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Q9SP32

- DCL1_ARATH

UniProt

Q9SP32 - DCL1_ARATH

Protein

Endoribonuclease Dicer homolog 1

Gene

DCL1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 120 (01 Oct 2014)
      Sequence version 2 (19 Sep 2003)
      Previous versions | rss
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    Functioni

    Ribonuclease (RNase) III involved in RNA-mediated post-transcriptional gene silencing (PTGS). Functions in the microRNAs (miRNAs) biogenesis pathway by cleaving primary miRNAs (pri-miRNAs) and precursor miRNAs (pre-miRNAs). Functions with DRB1/HYL1 and SERRATE proteins for accurate pri-miRNAs to miRNAs processing. Indirectly involved in the production of trans-acting small interfering RNAs (ta-siRNAs) derived from the TAS1, TAS2 or TAS3 endogenous transcripts by participating in the production of their initiating miRNAs. Involved in the processing of natural siRNAs (nat-siRNAs, derived from cis-natural antisense transcripts) by cleaving 24 nucleotide nat-siRNAs into 21 nucleotide nat-siRNAs. Can produce RDR6-dependent endogenous ta-siRNAs derived from TAS1 and TAS2. Required for the production of 30-40 nucleotide bacterial-induced long siRNAs (lsiRNA). Acts redundantly with DICER-LIKE 3 (DCL3) to promote flowering via repression of FLOWERING LOCUS C (FLC). Represses antiviral RNA silencing through negative regulation of the expression of DCL4 and DCL3.7 Publications

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi1597 – 15971Magnesium or manganeseBy similarity
    Sitei1689 – 16891Important for activityBy similarity
    Metal bindingi1693 – 16931Magnesium or manganeseBy similarity
    Metal bindingi1696 – 16961Magnesium or manganeseBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi269 – 2768ATPSequence Analysis

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. DNA binding Source: InterPro
    3. helicase activity Source: UniProtKB-KW
    4. metal ion binding Source: UniProtKB-KW
    5. protein binding Source: UniProtKB
    6. ribonuclease III activity Source: InterPro
    7. RNA binding Source: UniProtKB-KW

    GO - Biological processi

    1. gene silencing by RNA Source: UniProtKB-KW
    2. RNA processing Source: InterPro
    3. rRNA catabolic process Source: InterPro

    Keywords - Molecular functioni

    Endonuclease, Helicase, Hydrolase, Nuclease

    Keywords - Biological processi

    RNA-mediated gene silencing

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding, RNA-binding

    Enzyme and pathway databases

    BioCyciARA:AT1G01040-MONOMER.
    ARA:GQT-1487-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Endoribonuclease Dicer homolog 1 (EC:3.1.26.-)
    Alternative name(s):
    Dicer-like protein 1
    Short name:
    AtDCL1
    Protein ABNORMAL SUSPENSOR 1
    Protein CARPEL FACTORY
    Protein SHORT INTEGUMENTS 1
    Protein SUSPENSOR 1
    Gene namesi
    Name:DCL1
    Synonyms:ASU1, CAF SIN1, SUS1
    Ordered Locus Names:At1g01040
    ORF Names:T25K16.4
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 1

    Organism-specific databases

    TAIRiAT1G01040.

    Subcellular locationi

    Nucleus 2 Publications
    Note: Localizes to nuclear dicing body (also named D body), a nuclear body distributed throughout the nucleoplasm and involved in miRNA processing.

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Disruption phenotypei

    Embryonic lethality in sus-1 mutant. Weaker mutant (caf-1) also exists. Mutant caf-1 produces extra whorls of stamens, indefinite number of carpels and show an absence of axillary inflorescence meristems and abnormally shaped leaves and floral organs.2 Publications

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi395 – 3951E → K in dcl1-13; early-flowering and decreased number of leaves. Suppresses hyl1 mutant phenotype. 2 Publications
    Mutagenesisi415 – 4151P → S in sin1-1; impaired reproductive development. 2 Publications
    Mutagenesisi431 – 4311I → K in sin1-2; impaired reproductive development. 2 Publications
    Mutagenesisi1837 – 18437NDICLRK → IAEIDPG in caf-1; converts the floral meristem to an indeterminate state. 1 Publication
    Mutagenesisi1844 – 190966Missing in caf-1; converts the floral meristem to an indeterminate state. 1 PublicationAdd
    BLAST

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 19091909Endoribonuclease Dicer homolog 1PRO_0000180472Add
    BLAST

    Proteomic databases

    PaxDbiQ9SP32.
    PRIDEiQ9SP32.

    Expressioni

    Tissue specificityi

    Highly expressed in flowers and seeds and detected in leaves and stems. Found in ovule integuments, inflorescence and floral meristems, stigma of flowers until just before pollination, vasculature of the funiculus, and embryo.2 Publications

    Developmental stagei

    Detected in the embryo, but not in the suspensor, up to the globular stage.1 Publication

    Gene expression databases

    GenevestigatoriQ9SP32.

    Interactioni

    Subunit structurei

    Interacts (via N-terminus) with DDL. Interacts (via DRBM domains) with DRB1, DRB2 and DRB5. May interact with AGO1 or AGO10 through their common PAZ domains By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    DDLQ8W4D82EBI-632627,EBI-2015534
    DRB1O044923EBI-632627,EBI-632620

    Protein-protein interaction databases

    BioGridi24809. 8 interactions.
    DIPiDIP-33454N.
    IntActiQ9SP32. 5 interactions.

    Structurei

    Secondary structure

    1
    1909
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1838 – 18425
    Beta strandi1849 – 18546
    Beta strandi1864 – 18696
    Turni1873 – 18753
    Beta strandi1886 – 18883
    Helixi1889 – 190315
    Helixi1904 – 19063

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LRSNMR-A1837-1907[»]
    ProteinModelPortaliQ9SP32.
    SMRiQ9SP32. Positions 248-495, 647-803, 835-939, 1295-1440, 1559-1795.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini256 – 433178Helicase ATP-bindingAdd
    BLAST
    Domaini651 – 812162Helicase C-terminalAdd
    BLAST
    Domaini840 – 93596Dicer dsRNA-binding foldAdd
    BLAST
    Domaini1180 – 1318139PAZAdd
    BLAST
    Domaini1342 – 1518177RNase III 1Add
    BLAST
    Domaini1559 – 1707149RNase III 2Add
    BLAST
    Domaini1733 – 179664DRBM 1Add
    BLAST
    Domaini1831 – 190676DRBM 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi378 – 3814DECH box

    Sequence similaritiesi

    Belongs to the helicase family. Dicer subfamily.Curated
    Contains 1 helicase ATP-binding domain.Curated
    Contains 1 helicase C-terminal domain.Curated
    Contains 1 PAZ domain.Curated
    Contains 2 RNase III domains.Curated

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG1111.
    HOGENOMiHOG000239675.
    InParanoidiQ9SP32.
    KOiK11592.
    PhylomeDBiQ9SP32.

