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Q9SMQ6

- RAA4B_ARATH

UniProt

Q9SMQ6 - RAA4B_ARATH

Protein

Ras-related protein RABA4b

Gene

RABA4B

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 100 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Regulator of membrane trafficking. May be required for secretion of cell wall components in cells.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi24 – 318GTPBy similarity
    Nucleotide bindingi72 – 765GTPBy similarity
    Nucleotide bindingi130 – 1334GTPBy similarity
    Nucleotide bindingi160 – 1612GTPBy similarity

    GO - Molecular functioni

    1. GTP binding Source: UniProtKB-KW
    2. kinase binding Source: UniProtKB

    GO - Biological processi

    1. endocytic recycling Source: TAIR
    2. protein transport Source: UniProtKB-KW
    3. small GTPase mediated signal transduction Source: InterPro

    Keywords - Biological processi

    Protein transport, Transport

    Keywords - Ligandi

    GTP-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ras-related protein RABA4b
    Short name:
    AtRABA4b
    Alternative name(s):
    Ras-related protein GB3
    Short name:
    AtGB3
    Ras-related protein Rab11G
    Short name:
    AtRab11G
    Gene namesi
    Name:RABA4B
    Synonyms:GB3, RAB11G
    Ordered Locus Names:At4g39990
    ORF Names:T5J17.160
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 4

    Organism-specific databases

    TAIRiAT4G39990.

    Subcellular locationi

    Early endosome membrane 1 Publication. Golgi apparatustrans-Golgi network membrane 1 Publication; Lipid-anchor 1 Publication

    GO - Cellular componenti

    1. early endosome membrane Source: UniProtKB
    2. plasma membrane Source: TAIR
    3. trans-Golgi network membrane Source: UniProtKB

    Keywords - Cellular componenti

    Endosome, Golgi apparatus, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 224223Ras-related protein RABA4bPRO_0000407345Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication
    Lipidationi220 – 2201S-geranylgeranyl cysteineBy similarity
    Lipidationi221 – 2211S-geranylgeranyl cysteineBy similarity

    Keywords - PTMi

    Acetylation, Lipoprotein, Prenylation

    Proteomic databases

    PaxDbiQ9SMQ6.
    PRIDEiQ9SMQ6.

    Expressioni

    Tissue specificityi

    Expressed in roots, stems, leaves and flowers. Expressed in tips of growing root hair cells.1 Publication

    Gene expression databases

    GenevestigatoriQ9SMQ6.

    Interactioni

    Protein-protein interaction databases

    BioGridi15440. 1 interaction.
    IntActiQ9SMQ6. 1 interaction.
    STRINGi3702.AT4G39990.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SMQ6.
    SMRiQ9SMQ6. Positions 15-179.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi46 – 549Effector regionBy similarity

    Sequence similaritiesi

    Belongs to the small GTPase superfamily. Rab family.Curated

    Phylogenomic databases

    eggNOGiCOG1100.
    HOGENOMiHOG000233968.
    InParanoidiQ9SMQ6.
    OMAiFEHIPRW.
    PhylomeDBiQ9SMQ6.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    InterProiIPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view]
    PfamiPF00071. Ras. 1 hit.
    [Graphical view]
    PRINTSiPR00449. RASTRNSFRMNG.
    SMARTiSM00175. RAB. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00231. small_GTP. 1 hit.
    PROSITEiPS51419. RAB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9SMQ6-1 [UniParc]FASTAAdd to Basket

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    MAGGGGYGGA SGKVDYVFKV VLIGDSAVGK SQLLARFARD EFSMDSKATI    50
    GVEFQTRTLS IEQKSIKAQI WDTAGQERYR AVTSAYYRGA VGAMLVYDMT 100
    KRETFEHIPR WLEELRAHAD KNIVIILIGN KSDLEDQRAV PTEDAKEFAE 150
    KEGLFFLETS ALNATNVENS FNTLMTQIYN TVNKKNLASE GDSNNPGSLA 200
    GKKILIPGSG QEIPAKTSTC CTSS 224
    Length:224
    Mass (Da):24,407
    Last modified:May 1, 2000 - v1
    Checksum:iFA2C5E5A0DC2025B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti191 – 1911G → C in AAA87884. (PubMed:8843944)Curated
    Sequence conflicti208 – 2081G → A in AAM66946. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46926 mRNA. Translation: AAA87884.1.
    AL035708 Genomic DNA. Translation: CAB38912.1.
    AL161596 Genomic DNA. Translation: CAB80662.1.
    CP002687 Genomic DNA. Translation: AEE87150.1.
    AY072448 mRNA. Translation: AAL62440.1.
    AY128914 mRNA. Translation: AAM91314.1.
    AY088624 mRNA. Translation: AAM66946.1.
    PIRiT06105.
    RefSeqiNP_195709.1. NM_120163.4.
    UniGeneiAt.1649.
    At.48966.

    Genome annotation databases

    EnsemblPlantsiAT4G39990.1; AT4G39990.1; AT4G39990.
    GeneIDi830160.
    KEGGiath:AT4G39990.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U46926 mRNA. Translation: AAA87884.1 .
    AL035708 Genomic DNA. Translation: CAB38912.1 .
    AL161596 Genomic DNA. Translation: CAB80662.1 .
    CP002687 Genomic DNA. Translation: AEE87150.1 .
    AY072448 mRNA. Translation: AAL62440.1 .
    AY128914 mRNA. Translation: AAM91314.1 .
    AY088624 mRNA. Translation: AAM66946.1 .
    PIRi T06105.
    RefSeqi NP_195709.1. NM_120163.4.
    UniGenei At.1649.
    At.48966.

    3D structure databases

    ProteinModelPortali Q9SMQ6.
    SMRi Q9SMQ6. Positions 15-179.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 15440. 1 interaction.
    IntActi Q9SMQ6. 1 interaction.
    STRINGi 3702.AT4G39990.1-P.

    Proteomic databases

    PaxDbi Q9SMQ6.
    PRIDEi Q9SMQ6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT4G39990.1 ; AT4G39990.1 ; AT4G39990 .
    GeneIDi 830160.
    KEGGi ath:AT4G39990.

    Organism-specific databases

    TAIRi AT4G39990.

    Phylogenomic databases

    eggNOGi COG1100.
    HOGENOMi HOG000233968.
    InParanoidi Q9SMQ6.
    OMAi FEHIPRW.
    PhylomeDBi Q9SMQ6.

    Gene expression databases

    Genevestigatori Q9SMQ6.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    InterProi IPR027417. P-loop_NTPase.
    IPR005225. Small_GTP-bd_dom.
    IPR001806. Small_GTPase.
    IPR003579. Small_GTPase_Rab_type.
    [Graphical view ]
    Pfami PF00071. Ras. 1 hit.
    [Graphical view ]
    PRINTSi PR00449. RASTRNSFRMNG.
    SMARTi SM00175. RAB. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00231. small_GTP. 1 hit.
    PROSITEi PS51419. RAB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification and isoprenylation of plant GTP-binding proteins."
      Biermann B.J., Randall S.K., Crowell D.N.
      Plant Mol. Biol. 31:1021-1028(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana."
      Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T., Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B., Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M., de Simone V., Obermaier B.
      , Mache R., Mueller M., Kreis M., Delseny M., Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D., Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J., Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B., Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J., Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R., Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M., Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P., Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S., Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C., Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J., Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S., Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A., Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M., Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D., Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E., Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S., Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R., Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M., Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E., Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P., Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K., Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K., de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K., Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M., Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G., Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K., Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K., Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W., Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H., Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B., Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J., Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K., O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N., Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A., Martienssen R., McCombie W.R.
      Nature 402:769-777(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    3. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    5. "Full-length cDNA from Arabidopsis thaliana."
      Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Analysis of the small GTPase gene superfamily of Arabidopsis."
      Vernoud V., Horton A.C., Yang Z., Nielsen E.
      Plant Physiol. 131:1191-1208(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.
    7. "The Arabidopsis Rab GTPase RabA4b localizes to the tips of growing root hair cells."
      Preuss M.L., Serna J., Falbel T.G., Bednarek S.Y., Nielsen E.
      Plant Cell 16:1589-1603(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: TISSUE SPECIFICITY.
    8. "Electron tomography of RabA4b- and PI-4K?1-labeled trans Golgi network compartments in Arabidopsis."
      Kang B.H., Nielsen E., Preuss M.L., Mastronarde D., Staehelin L.A.
      Traffic 12:313-329(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    9. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiRAA4B_ARATH
    AccessioniPrimary (citable) accession number: Q9SMQ6
    Secondary accession number(s): Q38923, Q8L958
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 3, 2011
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 100 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3