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Protein

Ras-related protein RABH1c

Gene

RABH1C

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Protein transport. Regulator of membrane traffic from the Golgi apparatus towards the endoplasmic reticulum (ER) (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23GTPBy similarity8
Nucleotide bindingi64 – 68GTPBy similarity5
Nucleotide bindingi123 – 126GTPBy similarity4
Nucleotide bindingi153 – 154GTPBy similarity2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transport, Protein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-ATH-6798695. Neutrophil degranulation.
R-ATH-6811438. Intra-Golgi traffic.
R-ATH-8854214. TBC/RABGAPs.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein RABH1c
Short name:
AtRABH1c
Gene namesi
Name:RABH1C
Ordered Locus Names:At4g39890
ORF Names:T5J17.60
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 4

Organism-specific databases

AraportiAT4G39890.
TAIRilocus:2140045. AT4G39890.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi23T → N: No effect on targeting to Golgi. 1 Publication1
Mutagenesisi68Q → L: No effect on targeting to Golgi. 1 Publication1
Mutagenesisi123N → I: Loss of targeting to Golgi. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003485431 – 214Ras-related protein RABH1cAdd BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi212S-geranylgeranyl cysteineBy similarity1
Modified residuei214Cysteine methyl esterBy similarity1
Lipidationi214S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ9SMR4.
PRIDEiQ9SMR4.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SMR4. baseline and differential.
GenevisibleiQ9SMR4. AT.

Interactioni

Subunit structurei

Interacts with the C-terminus of GC5, but not with GC3.1 Publication

Protein-protein interaction databases

BioGridi15428. 20 interactors.
STRINGi3702.AT4G39890.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SMR4.
SMRiQ9SMR4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi38 – 46Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0094. Eukaryota.
ENOG410XPBI. LUCA.
HOGENOMiHOG000233968.
InParanoidiQ9SMR4.
KOiK07976.
OMAiKEYGVMF.
OrthoDBiEOG09360NEV.
PhylomeDBiQ9SMR4.

Family and domain databases

InterProiView protein in InterPro
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR001806. Small_GTPase.
PfamiView protein in Pfam
PF00071. Ras. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00231. small_GTP. 1 hit.
PROSITEiView protein in PROSITE
PS51419. RAB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9SMR4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVSPLAKF KLVFLGDQSV GKTSIITRFM YDKFDTTYQP TIGIDFLSKT
60 70 80 90 100
MYLEDRTVRL QLWDTAGQER FRSLIPSYIR DSSVAIVVYD VSNRQTFLNT
110 120 130 140 150
SKWIEDVHRE RGQSNVIIVL VGNKTDLVEK RQVSISEGED KGKEYGVMFI
160 170 180 190 200
ETSAKENFNI KALFRKIAAA LPGVDSYSLA TKSDDMVDVN LKTTSNSSQG
210
EQQGGAGGGG GCSC
Length:214
Mass (Da):23,681
Last modified:May 1, 2000 - v1
Checksum:i78F1EF5167E1E47E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL035708 Genomic DNA. Translation: CAB38902.1.
AL161596 Genomic DNA. Translation: CAB80652.1.
CP002687 Genomic DNA. Translation: AEE87134.1.
AF325109 mRNA. Translation: AAK17177.1.
AF386952 mRNA. Translation: AAK62397.1.
BT000043 mRNA. Translation: AAN15362.1.
PIRiT06095.
RefSeqiNP_195699.1. NM_120152.4.
UniGeneiAt.2863.

Genome annotation databases

EnsemblPlantsiAT4G39890.1; AT4G39890.1; AT4G39890.
GeneIDi830148.
GrameneiAT4G39890.1; AT4G39890.1; AT4G39890.
KEGGiath:AT4G39890.

Similar proteinsi

Entry informationi

Entry nameiRAH1C_ARATH
AccessioniPrimary (citable) accession number: Q9SMR4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: May 1, 2000
Last modified: August 30, 2017
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families