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Protein

Paired amphipathic helix protein Sin3-like 1

Gene

SNL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. An histone deacetylase (HDAC) activity is required for transcription repression. May play a role in telomere stability.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3-like 1
Gene namesi
Name:SNL1
Ordered Locus Names:At3g01320
ORF Names:T22N4.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G01320.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation1 Publication

GO - Cellular componenti

  • chromatin Source: GO_Central
  • histone deacetylase complex Source: GO_Central
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13721372Paired amphipathic helix protein Sin3-like 1PRO_0000394040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1049 – 10491PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SRH9.
PRIDEiQ9SRH9.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SRH9. baseline and differential.
GenevestigatoriQ9SRH9.

Interactioni

Subunit structurei

Interacts (via PAH3) with ALY2. Interacts (via PAH2) with TBP1. Interacts with ALY3, GATA21, TRP2, TKI1, VAL1, SKP1B, FBX5 and PUB14.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ALY2Q6A3332EBI-2616294,EBI-2616358
TRP4Q9FFY92EBI-2616294,EBI-2616485

Protein-protein interaction databases

BioGridi6598. 11 interactions.
IntActiQ9SRH9. 10 interactions.
STRINGi3702.AT3G01320.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9SRH9.
SMRiQ9SRH9. Positions 51-121, 137-206, 340-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 12171PAH 1PROSITE-ProRule annotationAdd
BLAST
Domaini136 – 20671PAH 2PROSITE-ProRule annotationAdd
BLAST
Domaini331 – 40070PAH 3PROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 435Poly-Glu
Compositional biasi987 – 106680Glu-richAdd
BLAST
Compositional biasi1346 – 13516Poly-Lys

Sequence similaritiesi

Contains 3 PAH (paired amphipathic helix) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5602.
HOGENOMiHOG000030343.
InParanoidiQ9SRH9.
KOiK11644.
OMAiDERSSAM.

Family and domain databases

Gene3Di1.20.1160.11. 3 hits.
InterProiIPR013194. HDAC_interact.
IPR003822. PAH.
[Graphical view]
PfamiPF02671. PAH. 3 hits.
PF08295. Sin3_corepress. 1 hit.
[Graphical view]
SMARTiSM00761. HDAC_interact. 1 hit.
[Graphical view]
SUPFAMiSSF47762. SSF47762. 3 hits.
PROSITEiPS51477. PAH. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9SRH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRIRDDVYA SGSQFRRPLG SSRGQLCGQS PVHGSGDTEE EEEGGSRRVS
60 70 80 90 100
QKLTTNDALS YLREVKEMFQ DQREKYDRFL EVMKDFKAQR TDTGGVIARV
110 120 130 140 150
KELFKGHNNL IYGFNTFLPK GYEITLIEED DALPKKTVEF EQAINFVNKI
160 170 180 190 200
KMRFKHDEHV YKSFLEILNM YRKENKEIKE VYNEVSILFQ GHLDLLEQFT
210 220 230 240 250
RFLPASLPSH SAAQHSRSQA QQYSDRGSDP PLLHQMQVEK ERRRERAVAL
260 270 280 290 300
RGDYSVERYD LNDDKTMVKI QREQRKRLDK ENRARRGRDL DDREAGQDNL
310 320 330 340 350
HHFPEKRKSS RRAEALEAYS GSASHSEKDN LKSMYKQAFV FCEKVKDRLC
360 370 380 390 400
SQDDYQTFLK CLNIFSNGII QRKDLQNLVS DLLGKFPDLM DEFNQFFERC
410 420 430 440 450
ESITDGFQRL AGVMSKKLFS SEEQLSRPMK VEEKESEHKP ELEAVKETEQ
460 470 480 490 500
CKKEYMGKSI QELDLSDCEC CTPSYRLLPA DYPIPIASQR SELGAEVLND
510 520 530 540 550
HWVSVTSGSE DYSFKHMRRN QYEESLFRCE DDRFELDMLL ESVSSAARSA
560 570 580 590 600
ESLLNIITEK KISFSGSFRI EDHFTALNLR CIERLYGDHG LDVIDILNKN
610 620 630 640 650
PATALPVILT RLKQKQGEWK KCRDDFDKVW ANVYAKNHYK SLDHRSFYFK
660 670 680 690 700
QQDSKNLSAK SLLAEIKELK EKSQNDDDVL LSISAGYRQP INPNLEYEYL
710 720 730 740 750
NRAIHEDMFK VVQFSCEELC STKEQLSKVL RLWENFLEAV LGVPPRAKGT
760 770 780 790 800
DLVEDVVINP KTLDVNHSTS PNGEAAVSSG GDTARLASRK LKSAANGDEN
810 820 830 840 850
SSSGTFKHGI GLLNKDSTGK ENLEDVEIAN RDGVACSAVK PQKEQETGNE
860 870 880 890 900
AEKRFGKPIP MDISERAAIS SISIPSGAEN NHCVVGKEVL PGAHEIQAKP
910 920 930 940 950
SDTLTDIHHD VDSIETVHST QGGDVGNSIV LANGLRSDSS KGTRNSDDPE
960 970 980 990 1000
GPSRNEKEEG ELSPNGDFED NFGVYKDHGV KSTSKPENSA EAEVEADAEV
1010 1020 1030 1040 1050
ENEDDADDVD SENASEASGT ESGGDVCSQD EDREEENGEH DEIDGKAESE
1060 1070 1080 1090 1100
GEAEGMDPHL LEGESELLPQ SERVLLSVRP LSKHVAAVLC DERTKDLQVF
1110 1120 1130 1140 1150
YGNDDFYVLF RLHQILYERI LYAKRNCSGG ELKSKNLKDT NAGDPYARFM
1160 1170 1180 1190 1200
RVLYGLLDGS AENTKFEDEC RAIIGNQSYV LFTLDKLIYR LVKQLQAIVA
1210 1220 1230 1240 1250
DEMDNKLLQL YEYEKSRKPG RVIDSVYYEN VRVLVHEENI YRLECSSLPS
1260 1270 1280 1290 1300
RLSIQLMDNI IEKPEAYAVS MDPTFASYMQ TELLSVSSGK KEEGHDIVLQ
1310 1320 1330 1340 1350
RNLTGLYDLC KAMEGVEVVN GLECKMSCSS YKIAYVLDTE DYFHRKKKKK
1360 1370
KTEQLWQRNK VRVERFHRFL SA
Length:1,372
Mass (Da):156,209
Last modified:May 18, 2010 - v2
Checksum:i60E5F3E09F38B0C0
GO

