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Protein

Paired amphipathic helix protein Sin3-like 1

Gene

SNL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a transcriptional repressor. An histone deacetylase (HDAC) activity is required for transcription repression. May play a role in telomere stability.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired amphipathic helix protein Sin3-like 1
Gene namesi
Name:SNL1
Ordered Locus Names:At3g01320
ORF Names:T22N4.5
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G01320
TAIRilocus:2100277 AT3G01320

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003940401 – 1372Paired amphipathic helix protein Sin3-like 1Add BLAST1372

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1049PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SRH9
PRIDEiQ9SRH9

PTM databases

iPTMnetiQ9SRH9

Expressioni

Gene expression databases

ExpressionAtlasiQ9SRH9 baseline and differential
GenevisibleiQ9SRH9 AT

Interactioni

Subunit structurei

Interacts (via PAH3) with ALY2. Interacts (via PAH2) with TBP1. Interacts with ALY3, GATA21, TRP2, TKI1, VAL1, SKP1B, FBX5 and PUB14.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi659811 interactors.
IntActiQ9SRH9 13 interactors.
STRINGi3702.AT3G01320.1

Structurei

3D structure databases

ProteinModelPortaliQ9SRH9
SMRiQ9SRH9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini51 – 121PAH 1PROSITE-ProRule annotationAdd BLAST71
Domaini136 – 206PAH 2PROSITE-ProRule annotationAdd BLAST71
Domaini331 – 400PAH 3PROSITE-ProRule annotationAdd BLAST70

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 43Poly-Glu5
Compositional biasi987 – 1066Glu-richAdd BLAST80
Compositional biasi1346 – 1351Poly-Lys6

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4204 Eukaryota
COG5602 LUCA
HOGENOMiHOG000030343
InParanoidiQ9SRH9
KOiK11644
OMAiFKHDEHV
OrthoDBiEOG093600I9

Family and domain databases

InterProiView protein in InterPro
IPR013194 HDAC_interact_dom
IPR003822 PAH
IPR036600 PAH_sf
IPR031693 Sin3_C
PfamiView protein in Pfam
PF02671 PAH, 3 hits
PF08295 Sin3_corepress, 1 hit
PF16879 Sin3a_C, 1 hit
SMARTiView protein in SMART
SM00761 HDAC_interact, 1 hit
SUPFAMiSSF47762 SSF47762, 3 hits
PROSITEiView protein in PROSITE
PS51477 PAH, 3 hits

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9SRH9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKRIRDDVYA SGSQFRRPLG SSRGQLCGQS PVHGSGDTEE EEEGGSRRVS
60 70 80 90 100
QKLTTNDALS YLREVKEMFQ DQREKYDRFL EVMKDFKAQR TDTGGVIARV
110 120 130 140 150
KELFKGHNNL IYGFNTFLPK GYEITLIEED DALPKKTVEF EQAINFVNKI
160 170 180 190 200
KMRFKHDEHV YKSFLEILNM YRKENKEIKE VYNEVSILFQ GHLDLLEQFT
210 220 230 240 250
RFLPASLPSH SAAQHSRSQA QQYSDRGSDP PLLHQMQVEK ERRRERAVAL
260 270 280 290 300
RGDYSVERYD LNDDKTMVKI QREQRKRLDK ENRARRGRDL DDREAGQDNL
310 320 330 340 350
HHFPEKRKSS RRAEALEAYS GSASHSEKDN LKSMYKQAFV FCEKVKDRLC
360 370 380 390 400
SQDDYQTFLK CLNIFSNGII QRKDLQNLVS DLLGKFPDLM DEFNQFFERC
410 420 430 440 450
ESITDGFQRL AGVMSKKLFS SEEQLSRPMK VEEKESEHKP ELEAVKETEQ
460 470 480 490 500
CKKEYMGKSI QELDLSDCEC CTPSYRLLPA DYPIPIASQR SELGAEVLND
510 520 530 540 550
HWVSVTSGSE DYSFKHMRRN QYEESLFRCE DDRFELDMLL ESVSSAARSA
560 570 580 590 600
ESLLNIITEK KISFSGSFRI EDHFTALNLR CIERLYGDHG LDVIDILNKN
610 620 630 640 650
PATALPVILT RLKQKQGEWK KCRDDFDKVW ANVYAKNHYK SLDHRSFYFK
660 670 680 690 700
QQDSKNLSAK SLLAEIKELK EKSQNDDDVL LSISAGYRQP INPNLEYEYL
710 720 730 740 750
NRAIHEDMFK VVQFSCEELC STKEQLSKVL RLWENFLEAV LGVPPRAKGT
760 770 780 790 800
DLVEDVVINP KTLDVNHSTS PNGEAAVSSG GDTARLASRK LKSAANGDEN
810 820 830 840 850
SSSGTFKHGI GLLNKDSTGK ENLEDVEIAN RDGVACSAVK PQKEQETGNE
860 870 880 890 900
AEKRFGKPIP MDISERAAIS SISIPSGAEN NHCVVGKEVL PGAHEIQAKP
910 920 930 940 950
SDTLTDIHHD VDSIETVHST QGGDVGNSIV LANGLRSDSS KGTRNSDDPE
960 970 980 990 1000
GPSRNEKEEG ELSPNGDFED NFGVYKDHGV KSTSKPENSA EAEVEADAEV
1010 1020 1030 1040 1050
ENEDDADDVD SENASEASGT ESGGDVCSQD EDREEENGEH DEIDGKAESE
1060 1070 1080 1090 1100
GEAEGMDPHL LEGESELLPQ SERVLLSVRP LSKHVAAVLC DERTKDLQVF
1110 1120 1130 1140 1150
YGNDDFYVLF RLHQILYERI LYAKRNCSGG ELKSKNLKDT NAGDPYARFM
1160 1170 1180 1190 1200
RVLYGLLDGS AENTKFEDEC RAIIGNQSYV LFTLDKLIYR LVKQLQAIVA
1210 1220 1230 1240 1250
DEMDNKLLQL YEYEKSRKPG RVIDSVYYEN VRVLVHEENI YRLECSSLPS
1260 1270 1280 1290 1300
RLSIQLMDNI IEKPEAYAVS MDPTFASYMQ TELLSVSSGK KEEGHDIVLQ
1310 1320 1330 1340 1350
RNLTGLYDLC KAMEGVEVVN GLECKMSCSS YKIAYVLDTE DYFHRKKKKK
1360 1370
KTEQLWQRNK VRVERFHRFL SA
Length:1,372
Mass (Da):156,209
Last modified:May 18, 2010 - v2
Checksum:i60E5F3E09F38B0C0
GO

Sequence cautioni

The sequence AAF03494 differs from that shown. Reason: Erroneous gene model prediction.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010676 Genomic DNA Translation: AAF03494.1 Sequence problems.
CP002686 Genomic DNA Translation: AEE73639.1
RefSeqiNP_186781.4, NM_110998.5 [Q9SRH9-1]
UniGeneiAt.41297

Genome annotation databases

EnsemblPlantsiAT3G01320.1; AT3G01320.1; AT3G01320 [Q9SRH9-1]
GeneIDi821265
GrameneiAT3G01320.1; AT3G01320.1; AT3G01320 [Q9SRH9-1]
KEGGiath:AT3G01320

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiSNL1_ARATH
AccessioniPrimary (citable) accession number: Q9SRH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: April 25, 2018
This is version 97 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome