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Protein

Glutathione S-transferase U8

Gene

GSTU8

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles and have a detoxification role against certain herbicides.By similarity

Catalytic activityi

RX + glutathione = HX + R-S-glutathione.

GO - Molecular functioni

GO - Biological processi

  • glutathione metabolic process Source: GO_Central
  • response to cadmium ion Source: TAIR
  • response to toxic substance Source: UniProtKB-KW
  • toxin catabolic process Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Detoxification

Enzyme and pathway databases

BioCyciARA:AT3G09270-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutathione S-transferase U8 (EC:2.5.1.18)
Short name:
AtGSTU8
Alternative name(s):
GST class-tau member 8
Gene namesi
Name:GSTU8
Ordered Locus Names:At3g09270
ORF Names:F3L24.14
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G09270.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004135541 – 224Glutathione S-transferase U8Add BLAST224

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei152PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SR36.
PRIDEiQ9SR36.

Expressioni

Gene expression databases

GenevisibleiQ9SR36. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G09270.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SR36.
SMRiQ9SR36.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 85GST N-terminalAdd BLAST81
Domaini91 – 213GST C-terminalAdd BLAST123

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni15 – 16Glutathione bindingBy similarity2
Regioni42 – 43Glutathione bindingBy similarity2
Regioni56 – 57Glutathione bindingBy similarity2
Regioni69 – 70Glutathione bindingBy similarity2

Sequence similaritiesi

Belongs to the GST superfamily. Tau family.Curated
Contains 1 GST C-terminal domain.Curated
Contains 1 GST N-terminal domain.Curated

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9SR36.
KOiK00799.
OMAiCWGPESE.
OrthoDBiEOG09360KSR.
PhylomeDBiQ9SR36.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SR36-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQEEHVKLL GLWGSPFSKR VEMVLKLKGI PYEYIEEDVY GNRSPMLLKY
60 70 80 90 100
NPIHKKVPVL IHNGRSIAES LVIVEYIEDT WKTTHTILPQ DPYERAMARF
110 120 130 140 150
WAKYVDEKVM LAVKKACWGP ESEREKEVKE AYEGLKCLEK ELGDKLFFGG
160 170 180 190 200
ETIGFVDIAA DFIGYWLGIF QEASGVTIMT AEEFPKLQRW SEDFVGNNFI
210 220
KEVLPPKEKL VAVLKAMFGS VTSN
Length:224
Mass (Da):25,714
Last modified:May 1, 2000 - v1
Checksum:i591EB6F220F88DE7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011436 Genomic DNA. Translation: AAF14025.1.
CP002686 Genomic DNA. Translation: AEE74745.1.
BT024844 mRNA. Translation: ABD60727.1.
AY086116 mRNA. Translation: AAM63323.1.
RefSeqiNP_187538.1. NM_111761.3.
UniGeneiAt.40136.

Genome annotation databases

EnsemblPlantsiAT3G09270.1; AT3G09270.1; AT3G09270.
GeneIDi820083.
GrameneiAT3G09270.1; AT3G09270.1; AT3G09270.
KEGGiath:AT3G09270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011436 Genomic DNA. Translation: AAF14025.1.
CP002686 Genomic DNA. Translation: AEE74745.1.
BT024844 mRNA. Translation: ABD60727.1.
AY086116 mRNA. Translation: AAM63323.1.
RefSeqiNP_187538.1. NM_111761.3.
UniGeneiAt.40136.

3D structure databases

ProteinModelPortaliQ9SR36.
SMRiQ9SR36.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G09270.1.

Proteomic databases

PaxDbiQ9SR36.
PRIDEiQ9SR36.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G09270.1; AT3G09270.1; AT3G09270.
GeneIDi820083.
GrameneiAT3G09270.1; AT3G09270.1; AT3G09270.
KEGGiath:AT3G09270.

Organism-specific databases

TAIRiAT3G09270.

Phylogenomic databases

eggNOGiKOG0406. Eukaryota.
ENOG410XSIX. LUCA.
HOGENOMiHOG000125749.
InParanoidiQ9SR36.
KOiK00799.
OMAiCWGPESE.
OrthoDBiEOG09360KSR.
PhylomeDBiQ9SR36.

Enzyme and pathway databases

BioCyciARA:AT3G09270-MONOMER.

Miscellaneous databases

PROiQ9SR36.

Gene expression databases

GenevisibleiQ9SR36. AT.

Family and domain databases

Gene3Di1.20.1050.10. 1 hit.
3.40.30.10. 1 hit.
InterProiIPR010987. Glutathione-S-Trfase_C-like.
IPR004045. Glutathione_S-Trfase_N.
IPR004046. GST_C.
IPR012336. Thioredoxin-like_fold.
[Graphical view]
PfamiPF00043. GST_C. 1 hit.
PF13417. GST_N_3. 1 hit.
[Graphical view]
SUPFAMiSSF47616. SSF47616. 1 hit.
SSF52833. SSF52833. 1 hit.
PROSITEiPS50405. GST_CTER. 1 hit.
PS50404. GST_NTER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGSTU8_ARATH
AccessioniPrimary (citable) accession number: Q9SR36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.