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Protein

Calreticulin

Gene

CRT

Organism
Zea mays (Maize)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei115CarbohydrateBy similarity1
Binding sitei117CarbohydrateBy similarity1
Binding sitei134CarbohydrateBy similarity1
Binding sitei141CarbohydrateBy similarity1
Binding sitei324CarbohydrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone
LigandCalcium, Lectin, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Calreticulin
Gene namesi
Name:CRT
OrganismiZea mays (Maize)
Taxonomic identifieri4577 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaePACMAD cladePanicoideaeAndropogonodaeAndropogoneaeTripsacinaeZea
Proteomesi
  • UP000007305 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25Sequence analysisAdd BLAST25
ChainiPRO_000000419126 – 420CalreticulinAdd BLAST395

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi57N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ9SP22.
PRIDEiQ9SP22.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi4577.GRMZM2G358059_P01.

Structurei

3D structure databases

ProteinModelPortaliQ9SP22.
SMRiQ9SP22.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati197 – 2081-1Add BLAST12
Repeati216 – 2271-2Add BLAST12
Repeati233 – 2441-3Add BLAST12
Repeati251 – 2621-4Add BLAST12
Repeati266 – 2762-1Add BLAST11
Repeati280 – 2902-2Add BLAST11
Repeati294 – 3042-3Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni197 – 2624 X approximate repeatsAdd BLAST66
Regioni266 – 3043 X approximate repeatsAdd BLAST39

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi417 – 420Prevents secretion from ERPROSITE-ProRule annotation4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi358 – 416Asp/Glu/Lys-richAdd BLAST59

Domaini

Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).By similarity
The interaction with glycans occurs through a binding site in the globular lectin domain.By similarity
The zinc binding sites are localized to the N-domain.By similarity

Sequence similaritiesi

Belongs to the calreticulin family.Curated

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG0674. Eukaryota.
ENOG410XRR7. LUCA.

Family and domain databases

InterProiView protein in InterPro
IPR001580. Calret/calnex.
IPR018124. Calret/calnex_CS.
IPR009169. Calreticulin.
IPR009033. Calreticulin/calnexin_P_dom_sf.
IPR013320. ConA-like_dom_sf.
PANTHERiPTHR11073. PTHR11073. 1 hit.
PfamiView protein in Pfam
PF00262. Calreticulin. 2 hits.
PIRSFiPIRSF002356. Calreticulin. 1 hit.
PRINTSiPR00626. CALRETICULIN.
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF63887. SSF63887. 1 hit.
PROSITEiView protein in PROSITE
PS00803. CALRETICULIN_1. 1 hit.
PS00805. CALRETICULIN_REPEAT. 2 hits.
PS00014. ER_TARGET. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SP22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIRKGSSYA VAALLALASV AAVAGEVFFQ EKFEDGWESR WVKSEWKKDE
60 70 80 90 100
NMAGEWNHTS GKWNGDAEDK GIQTSEDYRF YAISAEYPEF SNKDKTLVLQ
110 120 130 140 150
FSVKHEQKLD CGGGYVKLLG GDVDQKTLGG DTSYSIISRP DISRYSTKKV
160 170 180 190 200
HTILTKDGKN HLIKKDVPCQ TDQLTHVYTF IIRPDATYSI LIDNEEKHTG
210 220 230 240 250
SIYEHWDILP PKKIKDPEAK KPEDWDDKEY IPDPEDKKPE GYDDIPKEIP
260 270 280 290 300
DPDAKKPEDW DDEEDGEWTA PTIPNPEYKG PWKQKKIKNP NYQGKWKAPM
310 320 330 340 350
IDNPDFKDDP YIYAFDSLKY IGIELWQVKS GTLFDNIIIT DDPALAKTFA
360 370 380 390 400
EETWGKHKEA EKAAFDEAEK KKEEEDAAKG GDDEDDDLED EEDDEKADED
410 420
KADSDAEDGK DSDDEKHDEL
Length:420
Mass (Da):47,940
Last modified:May 1, 2000 - v1
Checksum:iE73B7F43E7494735
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF190454 mRNA. Translation: AAF01470.1.
UniGeneiZm.94182.

Similar proteinsi

Entry informationi

Entry nameiCALR_MAIZE
AccessioniPrimary (citable) accession number: Q9SP22
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: November 22, 2017
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families