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Q9SRV2

- SUVR3_ARATH

UniProt

Q9SRV2 - SUVR3_ARATH

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Protein

Histone-lysine N-methyltransferase SUVR3

Gene

SUVR3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Histone methyltransferase.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi145 – 1451Zinc 1By similarity
Metal bindingi145 – 1451Zinc 2By similarity
Metal bindingi147 – 1471Zinc 1By similarity
Metal bindingi150 – 1501Zinc 1By similarity
Metal bindingi150 – 1501Zinc 3By similarity
Metal bindingi155 – 1551Zinc 1By similarity
Metal bindingi157 – 1571Zinc 2By similarity
Metal bindingi170 – 1701Zinc 2By similarity
Metal bindingi170 – 1701Zinc 3By similarity
Metal bindingi174 – 1741Zinc 2By similarity
Metal bindingi176 – 1761Zinc 3By similarity
Metal bindingi180 – 1801Zinc 3By similarity
Binding sitei262 – 2621S-adenosyl-L-methioninePROSITE-ProRule annotation
Metal bindingi268 – 2681Zinc 4By similarity
Metal bindingi322 – 3221Zinc 4By similarity
Metal bindingi324 – 3241Zinc 4By similarity
Metal bindingi329 – 3291Zinc 4By similarity

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BioCyciARA:AT3G03750-MONOMER.
ARA:GQT-2353-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUVR3 (EC:2.1.1.43)
Alternative name(s):
Protein SET DOMAIN GROUP 20
Suppressor of variegation 3-9-related protein 3
Short name:
Su(var)3-9-related protein 3
Gene namesi
Name:SUVR3
Synonyms:SDG20, SET20
Ordered Locus Names:At3g03750
ORF Names:F20H23.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G03750.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity
Note: Associates with euchromatic regions.By similarity

GO - Cellular componenti

  1. chromosome Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Histone-lysine N-methyltransferase SUVR3PRO_0000233367Add
BLAST

Proteomic databases

PRIDEiQ9SRV2.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SRV2. baseline and differential.
GenevestigatoriQ9SRV2.

Structurei

3D structure databases

ProteinModelPortaliQ9SRV2.
SMRiQ9SRV2. Positions 66-338.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 18846Pre-SETAdd
BLAST
Domaini191 – 307117SETPROSITE-ProRule annotationAdd
BLAST
Domaini318 – 33417Post-SETPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni201 – 2033S-adenosyl-L-methionine bindingBy similarity
Regioni265 – 2662S-adenosyl-L-methionine bindingBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi145 – 18036Cys-richAdd
BLAST

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.Curated
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000029366.
InParanoidiQ9SRV2.
PhylomeDBiQ9SRV2.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9SRV2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLRESPPP KTRCLGEASD IIPAADRFLR CANLILPWLN PRELAVVAQT
60 70 80 90 100
CKTLSLISKS LTIHRSLDAA RSLENISIPF HNSIDSQRYA YFIYTPFQIP
110 120 130 140 150
ASSPPPPRQW WGAAANECGS ESRPCFDSVS ESGRFGVSLV DESGCECERC
160 170 180 190 200
EEGYCKCLAF AGMEEIANEC GSGCGCGSDC SNRVTQKGVS VSLKIVRDEK
210 220 230 240 250
KGWCLYADQL IKQARRRQNI YDKLRSTQSF ASALLVVREH LPSGQACLRI
260 270 280 290 300
NIDATRIGNV ARFINHSCDG GNLSTVLLRS SGALLPRLCF FAAKDIIAEE
310 320 330
ELSFSYGDVS VAGENRDDKL NCSCGSSCCL GTLPCENT
Length:338
Mass (Da):37,002
Last modified:February 5, 2008 - v3
Checksum:i4EB41770E4B2A0A3
GO

Sequence cautioni

The sequence AAF00642.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009540 Genomic DNA. Translation: AAF00642.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE73982.1.
BT008766 mRNA. Translation: AAP68205.1.
AK227335 mRNA. Translation: BAE99347.1.
RefSeqiNP_187025.2. NM_111246.3. [Q9SRV2-1]
NP_974212.1. NM_202483.1.
UniGeneiAt.40936.

Genome annotation databases

EnsemblPlantsiAT3G03750.1; AT3G03750.1; AT3G03750. [Q9SRV2-1]
GeneIDi821169.
KEGGiath:AT3G03750.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009540 Genomic DNA. Translation: AAF00642.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE73982.1 .
BT008766 mRNA. Translation: AAP68205.1 .
AK227335 mRNA. Translation: BAE99347.1 .
RefSeqi NP_187025.2. NM_111246.3. [Q9SRV2-1 ]
NP_974212.1. NM_202483.1.
UniGenei At.40936.

3D structure databases

ProteinModelPortali Q9SRV2.
SMRi Q9SRV2. Positions 66-338.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9SRV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G03750.1 ; AT3G03750.1 ; AT3G03750 . [Q9SRV2-1 ]
GeneIDi 821169.
KEGGi ath:AT3G03750.

Organism-specific databases

TAIRi AT3G03750.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000029366.
InParanoidi Q9SRV2.
PhylomeDBi Q9SRV2.

Enzyme and pathway databases

BioCyci ARA:AT3G03750-MONOMER.
ARA:GQT-2353-MONOMER.

Gene expression databases

ExpressionAtlasi Q9SRV2. baseline and differential.
Genevestigatori Q9SRV2.

Family and domain databases

InterProi IPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
    Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
    Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiSUVR3_ARATH
AccessioniPrimary (citable) accession number: Q9SRV2
Secondary accession number(s): Q1HAZ4, Q7Y033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 5, 2008
Last modified: October 29, 2014
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3