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Protein

Mitochondrial outer membrane protein porin 1

Gene

VDAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant development at reproductive stage, is important for pollen development and may regulate hydrogen peroxide generation during disease resistance.By similarity1 Publication

GO - Molecular functioni

  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: TAIR

GO - Biological processi

  • defense response Source: UniProtKB-KW
  • response to bacterium Source: TAIR

Keywordsi

Molecular functionPorin
Biological processIon transport, Plant defense, Transport

Protein family/group databases

TCDBi1.B.8.1.15 the mitochondrial and plastid porin (mpp) family

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial outer membrane protein porin 1
Alternative name(s):
Voltage-dependent anion-selective channel protein 1
Short name:
AtVDAC1
Short name:
VDAC-1
Gene namesi
Name:VDAC1
Ordered Locus Names:At3g01280
ORF Names:T22N4.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G01280
TAIRilocus:2100252 AT3G01280

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Disruption phenotypei

In vdac1-6 homozygous plants, normal growth, but small siliques and decreased pollen germination rate and tube length.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi223P → H: Alteration of subcellular localization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000505262 – 276Mitochondrial outer membrane protein porin 1Add BLAST275

Proteomic databases

PaxDbiQ9SRH5
PRIDEiQ9SRH5

PTM databases

iPTMnetiQ9SRH5

Expressioni

Tissue specificityi

Expressed in shoot meristems, root meristematic zone, lateral roots, leaves, stigma and anthers.1 Publication

Inductioni

By the bacterial pathogen P.syringae pv. tomato.2 Publications

Gene expression databases

ExpressionAtlasiQ9SRH5 baseline and differential
GenevisibleiQ9SRH5 AT

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HXK1Q425252EBI-1644501,EBI-1644489

Protein-protein interaction databases

BioGridi6248, 2 interactors
IntActiQ9SRH5, 4 interactors
MINTiQ9SRH5
STRINGi3702.AT3G01280.1

Structurei

3D structure databases

ProteinModelPortaliQ9SRH5
SMRiQ9SRH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126 Eukaryota
ENOG410ZBK1 LUCA
HOGENOMiHOG000238012
InParanoidiQ9SRH5
KOiK15040
OMAiKYKWAEH
OrthoDBiEOG09360J2F
PhylomeDBiQ9SRH5

Family and domain databases

Gene3Di2.40.160.10, 1 hit
InterProiView protein in InterPro
IPR023614 Porin_dom_sf
IPR001925 Porin_Euk
IPR027246 Porin_Euk/Tom40
PfamiView protein in Pfam
PF01459 Porin_3, 1 hit
PROSITEiView protein in PROSITE
PS00558 EUKARYOTIC_PORIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SRH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKGPGLYTE IGKKARDLLY KDHNSDQKFS ITTFSPAGVA ITSTGTKKGD
60 70 80 90 100
LLLGDVAFQS RRKNITTDLK VCTDSTFLIT ATVDEAAPGL RSIFSFKVPD
110 120 130 140 150
QNSGKVELQY LHEYAGISTS MGLTQNPTVN FSGVIGSNVL AVGTDVSFDT
160 170 180 190 200
KSGNFTKINA GLSFTKEDLI ASLTVNDKGD LLNASYYHIV NPLFNTAVGA
210 220 230 240 250
EVSHKLSSKD STITVGTQHS LDPLTSVKAR VNSAGIASAL IQHEWKPKSF
260 270
FTISGEVDTK SIDKSAKVGL ALALKP
Length:276
Mass (Da):29,425
Last modified:January 23, 2007 - v3
Checksum:i7F33F53E56E9765C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010676 Genomic DNA Translation: AAF03498.1
CP002686 Genomic DNA Translation: AEE73632.1
AY037217 mRNA Translation: AAK59817.1
AY113169 mRNA Translation: AAM47472.1
RefSeqiNP_186777.1, NM_110994.4
UniGeneiAt.24885

Genome annotation databases

EnsemblPlantsiAT3G01280.1; AT3G01280.1; AT3G01280
GeneIDi820914
GrameneiAT3G01280.1; AT3G01280.1; AT3G01280
KEGGiath:AT3G01280

Similar proteinsi

Entry informationi

Entry nameiVDAC1_ARATH
AccessioniPrimary (citable) accession number: Q9SRH5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 121 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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