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Protein

Ferritin-2, chloroplastic

Gene

FER2

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation (By similarity).By similarity

Catalytic activityi

4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi100Iron 1PROSITE-ProRule annotation1
Metal bindingi135Iron 1PROSITE-ProRule annotation1
Metal bindingi135Iron 2PROSITE-ProRule annotation1
Metal bindingi138Iron 1PROSITE-ProRule annotation1
Metal bindingi184Iron 2PROSITE-ProRule annotation1
Metal bindingi218Iron 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • intracellular sequestering of iron ion Source: GO_Central
  • iron ion transport Source: InterPro
  • response to abscisic acid Source: TAIR
  • response to oxidative stress Source: TAIR

Keywordsi

Molecular functionOxidoreductase
Biological processIron storage
LigandIron, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G11050-MONOMER
ReactomeiR-ATH-6798695 Neutrophil degranulation
R-ATH-917937 Iron uptake and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Ferritin-2, chloroplastic (EC:1.16.3.1)
Gene namesi
Name:FER2
Ordered Locus Names:At3g11050
ORF Names:F11B9.26, F9F8.13
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G11050
TAIRilocus:2074683 AT3G11050

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chloroplast, Plastid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 45ChloroplastSequence analysisAdd BLAST45
ChainiPRO_000000885546 – 253Ferritin-2, chloroplasticAdd BLAST208

Proteomic databases

PaxDbiQ9SRL5
PRIDEiQ9SRL5

Expressioni

Inductioni

By abscisic acid (ABA).1 Publication

Gene expression databases

ExpressionAtlasiQ9SRL5 baseline and differential
GenevisibleiQ9SRL5 AT

Interactioni

Subunit structurei

Oligomer of 24 subunits. There are two types of subunits: L (light) chain and H (heavy) chain. The major chain can be light or heavy, depending on the species and tissue type. The functional molecule forms a roughly spherical shell with a diameter of 12 nm and contains a central cavity into which the insoluble mineral iron core is deposited (By similarity).By similarity

Protein-protein interaction databases

BioGridi5610, 1 interactor
STRINGi3702.AT3G11050.1

Structurei

3D structure databases

ProteinModelPortaliQ9SRL5
SMRiQ9SRL5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini83 – 236Ferritin-like diironPROSITE-ProRule annotationAdd BLAST154

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni46 – 82Extension peptide (EP)Add BLAST37

Sequence similaritiesi

Belongs to the ferritin family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2332 Eukaryota
COG1528 LUCA
HOGENOMiHOG000223383
InParanoidiQ9SRL5
KOiK00522
OMAiYYASYVY
OrthoDBiEOG09360PX4
PhylomeDBiQ9SRL5

Family and domain databases

Gene3Di1.20.1260.10, 1 hit
InterProiView protein in InterPro
IPR001519 Ferritin
IPR012347 Ferritin-like
IPR009040 Ferritin-like_diiron
IPR009078 Ferritin-like_SF
IPR014034 Ferritin_CS
IPR008331 Ferritin_DPS_dom
PANTHERiPTHR11431 PTHR11431, 1 hit
PfamiView protein in Pfam
PF00210 Ferritin, 1 hit
SUPFAMiSSF47240 SSF47240, 1 hit
PROSITEiView protein in PROSITE
PS00204 FERRITIN_2, 1 hit
PS50905 FERRITIN_LIKE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SRL5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLHKASPALS LLSSGYTGGG NLFPPSRNSS NLLFSPSGSR FSVQAAKGTN
60 70 80 90 100
TKSLTGVVFE PFEEVKKEME LVPTTPFVSL ARHKFSDDSE SAINDQINVE
110 120 130 140 150
YNVSYVYHAL YAYFDRDNVG LKGFAKFFND SSLEERGHAE MFMEYQNKRG
160 170 180 190 200
GRVKLQSILM PVSEFDHEEK GDALHAMELA LSLEKLTNEK LLKLQSVGVK
210 220 230 240 250
NNDVQLVDFV ESEFLGEQVE AIKKISEYVA QLRRIGKGHG VWHFDQMLLN

DEV
Length:253
Mass (Da):28,378
Last modified:May 1, 2000 - v1
Checksum:i92A59DCA3B8EBE3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3H → L in AAM65872 (Ref. 5) Curated1
Sequence conflicti16Y → S in AAM65872 (Ref. 5) Curated1
Sequence conflicti32L → R in AAM65872 (Ref. 5) Curated1
Sequence conflicti40R → K in AAM65872 (Ref. 5) Curated1
Sequence conflicti69 – 70ME → LD in AAM65872 (Ref. 5) Curated2
Sequence conflicti89S → A in AAM65872 (Ref. 5) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ312192 mRNA Translation: CAC85498.1
AC009991 Genomic DNA Translation: AAF01516.1
AC073395 Genomic DNA Translation: AAG50984.1
CP002686 Genomic DNA Translation: AEE74997.1
AK175807 mRNA Translation: BAD43570.1
AK175899 mRNA Translation: BAD43662.1
AK175901 mRNA Translation: BAD43664.1
AK175910 mRNA Translation: BAD43673.1
AY088333 mRNA Translation: AAM65872.1
Z34949 mRNA Translation: CAA84408.1
RefSeqiNP_187716.1, NM_111942.4
UniGeneiAt.17409

Genome annotation databases

EnsemblPlantsiAT3G11050.1; AT3G11050.1; AT3G11050
GeneIDi820276
GrameneiAT3G11050.1; AT3G11050.1; AT3G11050
KEGGiath:AT3G11050

Similar proteinsi

Entry informationi

Entry nameiFRI2_ARATH
AccessioniPrimary (citable) accession number: Q9SRL5
Secondary accession number(s): Q42288, Q8L9N6, Q8WHW4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 11, 2003
Last sequence update: May 1, 2000
Last modified: April 25, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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