proteinsi

Entry informationi

Entry nameiSDP6_ARATH
AccessioniPrimary (citable) accession number: Q9SS48
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome