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Q9SRV2

- SUVR3_ARATH

UniProt

Q9SRV2 - SUVR3_ARATH

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Protein
Histone-lysine N-methyltransferase SUVR3
Gene
SUVR3, SDG20, SET20, At3g03750, F20H23.22
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Histone methyltransferase By similarity.

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi145 – 1451Zinc 1 By similarity
Metal bindingi145 – 1451Zinc 2 By similarity
Metal bindingi147 – 1471Zinc 1 By similarity
Metal bindingi150 – 1501Zinc 1 By similarity
Metal bindingi150 – 1501Zinc 3 By similarity
Metal bindingi155 – 1551Zinc 1 By similarity
Metal bindingi157 – 1571Zinc 2 By similarity
Metal bindingi170 – 1701Zinc 2 By similarity
Metal bindingi170 – 1701Zinc 3 By similarity
Metal bindingi174 – 1741Zinc 2 By similarity
Metal bindingi176 – 1761Zinc 3 By similarity
Metal bindingi180 – 1801Zinc 3 By similarity
Binding sitei262 – 2621S-adenosyl-L-methionine By similarity
Metal bindingi268 – 2681Zinc 4 By similarity
Metal bindingi322 – 3221Zinc 4 By similarity
Metal bindingi324 – 3241Zinc 4 By similarity
Metal bindingi329 – 3291Zinc 4 By similarity

GO - Molecular functioni

  1. histone-lysine N-methyltransferase activity Source: UniProtKB-EC
  2. zinc ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulator, Methyltransferase, Transferase

Keywords - Ligandi

Metal-binding, S-adenosyl-L-methionine, Zinc

Enzyme and pathway databases

BioCyciARA:AT3G03750-MONOMER.
ARA:GQT-2353-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUVR3 (EC:2.1.1.43)
Alternative name(s):
Protein SET DOMAIN GROUP 20
Suppressor of variegation 3-9-related protein 3
Short name:
Su(var)3-9-related protein 3
Gene namesi
Name:SUVR3
Synonyms:SDG20, SET20
Ordered Locus Names:At3g03750
ORF Names:F20H23.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G03750.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity
Note: Associates with euchromatic regions By similarity.

GO - Cellular componenti

  1. chromosome Source: UniProtKB-SubCell
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338Histone-lysine N-methyltransferase SUVR3
PRO_0000233367Add
BLAST

Proteomic databases

PRIDEiQ9SRV2.

Expressioni

Gene expression databases

GenevestigatoriQ9SRV2.

Structurei

3D structure databases

ProteinModelPortaliQ9SRV2.
SMRiQ9SRV2. Positions 66-338.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 18846Pre-SET
Add
BLAST
Domaini191 – 307117SET
Add
BLAST
Domaini318 – 33417Post-SET
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni201 – 2033S-adenosyl-L-methionine binding By similarity
Regioni265 – 2662S-adenosyl-L-methionine binding By similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi145 – 18036Cys-rich
Add
BLAST

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster By similarity.

Sequence similaritiesi

Contains 1 post-SET domain.
Contains 1 pre-SET domain.
Contains 1 SET domain.

Phylogenomic databases

eggNOGiCOG2940.
HOGENOMiHOG000029366.
InParanoidiQ9SRV2.
PhylomeDBiQ9SRV2.

Family and domain databases

InterProiIPR006560. AWS.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view]
PfamiPF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view]
SMARTiSM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view]
PROSITEiPS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9SRV2-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MQRLRESPPP KTRCLGEASD IIPAADRFLR CANLILPWLN PRELAVVAQT    50
CKTLSLISKS LTIHRSLDAA RSLENISIPF HNSIDSQRYA YFIYTPFQIP 100
ASSPPPPRQW WGAAANECGS ESRPCFDSVS ESGRFGVSLV DESGCECERC 150
EEGYCKCLAF AGMEEIANEC GSGCGCGSDC SNRVTQKGVS VSLKIVRDEK 200
KGWCLYADQL IKQARRRQNI YDKLRSTQSF ASALLVVREH LPSGQACLRI 250
NIDATRIGNV ARFINHSCDG GNLSTVLLRS SGALLPRLCF FAAKDIIAEE 300
ELSFSYGDVS VAGENRDDKL NCSCGSSCCL GTLPCENT 338
Length:338
Mass (Da):37,002
Last modified:February 5, 2008 - v3
Checksum:i4EB41770E4B2A0A3
GO

Sequence cautioni

The sequence AAF00642.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009540 Genomic DNA. Translation: AAF00642.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE73982.1.
BT008766 mRNA. Translation: AAP68205.1.
AK227335 mRNA. Translation: BAE99347.1.
RefSeqiNP_187025.2. NM_111246.3. [Q9SRV2-1]
NP_974212.1. NM_202483.1.
UniGeneiAt.40936.

Genome annotation databases

EnsemblPlantsiAT3G03750.1; AT3G03750.1; AT3G03750. [Q9SRV2-1]
GeneIDi821169.
KEGGiath:AT3G03750.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC009540 Genomic DNA. Translation: AAF00642.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE73982.1 .
BT008766 mRNA. Translation: AAP68205.1 .
AK227335 mRNA. Translation: BAE99347.1 .
RefSeqi NP_187025.2. NM_111246.3. [Q9SRV2-1 ]
NP_974212.1. NM_202483.1.
UniGenei At.40936.

3D structure databases

ProteinModelPortali Q9SRV2.
SMRi Q9SRV2. Positions 66-338.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi Q9SRV2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G03750.1 ; AT3G03750.1 ; AT3G03750 . [Q9SRV2-1 ]
GeneIDi 821169.
KEGGi ath:AT3G03750.

Organism-specific databases

TAIRi AT3G03750.

Phylogenomic databases

eggNOGi COG2940.
HOGENOMi HOG000029366.
InParanoidi Q9SRV2.
PhylomeDBi Q9SRV2.

Enzyme and pathway databases

BioCyci ARA:AT3G03750-MONOMER.
ARA:GQT-2353-MONOMER.

Gene expression databases

Genevestigatori Q9SRV2.

Family and domain databases

InterProi IPR006560. AWS.
IPR003616. Post-SET_dom.
IPR007728. Pre-SET_dom.
IPR001214. SET_dom.
[Graphical view ]
Pfami PF05033. Pre-SET. 1 hit.
PF00856. SET. 1 hit.
[Graphical view ]
SMARTi SM00570. AWS. 1 hit.
SM00508. PostSET. 1 hit.
SM00317. SET. 1 hit.
[Graphical view ]
PROSITEi PS50868. POST_SET. 1 hit.
PS50280. SET. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes."
    Baumbusch L.O., Thorstensen T., Krauss V., Fischer A., Naumann K., Assalkhou R., Schulz I., Reuter G., Aalen R.B.
    Nucleic Acids Res. 29:4319-4333(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NOMENCLATURE.

Entry informationi

Entry nameiSUVR3_ARATH
AccessioniPrimary (citable) accession number: Q9SRV2
Secondary accession number(s): Q1HAZ4, Q7Y033
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: February 5, 2008
Last modified: May 14, 2014
This is version 84 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi