Protein GIGANTEA - Arabidopsis thaliana (Mouse-ear cress)

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Q9SQI2 (GIGAN_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 75. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Protein GIGANTEA

Gene names

Name:	GI
Ordered Locus Names:	At1g22770
ORF Names:	T22J18.6

Organism

Arabidopsis thaliana (Mouse-ear cress)

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	1173 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Involved in regulation of circadian rhythm and photoperiodic flowering. May play a role in maintenance of circadian amplitude and period length. Is involved in phytochrome B signaling. Regulates 'CONSTANS' in the long-day flowering pathway. Ref.6
Subunit structure	Interacts with SPY. Ref.7
Subcellular location	Nucleus Ref.6.
Tissue specificity	Widely expressed with highest levels in inflorescence apices, young flowers and young siliques.
Developmental stage	Found at all stages.
Induction	Expressed with a circadian rhythm with the highest level 10 hours into the light and the lowest level at dawn. The peak of expression in long days is slightly lower, shifted later and the decrease is slower.
Sequence similarities	Belongs to the GIGANTEA family.
Sequence caution	The sequence AAC25507.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence AAF00023.1 differs from that shown. Reason: Erroneous gene model prediction. The sequence CAA72908.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
Biological process	Biological rhythms Differentiation Flowering Phytochrome signaling pathway
Cellular component	Nucleus
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW circadian rhythm Inferred from direct assay. Source: TAIR flower development Traceable author statement. Source: TAIR positive regulation of long-day photoperiodism, flowering Inferred from mutant phenotype. Source: TAIR red, far-red light phototransduction Inferred from electronic annotation. Source: UniProtKB-KW regulation of transcription, DNA-dependent Inferred from direct assay. Source: TAIR response to blue light Inferred from direct assay. Source: TAIR response to cold Inferred from mutant phenotype. Source: TAIR response to far red light Inferred from mutant phenotype. Source: TAIR response to hydrogen peroxide Inferred from mutant phenotype. Source: TAIR response to karrikin Inferred from expression pattern. Source: TAIR temperature compensation of the circadian clock Inferred from mutant phenotype. Source: TAIR
Cellular component	nucleoplasm Inferred from direct assay Ref.6. Source: TAIR
Molecular function	protein binding Inferred from physical interaction Ref.7. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct
ADO1	Q94BT6	5	EBI-446380,EBI-300691
ADO2	Q8W420	3	EBI-446380,EBI-1015688
ADO3	Q9C9W9	10	EBI-446380,EBI-401228
DOF5.5	Q8W1E3	3	EBI-446380,EBI-1536051
SPY	Q96301	4	EBI-446380,EBI-446372

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1173

1173

Protein GIGANTEA

PRO_0000087489

Sequences

Sequence

Length

Mass (Da)

Tools

Q9SQI2 [UniParc].

Last modified December 5, 2001. Version 2.
Checksum: 71CFDE7D39E73549
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FASTA

1,173

127,876

        10         20         30         40         50         60 
MASSSSSERW IDGLQFSSLL WPPPRDPQQH KDQVVAYVEY FGQFTSEQFP DDIAELVRHQ 

        70         80         90        100        110        120 
YPSTEKRLLD DVLAMFVLHH PEHGHAVILP IISCLIDGSL VYSKEAHPFA SFISLVCPSS 

       130        140        150        160        170        180 
ENDYSEQWAL ACGEILRILT HYNRPIYKTE QQNGDTERNC LSKATTSGSP TSEPKAGSPT 

       190        200        210        220        230        240 
QHERKPLRPL SPWISDILLA APLGIRSDYF RWCSGVMGKY AAGELKPPTI ASRGSGKHPQ 

       250        260        270        280        290        300 
LMPSTPRWAV ANGAGVILSV CDDEVARYET ATLTAVAVPA LLLPPPTTSL DEHLVAGLPA 

       310        320        330        340        350        360 
LEPYARLFHR YYAIATPSAT QRLLLGLLEA PPSWAPDALD AAVQLVELLR AAEDYASGVR 

       370        380        390        400        410        420 
LPRNWMHLHF LRAIGIAMSM RAGVAADAAA ALLFRILSQP ALLFPPLSQV EGVEIQHAPI 

       430        440        450        460        470        480 
GGYSSNYRKQ IEVPAAEATI EATAQGIASM LCAHGPEVEW RICTIWEAAY GLIPLNSSAV 

       490        500        510        520        530        540 
DLPEIIVATP LQPPILSWNL YIPLLKVLEY LPRGSPSEAC LMKIFVATVE TILSRTFPPE 

       550        560        570        580        590        600 
SSRELTRKAR SSFTTRSATK NLAMSELRAM VHALFLESCA GVELASRLLF VVLTVCVSHE 

       610        620        630        640        650        660 
AQSSGSKRPR SEYASTTENI EANQPVSNNQ TANRKSRNVK GQGPVAAFDS YVLAAVCALA 

       670        680        690        700        710        720 
CEVQLYPMIS GGGNFSNSAV AGTITKPVKI NGSSKEYGAG IDSAISHTRR ILAILEALFS 

