Q9SQ76 (HXK2_SOLTU) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Hexokinase-2
EC=2.7.1.1

Alternative name(s):
StHK2

Gene names

Name:

HXK2

Organism

Solanum tuberosum (Potato)

Taxonomic identifier

4113 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum

Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Fructose and glucose phosphorylating enzyme. May be involved in the phosphorylation of glucose during the export from plastids to cytosol. Seems neither to be involved in cell sugar sensing nor in carbohydrate metabolism in tuber. Ref.1
Catalytic activity	ATP + D-hexose = ADP + D-hexose 6-phosphate.
Subcellular location	Plastid › chloroplast outer membrane; Single-pass membrane protein By similarity.
Sequence similarities	Belongs to the hexokinase family.

Ontologies

Keywords
Biological process	Glycolysis
Cellular component	Chloroplast Membrane Plastid Plastid outer membrane
Domain	Transmembrane Transmembrane helix
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	chloroplast outer membrane Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hexokinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 496	496	Hexokinase-2		PRO_0000197616
Regions
	Transmembrane	4 – 24	21	Helical; Potential
	Nucleotide binding	101 – 106	6	ATP Potential
	Region	171 – 197	27	Glucose-binding Potential

Sequences

	Sequence		Length	Mass (Da)
	Q9SQ76 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: 786F08093EEE5B8C	FASTA	496	53,722
	10 20 30 40 50 60 MKKATVGAVV VGTAAAVAVA ALIMRHRMGK SSKWARARAI LKEFEEKCAT PDGKLKQVAD 70 80 90 100 110 120 AMTVEMHAGL ASEGGSKLKM LISYVDNLPT GDEGGVFYAL DLGGTNFRVL RVQLGGKDGG 130 140 150 160 170 180 IIHQEFAEAS IPPNLMVGTS EALFDYIAAE LAKFVAEEGE EFHPPPGRQR ELGFTFSFPI 190 200 210 220 230 240 MQTSINSGTL IRWTKGFSID DTVGKDVVAE LTKAMQKREI DMRVSALVND TVGTLAGGRF 250 260 270 280 290 300 TNKDVSIAVI LGTGTNAAYV ERAQAIPKWH GPLPKSGEMV INMEWGNFRS SHLPLTEYDH 310 320 330 340 350 360 AMDTNSLNPG EQIFEKICSG MYLGEILRRV LLRMAEEAGI FGEEVPPKLK NSFILRTPEM 370 380 390 400 410 420 SAMHHDTSSD LRVVGDKLKD ILEISNSSLK TRRLVVELCN IVATRGARLA AAGILGIIKK 430 440 450 460 470 480 MGKDTPRESG PEKIVVAMDG GLYEHYTEYS KCLENTLVEL LGKEMATSIV FKHANDGSGI 490 GAALLAASNS VYVEDK

References

[1]	"Potato hexokinase 2 complements transgenic Arabidopsis plants deficient in hexokinase 1 but does not play a key role in tuber carbohydrate metabolism." Veramendi J., Fernie A.R., Leisse A., Willmitzer L., Trethewey R.N. Plant Mol. Biol. 49:491-501(2002) [PubMed: 12090625] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF106068 mRNA. Translation: AAF14186.1.
3D structure databases
ProteinModelPortal	Q9SQ76.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Family and domain databases
InterPro	IPR001312. Hexokinase. IPR022673. Hexokinase_C. IPR019807. Hexokinase_CS. IPR022672. Hexokinase_N. [Graphical view]
PANTHER	PTHR19443. Hexokinase. 1 hit.
Pfam	PF00349. Hexokinase_1. 1 hit. PF03727. Hexokinase_2. 1 hit. [Graphical view]
PRINTS	PR00475. HEXOKINASE.
PROSITE	PS00378. HEXOKINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HXK2_SOLTU

Accession

Primary (citable) accession number: Q9SQ76

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	May 1, 2000
Last modified:	September 21, 2011
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program