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Protein

Histone-lysine N-methyltransferase SUVR3

Gene

SUVR3

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Histone methyltransferase.By similarity

Catalytic activityi

S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N6-methyl-L-lysine-[histone].

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi145Zinc 1By similarity1
Metal bindingi145Zinc 2By similarity1
Metal bindingi147Zinc 1By similarity1
Metal bindingi150Zinc 1By similarity1
Metal bindingi150Zinc 3By similarity1
Metal bindingi155Zinc 1By similarity1
Metal bindingi157Zinc 2By similarity1
Metal bindingi170Zinc 2By similarity1
Metal bindingi170Zinc 3By similarity1
Metal bindingi174Zinc 2By similarity1
Metal bindingi176Zinc 3By similarity1
Metal bindingi180Zinc 3By similarity1
Metal bindingi284Zinc 4By similarity1
Binding sitei322S-adenosyl-L-methioninePROSITE-ProRule annotation1
Metal bindingi338Zinc 4By similarity1
Metal bindingi340Zinc 4By similarity1
Metal bindingi345Zinc 4By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionChromatin regulator, Methyltransferase, Transferase
LigandMetal-binding, S-adenosyl-L-methionine, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Histone-lysine N-methyltransferase SUVR3 (EC:2.1.1.43)
Alternative name(s):
Protein SET DOMAIN GROUP 20
Suppressor of variegation 3-9-related protein 3
Short name:
Su(var)3-9-related protein 3
Gene namesi
Name:SUVR3
Synonyms:SDG20, SET20
Ordered Locus Names:At3g03750
ORF Names:F20H23.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G03750
TAIRilocus:2079369 AT3G03750

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002333671 – 354Histone-lysine N-methyltransferase SUVR3Add BLAST354

Proteomic databases

PaxDbiQ9SRV2

PTM databases

iPTMnetiQ9SRV2

Expressioni

Gene expression databases

ExpressionAtlasiQ9SRV2 differential
GenevisibleiQ9SRV2 AT

Interactioni

Protein-protein interaction databases

IntActiQ9SRV2, 8 interactors
STRINGi3702.AT3G03750.2

Structurei

3D structure databases

ProteinModelPortaliQ9SRV2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 188Pre-SETAdd BLAST46
Domaini191 – 323SETPROSITE-ProRule annotationAdd BLAST133
Domaini334 – 350Post-SETPROSITE-ProRule annotationAdd BLAST17

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni201 – 203S-adenosyl-L-methionine bindingBy similarity3
Regioni281 – 282S-adenosyl-L-methionine bindingBy similarity2

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi145 – 180Cys-richAdd BLAST36

Domaini

In the pre-SET domain, Cys residues bind 3 zinc ions that are arranged in a triangular cluster; some of these Cys residues contribute to the binding of two zinc ions within the cluster.By similarity

Sequence similaritiesi

Belongs to the class V-like SAM-binding methyltransferase superfamily.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1082 Eukaryota
COG2940 LUCA
HOGENOMiHOG000029366
InParanoidiQ9SRV2
KOiK11433
OMAiCCLGTLP
OrthoDBiEOG09360K1Q

Family and domain databases

InterProiView protein in InterPro
IPR006560 AWS_dom
IPR003616 Post-SET_dom
IPR001214 SET_dom
PfamiView protein in Pfam
PF00856 SET, 1 hit
SMARTiView protein in SMART
SM00570 AWS, 1 hit
SM00317 SET, 1 hit
PROSITEiView protein in PROSITE
PS50868 POST_SET, 1 hit
PS50280 SET, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q9SRV2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQRLRESPPP KTRCLGEASD IIPAADRFLR CANLILPWLN PRELAVVAQT
60 70 80 90 100
CKTLSLISKS LTIHRSLDAA RSLENISIPF HNSIDSQRYA YFIYTPFQIP
110 120 130 140 150
ASSPPPPRQW WGAAANECGS ESRPCFDSVS ESGRFGVSLV DESGCECERC
160 170 180 190 200
EEGYCKCLAF AGMEEIANEC GSGCGCGSDC SNRVTQKGVS VSLKIVRDEK
210 220 230 240 250
KGWCLYADQL IKQGQFICEY AGELLTTDEA RRRQNIYDKL RSTQSFASAL
260 270 280 290 300
LVVREHLPSG QACLRINIDA TRIGNVARFI NHSCDGGNLS TVLLRSSGAL
310 320 330 340 350
LPRLCFFAAK DIIAEEELSF SYGDVSVAGE NRDDKLNCSC GSSCCLGTLP

CENT
Length:354
Mass (Da):38,773
Last modified:December 9, 2015 - v4
Checksum:i4DAA060DC3EEAF0D
GO
Isoform 2 (identifier: Q9SRV2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     214-229: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:338
Mass (Da):37,002
Checksum:i4EB41770E4B2A0A3
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_058013214 – 229Missing in isoform 2. Add BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC009540 Genomic DNA Translation: AAF00642.1
CP002686 Genomic DNA Translation: AEE73981.1
CP002686 Genomic DNA Translation: AEE73982.1
BT008766 mRNA Translation: AAP68205.1
AK227335 mRNA Translation: BAE99347.1
AB493599 mRNA Translation: BAH30437.1
RefSeqiNP_187025.2, NM_111246.3 [Q9SRV2-2]
NP_974212.1, NM_202483.2 [Q9SRV2-1]
UniGeneiAt.40936

Genome annotation databases

EnsemblPlantsiAT3G03750.1; AT3G03750.1; AT3G03750 [Q9SRV2-2]
AT3G03750.2; AT3G03750.2; AT3G03750 [Q9SRV2-1]
GeneIDi821169
GrameneiAT3G03750.1; AT3G03750.1; AT3G03750 [Q9SRV2-2]
AT3G03750.2; AT3G03750.2; AT3G03750 [Q9SRV2-1]
KEGGiath:AT3G03750

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSUVR3_ARATH
AccessioniPrimary (citable) accession number: Q9SRV2
Secondary accession number(s): C0SV96, Q1HAZ4, Q7Y033
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2006
Last sequence update: December 9, 2015
Last modified: May 23, 2018
This is version 114 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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