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Protein

Laccase-7

Gene

LAC7

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products.By similarity

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Cu cationBy similarityNote: Binds 4 Cu cations per monomer.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi81Copper 1; type 2By similarity1
Metal bindingi83Copper 2; type 3By similarity1
Metal bindingi126Copper 2; type 3By similarity1
Metal bindingi128Copper 3; type 3By similarity1
Metal bindingi468Copper 4; type 1By similarity1
Metal bindingi471Copper 1; type 2By similarity1
Metal bindingi473Copper 3; type 3By similarity1
Metal bindingi530Copper 3; type 3By similarity1
Metal bindingi531Copper 4; type 1By similarity1
Metal bindingi532Copper 2; type 3By similarity1
Metal bindingi536Copper 4; type 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processLignin degradation
LigandCopper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G09220-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-7 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 7
Diphenol oxidase 7
Urishiol oxidase 7
Gene namesi
Name:LAC7
Ordered Locus Names:At3g09220
ORF Names:F3L24.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G09220.
TAIRilocus:2083604. AT3G09220.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000028363524 – 567Laccase-7Add BLAST544

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi298N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi339N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi374N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi427N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi450N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SR40.
PRIDEiQ9SR40.

Expressioni

Tissue specificityi

Predominantly expressed in tissues other than the inflorescence stem.2 Publications

Gene expression databases

ExpressionAtlasiQ9SR40. baseline and differential.
GenevisibleiQ9SR40. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G09220.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SR40.
SMRiQ9SR40.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 147Plastocyanin-like 1Add BLAST117
Domaini157 – 310Plastocyanin-like 2Add BLAST154
Domaini412 – 551Plastocyanin-like 3Add BLAST140

Sequence similaritiesi

Belongs to the multicopper oxidase family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG1263. Eukaryota.
COG2132. LUCA.
HOGENOMiHOG000241916.
InParanoidiQ9SR40.
KOiK05909.
OMAiGVPPNNS.
OrthoDBiEOG093605LR.
PhylomeDBiQ9SR40.

Family and domain databases

CDDicd13849. CuRO_1_LCC_plant. 1 hit.
cd13875. CuRO_2_LCC_plant. 1 hit.
Gene3Di2.60.40.420. 3 hits.
InterProiView protein in InterPro
IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR034288. CuRO_1_LCC.
IPR034285. CuRO_2_LCC.
IPR017761. Laccase.
PfamiView protein in Pfam
PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiView protein in PROSITE
PS00080. MULTICOPPER_OXIDASE2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SR40-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEGVRVPIAC ALILLAISSI TSASIVEHTF NVQNLTVSRL CKRQVITVVN
60 70 80 90 100
GSLPGPTIRV KEGDSLVIHV LNHSPHNITI HWHGIFHKLT VWADGPSMIT
110 120 130 140 150
QCPIQPGQRY AYRFNITGQE GTLWWHAHAS FLRATVYGAL VIRPKSGHSY
160 170 180 190 200
PFPKPHKEVP ILFGEWWNTD VVALEEAAIA TGVPPNNSDA YTINGRPGNL
210 220 230 240 250
YPCSKDRMFS LNVVKGKRYL LRIINAAMNI QLFFKIANHR LTVVAADAVY
260 270 280 290 300
TAPYVTDVIV IAPGQTIDAL LFADQSVDTS YYMAAHPYAS APAVPFPNTT
310 320 330 340 350
TRGVIHYGGA SKTGRSKPVL MPKLPSFFDT LTAYRFYSNL TALVNGPHWV
360 370 380 390 400
PVPRYVDEEM LVTIGLGLEA CADNTTCPKF SASMSNHSFV LPKKLSILEA
410 420 430 440 450
VFHDVKGIFT ADFPDQPPVK FDYTNPNVTQ TNPGLLFTQK STSAKILKFN
460 470 480 490 500
TTVEVVLQNH ALIAAESHPM HLHGFNFHVL AQGFGNYDPS RDRSKLNLVD
510 520 530 540 550
PQSRNTLAVP VGGWAVIRFT ANNPGAWIFH CHIDVHLPFG LGMIFVVKNG
560
PTKSTTLPPP PPDLPKC
Length:567
Mass (Da):62,403
Last modified:May 1, 2000 - v1
Checksum:iBA4EFEAA57734D2B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011436 Genomic DNA. Translation: AAF14041.1.
CP002686 Genomic DNA. Translation: AEE74739.1.
AK117639 mRNA. Translation: BAC42295.1.
BT004971 mRNA. Translation: AAO50504.1.
RefSeqiNP_187533.1. NM_111756.3.
UniGeneiAt.40144.

Genome annotation databases

EnsemblPlantsiAT3G09220.1; AT3G09220.1; AT3G09220.
GeneIDi820078.
GrameneiAT3G09220.1; AT3G09220.1; AT3G09220.
KEGGiath:AT3G09220.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiLAC7_ARATH
AccessioniPrimary (citable) accession number: Q9SR40
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families