    Family and domain databases

    Gene3Di1.10.1520.10. 3 hits.
    3.30.160.20. 2 hits.
    3.40.50.300. 2 hits.
    HAMAPiMF_00104. RNase_III.
    InterProiIPR005034. Dicer_dimerisation_dom.
    IPR014720. dsRNA-bd_dom.
    IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR003100. PAZ_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view]
    PfamiPF03368. Dicer_dimer. 1 hit.
    PF00035. dsrm. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF02170. PAZ. 1 hit.
    PF04851. ResIII. 1 hit.
    PF00636. Ribonuclease_3. 2 hits.
    [Graphical view]
    SMARTiSM00487. DEXDc. 1 hit.
    SM00358. DSRM. 2 hits.
    SM00490. HELICc. 1 hit.
    SM00949. PAZ. 1 hit.
    SM00535. RIBOc. 2 hits.
    [Graphical view]
    SUPFAMiSSF101690. SSF101690. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF69065. SSF69065. 4 hits.
    PROSITEiPS51327. DICER_DSRBF. 1 hit.
    PS50137. DS_RBD. 2 hits.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50821. PAZ. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q9SP32-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MVMEDEPREA TIKPSYWLDA CEDISCDLID DLVSEFDPSS VAVNESTDEN     50
    GVINDFFGGI DHILDSIKNG GGLPNNGVSD TNSQINEVTV TPQVIAKETV 100
    KENGLQKNGG KRDEFSKEEG DKDRKRARVC SYQSERSNLS GRGHVNNSRE 150
    GDRFMNRKRT RNWDEAGNNK KKRECNNYRR DGRDREVRGY WERDKVGSNE 200
    LVYRSGTWEA DHERDVKKVS GGNRECDVKA EENKSKPEER KEKVVEEQAR 250
    RYQLDVLEQA KAKNTIAFLE TGAGKTLIAI LLIKSVHKDL MSQNRKMLSV 300
    FLVPKVPLVY QQAEVIRNQT CFQVGHYCGE MGQDFWDSRR WQREFESKQV 350
    LVMTAQILLN ILRHSIIRME TIDLLILDEC HHAVKKHPYS LVMSEFYHTT 400
    PKDKRPAIFG MTASPVNLKG VSSQVDCAIK IRNLETKLDS TVCTIKDRKE 450
    LEKHVPMPSE IVVEYDKAAT MWSLHETIKQ MIAAVEEAAQ ASSRKSKWQF 500
    MGARDAGAKD ELRQVYGVSE RTESDGAANL IHKLRAINYT LAELGQWCAY 550
    KVGQSFLSAL QSDERVNFQV DVKFQESYLS EVVSLLQCEL LEGAAAEKVA 600
    AEVGKPENGN AHDEMEEGEL PDDPVVSGGE HVDEVIGAAV ADGKVTPKVQ 650
    SLIKLLLKYQ HTADFRAIVF VERVVAALVL PKVFAELPSL SFIRCASMIG 700
    HNNSQEMKSS QMQDTISKFR DGHVTLLVAT SVAEEGLDIR QCNVVMRFDL 750
    AKTVLAYIQS RGRARKPGSD YILMVERGNV SHAAFLRNAR NSEETLRKEA 800
    IERTDLSHLK DTSRLISIDA VPGTVYKVEA TGAMVSLNSA VGLVHFYCSQ 850
    LPGDRYAILR PEFSMEKHEK PGGHTEYSCR LQLPCNAPFE ILEGPVCSSM 900
    RLAQQAVCLA ACKKLHEMGA FTDMLLPDKG SGQDAEKADQ DDEGEPVPGT 950
    ARHREFYPEG VADVLKGEWV SSGKEVCESS KLFHLYMYNV RCVDFGSSKD 1000
    PFLSEVSEFA ILFGNELDAE VLSMSMDLYV ARAMITKASL AFKGSLDITE 1050
    NQLSSLKKFH VRLMSIVLDV DVEPSTTPWD PAKAYLFVPV TDNTSMEPIK 1100
    GINWELVEKI TKTTAWDNPL QRARPDVYLG TNERTLGGDR REYGFGKLRH 1150
    NIVFGQKSHP TYGIRGAVAS FDVVRASGLL PVRDAFEKEV EEDLSKGKLM 1200
    MADGCMVAED LIGKIVTAAH SGKRFYVDSI CYDMSAETSF PRKEGYLGPL 1250
    EYNTYADYYK QKYGVDLNCK QQPLIKGRGV SYCKNLLSPR FEQSGESETV 1300
    LDKTYYVFLP PELCVVHPLS GSLIRGAQRL PSIMRRVESM LLAVQLKNLI 1350
    SYPIPTSKIL EALTAASCQE TFCYERAELL GDAYLKWVVS RFLFLKYPQK 1400
    HEGQLTRMRQ QMVSNMVLYQ FALVKGLQSY IQADRFAPSR WSAPGVPPVF 1450
    DEDTKDGGSS FFDEEQKPVS EENSDVFEDG EMEDGELEGD LSSYRVLSSK 1500
    TLADVVEALI GVYYVEGGKI AANHLMKWIG IHVEDDPDEV DGTLKNVNVP 1550
    ESVLKSIDFV GLERALKYEF KEKGLLVEAI THASRPSSGV SCYQRLEFVG 1600
    DAVLDHLITR HLFFTYTSLP PGRLTDLRAA AVNNENFARV AVKHKLHLYL 1650
    RHGSSALEKQ IREFVKEVQT ESSKPGFNSF GLGDCKAPKV LGDIVESIAG 1700
    AIFLDSGKDT TAAWKVFQPL LQPMVTPETL PMHPVRELQE RCQQQAEGLE 1750
    YKASRSGNTA TVEVFIDGVQ VGVAQNPQKK MAQKLAARNA LAALKEKEIA 1800
    ESKEKHINNG NAGEDQGENE NGNKKNGHQP FTRQTLNDIC LRKNWPMPSY 1850
    RCVKEGGPAH AKRFTFGVRV NTSDRGWTDE CIGEPMPSVK KAKDSAAVLL 1900
    LELLNKTFS 1909
    Length:1,909
    Mass (Da):213,574
    Last modified:September 19, 2003 - v2
    Checksum:iEAA944F0C0C81D4C
    GO

