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Q9SRH9 (SNL1_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Paired amphipathic helix protein Sin3-like 1
Gene names
Name:SNL1
Ordered Locus Names:At3g01320
ORF Names:T22N4.5
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length1372 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a transcriptional repressor. An histone deacetylase (HDAC) activity is required for transcription repression. May play a role in telomere stability. Ref.1

Subunit structure

Interacts (via PAH3) with ALY2. Interacts (via PAH2) with TBP1. Interacts with ALY3, GATA21, TRP2, TKI1, VAL1, SKP1B, FBX5 and PUB14. Ref.1

Subcellular location

Nucleus Ref.1.

Sequence similarities

Contains 3 PAH (paired amphipathic helix) domains.

Sequence caution

The sequence AAF03494.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityAlternative splicing
   DomainRepeat
   Molecular functionRepressor
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processnegative regulation of transcription, DNA-templated

Inferred from direct assay Ref.1. Source: UniProtKB

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from direct assay Ref.1. Source: UniProtKB

   Molecular_functionprotein binding

Inferred from physical interaction Ref.1. Source: UniProtKB

Complete GO annotation...

Binary interactions

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9SRH9-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 13721372Paired amphipathic helix protein Sin3-like 1
PRO_0000394040

Regions

Domain51 – 12171PAH 1
Domain136 – 20671PAH 2
Domain331 – 40070PAH 3
Compositional bias39 – 435Poly-Glu
Compositional bias987 – 106680Glu-rich
Compositional bias1346 – 13516Poly-Lys

Amino acid modifications

Modified residue10491Phosphoserine By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified May 18, 2010. Version 2.
Checksum: 60E5F3E09F38B0C0

FASTA1,372156,209
        10         20         30         40         50         60 
MKRIRDDVYA SGSQFRRPLG SSRGQLCGQS PVHGSGDTEE EEEGGSRRVS QKLTTNDALS 

        70         80         90        100        110        120 
YLREVKEMFQ DQREKYDRFL EVMKDFKAQR TDTGGVIARV KELFKGHNNL IYGFNTFLPK 

       130        140        150        160        170        180 
GYEITLIEED DALPKKTVEF EQAINFVNKI KMRFKHDEHV YKSFLEILNM YRKENKEIKE 

       190        200        210        220        230        240 
VYNEVSILFQ GHLDLLEQFT RFLPASLPSH SAAQHSRSQA QQYSDRGSDP PLLHQMQVEK 

       250        260        270        280        290        300 
ERRRERAVAL RGDYSVERYD LNDDKTMVKI QREQRKRLDK ENRARRGRDL DDREAGQDNL 

       310        320        330        340        350        360 
HHFPEKRKSS RRAEALEAYS GSASHSEKDN LKSMYKQAFV FCEKVKDRLC SQDDYQTFLK 

       370        380        390        400        410        420 
CLNIFSNGII QRKDLQNLVS DLLGKFPDLM DEFNQFFERC ESITDGFQRL AGVMSKKLFS 

       430        440        450        460        470        480 
SEEQLSRPMK VEEKESEHKP ELEAVKETEQ CKKEYMGKSI QELDLSDCEC CTPSYRLLPA 

       490        500        510        520        530        540 
DYPIPIASQR SELGAEVLND HWVSVTSGSE DYSFKHMRRN QYEESLFRCE DDRFELDMLL 

       550        560        570        580        590        600 
ESVSSAARSA ESLLNIITEK KISFSGSFRI EDHFTALNLR CIERLYGDHG LDVIDILNKN 

       610        620        630        640        650        660 
PATALPVILT RLKQKQGEWK KCRDDFDKVW ANVYAKNHYK SLDHRSFYFK QQDSKNLSAK 

       670        680        690        700        710        720 
SLLAEIKELK EKSQNDDDVL LSISAGYRQP INPNLEYEYL NRAIHEDMFK VVQFSCEELC 

       730        740        750        760        770        780 
STKEQLSKVL RLWENFLEAV LGVPPRAKGT DLVEDVVINP KTLDVNHSTS PNGEAAVSSG 

       790        800        810        820        830        840 
GDTARLASRK LKSAANGDEN SSSGTFKHGI GLLNKDSTGK ENLEDVEIAN RDGVACSAVK 

       850        860        870        880        890        900 
PQKEQETGNE AEKRFGKPIP MDISERAAIS SISIPSGAEN NHCVVGKEVL PGAHEIQAKP 

       910        920        930        940        950        960 
SDTLTDIHHD VDSIETVHST QGGDVGNSIV LANGLRSDSS KGTRNSDDPE GPSRNEKEEG 

       970        980        990       1000       1010       1020 
ELSPNGDFED NFGVYKDHGV KSTSKPENSA EAEVEADAEV ENEDDADDVD SENASEASGT 

      1030       1040       1050       1060       1070       1080 
ESGGDVCSQD EDREEENGEH DEIDGKAESE GEAEGMDPHL LEGESELLPQ SERVLLSVRP 

      1090       1100       1110       1120       1130       1140 
LSKHVAAVLC DERTKDLQVF YGNDDFYVLF RLHQILYERI LYAKRNCSGG ELKSKNLKDT 

      1150       1160       1170       1180       1190       1200 
NAGDPYARFM RVLYGLLDGS AENTKFEDEC RAIIGNQSYV LFTLDKLIYR LVKQLQAIVA 

      1210       1220       1230       1240       1250       1260 
DEMDNKLLQL YEYEKSRKPG RVIDSVYYEN VRVLVHEENI YRLECSSLPS RLSIQLMDNI 

      1270       1280       1290       1300       1310       1320 
IEKPEAYAVS MDPTFASYMQ TELLSVSSGK KEEGHDIVLQ RNLTGLYDLC KAMEGVEVVN 

      1330       1340       1350       1360       1370 
GLECKMSCSS YKIAYVLDTE DYFHRKKKKK KTEQLWQRNK VRVERFHRFL SA 

« Hide

References

« Hide 'large scale' references
[1]"PAH-domain-specific interactions of the Arabidopsis transcription coregulator SIN3-LIKE1 (SNL1) with telomere-binding protein 1 and ALWAYS EARLY2 Myb-DNA binding factors."
Bowen A.J., Gonzalez D., Mullins J.G., Bhatt A.M., Martinez A., Conlan R.S.
J. Mol. Biol. 395:937-949(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH ALY2; ALY3; GATA21; TBP1; TRP2; TKI1; VAL1; SKP1B; FBX5 AND PUB14, GENE FAMILY, NOMENCLATURE.
[2]"Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F. expand/collapse author list , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC010676 Genomic DNA. Translation: AAF03494.1. Sequence problems.
CP002686 Genomic DNA. Translation: AEE73639.1.
RefSeqNP_186781.4. NM_110998.4. [Q9SRH9-1]
UniGeneAt.41297.

3D structure databases

ProteinModelPortalQ9SRH9.
SMRQ9SRH9. Positions 51-121, 137-206, 340-402.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid6598. 11 interactions.
IntActQ9SRH9. 10 interactions.
STRING3702.AT3G01320.1-P.

Proteomic databases

PaxDbQ9SRH9.
PRIDEQ9SRH9.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT3G01320.1; AT3G01320.1; AT3G01320. [Q9SRH9-1]
GeneID821265.
KEGGath:AT3G01320.

Organism-specific databases

TAIRAT3G01320.

Phylogenomic databases

eggNOGCOG5602.
HOGENOMHOG000030343.
KOK11644.
OMAEEKESEH.

Gene expression databases

GenevestigatorQ9SRH9.

Family and domain databases

Gene3D1.20.1160.11. 3 hits.
InterProIPR013194. HDAC_interact.
IPR003822. PAH.
[Graphical view]
PfamPF02671. PAH. 3 hits.
PF08295. Sin3_corepress. 1 hit.
[Graphical view]
SMARTSM00761. HDAC_interact. 1 hit.
[Graphical view]
SUPFAMSSF47762. SSF47762. 3 hits.
PROSITEPS51477. PAH. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSNL1_ARATH
AccessionPrimary (citable) accession number: Q9SRH9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: June 11, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names