Sequence cautioni

The sequence AAF03494.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010676 Genomic DNA. Translation: AAF03494.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE73639.1.
RefSeqiNP_186781.4. NM_110998.4. [Q9SRH9-1]
UniGeneiAt.41297.

Genome annotation databases

EnsemblPlantsiAT3G01320.1; AT3G01320.1; AT3G01320. [Q9SRH9-1]
GeneIDi821265.
KEGGiath:AT3G01320.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010676 Genomic DNA. Translation: AAF03494.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE73639.1.
RefSeqiNP_186781.4. NM_110998.4. [Q9SRH9-1]
UniGeneiAt.41297.

3D structure databases

ProteinModelPortaliQ9SRH9.
SMRiQ9SRH9. Positions 51-121, 137-206, 340-402.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi6598. 11 interactions.
IntActiQ9SRH9. 10 interactions.
STRINGi3702.AT3G01320.1-P.

Proteomic databases

PaxDbiQ9SRH9.
PRIDEiQ9SRH9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G01320.1; AT3G01320.1; AT3G01320. [Q9SRH9-1]
GeneIDi821265.
KEGGiath:AT3G01320.

Organism-specific databases

TAIRiAT3G01320.

Phylogenomic databases

eggNOGiCOG5602.
HOGENOMiHOG000030343.
InParanoidiQ9SRH9.
KOiK11644.
OMAiDERSSAM.

Miscellaneous databases

PROiQ9SRH9.

Gene expression databases

ExpressionAtlasiQ9SRH9. baseline and differential.
GenevestigatoriQ9SRH9.

Family and domain databases

Gene3Di1.20.1160.11. 3 hits.
InterProiIPR013194. HDAC_interact.
IPR003822. PAH.
[Graphical view]
PfamiPF02671. PAH. 3 hits.
PF08295. Sin3_corepress. 1 hit.
[Graphical view]
SMARTiSM00761. HDAC_interact. 1 hit.
[Graphical view]
SUPFAMiSSF47762. SSF47762. 3 hits.
PROSITEiPS51477. PAH. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "PAH-domain-specific interactions of the Arabidopsis transcription coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS EARLY2 Myb-DNA binding factors."
    Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A., Conlan R.S.
    J. Mol. Biol. 395:937-949(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ALY2; ALY3; GATA21; TBP1; TRP2; TKI1; VAL1; SKP1B; FBX5 AND PUB14, GENE FAMILY, NOMENCLATURE.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiSNL1_ARATH
AccessioniPrimary (citable) accession number: Q9SRH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: April 29, 2015
This is version 76 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.