    Sequence cautioni

    The sequence AAF26461.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti148 – 1481S → F in AAF03534. (PubMed:10556049)Curated
    Sequence conflicti988 – 9881Y → H in AAF03534. (PubMed:10556049)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187317 mRNA. Translation: AAF03534.1.
    AF292940 mRNA. Translation: AAG38019.1.
    AF292941 Genomic DNA. Translation: AAG38020.1.
    AC007323 Genomic DNA. Translation: AAF26461.1. Sequence problems.
    CP002684 Genomic DNA. Translation: AEE27220.1.
    RefSeqiNP_171612.1. NM_099986.3. [Q9SP32-1]
    UniGeneiAt.22088.
    At.57123.

    Genome annotation databases

    EnsemblPlantsiAT1G01040.1; AT1G01040.1; AT1G01040. [Q9SP32-1]
    GeneIDi839574.
    KEGGiath:AT1G01040.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF187317 mRNA. Translation: AAF03534.1 .
    AF292940 mRNA. Translation: AAG38019.1 .
    AF292941 Genomic DNA. Translation: AAG38020.1 .
    AC007323 Genomic DNA. Translation: AAF26461.1 . Sequence problems.
    CP002684 Genomic DNA. Translation: AEE27220.1 .
    RefSeqi NP_171612.1. NM_099986.3. [Q9SP32-1 ]
    UniGenei At.22088.
    At.57123.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LRS NMR - A 1837-1907 [» ]
    ProteinModelPortali Q9SP32.
    SMRi Q9SP32. Positions 248-495, 647-803, 835-939, 1295-1440, 1559-1795.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 24809. 8 interactions.
    DIPi DIP-33454N.
    IntActi Q9SP32. 5 interactions.

    Proteomic databases

    PaxDbi Q9SP32.
    PRIDEi Q9SP32.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT1G01040.1 ; AT1G01040.1 ; AT1G01040 . [Q9SP32-1 ]
    GeneIDi 839574.
    KEGGi ath:AT1G01040.

    Organism-specific databases

    TAIRi AT1G01040.

    Phylogenomic databases

    eggNOGi COG1111.
    HOGENOMi HOG000239675.
    InParanoidi Q9SP32.
    KOi K11592.
    PhylomeDBi Q9SP32.

    Enzyme and pathway databases

    BioCyci ARA:AT1G01040-MONOMER.
    ARA:GQT-1487-MONOMER.

    Gene expression databases

    Genevestigatori Q9SP32.

