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Q9SR40

- LAC7_ARATH

UniProt

Q9SR40 - LAC7_ARATH

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Protein

Laccase-7

Gene

LAC7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Copper 1; type 2By similarity
Metal bindingi83 – 831Copper 2; type 3By similarity
Metal bindingi126 – 1261Copper 2; type 3By similarity
Metal bindingi128 – 1281Copper 3; type 3By similarity
Metal bindingi468 – 4681Copper 4; type 1By similarity
Metal bindingi471 – 4711Copper 1; type 2By similarity
Metal bindingi473 – 4731Copper 3; type 3By similarity
Metal bindingi530 – 5301Copper 3; type 3By similarity
Metal bindingi531 – 5311Copper 4; type 1By similarity
Metal bindingi532 – 5321Copper 2; type 3By similarity
Metal bindingi536 – 5361Copper 4; type 1By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G09220-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-7 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 7
Diphenol oxidase 7
Urishiol oxidase 7
Gene namesi
Name:LAC7
Ordered Locus Names:At3g09220
ORF Names:F3L24.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G09220.

Subcellular locationi

GO - Cellular componenti

  1. apoplast Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Sequence AnalysisAdd
BLAST
Chaini24 – 567544Laccase-7PRO_0000283635Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...)Sequence Analysis
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
Glycosylationi77 – 771N-linked (GlcNAc...)Sequence Analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi186 – 1861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi298 – 2981N-linked (GlcNAc...)Sequence Analysis
Glycosylationi339 – 3391N-linked (GlcNAc...)Sequence Analysis
Glycosylationi374 – 3741N-linked (GlcNAc...)Sequence Analysis
Glycosylationi386 – 3861N-linked (GlcNAc...)Sequence Analysis
Glycosylationi427 – 4271N-linked (GlcNAc...)Sequence Analysis
Glycosylationi450 – 4501N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SR40.
PRIDEiQ9SR40.

Expressioni

Tissue specificityi

Predominantly expressed in tissues other than the inflorescence stem.2 Publications

Gene expression databases

GenevestigatoriQ9SR40.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G09220.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9SR40.
SMRiQ9SR40. Positions 23-559.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 147117Plastocyanin-like 1Add
BLAST
Domaini157 – 310154Plastocyanin-like 2Add
BLAST
Domaini412 – 551140Plastocyanin-like 3Add
BLAST

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated
Contains 3 plastocyanin-like domains.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9SR40.
OMAiWHAHASF.
PhylomeDBiQ9SR40.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SR40 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEGVRVPIAC ALILLAISSI TSASIVEHTF NVQNLTVSRL CKRQVITVVN
60 70 80 90 100
GSLPGPTIRV KEGDSLVIHV LNHSPHNITI HWHGIFHKLT VWADGPSMIT
110 120 130 140 150
QCPIQPGQRY AYRFNITGQE GTLWWHAHAS FLRATVYGAL VIRPKSGHSY
160 170 180 190 200
PFPKPHKEVP ILFGEWWNTD VVALEEAAIA TGVPPNNSDA YTINGRPGNL
210 220 230 240 250
YPCSKDRMFS LNVVKGKRYL LRIINAAMNI QLFFKIANHR LTVVAADAVY
260 270 280 290 300
TAPYVTDVIV IAPGQTIDAL LFADQSVDTS YYMAAHPYAS APAVPFPNTT
310 320 330 340 350
TRGVIHYGGA SKTGRSKPVL MPKLPSFFDT LTAYRFYSNL TALVNGPHWV
360 370 380 390 400
PVPRYVDEEM LVTIGLGLEA CADNTTCPKF SASMSNHSFV LPKKLSILEA
410 420 430 440 450
VFHDVKGIFT ADFPDQPPVK FDYTNPNVTQ TNPGLLFTQK STSAKILKFN
460 470 480 490 500
TTVEVVLQNH ALIAAESHPM HLHGFNFHVL AQGFGNYDPS RDRSKLNLVD
510 520 530 540 550
PQSRNTLAVP VGGWAVIRFT ANNPGAWIFH CHIDVHLPFG LGMIFVVKNG
560
PTKSTTLPPP PPDLPKC
Length:567
Mass (Da):62,403
Last modified:May 1, 2000 - v1
Checksum:iBA4EFEAA57734D2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011436 Genomic DNA. Translation: AAF14041.1.
CP002686 Genomic DNA. Translation: AEE74739.1.
AK117639 mRNA. Translation: BAC42295.1.
BT004971 mRNA. Translation: AAO50504.1.
RefSeqiNP_187533.1. NM_111756.2.
UniGeneiAt.40144.

Genome annotation databases

EnsemblPlantsiAT3G09220.1; AT3G09220.1; AT3G09220.
GeneIDi820078.
KEGGiath:AT3G09220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011436 Genomic DNA. Translation: AAF14041.1 .
CP002686 Genomic DNA. Translation: AEE74739.1 .
AK117639 mRNA. Translation: BAC42295.1 .
BT004971 mRNA. Translation: AAO50504.1 .
RefSeqi NP_187533.1. NM_111756.2.
UniGenei At.40144.

3D structure databases

ProteinModelPortali Q9SR40.
SMRi Q9SR40. Positions 23-559.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 3702.AT3G09220.1-P.

Proteomic databases

PaxDbi Q9SR40.
PRIDEi Q9SR40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G09220.1 ; AT3G09220.1 ; AT3G09220 .
GeneIDi 820078.
KEGGi ath:AT3G09220.

Organism-specific databases

TAIRi AT3G09220.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9SR40.
OMAi WHAHASF.
PhylomeDBi Q9SR40.

Enzyme and pathway databases

BioCyci ARA:AT3G09220-MONOMER.

Gene expression databases

Genevestigatori Q9SR40.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 4 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC7_ARATH
AccessioniPrimary (citable) accession number: Q9SR40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 2000
Last modified: October 29, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3