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Q9SR40

- LAC7_ARATH

UniProt

Q9SR40 - LAC7_ARATH

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Protein
Laccase-7
Gene
LAC7, At3g09220, F3L24.9
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Lignin degradation and detoxification of lignin-derived products By similarity.

Catalytic activityi

4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O.

Cofactori

Binds 4 copper ions per monomer By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi81 – 811Copper 1; type 2 By similarity
Metal bindingi83 – 831Copper 2; type 3 By similarity
Metal bindingi126 – 1261Copper 2; type 3 By similarity
Metal bindingi128 – 1281Copper 3; type 3 By similarity
Metal bindingi468 – 4681Copper 4; type 1 By similarity
Metal bindingi471 – 4711Copper 1; type 2 By similarity
Metal bindingi473 – 4731Copper 3; type 3 By similarity
Metal bindingi530 – 5301Copper 3; type 3 By similarity
Metal bindingi531 – 5311Copper 4; type 1 By similarity
Metal bindingi532 – 5321Copper 2; type 3 By similarity
Metal bindingi536 – 5361Copper 4; type 1 By similarity

GO - Molecular functioni

  1. copper ion binding Source: InterPro
  2. hydroquinone:oxygen oxidoreductase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. lignin catabolic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Lignin degradation

Keywords - Ligandi

Copper, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT3G09220-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Laccase-7 (EC:1.10.3.2)
Alternative name(s):
Benzenediol:oxygen oxidoreductase 7
Diphenol oxidase 7
Urishiol oxidase 7
Gene namesi
Name:LAC7
Ordered Locus Names:At3g09220
ORF Names:F3L24.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 3

Organism-specific databases

TAIRiAT3G09220.

Subcellular locationi

Secretedextracellular spaceapoplast Reviewed prediction

GO - Cellular componenti

  1. apoplast Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Apoplast, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323 Reviewed prediction
Add
BLAST
Chaini24 – 567544Laccase-7
PRO_0000283635Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi34 – 341N-linked (GlcNAc...) Reviewed prediction
Glycosylationi50 – 501N-linked (GlcNAc...) Reviewed prediction
Glycosylationi77 – 771N-linked (GlcNAc...) Reviewed prediction
Glycosylationi115 – 1151N-linked (GlcNAc...) Reviewed prediction
Glycosylationi186 – 1861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi298 – 2981N-linked (GlcNAc...) Reviewed prediction
Glycosylationi339 – 3391N-linked (GlcNAc...) Reviewed prediction
Glycosylationi374 – 3741N-linked (GlcNAc...) Reviewed prediction
Glycosylationi386 – 3861N-linked (GlcNAc...) Reviewed prediction
Glycosylationi427 – 4271N-linked (GlcNAc...) Reviewed prediction
Glycosylationi450 – 4501N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SR40.
PRIDEiQ9SR40.

Expressioni

Tissue specificityi

Predominantly expressed in tissues other than the inflorescence stem.2 Publications

Gene expression databases

GenevestigatoriQ9SR40.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G09220.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9SR40.
SMRiQ9SR40. Positions 23-559.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini31 – 147117Plastocyanin-like 1
Add
BLAST
Domaini157 – 310154Plastocyanin-like 2
Add
BLAST
Domaini412 – 551140Plastocyanin-like 3
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiCOG2132.
HOGENOMiHOG000241916.
InParanoidiQ9SR40.
OMAiWHAHASF.
PhylomeDBiQ9SR40.

Family and domain databases

Gene3Di2.60.40.420. 3 hits.
InterProiIPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view]
PfamiPF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view]
SUPFAMiSSF49503. SSF49503. 4 hits.
TIGRFAMsiTIGR03389. laccase. 1 hit.
PROSITEiPS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SR40-1 [UniParc]FASTAAdd to Basket