    Family and domain databases

    Gene3Di 1.10.1520.10. 3 hits.
    3.30.160.20. 2 hits.
    3.40.50.300. 2 hits.
    HAMAPi MF_00104. RNase_III.
    InterProi IPR005034. Dicer_dimerisation_dom.
    IPR014720. dsRNA-bd_dom.
    IPR006935. Helicase/UvrB_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR003100. PAZ_dom.
    IPR011907. RNase_III.
    IPR000999. RNase_III_dom.
    [Graphical view ]
    Pfami PF03368. Dicer_dimer. 1 hit.
    PF00035. dsrm. 1 hit.
    PF00271. Helicase_C. 1 hit.
    PF02170. PAZ. 1 hit.
    PF04851. ResIII. 1 hit.
    PF00636. Ribonuclease_3. 2 hits.
    [Graphical view ]
    SMARTi SM00487. DEXDc. 1 hit.
    SM00358. DSRM. 2 hits.
    SM00490. HELICc. 1 hit.
    SM00949. PAZ. 1 hit.
    SM00535. RIBOc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF101690. SSF101690. 1 hit.
    SSF52540. SSF52540. 2 hits.
    SSF69065. SSF69065. 4 hits.
    PROSITEi PS51327. DICER_DSRBF. 1 hit.
    PS50137. DS_RBD. 2 hits.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS50821. PAZ. 1 hit.
    PS00517. RNASE_3_1. 1 hit.
    PS50142. RNASE_3_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Disruption of an RNA helicase/RNase III gene in Arabidopsis causes unregulated cell division in floral meristems."
      Jacobsen S.E., Running M.P., Meyerowitz E.M.
      Development 126:5231-5243(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, MUTAGENESIS OF 1837-ASN--LYS-1843 AND 1844-ASN--SER-1909.
      Strain: cv. Wassilewskija.
    2. "SHORT INTEGUMENTS1/SUSPENSOR1/CARPEL FACTORY, a Dicer homolog, is a maternal effect gene required for embryo development in Arabidopsis."
      Golden T.A., Schauer S.E., Lang J.D., Pien S., Mushegian A.R., Grossniklaus U., Meinke D.W., Ray A.
      Plant Physiol. 130:808-822(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, DISRUPTION PHENOTYPE, MUTAGENESIS OF PRO-415 AND ILE-431.
      Strain: cv. Landsberg erecta.
    3. "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
      Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K.
      , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
      Nature 408:816-820(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    4. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    5. "Partially redundant functions of Arabidopsis DICER-like enzymes and a role for DCL4 in producing trans-acting siRNAs."
      Gasciolli V., Mallory A.C., Bartel D.P., Vaucheret H.
      Curr. Biol. 15:1494-1500(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    6. "Specific interactions between Dicer-like proteins and HYL1/DRB-family dsRNA-binding proteins in Arabidopsis thaliana."
      Hiraguri A., Itoh R., Kondo N., Nomura Y., Aizawa D., Murai Y., Koiwa H., Seki M., Shinozaki K., Fukuhara T.
      Plant Mol. Biol. 57:173-188(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH DRB1; DRB2 AND DRB5.
    7. "The interaction between DCL1 and HYL1 is important for efficient and precise processing of pri-miRNA in plant microRNA biogenesis."
      Kurihara Y., Takashi Y., Watanabe Y.
      RNA 12:206-212(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH DRB1.
    8. "Identification of nuclear dicing bodies containing proteins for microRNA biogenesis in living Arabidopsis plants."
      Fang Y., Spector D.L.
      Curr. Biol. 17:818-823(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "A novel class of bacteria-induced small RNAs in Arabidopsis."
      Katiyar-Agarwal S., Gao S., Vivian-Smith A., Jin H.
      Genes Dev. 21:3123-3134(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    10. "DICER-LIKE 1 and DICER-LIKE 3 redundantly act to promote flowering via repression of FLOWERING LOCUS C in Arabidopsis thaliana."
      Schmitz R.J., Hong L., Fitzpatrick K.E., Amasino R.M.
      Genetics 176:1359-1362(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    11. "The RNA-binding proteins HYL1 and SE promote accurate in vitro processing of pri-miRNA by DCL1."
      Dong Z., Han M.-H., Fedoroff N.
      Proc. Natl. Acad. Sci. U.S.A. 105:9970-9975(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    12. "The FHA domain proteins DAWDLE in Arabidopsis and SNIP1 in humans act in small RNA biogenesis."
      Yu B., Bi L., Zheng B., Ji L., Chevalier D., Agarwal M., Ramachandran V., Li W., Lagrange T., Walker J.C., Chen X.
      Proc. Natl. Acad. Sci. U.S.A. 105:10073-10078(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DDL.
    13. "Arabidopsis DRB4, AGO1, AGO7, and RDR6 participate in a DCL4-initiated antiviral RNA silencing pathway negatively regulated by DCL1."
      Qu F., Ye X., Morris T.J.
      Proc. Natl. Acad. Sci. U.S.A. 105:14732-14737(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.
    14. "A dominant mutation in DCL1 suppresses the hyl1 mutant phenotype by promoting the processing of miRNA."
      Tagami Y., Motose H., Watanabe Y.
      RNA 15:450-458(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: MUTAGENESIS OF GLU-395.

    Entry informationi

    Entry nameiDCL1_ARATH
    AccessioniPrimary (citable) accession number: Q9SP32
    Secondary accession number(s): Q9FDY6, Q9MAN0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 19, 2003
    Last sequence update: September 19, 2003
    Last modified: October 1, 2014
    This is version 120 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Expression in the early embryo is from the maternally contributed genome.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3