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Protein

Histone-lysine N-methyltransferase SUVR3

Gene

SUVR3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Histone methyltransferase.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi145Zinc 1By similarity1
Metal bindingi145Zinc 2By similarity1
Metal bindingi147Zinc 1By similarity1
Metal bindingi150Zinc 1By similarity1
Metal bindingi150Zinc 3By similarity1
Metal bindingi155Zinc 1By similarity1
Metal bindingi157Zinc 2By similarity1
Metal bindingi170Zinc 2By similarity1
Metal bindingi170Zinc 3By similarity1
Metal bindingi174Zinc 2By similarity1
Metal bindingi176Zinc 3By similarity1
Metal bindingi180Zinc 3By similarity1
Metal bindingi284Zinc 4By similarity1
Binding sitei322S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi338Zinc 4By similarity1
Metal bindingi340Zinc 4By similarity1
Metal bindingi345Zinc 4By similarity1

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUVR3 (EC:2.1.1.43)
Alternative name(s):
Protein SET DOMAIN GROUP 20
Suppressor of variegation 3-9-related protein 3
Short name:
Su(var)3-9-related protein 3
Gene namesi
Name:SUVR3
Synonyms:SDG20, SET20
Ordered Locus Names:At3g03750
ORF Names:F20H23.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G03750.

Subcellular locationi

  • Nucleus By similarity
  • Chromosome By similarity

  • Note: Associates with euchromatic regions.By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333671 – 354Histone-lysine N-methyltransferase SUVR3Add BLAST354

Proteomic databases

PaxDbiQ9SRV2.

PTM databases

iPTMnetiQ9SRV2.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SRV2. baseline and differential.
GenevisibleiQ9SRV2. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G03750.2.

Structurei

3D structure databases

ProteinModelPortaliQ9SRV2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 188Pre-SETAdd BLAST46
Domaini191 – 323SETPROSITE-ProRule annotationAdd BLAST133
Domaini334 – 350Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 203S-adenosyl-L-methionine bindingBy similarity3
Regioni281 – 282S-adenosyl-L-methionine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi145 – 180Cys-richAdd BLAST36

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation
Contains 1 post-SET domain.PROSITE-ProRule annotation
Contains 1 pre-SET domain.Curated
Contains 1 SET domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000029366.
InParanoidiQ9SRV2.
OMAiRINIDAT.
OrthoDBiEOG09360K1Q.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SRV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLRESPPP KTRCLGEASD IIPAADRFLR CANLILPWLN PRELAVVAQT
60 70 80 90 100
CKTLSLISKS LTIHRSLDAA RSLENISIPF HNSIDSQRYA YFIYTPFQIP
110 120 130 140 150
ASSPPPPRQW WGAAANECGS ESRPCFDSVS ESGRFGVSLV DESGCECERC
160 170 180 190 200
EEGYCKCLAF AGMEEIANEC GSGCGCGSDC SNRVTQKGVS VSLKIVRDEK
210 220 230 240 250
KGWCLYADQL IKQGQFICEY AGELLTTDEA RRRQNIYDKL RSTQSFASAL
260 270 280 290 300
LVVREHLPSG QACLRINIDA TRIGNVARFI NHSCDGGNLS TVLLRSSGAL
310 320 330 340 350
LPRLCFFAAK DIIAEEELSF SYGDVSVAGE NRDDKLNCSC GSSCCLGTLP

CENT
Length:354
Mass (Da):38,773
Last modified:December 9, 2015 - v4
Checksum:i4DAA060DC3EEAF0D
GO
Isoform 2 (identifier: Q9SRV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-229: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:338
Mass (Da):37,002
Checksum:i4EB41770E4B2A0A3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058013214 – 229Missing in isoform 2. Add BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009540 Genomic DNA. Translation: AAF00642.1.
CP002686 Genomic DNA. Translation: AEE73981.1.
CP002686 Genomic DNA. Translation: AEE73982.1.
BT008766 mRNA. Translation: AAP68205.1.
AK227335 mRNA. Translation: BAE99347.1.
AB493599 mRNA. Translation: BAH30437.1.
RefSeqiNP_187025.2. NM_111246.3. [Q9SRV2-2]
NP_974212.1. NM_202483.2. [Q9SRV2-1]
UniGeneiAt.40936.

Genome annotation databases

EnsemblPlantsiAT3G03750.1; AT3G03750.1; AT3G03750. [Q9SRV2-2]
AT3G03750.2; AT3G03750.2; AT3G03750. [Q9SRV2-1]
GeneIDi821169.
GrameneiAT3G03750.1; AT3G03750.1; AT3G03750.
AT3G03750.2; AT3G03750.2; AT3G03750.
KEGGiath:AT3G03750.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009540 Genomic DNA. Translation: AAF00642.1.
CP002686 Genomic DNA. Translation: AEE73981.1.
CP002686 Genomic DNA. Translation: AEE73982.1.
BT008766 mRNA. Translation: AAP68205.1.
AK227335 mRNA. Translation: BAE99347.1.
AB493599 mRNA. Translation: BAH30437.1.
RefSeqiNP_187025.2. NM_111246.3. [Q9SRV2-2]
NP_974212.1. NM_202483.2. [Q9SRV2-1]
UniGeneiAt.40936.

3D structure databases

ProteinModelPortaliQ9SRV2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G03750.2.

PTM databases

iPTMnetiQ9SRV2.

Proteomic databases

PaxDbiQ9SRV2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G03750.1; AT3G03750.1; AT3G03750. [Q9SRV2-2]
AT3G03750.2; AT3G03750.2; AT3G03750. [Q9SRV2-1]
GeneIDi821169.
GrameneiAT3G03750.1; AT3G03750.1; AT3G03750.
AT3G03750.2; AT3G03750.2; AT3G03750.
KEGGiath:AT3G03750.

Organism-specific databases

TAIRiAT3G03750.

Phylogenomic databases

eggNOGiKOG1082. Eukaryota.
COG2940. LUCA.
HOGENOMiHOG000029366.
InParanoidiQ9SRV2.
OMAiRINIDAT.
OrthoDBiEOG09360K1Q.

Miscellaneous databases

PROiQ9SRV2.

Gene expression databases

ExpressionAtlasiQ9SRV2. baseline and differential.
GenevisibleiQ9SRV2. AT.

Family and domain databases

InterProiIPR006560. AWS_dom.
IPR003616. Post-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSUVR3_ARATH
AccessioniPrimary (citable) accession number: Q9SRV2
Secondary accession number(s): C0SV96, Q1HAZ4, Q7Y033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 9, 2015
Last modified: November 30, 2016
This is version 102 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.