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Q9SRH9

- SNL1_ARATH

UniProt

Q9SRH9 - SNL1_ARATH

Protein

Paired amphipathic helix protein Sin3-like 1

Gene

SNL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 71 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Acts as a transcriptional repressor. An histone deacetylase (HDAC) activity is required for transcription repression. May play a role in telomere stability.1 Publication

    GO - Molecular functioni

    1. protein binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of transcription, DNA-templated Source: UniProtKB
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Repressor

    Keywords - Biological processi

    Transcription, Transcription regulation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Paired amphipathic helix protein Sin3-like 1
    Gene namesi
    Name:SNL1
    Ordered Locus Names:At3g01320
    ORF Names:T22N4.5
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 3

    Organism-specific databases

    TAIRiAT3G01320.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 13721372Paired amphipathic helix protein Sin3-like 1PRO_0000394040Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1049 – 10491PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ9SRH9.
    PRIDEiQ9SRH9.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9SRH9.

    Interactioni

    Subunit structurei

    Interacts (via PAH3) with ALY2. Interacts (via PAH2) with TBP1. Interacts with ALY3, GATA21, TRP2, TKI1, VAL1, SKP1B, FBX5 and PUB14.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ALY2Q6A3332EBI-2616294,EBI-2616358
    TRP4Q9FFY92EBI-2616294,EBI-2616485

    Protein-protein interaction databases

    BioGridi6598. 11 interactions.
    IntActiQ9SRH9. 10 interactions.
    STRINGi3702.AT3G01320.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SRH9.
    SMRiQ9SRH9. Positions 51-121, 137-206, 340-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini51 – 12171PAH 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini136 – 20671PAH 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini331 – 40070PAH 3PROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi39 – 435Poly-Glu
    Compositional biasi987 – 106680Glu-richAdd
    BLAST
    Compositional biasi1346 – 13516Poly-Lys

    Sequence similaritiesi

    Contains 3 PAH (paired amphipathic helix) domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5602.
    HOGENOMiHOG000030343.
    KOiK11644.
    OMAiEEKESEH.

    Family and domain databases

    Gene3Di1.20.1160.11. 3 hits.
    InterProiIPR013194. HDAC_interact.
    IPR003822. PAH.
    [Graphical view]
    PfamiPF02671. PAH. 3 hits.
    PF08295. Sin3_corepress. 1 hit.
    [Graphical view]
    SMARTiSM00761. HDAC_interact. 1 hit.
    [Graphical view]
    SUPFAMiSSF47762. SSF47762. 3 hits.
    PROSITEiPS51477. PAH. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q9SRH9-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MKRIRDDVYA SGSQFRRPLG SSRGQLCGQS PVHGSGDTEE EEEGGSRRVS     50
    QKLTTNDALS YLREVKEMFQ DQREKYDRFL EVMKDFKAQR TDTGGVIARV 100
    KELFKGHNNL IYGFNTFLPK GYEITLIEED DALPKKTVEF EQAINFVNKI 150
    KMRFKHDEHV YKSFLEILNM YRKENKEIKE VYNEVSILFQ GHLDLLEQFT 200
    RFLPASLPSH SAAQHSRSQA QQYSDRGSDP PLLHQMQVEK ERRRERAVAL 250
    RGDYSVERYD LNDDKTMVKI QREQRKRLDK ENRARRGRDL DDREAGQDNL 300
    HHFPEKRKSS RRAEALEAYS GSASHSEKDN LKSMYKQAFV FCEKVKDRLC 350
    SQDDYQTFLK CLNIFSNGII QRKDLQNLVS DLLGKFPDLM DEFNQFFERC 400
    ESITDGFQRL AGVMSKKLFS SEEQLSRPMK VEEKESEHKP ELEAVKETEQ 450
    CKKEYMGKSI QELDLSDCEC CTPSYRLLPA DYPIPIASQR SELGAEVLND 500
    HWVSVTSGSE DYSFKHMRRN QYEESLFRCE DDRFELDMLL ESVSSAARSA 550
    ESLLNIITEK KISFSGSFRI EDHFTALNLR CIERLYGDHG LDVIDILNKN 600
    PATALPVILT RLKQKQGEWK KCRDDFDKVW ANVYAKNHYK SLDHRSFYFK 650
    QQDSKNLSAK SLLAEIKELK EKSQNDDDVL LSISAGYRQP INPNLEYEYL 700
    NRAIHEDMFK VVQFSCEELC STKEQLSKVL RLWENFLEAV LGVPPRAKGT 750
    DLVEDVVINP KTLDVNHSTS PNGEAAVSSG GDTARLASRK LKSAANGDEN 800
    SSSGTFKHGI GLLNKDSTGK ENLEDVEIAN RDGVACSAVK PQKEQETGNE 850
    AEKRFGKPIP MDISERAAIS SISIPSGAEN NHCVVGKEVL PGAHEIQAKP 900
    SDTLTDIHHD VDSIETVHST QGGDVGNSIV LANGLRSDSS KGTRNSDDPE 950
    GPSRNEKEEG ELSPNGDFED NFGVYKDHGV KSTSKPENSA EAEVEADAEV 1000
    ENEDDADDVD SENASEASGT ESGGDVCSQD EDREEENGEH DEIDGKAESE 1050
    GEAEGMDPHL LEGESELLPQ SERVLLSVRP LSKHVAAVLC DERTKDLQVF 1100
    YGNDDFYVLF RLHQILYERI LYAKRNCSGG ELKSKNLKDT NAGDPYARFM 1150
    RVLYGLLDGS AENTKFEDEC RAIIGNQSYV LFTLDKLIYR LVKQLQAIVA 1200
    DEMDNKLLQL YEYEKSRKPG RVIDSVYYEN VRVLVHEENI YRLECSSLPS 1250
    RLSIQLMDNI IEKPEAYAVS MDPTFASYMQ TELLSVSSGK KEEGHDIVLQ 1300
    RNLTGLYDLC KAMEGVEVVN GLECKMSCSS YKIAYVLDTE DYFHRKKKKK 1350
    KTEQLWQRNK VRVERFHRFL SA 1372
    Length:1,372
    Mass (Da):156,209
    Last modified:May 18, 2010 - v2
    Checksum:i60E5F3E09F38B0C0
    GO

    Sequence cautioni

    The sequence AAF03494.1 differs from that shown. Reason: Erroneous gene model prediction.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010676 Genomic DNA. Translation: AAF03494.1. Sequence problems.
    CP002686 Genomic DNA. Translation: AEE73639.1.
    RefSeqiNP_186781.4. NM_110998.4. [Q9SRH9-1]
    UniGeneiAt.41297.

    Genome annotation databases

    EnsemblPlantsiAT3G01320.1; AT3G01320.1; AT3G01320. [Q9SRH9-1]
    GeneIDi821265.
    KEGGiath:AT3G01320.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC010676 Genomic DNA. Translation: AAF03494.1 . Sequence problems.
    CP002686 Genomic DNA. Translation: AEE73639.1 .
    RefSeqi NP_186781.4. NM_110998.4. [Q9SRH9-1 ]
    UniGenei At.41297.

    3D structure databases

    ProteinModelPortali Q9SRH9.
    SMRi Q9SRH9. Positions 51-121, 137-206, 340-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 6598. 11 interactions.
    IntActi Q9SRH9. 10 interactions.
    STRINGi 3702.AT3G01320.1-P.

    Proteomic databases

    PaxDbi Q9SRH9.
    PRIDEi Q9SRH9.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT3G01320.1 ; AT3G01320.1 ; AT3G01320 . [Q9SRH9-1 ]
    GeneIDi 821265.
    KEGGi ath:AT3G01320.

    Organism-specific databases

    TAIRi AT3G01320.

    Phylogenomic databases

    eggNOGi COG5602.
    HOGENOMi HOG000030343.
    KOi K11644.
    OMAi EEKESEH.

    Gene expression databases

    Genevestigatori Q9SRH9.

    Family and domain databases

    Gene3Di 1.20.1160.11. 3 hits.
    InterProi IPR013194. HDAC_interact.
    IPR003822. PAH.
    [Graphical view ]
    Pfami PF02671. PAH. 3 hits.
    PF08295. Sin3_corepress. 1 hit.
    [Graphical view ]
    SMARTi SM00761. HDAC_interact. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47762. SSF47762. 3 hits.
    PROSITEi PS51477. PAH. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "PAH-domain-specific interactions of the Arabidopsis transcription coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS EARLY2 Myb-DNA binding factors."
      Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A., Conlan R.S.
      J. Mol. Biol. 395:937-949(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ALY2; ALY3; GATA21; TBP1; TRP2; TKI1; VAL1; SKP1B; FBX5 AND PUB14, GENE FAMILY, NOMENCLATURE.
    2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
      Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
      , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
      Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.

    Entry informationi

    Entry nameiSNL1_ARATH
    AccessioniPrimary (citable) accession number: Q9SRH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 18, 2010
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 71 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3