ID   SNL1_ARATH              Reviewed;        1372 AA.
AC   Q9SRH9;
DT   18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   27-MAR-2024, entry version 123.
DE   RecName: Full=Paired amphipathic helix protein Sin3-like 1;
GN   Name=SNL1; OrderedLocusNames=At3g01320; ORFNames=T22N4.5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION
RP   WITH ALY2; ALY3; GATA21; TBP1; TRP2; TKI1; VAL1; SKP1B; FBX5 AND PUB14,
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=19962994; DOI=10.1016/j.jmb.2009.11.065;
RA   Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A.,
RA   Conlan R.S.;
RT   "PAH-domain-specific interactions of the Arabidopsis transcription
RT   coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS
RT   EARLY2 Myb-DNA binding factors.";
RL   J. Mol. Biol. 395:937-949(2010).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=11130713; DOI=10.1038/35048706;
RA   Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA   Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA   Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA   Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA   Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA   Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA   Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA   Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA   Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA   Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA   Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA   de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA   Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA   Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA   Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA   Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA   Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA   Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA   Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA   Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA   Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA   Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA   Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL   Nature 408:820-822(2000).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
CC   -!- FUNCTION: Acts as a transcriptional repressor. An histone deacetylase
CC       (HDAC) activity is required for transcription repression. May play a
CC       role in telomere stability. {ECO:0000269|PubMed:19962994}.
CC   -!- SUBUNIT: Interacts (via PAH3) with ALY2. Interacts (via PAH2) with
CC       TBP1. Interacts with ALY3, GATA21, TRP2, TKI1, VAL1, SKP1B, FBX5 and
CC       PUB14. {ECO:0000269|PubMed:19962994}.
CC   -!- INTERACTION:
CC       Q9SRH9; Q6A333: ALY2; NbExp=2; IntAct=EBI-2616294, EBI-2616358;
CC       Q9SRH9; Q9FFY9: TRP4; NbExp=2; IntAct=EBI-2616294, EBI-2616485;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00810,
CC       ECO:0000269|PubMed:19962994}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced. According to EST
CC         sequences.;
CC       Name=1;
CC         IsoId=Q9SRH9-1; Sequence=Displayed;
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAF03494.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AC010676; AAF03494.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002686; AEE73639.1; -; Genomic_DNA.
DR   RefSeq; NP_186781.4; NM_110998.5. [Q9SRH9-1]
DR   AlphaFoldDB; Q9SRH9; -.
DR   SMR; Q9SRH9; -.
DR   BioGRID; 6598; 14.
DR   IntAct; Q9SRH9; 13.
DR   STRING; 3702.Q9SRH9; -.
DR   iPTMnet; Q9SRH9; -.
DR   PaxDb; 3702-AT3G01320-1; -.
DR   ProteomicsDB; 232626; -. [Q9SRH9-1]
DR   EnsemblPlants; AT3G01320.1; AT3G01320.1; AT3G01320. [Q9SRH9-1]
DR   GeneID; 821265; -.
DR   Gramene; AT3G01320.1; AT3G01320.1; AT3G01320. [Q9SRH9-1]
DR   KEGG; ath:AT3G01320; -.
DR   Araport; AT3G01320; -.
DR   TAIR; AT3G01320; SNL1.
DR   eggNOG; KOG4204; Eukaryota.
DR   InParanoid; Q9SRH9; -.
DR   OMA; NYFKSFD; -.
DR   OrthoDB; 199155at2759; -.
DR   PRO; PR:Q9SRH9; -.
DR   Proteomes; UP000006548; Chromosome 3.
DR   ExpressionAtlas; Q9SRH9; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0003714; F:transcription corepressor activity; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of DNA-templated transcription; IDA:UniProtKB.
DR   Gene3D; 1.20.1160.11; Paired amphipathic helix; 3.
DR   InterPro; IPR013194; HDAC_interact_dom.
DR   InterPro; IPR003822; PAH.
DR   InterPro; IPR036600; PAH_sf.
DR   InterPro; IPR039774; Sin3-like.
DR   InterPro; IPR031693; Sin3_C.
DR   PANTHER; PTHR12346:SF67; PAIRED AMPHIPATHIC HELIX PROTEIN SIN3-LIKE 1; 1.
DR   PANTHER; PTHR12346; SIN3B-RELATED; 1.
DR   Pfam; PF02671; PAH; 3.
DR   Pfam; PF08295; Sin3_corepress; 1.
