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Q9SRH9

- SNL1_ARATH

UniProt

Q9SRH9 - SNL1_ARATH

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Protein
Paired amphipathic helix protein Sin3-like 1
Gene
SNL1, At3g01320, T22N4.5
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. An histone deacetylase (HDAC) activity is required for transcription repression. May play a role in telomere stability.1 Publication

GO - Molecular functioni

  1. protein binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of transcription, DNA-templated Source: UniProtKB
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3-like 1
Gene namesi
Name:SNL1
Ordered Locus Names:At3g01320
ORF Names:T22N4.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G01320.

Subcellular locationi

Nucleus 1 Publication

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 13721372Paired amphipathic helix protein Sin3-like 1
PRO_0000394040Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1049 – 10491Phosphoserine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SRH9.
PRIDEiQ9SRH9.

Expressioni

Gene expression databases

GenevestigatoriQ9SRH9.

Interactioni

Subunit structurei

Interacts (via PAH3) with ALY2. Interacts (via PAH2) with TBP1. Interacts with ALY3, GATA21, TRP2, TKI1, VAL1, SKP1B, FBX5 and PUB14.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ALY2Q6A3332EBI-2616294,EBI-2616358
TRP4Q9FFY92EBI-2616294,EBI-2616485

Protein-protein interaction databases

BioGridi6598. 11 interactions.
IntActiQ9SRH9. 10 interactions.
STRINGi3702.AT3G01320.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9SRH9.
SMRiQ9SRH9. Positions 51-121, 137-206, 340-402.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini51 – 12171PAH 1
Add
BLAST
Domaini136 – 20671PAH 2
Add
BLAST
Domaini331 – 40070PAH 3
Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi39 – 435Poly-Glu
Compositional biasi987 – 106680Glu-rich
Add
BLAST
Compositional biasi1346 – 13516Poly-Lys

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5602.
HOGENOMiHOG000030343.
KOiK11644.
OMAiEEKESEH.

Family and domain databases

Gene3Di1.20.1160.11. 3 hits.
InterProiIPR013194. HDAC_interact.
IPR003822. PAH.
[Graphical view]
PfamiPF02671. PAH. 3 hits.
PF08295. Sin3_corepress. 1 hit.
[Graphical view]
SMARTiSM00761. HDAC_interact. 1 hit.
[Graphical view]
SUPFAMiSSF47762. SSF47762. 3 hits.
PROSITEiPS51477. PAH. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9SRH9-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MKRIRDDVYA SGSQFRRPLG SSRGQLCGQS PVHGSGDTEE EEEGGSRRVS     50
QKLTTNDALS YLREVKEMFQ DQREKYDRFL EVMKDFKAQR TDTGGVIARV 100
KELFKGHNNL IYGFNTFLPK GYEITLIEED DALPKKTVEF EQAINFVNKI 150
KMRFKHDEHV YKSFLEILNM YRKENKEIKE VYNEVSILFQ GHLDLLEQFT 200
RFLPASLPSH SAAQHSRSQA QQYSDRGSDP PLLHQMQVEK ERRRERAVAL 250
RGDYSVERYD LNDDKTMVKI QREQRKRLDK ENRARRGRDL DDREAGQDNL 300
HHFPEKRKSS RRAEALEAYS GSASHSEKDN LKSMYKQAFV FCEKVKDRLC 350
SQDDYQTFLK CLNIFSNGII QRKDLQNLVS DLLGKFPDLM DEFNQFFERC 400
ESITDGFQRL AGVMSKKLFS SEEQLSRPMK VEEKESEHKP ELEAVKETEQ 450
CKKEYMGKSI QELDLSDCEC CTPSYRLLPA DYPIPIASQR SELGAEVLND 500
HWVSVTSGSE DYSFKHMRRN QYEESLFRCE DDRFELDMLL ESVSSAARSA 550
ESLLNIITEK KISFSGSFRI EDHFTALNLR CIERLYGDHG LDVIDILNKN 600
PATALPVILT RLKQKQGEWK KCRDDFDKVW ANVYAKNHYK SLDHRSFYFK 650
QQDSKNLSAK SLLAEIKELK EKSQNDDDVL LSISAGYRQP INPNLEYEYL 700
NRAIHEDMFK VVQFSCEELC STKEQLSKVL RLWENFLEAV LGVPPRAKGT 750
DLVEDVVINP KTLDVNHSTS PNGEAAVSSG GDTARLASRK LKSAANGDEN 800
SSSGTFKHGI GLLNKDSTGK ENLEDVEIAN RDGVACSAVK PQKEQETGNE 850
AEKRFGKPIP MDISERAAIS SISIPSGAEN NHCVVGKEVL PGAHEIQAKP 900
SDTLTDIHHD VDSIETVHST QGGDVGNSIV LANGLRSDSS KGTRNSDDPE 950
GPSRNEKEEG ELSPNGDFED NFGVYKDHGV KSTSKPENSA EAEVEADAEV 1000
ENEDDADDVD SENASEASGT ESGGDVCSQD EDREEENGEH DEIDGKAESE 1050
GEAEGMDPHL LEGESELLPQ SERVLLSVRP LSKHVAAVLC DERTKDLQVF 1100
YGNDDFYVLF RLHQILYERI LYAKRNCSGG ELKSKNLKDT NAGDPYARFM 1150
RVLYGLLDGS AENTKFEDEC RAIIGNQSYV LFTLDKLIYR LVKQLQAIVA 1200
DEMDNKLLQL YEYEKSRKPG RVIDSVYYEN VRVLVHEENI YRLECSSLPS 1250
RLSIQLMDNI IEKPEAYAVS MDPTFASYMQ TELLSVSSGK KEEGHDIVLQ 1300
RNLTGLYDLC KAMEGVEVVN GLECKMSCSS YKIAYVLDTE DYFHRKKKKK 1350
KTEQLWQRNK VRVERFHRFL SA 1372
Length:1,372
Mass (Da):156,209
Last modified:May 18, 2010 - v2
Checksum:i60E5F3E09F38B0C0
GO