« Hide

MEGVRVPIAC ALILLAISSI TSASIVEHTF NVQNLTVSRL CKRQVITVVN    50
GSLPGPTIRV KEGDSLVIHV LNHSPHNITI HWHGIFHKLT VWADGPSMIT 100
QCPIQPGQRY AYRFNITGQE GTLWWHAHAS FLRATVYGAL VIRPKSGHSY 150
PFPKPHKEVP ILFGEWWNTD VVALEEAAIA TGVPPNNSDA YTINGRPGNL 200
YPCSKDRMFS LNVVKGKRYL LRIINAAMNI QLFFKIANHR LTVVAADAVY 250
TAPYVTDVIV IAPGQTIDAL LFADQSVDTS YYMAAHPYAS APAVPFPNTT 300
TRGVIHYGGA SKTGRSKPVL MPKLPSFFDT LTAYRFYSNL TALVNGPHWV 350
PVPRYVDEEM LVTIGLGLEA CADNTTCPKF SASMSNHSFV LPKKLSILEA 400
VFHDVKGIFT ADFPDQPPVK FDYTNPNVTQ TNPGLLFTQK STSAKILKFN 450
TTVEVVLQNH ALIAAESHPM HLHGFNFHVL AQGFGNYDPS RDRSKLNLVD 500
PQSRNTLAVP VGGWAVIRFT ANNPGAWIFH CHIDVHLPFG LGMIFVVKNG 550
PTKSTTLPPP PPDLPKC 567
Length:567
Mass (Da):62,403
Last modified:May 1, 2000 - v1
Checksum:iBA4EFEAA57734D2B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011436 Genomic DNA. Translation: AAF14041.1.
CP002686 Genomic DNA. Translation: AEE74739.1.
AK117639 mRNA. Translation: BAC42295.1.
BT004971 mRNA. Translation: AAO50504.1.
RefSeqiNP_187533.1. NM_111756.2.
UniGeneiAt.40144.

Genome annotation databases

EnsemblPlantsiAT3G09220.1; AT3G09220.1; AT3G09220.
GeneIDi820078.
KEGGiath:AT3G09220.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC011436 Genomic DNA. Translation: AAF14041.1 .
CP002686 Genomic DNA. Translation: AEE74739.1 .
AK117639 mRNA. Translation: BAC42295.1 .
BT004971 mRNA. Translation: AAO50504.1 .
RefSeqi NP_187533.1. NM_111756.2.
UniGenei At.40144.

3D structure databases

ProteinModelPortali Q9SR40.
SMRi Q9SR40. Positions 23-559.
ModBasei Search...

Protein-protein interaction databases

STRINGi 3702.AT3G09220.1-P.

Proteomic databases

PaxDbi Q9SR40.
PRIDEi Q9SR40.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT3G09220.1 ; AT3G09220.1 ; AT3G09220 .
GeneIDi 820078.
KEGGi ath:AT3G09220.

Organism-specific databases

TAIRi AT3G09220.

Phylogenomic databases

eggNOGi COG2132.
HOGENOMi HOG000241916.
InParanoidi Q9SR40.
OMAi WHAHASF.
PhylomeDBi Q9SR40.

Enzyme and pathway databases

BioCyci ARA:AT3G09220-MONOMER.

Gene expression databases

Genevestigatori Q9SR40.

Family and domain databases

Gene3Di 2.60.40.420. 3 hits.
InterProi IPR001117. Cu-oxidase.
IPR011706. Cu-oxidase_2.
IPR011707. Cu-oxidase_3.
IPR002355. Cu_oxidase_Cu_BS.
IPR008972. Cupredoxin.
IPR017761. Laccase.
[Graphical view ]
Pfami PF00394. Cu-oxidase. 1 hit.
PF07731. Cu-oxidase_2. 1 hit.
PF07732. Cu-oxidase_3. 1 hit.
[Graphical view ]
SUPFAMi SSF49503. SSF49503. 4 hits.
TIGRFAMsi TIGR03389. laccase. 1 hit.
PROSITEi PS00080. MULTICOPPER_OXIDASE2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana."
    Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B., Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M., Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V., Choisne N., Artiguenave F.
    , Robert C., Brottier P., Wincker P., Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H., Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H., Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A., Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H., Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J., Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B., Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D., de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E., Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G., Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X., Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M., Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B., Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J., Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C., Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y., Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K., Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.
    Nature 408:820-822(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Gene structure and molecular analysis of the laccase-like multicopper oxidase (LMCO) gene family in Arabidopsis thaliana."
    McCaig B.C., Meagher R.B., Dean J.F.D.
    Planta 221:619-636(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
  6. "Mutant identification and characterization of the laccase gene family in Arabidopsis."
    Cai X., Davis E.J., Ballif J., Liang M., Bushman E., Haroldsen V., Torabinejad J., Wu Y.
    J. Exp. Bot. 57:2563-2569(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiLAC7_ARATH
AccessioniPrimary (citable) accession number: Q9SR40
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2007
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi