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Protein

Arginine decarboxylase 1

Gene

ADC1

Organism
Oryza sativa subsp. japonica (Rice)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.

Cofactori

Protein has several cofactor binding sites:

Pathwayi: agmatine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes agmatine from L-arginine.
Proteins known to be involved in this subpathway in this organism are:
  1. Arginine decarboxylase (P0431A03.15), Arginine decarboxylase (OsJ_20004), Arginine decarboxylase 1 (ADC1), Arginine decarboxylase 2 (ADC2), Arginine decarboxylase (Os08g0433000), Arginine decarboxylase (Os08g0433000), Arginine decarboxylase (OsJ_27424)
This subpathway is part of the pathway agmatine biosynthesis, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes agmatine from L-arginine, the pathway agmatine biosynthesis and in Amine and polyamine biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylase, Lyase
Biological processPutrescine biosynthesis, Spermidine biosynthesis
LigandMagnesium, Pyridoxal phosphate

Enzyme and pathway databases

BRENDAi4.1.1.19 4460
UniPathwayiUPA00186; UER00284

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine decarboxylase 1 (EC:4.1.1.19)
Short name:
ARGDC1
Short name:
OsADC1
Gene namesi
Name:ADC1
Ordered Locus Names:Os06g0131300, LOC_Os06g04070
ORF Names:P0493C11.18
OrganismiOryza sativa subsp. japonica (Rice)
Taxonomic identifieri39947 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladeOryzoideaeOryzeaeOryzinaeOryzaOryza sativa
Proteomesi
  • UP000059680 Componenti: Chromosome 6

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001499521 – 702Arginine decarboxylase 1Add BLAST702

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei151N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PaxDbiQ9SNN0

Expressioni

Tissue specificityi

Expressed in roots, leaves and stems (at protein level).2 Publications

Inductioni

By cold stress.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi39947.LOC_Os06g04070.1

Structurei

3D structure databases

ProteinModelPortaliQ9SNN0
SMRiQ9SNN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni336 – 346Substrate-bindingBy similarityAdd BLAST11

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi31 – 38Poly-Ala8

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IKSU Eukaryota
COG1166 LUCA
HOGENOMiHOG000029191
InParanoidiQ9SNN0
KOiK01583
OMAiLFPIMPI
OrthoDBiEOG09360480

Family and domain databases

CDDicd06830 PLPDE_III_ADC, 1 hit
Gene3Di2.40.37.10, 3 hits
3.20.20.10, 1 hit
InterProiView protein in InterPro
IPR009006 Ala_racemase/Decarboxylase_C
IPR002985 Arg_decrbxlase
IPR022644 De-COase2_N
IPR022653 De-COase2_pyr-phos_BS
IPR000183 Orn/DAP/Arg_de-COase
IPR029066 PLP-binding_barrel
PANTHERiPTHR43295 PTHR43295, 1 hit
PfamiView protein in Pfam
PF02784 Orn_Arg_deC_N, 1 hit
PIRSFiPIRSF001336 Arg_decrbxlase, 1 hit
PRINTSiPR01180 ARGDCRBXLASE
PR01179 ODADCRBXLASE
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR01273 speA, 1 hit
PROSITEiView protein in PROSITE
PS00878 ODR_DC_2_1, 1 hit
PS00879 ODR_DC_2_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SNN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPALAVDAAA PVAHAFACDA ARFPAPLLGP AAAAAAVAEK PDAAAWSADL
60 70 80 90 100
SSALYNVDGW GAPYFFVNDD GDVAVRPHGA ATLPGQEIDL AKVVAKAAGP
110 120 130 140 150
RSGGGLGLPL PLLVRFPDVL RHRVEALNAA FDYAVRSTGY GGRYQGVYPV
160 170 180 190 200
KCNQDRHVVE DIVEFGEPFR FGLEAGSKPE LLLAMSCLAA RGNPDALLIC
210 220 230 240 250
NGYKDDEYVS LALIARTMGL NTVIVLEQEE ELDIVVDASR RLGVRPVVGM
260 270 280 290 300
RAKLRTKHAG HFGSTSGEKG KFGLNAAQIL SVVAKLKTLG MLDCLQLLHF
310 320 330 340 350
HIGSQIPTTA LLGDGVGEAA QIYCELARLG AAMRVIDVGG GLGIDYDGSH
360 370 380 390 400
SAQTDMSVAY SLEEYAAAVV AAVGRVCDRK GVAHPIICSE SGRALVSHHS
410 420 430 440 450
VLVFEAFSAS APGRIDPATG YLLDELTDDC HADYRNLMAA AVRGDFDTCA
460 470 480 490 500
LYADQLKRRC ADQFKDGVLG LEHLAAVDSL CEIVARGMGA AEPPRTYHIN
510 520 530 540 550
LSVFTSLPDM WAIGQMFPII PIQRLGERPA VDGVLSDLTC DSDGKVDHFI
560 570 580 590 600
GGRHSLPLHE LPVHGTRGYY LGMFLGGAYQ EALGGLHNLF GGPSVVRVSQ
610 620 630 640 650
SDGPHCFAVT RAAAGPSCAD VLRSMQHEPE VMFEVLKQRT DGATAAALAR
660 670 680 690 700
AFGAMPYLSF DPEAAAMASG ESSGMSSDSE GSAAGAAEED DDEWEFMRGL

TV
Length:702
Mass (Da):74,064
Last modified:May 1, 2000 - v1
Checksum:i3B6B8E7AF4959126
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti235V → M in ABY47890 (PubMed:20082138).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY604047 mRNA Translation: AAT37534.1
EU220429 mRNA Translation: ABY47890.1
AP000559 Genomic DNA Translation: BAA84799.1
AP008212 Genomic DNA Translation: BAF18609.1
AP014962 Genomic DNA Translation: BAS95983.1
RefSeqiXP_015643038.1, XM_015787552.1
UniGeneiOs.75600

Genome annotation databases

EnsemblPlantsiOs06t0131300-01; Os06t0131300-01; Os06g0131300
GeneIDi4340008
GrameneiOs06t0131300-01; Os06t0131300-01; Os06g0131300
KEGGiosa:4340008

Similar proteinsi

Entry informationi

Entry nameiSPE1_ORYSJ
AccessioniPrimary (citable) accession number: Q9SNN0
Secondary accession number(s): A0A0P0WSJ3
, A9YLB8, Q0DEW4, Q6J285
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 108 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Oryza sativa (rice)
    Index of Oryza sativa entries and their corresponding gene designations
  3. SIMILARITY comments
    Index of protein domains and families

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