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Q9SRV2

- SUVR3_ARATH

UniProt

Q9SRV2 - SUVR3_ARATH

Protein

Histone-lysine N-methyltransferase SUVR3

Gene

SUVR3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 3 (05 Feb 2008)
      Previous versions | rss
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    Functioni

    Histone methyltransferase.By similarity

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi145 – 1451Zinc 1By similarity
    Metal bindingi145 – 1451Zinc 2By similarity
    Metal bindingi147 – 1471Zinc 1By similarity
    Metal bindingi150 – 1501Zinc 1By similarity
    Metal bindingi150 – 1501Zinc 3By similarity
    Metal bindingi155 – 1551Zinc 1By similarity
    Metal bindingi157 – 1571Zinc 2By similarity
    Metal bindingi170 – 1701Zinc 2By similarity
    Metal bindingi170 – 1701Zinc 3By similarity
    Metal bindingi174 – 1741Zinc 2By similarity
    Metal bindingi176 – 1761Zinc 3By similarity
    Metal bindingi180 – 1801Zinc 3By similarity
    Binding sitei262 – 2621S-adenosyl-L-methioninePROSITE-ProRule annotation
    Metal bindingi268 – 2681Zinc 4By similarity
    Metal bindingi322 – 3221Zinc 4By similarity
    Metal bindingi324 – 3241Zinc 4By similarity
    Metal bindingi329 – 3291Zinc 4By similarity

    GO - Molecular functioni

    1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
    2. zinc ion binding Source: InterPro

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Transferase

    Keywords - Ligandi

    Metal-binding, S-adenosyl-L-methionine, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT3G03750-MONOMER.
    ARA:GQT-2353-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase SUVR3 (EC:2.1.1.43)
    Alternative name(s):
    Protein SET DOMAIN GROUP 20
    Suppressor of variegation 3-9-related protein 3
    Short name:
    Su(var)3-9-related protein 3
    Gene namesi
    Name:SUVR3
    Synonyms:SDG20, SET20
    Ordered Locus Names:At3g03750
    ORF Names:F20H23.22
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G03750.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity
    Note: Associates with euchromatic regions.By similarity

    GO - Cellular componenti

    1. chromosome Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Chromosome, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338Histone-lysine N-methyltransferase SUVR3PRO_0000233367Add
    BLAST

    Proteomic databases

    PRIDEiQ9SRV2.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9SRV2.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SRV2.
    SMRiQ9SRV2. Positions 66-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini143 – 18846Pre-SETAdd
    BLAST
    Domaini191 – 307117SETPROSITE-ProRule annotationAdd
    BLAST
    Domaini318 – 33417Post-SETPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni201 – 2033S-adenosyl-L-methionine bindingBy similarity
    Regioni265 – 2662S-adenosyl-L-methionine bindingBy similarity

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi145 – 18036Cys-richAdd
    BLAST

    Domaini

    In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
    Contains 1 post-SET domain.PROSITE-ProRule annotation
    Contains 1 pre-SET domain.Curated
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    HOGENOMiHOG000029366.
    InParanoidiQ9SRV2.
    PhylomeDBiQ9SRV2.

    Family and domain databases

    InterProiIPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q9SRV2-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQRLRESPPP KTRCLGEASD IIPAADRFLR CANLILPWLN PRELAVVAQT    50
    CKTLSLISKS LTIHRSLDAA RSLENISIPF HNSIDSQRYA YFIYTPFQIP 100
    ASSPPPPRQW WGAAANECGS ESRPCFDSVS ESGRFGVSLV DESGCECERC 150
    EEGYCKCLAF AGMEEIANEC GSGCGCGSDC SNRVTQKGVS VSLKIVRDEK 200
    KGWCLYADQL IKQARRRQNI YDKLRSTQSF ASALLVVREH LPSGQACLRI 250
    NIDATRIGNV ARFINHSCDG GNLSTVLLRS SGALLPRLCF FAAKDIIAEE 300
    ELSFSYGDVS VAGENRDDKL NCSCGSSCCL GTLPCENT 338
    Length:338
    Mass (Da):37,002
    Last modified:February 5, 2008 - v3
    Checksum:i4EB41770E4B2A0A3
    GO

    Sequence cautioni

    The sequence AAF00642.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009540 Genomic DNA. Translation: AAF00642.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE73982.1.
    BT008766 mRNA. Translation: AAP68205.1.
    AK227335 mRNA. Translation: BAE99347.1.
    RefSeqiNP_187025.2. NM_111246.3. [Q9SRV2-1]
    NP_974212.1. NM_202483.1.
    UniGeneiAt.40936.

    Genome annotation databases

    EnsemblPlantsiAT3G03750.1; AT3G03750.1; AT3G03750. [Q9SRV2-1]
    GeneIDi821169.
    KEGGiath:AT3G03750.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC009540 Genomic DNA. Translation: AAF00642.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE73982.1 .
    BT008766 mRNA. Translation: AAP68205.1 .
    AK227335 mRNA. Translation: BAE99347.1 .
    RefSeqi NP_187025.2. NM_111246.3. [Q9SRV2-1 ]
    NP_974212.1. NM_202483.1.
    UniGenei At.40936.

    3D structure databases

    ProteinModelPortali Q9SRV2.
    SMRi Q9SRV2. Positions 66-338.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q9SRV2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G03750.1 ; AT3G03750.1 ; AT3G03750 . [Q9SRV2-1 ]
    GeneIDi 821169.
    KEGGi ath:AT3G03750.

    Organism-specific databases

    TAIRi AT3G03750.

    Phylogenomic databases

    eggNOGi COG2940.
    HOGENOMi HOG000029366.
    InParanoidi Q9SRV2.
    PhylomeDBi Q9SRV2.

    Enzyme and pathway databases

    BioCyci ARA:AT3G03750-MONOMER.
    ARA:GQT-2353-MONOMER.

    Gene expression databases

    Genevestigatori Q9SRV2.

    Family and domain databases

    InterProi IPR006560. AWS.
    IPR003616. Post-SET_dom.
    IPR007728. Pre-SET_dom.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF05033. Pre-SET. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00570. AWS. 1 hit.
    SM00508. PostSET. 1 hit.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS50868. POST_SET. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
      Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
      , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
      Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
      Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
      Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NOMENCLATURE.

    Entry informationi

    Entry nameiSUVR3_ARATH
    AccessioniPrimary (citable) accession number: Q9SRV2
    Secondary accession number(s): Q1HAZ4, Q7Y033
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 2, 2006
    Last sequence update: February 5, 2008
    Last modified: October 1, 2014
    This is version 85 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3