       730        740        750        760        770        780 
LKPSSVGTPW SYSSSEIVAA AMVAAHISEL FRRSKALTHA LSGLMRCKWD KEIHKRASSL 

       790        800        810        820        830        840 
YNLIDVHSKV VASIVDKAEP LEAYLKNTPV QKDSVTCLNW KQENTCASTT CFDTAVTSAS 

       850        860        870        880        890        900 
RTEMNPRGNH KYARHSDEGS GRPSEKGIKD FLLDASDLAN FLTADRLAGF YCGTQKLLRS 

       910        920        930        940        950        960 
VLAEKPELSF SVVSLLWHKL IAAPEIQPTA ESTSAQQGWR QVVDALCNVV SATPAKAAAA 

       970        980        990       1000       1010       1020 
VVLQAERELQ PWIAKDDEEG QKMWKINQRI VKVLVELMRN HDRPESLVIL ASASDLLLRA 

      1030       1040       1050       1060       1070       1080 
TDGMLVDGEA CTLPQLELLE ATARAIQPVL AWGPSGLAVV DGLSNLLKCR LPATIRCLSH 

      1090       1100       1110       1120       1130       1140 
PSAHVRALST SVLRDIMNQS SIPIKVTPKL PTTEKNGMNS PSYRFFNAAS IDWKADIQNC 

      1150       1160       1170 
LNWEAHSLLS TTMPTQFLDT AARELGCTIS LSQ

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"GIGANTEA: a circadian clock-controlled gene that regulates photoperiodic flowering in Arabidopsis and encodes a protein with several possible membrane-spanning domains." Fowler S., Lee K., Onouchi H., Samach A., Richardson K., Morris B., Coupland G., Putterill J. EMBO J. 18:4679-4688(1999) [PubMed: 10469647] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia.
[2]	"Control of circadian rhythms and photoperiodic flowering by the Arabidopsis GIGANTEA gene." Park D.H., Somers D.E., Kim Y.S., Choy Y.H., Lim H.K., Soh M.S., Kim H.J., Kay S.A., Nam H.G. Science 285:1579-1582(1999) [PubMed: 10477524] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: cv. Columbia. Tissue: Leaf and Stem.
[3]	"Sequence analysis of a 24-kb contiguous genomic region at the Arabidopsis thaliana PFL locus on chromosome 1." Terryn N., Neyt P., de Clercq R., de Keyser A., van den Daele H., Ardiles W., Dehais P., Rouze P., Gielen J., Villarroel R., van Montagu M. FEBS Lett. 416:156-160(1997) [PubMed: 9369203] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. Columbia.
[4]	"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana." Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. Davis R.W. Nature 408:816-820(2000) [PubMed: 11130712] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[5]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[6]	"GIGANTEA is a nuclear protein involved in phytochrome signaling in Arabidopsis." Huq E., Tepperman J.M., Quail P.H. Proc. Natl. Acad. Sci. U.S.A. 97:9789-9794(2000) [PubMed: 10920210] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION.
[7]	"SPINDLY and GIGANTEA interact and act in Arabidopsis thaliana pathways involved in light responses, flowering, and rhythms in cotyledon movements." Tseng T.-S., Salome P.A., McClung C.R., Olszewski N.E. Plant Cell 16:1550-1563(2004) [PubMed: 15155885] [Abstract] Cited for: INTERACTION WITH SPY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AJ133786 mRNA. Translation: CAB56039.1. AF105064 mRNA. Translation: AAF00092.1. AF076686 Genomic DNA. Translation: AAF00023.1. Sequence problems. Y12227 Genomic DNA. Translation: CAA72908.1. Sequence problems. AC003979 Genomic DNA. Translation: AAC25507.1. Sequence problems. CP002684 Genomic DNA. Translation: AEE30286.1.
IPI	IPI00531066.
PIR	T52575.
RefSeq	NP_564180.1. NM_102124.2.
UniGene	At.209.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q9SQI2. 5 interactions.
STRING	Q9SQI2.
Proteomic databases
PRIDE	Q9SQI2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT1G22770.1; AT1G22770.1; AT1G22770.
GeneID	838883.
GenomeReviews	Gene locus AT1G22770 in contig CT485782_GR.
KEGG	ath:AT1G22770.
NMPDR	fig\|3702.1.peg.2647.
Organism-specific databases
TAIR	At1g22770.
Phylogenomic databases
GeneTree	EPGT00050000017381.
HOGENOM	HBG592018.
InParanoid	Q9SQI2.
OMA	LVCPSSE.
PhylomeDB	Q9SQI2.
ProtClustDB	CLSN2687916.
Gene expression databases
ArrayExpress	Q9SQI2.
Genevestigator	Q9SQI2.
GermOnline	AT1G22770. Arabidopsis thaliana.
Family and domain databases
KO	K12124.
ProtoNet	Search...

Entry information

Entry name

GIGAN_ARATH

Accession

Primary (citable) accession number: Q9SQI2
Secondary accession number(s): O64381, O80545, Q9S7N0

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 5, 2001
Last sequence update:	December 5, 2001
Last modified:	December 14, 2011
This is version 75 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents