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Protein

Glutathione S-transferase U8

Gene

GSTU8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • response to cadmium ion Source: TAIR
  • toxin catabolic process Source: TAIR

Keywordsi

Molecular functionTransferase
Biological processDetoxification

Enzyme and pathway databases

BioCyciARA:AT3G09270-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U8 (EC:2.5.1.18)
Short name:
AtGSTU8
Alternative name(s):
GST class-tau member 8
Gene namesi
Name:GSTU8
Ordered Locus Names:At3g09270
ORF Names:F3L24.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G09270
TAIRilocus:2083544 AT3G09270

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135541 – 224Glutathione S-transferase U8Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SR36
PRIDEiQ9SR36

Expressioni

Gene expression databases

ExpressionAtlasiQ9SR36 differential
GenevisibleiQ9SR36 AT

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G09270.1

Structurei

3D structure databases

ProteinModelPortaliQ9SR36
SMRiQ9SR36
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 85GST N-terminalAdd BLAST81
Domaini91 – 213GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 16Glutathione bindingBy similarity2
Regioni42 – 43Glutathione bindingBy similarity2
Regioni56 – 57Glutathione bindingBy similarity2
Regioni69 – 70Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated

Phylogenomic databases

eggNOGiKOG0406 Eukaryota
ENOG410XSIX LUCA
HOGENOMiHOG000125749
InParanoidiQ9SR36
KOiK00799
OMAiVTIMTAE
OrthoDBiEOG09360KSR
PhylomeDBiQ9SR36

Family and domain databases

InterProiView protein in InterPro
IPR010987 Glutathione-S-Trfase_C-like
IPR036282 Glutathione-S-Trfase_C_sf
IPR004045 Glutathione_S-Trfase_N
IPR004046 GST_C
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00043 GST_C, 1 hit
PF13417 GST_N_3, 1 hit
SUPFAMiSSF47616 SSF47616, 1 hit
SSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS50405 GST_CTER, 1 hit
PS50404 GST_NTER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SR36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQEEHVKLL GLWGSPFSKR VEMVLKLKGI PYEYIEEDVY GNRSPMLLKY
60 70 80 90 100
NPIHKKVPVL IHNGRSIAES LVIVEYIEDT WKTTHTILPQ DPYERAMARF
110 120 130 140 150
WAKYVDEKVM LAVKKACWGP ESEREKEVKE AYEGLKCLEK ELGDKLFFGG
160 170 180 190 200
ETIGFVDIAA DFIGYWLGIF QEASGVTIMT AEEFPKLQRW SEDFVGNNFI
210 220
KEVLPPKEKL VAVLKAMFGS VTSN
Length:224
Mass (Da):25,714
Last modified:May 1, 2000 - v1
Checksum:i591EB6F220F88DE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011436 Genomic DNA Translation: AAF14025.1
CP002686 Genomic DNA Translation: AEE74745.1
BT024844 mRNA Translation: ABD60727.1
AY086116 mRNA Translation: AAM63323.1
RefSeqiNP_187538.1, NM_111761.3
UniGeneiAt.40136

Genome annotation databases

EnsemblPlantsiAT3G09270.1; AT3G09270.1; AT3G09270
GeneIDi820083
GrameneiAT3G09270.1; AT3G09270.1; AT3G09270
KEGGiath:AT3G09270

Similar proteinsi

Entry informationi

Entry nameiGSTU8_ARATH
AccessioniPrimary (citable) accession number: Q9SR36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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