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Protein

Tryptophan--tRNA ligase, cytoplasmic

Gene

At3g04600

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).Curated

GO - Molecular functioni

GO - Biological processi

  • tryptophanyl-tRNA aminoacylation Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT3G04600-MONOMER.
ARA:GQT-688-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase, cytoplasmicCurated (EC:6.1.1.2Curated)
Alternative name(s):
Tryptophanyl-tRNA synthetaseCurated
Short name:
TrpRSCurated
Gene namesi
Ordered Locus Names:At3g04600Imported
ORF Names:F7O18.7Imported
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G04600.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 402402Tryptophan--tRNA ligase, cytoplasmicPRO_0000433538Add
BLAST

Proteomic databases

PaxDbiQ9SR15.
PRIDEiQ9SR15.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SR15. baseline and differential.
GenevisibleiQ9SR15. AT.

Interactioni

Protein-protein interaction databases

STRINGi3702.AT3G04600.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SR15.
SMRiQ9SR15. Positions 31-397.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi97 – 10610"HIGH" regionCurated
Motifi280 – 2845"KMSKS" regionCurated

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2145. Eukaryota.
COG0180. LUCA.
HOGENOMiHOG000224742.
KOiK01867.
OMAiFFFSHRD.
OrthoDBiEOG09360D5R.
PhylomeDBiQ9SR15.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced. According to EST sequences.Curated
Isoform 1 (identifier: Q9SR15-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MEVDKKDERE AESSEQVVNP WEVSAKDGGK IDYDKLIDKF GCQRLDESLI
60 70 80 90 100
DRVQRLTSRQ PHVFLRRSVF FAHRDFNEIL DAYERGDKFY LYTGRGPSSE
110 120 130 140 150
ALHLGHLIPF MFTKYLQEAF KVPLVIQLTD DEKSIWKNLS VEESQRLARE
160 170 180 190 200
NAKDIIACGF DVTKTFIFSD FDYVGGAFYK NMVKVGKCVT LNKAMGIFGF
210 220 230 240 250
SGEDPIAKLS FPPVQAVPSF PSSFPHLFPG KDNLRCLIPC AIDQDPYFRM
260 270 280 290 300
TRDVAPRLGY SKPALIESTF FPALQGENGK MSASDPNSAI YVTDSAKDIK
310 320 330 340 350
NKINRYAFSG GQDSIEKHRE LGANLEVDIP VKYLSFFLED DSELEHIKKE
360 370 380 390 400
YGEGRMLTGE VKKRLTEVLT EIVERHRRAR AAVTDEMVDA FMAVRPLPSM

FE
Length:402
Mass (Da):45,754
Last modified:May 1, 2000 - v1
Checksum:iB9BEA75EE5D6CD15
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011437 Genomic DNA. Translation: AAF04890.1.
CP002686 Genomic DNA. Translation: AEE74103.1.
CP002686 Genomic DNA. Translation: AEE74105.1.
AY080709 mRNA. Translation: AAL85027.1.
AY117275 mRNA. Translation: AAM51350.1.
AK226252 mRNA. Translation: BAE98413.1.
RefSeqiNP_001078104.1. NM_001084635.1. [Q9SR15-1]
NP_187110.1. NM_111331.4. [Q9SR15-1]
UniGeneiAt.18547.

Genome annotation databases

EnsemblPlantsiAT3G04600.1; AT3G04600.1; AT3G04600. [Q9SR15-1]
AT3G04600.3; AT3G04600.3; AT3G04600. [Q9SR15-1]
GeneIDi819617.
KEGGiath:AT3G04600.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011437 Genomic DNA. Translation: AAF04890.1.
CP002686 Genomic DNA. Translation: AEE74103.1.
CP002686 Genomic DNA. Translation: AEE74105.1.
AY080709 mRNA. Translation: AAL85027.1.
AY117275 mRNA. Translation: AAM51350.1.
AK226252 mRNA. Translation: BAE98413.1.
RefSeqiNP_001078104.1. NM_001084635.1. [Q9SR15-1]
NP_187110.1. NM_111331.4. [Q9SR15-1]
UniGeneiAt.18547.

3D structure databases

ProteinModelPortaliQ9SR15.
SMRiQ9SR15. Positions 31-397.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi3702.AT3G04600.1.

Proteomic databases

PaxDbiQ9SR15.
PRIDEiQ9SR15.

Protocols and materials databases

DNASUi819617.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G04600.1; AT3G04600.1; AT3G04600. [Q9SR15-1]
AT3G04600.3; AT3G04600.3; AT3G04600. [Q9SR15-1]
GeneIDi819617.
KEGGiath:AT3G04600.

Organism-specific databases

TAIRiAT3G04600.

Phylogenomic databases

eggNOGiKOG2145. Eukaryota.
COG0180. LUCA.
HOGENOMiHOG000224742.
KOiK01867.
OMAiFFFSHRD.
OrthoDBiEOG09360D5R.
PhylomeDBiQ9SR15.

Enzyme and pathway databases

BioCyciARA:AT3G04600-MONOMER.
ARA:GQT-688-MONOMER.

Miscellaneous databases

PROiQ9SR15.

Gene expression databases

ExpressionAtlasiQ9SR15. baseline and differential.
GenevisibleiQ9SR15. AT.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 1 hit.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.
TIGRFAMsiTIGR00233. trpS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYWC_ARATH
AccessioniPrimary (citable) accession number: Q9SR15
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 22, 2015
Last sequence update: May 1, 2000
Last modified: September 7, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.