DR   Pfam; PF16879; Sin3a_C; 1.
DR   SMART; SM00761; HDAC_interact; 1.
DR   SUPFAM; SSF47762; PAH2 domain; 3.
DR   PROSITE; PS51477; PAH; 3.
DR   Genevisible; Q9SRH9; AT.
PE   1: Evidence at protein level;
KW   Alternative splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..1372
FT                   /note="Paired amphipathic helix protein Sin3-like 1"
FT                   /id="PRO_0000394040"
FT   DOMAIN          51..121
FT                   /note="PAH 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT   DOMAIN          136..206
FT                   /note="PAH 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT   DOMAIN          331..400
FT                   /note="PAH 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00810"
FT   REGION          1..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          210..244
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          272..323
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          764..783
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          791..817
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          934..1056
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..32
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        210..228
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        272..314
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        794..808
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        941..964
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        971..992
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        993..1014
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1039..1056
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         1049
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9LFQ3"
SQ   SEQUENCE   1372 AA;  156209 MW;  60E5F3E09F38B0C0 CRC64;
     MKRIRDDVYA SGSQFRRPLG SSRGQLCGQS PVHGSGDTEE EEEGGSRRVS QKLTTNDALS
     YLREVKEMFQ DQREKYDRFL EVMKDFKAQR TDTGGVIARV KELFKGHNNL IYGFNTFLPK
     GYEITLIEED DALPKKTVEF EQAINFVNKI KMRFKHDEHV YKSFLEILNM YRKENKEIKE
     VYNEVSILFQ GHLDLLEQFT RFLPASLPSH SAAQHSRSQA QQYSDRGSDP PLLHQMQVEK
     ERRRERAVAL RGDYSVERYD LNDDKTMVKI QREQRKRLDK ENRARRGRDL DDREAGQDNL
     HHFPEKRKSS RRAEALEAYS GSASHSEKDN LKSMYKQAFV FCEKVKDRLC SQDDYQTFLK
     CLNIFSNGII QRKDLQNLVS DLLGKFPDLM DEFNQFFERC ESITDGFQRL AGVMSKKLFS
     SEEQLSRPMK VEEKESEHKP ELEAVKETEQ CKKEYMGKSI QELDLSDCEC CTPSYRLLPA
     DYPIPIASQR SELGAEVLND HWVSVTSGSE DYSFKHMRRN QYEESLFRCE DDRFELDMLL
     ESVSSAARSA ESLLNIITEK KISFSGSFRI EDHFTALNLR CIERLYGDHG LDVIDILNKN
     PATALPVILT RLKQKQGEWK KCRDDFDKVW ANVYAKNHYK SLDHRSFYFK QQDSKNLSAK
     SLLAEIKELK EKSQNDDDVL LSISAGYRQP INPNLEYEYL NRAIHEDMFK VVQFSCEELC
     STKEQLSKVL RLWENFLEAV LGVPPRAKGT DLVEDVVINP KTLDVNHSTS PNGEAAVSSG
     GDTARLASRK LKSAANGDEN SSSGTFKHGI GLLNKDSTGK ENLEDVEIAN RDGVACSAVK
     PQKEQETGNE AEKRFGKPIP MDISERAAIS SISIPSGAEN NHCVVGKEVL PGAHEIQAKP
     SDTLTDIHHD VDSIETVHST QGGDVGNSIV LANGLRSDSS KGTRNSDDPE GPSRNEKEEG
     ELSPNGDFED NFGVYKDHGV KSTSKPENSA EAEVEADAEV ENEDDADDVD SENASEASGT
     ESGGDVCSQD EDREEENGEH DEIDGKAESE GEAEGMDPHL LEGESELLPQ SERVLLSVRP
     LSKHVAAVLC DERTKDLQVF YGNDDFYVLF RLHQILYERI LYAKRNCSGG ELKSKNLKDT
     NAGDPYARFM RVLYGLLDGS AENTKFEDEC RAIIGNQSYV LFTLDKLIYR LVKQLQAIVA
     DEMDNKLLQL YEYEKSRKPG RVIDSVYYEN VRVLVHEENI YRLECSSLPS RLSIQLMDNI
     IEKPEAYAVS MDPTFASYMQ TELLSVSSGK KEEGHDIVLQ RNLTGLYDLC KAMEGVEVVN
     GLECKMSCSS YKIAYVLDTE DYFHRKKKKK KTEQLWQRNK VRVERFHRFL SA
//