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Protein

Mitochondrial outer membrane protein porin 1

Gene

VDAC1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant development at reproductive stage, is important for pollen development and may regulate hydrogen peroxide generation during disease resistance.By similarity1 Publication

GO - Molecular functioni

  • porin activity Source: UniProtKB-KW
  • voltage-gated anion channel activity Source: TAIR

GO - Biological processi

  • defense response Source: UniProtKB-KW
  • response to bacterium Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Porin

Keywords - Biological processi

Ion transport, Plant defense, Transport

Protein family/group databases

TCDBi1.B.8.1.15. the mitochondrial and plastid porin (mpp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial outer membrane protein porin 1
Alternative name(s):
Voltage-dependent anion-selective channel protein 1
Short name:
AtVDAC1
Short name:
VDAC-1
Gene namesi
Name:VDAC1
Ordered Locus Names:At3g01280
ORF Names:T22N4.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G01280.

Subcellular locationi

GO - Cellular componenti

  • chloroplast Source: TAIR
  • chloroplast envelope Source: TAIR
  • mitochondrial outer membrane Source: UniProtKB-SubCell
  • mitochondrion Source: TAIR
  • plasma membrane Source: TAIR
  • plastid Source: TAIR
  • pore complex Source: UniProtKB-KW
  • vacuolar membrane Source: TAIR
  • vacuole Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Disruption phenotypei

In vdac1-6 homozygous plants, normal growth, but small siliques and decreased pollen germination rate and tube length.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi223P → H: Alteration of subcellular localization. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00000505262 – 276Mitochondrial outer membrane protein porin 1Add BLAST275

Proteomic databases

PaxDbiQ9SRH5.
PRIDEiQ9SRH5.

PTM databases

iPTMnetiQ9SRH5.

Expressioni

Tissue specificityi

Expressed in shoot meristems, root meristematic zone, lateral roots, leaves, stigma and anthers.1 Publication

Inductioni

By the bacterial pathogen P.syringae pv. tomato.2 Publications

Gene expression databases

GenevisibleiQ9SRH5. AT.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HXK1Q425252EBI-1644501,EBI-1644489

Protein-protein interaction databases

BioGridi6248. 2 interactors.
IntActiQ9SRH5. 4 interactors.
MINTiMINT-7046723.
STRINGi3702.AT3G01280.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SRH5.
SMRiQ9SRH5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domaini

Consists mainly of membrane-spanning sided beta-sheets.

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane beta strand

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
HOGENOMiHOG000238012.
InParanoidiQ9SRH5.
KOiK15040.
OMAiWTTSNAL.
OrthoDBiEOG09360J2F.
PhylomeDBiQ9SRH5.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SRH5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKGPGLYTE IGKKARDLLY KDHNSDQKFS ITTFSPAGVA ITSTGTKKGD
60 70 80 90 100
LLLGDVAFQS RRKNITTDLK VCTDSTFLIT ATVDEAAPGL RSIFSFKVPD
110 120 130 140 150
QNSGKVELQY LHEYAGISTS MGLTQNPTVN FSGVIGSNVL AVGTDVSFDT
160 170 180 190 200
KSGNFTKINA GLSFTKEDLI ASLTVNDKGD LLNASYYHIV NPLFNTAVGA
210 220 230 240 250
EVSHKLSSKD STITVGTQHS LDPLTSVKAR VNSAGIASAL IQHEWKPKSF
260 270
FTISGEVDTK SIDKSAKVGL ALALKP
Length:276
Mass (Da):29,425
Last modified:January 23, 2007 - v3
Checksum:i7F33F53E56E9765C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010676 Genomic DNA. Translation: AAF03498.1.
CP002686 Genomic DNA. Translation: AEE73632.1.
AY037217 mRNA. Translation: AAK59817.1.
AY113169 mRNA. Translation: AAM47472.1.
RefSeqiNP_186777.1. NM_110994.4.
UniGeneiAt.24885.

Genome annotation databases

EnsemblPlantsiAT3G01280.1; AT3G01280.1; AT3G01280.
GeneIDi820914.
GrameneiAT3G01280.1; AT3G01280.1; AT3G01280.
KEGGiath:AT3G01280.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC010676 Genomic DNA. Translation: AAF03498.1.
CP002686 Genomic DNA. Translation: AEE73632.1.
AY037217 mRNA. Translation: AAK59817.1.
AY113169 mRNA. Translation: AAM47472.1.
RefSeqiNP_186777.1. NM_110994.4.
UniGeneiAt.24885.

3D structure databases

ProteinModelPortaliQ9SRH5.
SMRiQ9SRH5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi6248. 2 interactors.
IntActiQ9SRH5. 4 interactors.
MINTiMINT-7046723.
STRINGi3702.AT3G01280.1.

Protein family/group databases

TCDBi1.B.8.1.15. the mitochondrial and plastid porin (mpp) family.

PTM databases

iPTMnetiQ9SRH5.

Proteomic databases

PaxDbiQ9SRH5.
PRIDEiQ9SRH5.

Protocols and materials databases

DNASUi820914.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G01280.1; AT3G01280.1; AT3G01280.
GeneIDi820914.
GrameneiAT3G01280.1; AT3G01280.1; AT3G01280.
KEGGiath:AT3G01280.

Organism-specific databases

TAIRiAT3G01280.

Phylogenomic databases

eggNOGiKOG3126. Eukaryota.
ENOG410ZBK1. LUCA.
HOGENOMiHOG000238012.
InParanoidiQ9SRH5.
KOiK15040.
OMAiWTTSNAL.
OrthoDBiEOG09360J2F.
PhylomeDBiQ9SRH5.

Miscellaneous databases

PROiQ9SRH5.

Gene expression databases

GenevisibleiQ9SRH5. AT.

Family and domain databases

Gene3Di2.40.160.10. 1 hit.
InterProiIPR023614. Porin_dom.
IPR001925. Porin_Euk.
IPR027246. Porin_Euk/Tom40.
[Graphical view]
PfamiPF01459. Porin_3. 1 hit.
[Graphical view]
PROSITEiPS00558. EUKARYOTIC_PORIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiVDAC1_ARATH
AccessioniPrimary (citable) accession number: Q9SRH5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.