Sequence cautioni

The sequence AAF03494.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010676 Genomic DNA. Translation: AAF03494.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE73639.1.
RefSeqiNP_186781.4. NM_110998.4. [Q9SRH9-1]
UniGeneiAt.41297.

Genome annotation databases

EnsemblPlantsiAT3G01320.1; AT3G01320.1; AT3G01320. [Q9SRH9-1]
GeneIDi821265.
KEGGiath:AT3G01320.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC010676 Genomic DNA. Translation: AAF03494.1 . Sequence problems.
CP002686 Genomic DNA. Translation: AEE73639.1 .
RefSeqi NP_186781.4. NM_110998.4. [Q9SRH9-1 ]
UniGenei At.41297.

3D structure databases

ProteinModelPortali Q9SRH9.
SMRi Q9SRH9. Positions 51-121, 137-206, 340-402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 6598. 11 interactions.
IntActi Q9SRH9. 10 interactions.
STRINGi 3702.AT3G01320.1-P.

Proteomic databases

PaxDbi Q9SRH9.
PRIDEi Q9SRH9.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G01320.1 ; AT3G01320.1 ; AT3G01320 . [Q9SRH9-1 ]
GeneIDi 821265.
KEGGi ath:AT3G01320.

Organism-specific databases

TAIRi AT3G01320.

Phylogenomic databases

eggNOGi COG5602.
HOGENOMi HOG000030343.
KOi K11644.
OMAi EEKESEH.

Gene expression databases

Genevestigatori Q9SRH9.

Family and domain databases

Gene3Di 1.20.1160.11. 3 hits.
InterProi IPR013194. HDAC_interact.
IPR003822. PAH.
[Graphical view ]
Pfami PF02671. PAH. 3 hits.
PF08295. Sin3_corepress. 1 hit.
[Graphical view ]
SMARTi SM00761. HDAC_interact. 1 hit.
[Graphical view ]
SUPFAMi SSF47762. SSF47762. 3 hits.
PROSITEi PS51477. PAH. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PAH-domain-specific interactions of the Arabidopsis transcription coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS EARLY2 Myb-DNA binding factors."
    Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A., Conlan R.S.
    J. Mol. Biol. 395:937-949(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ALY2; ALY3; GATA21; TBP1; TRP2; TKI1; VAL1; SKP1B; FBX5 AND PUB14, GENE FAMILY, NOMENCLATURE.
  2. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.

Entry informationi

Entry nameiSNL1_ARATH
AccessioniPrimary (citable) accession number: Q9SRH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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