Q9SRY6 (GSTF5_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glutathione S-transferase F5
Short name=AtGSTF5
EC=2.5.1.18

Alternative name(s):
GST class-phi member 5

Gene names

Name:	GSTF5
Ordered Locus Names:	At1g02940
ORF Names:	F22D16.6

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides By similarity.
Catalytic activity	RX + glutathione = HX + R-S-glutathione.
Subcellular location	Cytoplasm › cytosol Probable.
Sequence similarities	Belongs to the GST superfamily. Phi family. Contains 1 GST C-terminal domain. Contains 1 GST N-terminal domain.
Sequence caution	The sequence AAF02872.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Detoxification
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	response to toxin Inferred from electronic annotation. Source: UniProtKB-KW toxin catabolic process Traceable author statement Ref.3. Source: TAIR
Cellular_component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from direct assay PubMed 14671022. Source: TAIR
Molecular_function	glutathione transferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Glutathione S-transferase F5		PRO_0000413543
Regions
	Domain	37 – 118	82	GST N-terminal
	Domain	126 – 256	131	GST C-terminal
	Region	47 – 48	2	Glutathione binding By similarity
	Region	76 – 77	2	Glutathione binding By similarity
	Region	89 – 90	2	Glutathione binding By similarity
	Region	102 – 103	2	Glutathione binding By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9SRY6 [UniParc]. Last modified October 19, 2011. Version 2. Checksum: CF93E7D6D804C46F	FASTA	256	29,849
	10 20 30 40 50 60 MGINASHVPE TCYHHCNQTF ESSRQCFKWC QELARKDEYK IYGYPYSTNT RRVLAVLHEK 70 80 90 100 110 120 GLSYDPITVN LIAGDQKKPS FLAINPFGQV PVFLDGGLKL TESRAISEYI ATVHKSRGTQ 130 140 150 160 170 180 LLNYKSYKTM GTQRMWMAIE SFEFDPLTST LTWEQSIKPM YGLKTDYKVV NETEAKLEKV 190 200 210 220 230 240 LDIYEERLKN SSFLASNSFT MADLYHLPNI QYLMDTHTKR MFVNRPSVRR WVAEITARPA 250 WKRACDVKAW YHKKKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W. Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[3]	"Probing the diversity of the Arabidopsis glutathione S-transferase gene family." Wagner U., Edwards R., Dixon D.P., Mauch F. Plant Mol. Biol. 49:515-532(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC009525 Genomic DNA. Translation: AAF02872.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE27499.1.
IPI	IPI00538886.
PIR	H86159.
RefSeq	NP_171793.1. NM_100175.1.
UniGene	At.51463.
3D structure databases
HSSP	HSSP built from PDB template 1GNW based on UniProtKB P46422.
ProteinModelPortal	Q9SRY6.
SMR	Q9SRY6. Positions 40-243.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT1G02940.1-P.
Proteomic databases
PaxDb	Q9SRY6.
PRIDE	Q9SRY6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	839479.
KEGG	ath:AT1G02940.
Organism-specific databases
TAIR	At1g02940.
Phylogenomic databases
eggNOG	COG0625.
HOGENOM	HOG000125746.
InParanoid	Q9SRY6.
KO	K00799.
OMA	VNETEAK.
Gene expression databases
ArrayExpress	Q9SRY6.
Genevestigator	Q9SRY6.
Family and domain databases
Gene3D	1.20.1050.10. 1 hit. 3.40.30.10. 1 hit.
InterPro	IPR010987. Glutathione-S-Trfase_C-like. IPR004045. Glutathione_S-Trfase_N. IPR017933. Glutathione_S_Trfase/Cl_chnl_C. IPR004046. GST_C. IPR012336. Thioredoxin-like_fold. [Graphical view]
Pfam	PF00043. GST_C. 1 hit. [Graphical view]
SUPFAM	SSF47616. GST_C_like. 1 hit. SSF52833. Thiordxn-like_fd. 1 hit.
PROSITE	PS50405. GST_CTER. 1 hit. PS50404. GST_NTER. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GSTF5_ARATH

Accession

Primary (citable) accession number: Q9SRY6
Secondary accession number(s): F4HZ88

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2011
Last sequence update:	October 19, 2011
Last modified:	May 1, 2013
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program