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Protein

Probable carboxylesterase 12

Gene

CXE12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Carboxylesterase acting on esters with varying acyl chain length.By similarity

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162PROSITE-ProRule annotation1
Active sitei265PROSITE-ProRule annotation1
Active sitei297PROSITE-ProRule annotation1

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: TAIR

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Serine esterase

Enzyme and pathway databases

BioCyciARA:AT3G48690-MONOMER.

Protein family/group databases

ESTHERiarath-CXE12. Plant_carboxylesterase.
MEROPSiS09.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxylesterase 12
Alternative name(s):
AtCXE12 (EC:3.1.1.1)
Gene namesi
Name:CXE12
Ordered Locus Names:At3g48690
ORF Names:T8P19.200
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

TAIRiAT3G48690.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: TAIR
  • cytosol Source: TAIR
Complete GO annotation...

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1932906.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004025571 – 324Probable carboxylesterase 12Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9SMN0.

Expressioni

Tissue specificityi

Expressed in leaves, stems, flowers and siliques.1 Publication

Gene expression databases

GenevisibleiQ9SMN0. AT.

Interactioni

Protein-protein interaction databases

BioGridi9348. 3 interactors.
IntActiQ9SMN0. 3 interactors.
STRINGi3702.AT3G48690.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SMN0.
SMRiQ9SMN0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi78 – 80Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152317.
InParanoidiQ9SMN0.
OMAiWMMASPN.
OrthoDBiEOG09360JK5.
PhylomeDBiQ9SMN0.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SMN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSEIAVDCS PLLKIYKSGR IERLMGEATV PPSSEPQNGV VSKDVVYSAD
60 70 80 90 100
NNLSVRIYLP EKAAAETDSK LPLLVYFHGG GFIIETAFSP TYHTFLTTSV
110 120 130 140 150
SASNCVAVSV DYRRAPEHPI SVPFDDSWTA LKWVFTHITG SGQEDWLNKH
160 170 180 190 200
ADFSRVFLSG DSAGANIVHH MAMRAAKEKL SPGLNDTGIS GIILLHPYFW
210 220 230 240 250
SKTPIDEKDT KDETLRMKIE AFWMMASPNS KDGTDDPLLN VVQSESVDLS
260 270 280 290 300
GLGCGKVLVM VAEKDALVRQ GWGYAAKLEK SGWKGEVEVV ESEGEDHVFH
310 320
LLKPECDNAI EVMHKFSGFI KGGN
Length:324
Mass (Da):35,567
Last modified:May 1, 2000 - v1
Checksum:iF47FC29B48B7888C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95F → L in BAE98942 (Ref. 5) Curated1
Sequence conflicti144E → D in AAL57633 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133315 Genomic DNA. Translation: CAB62358.1.
CP002686 Genomic DNA. Translation: AEE78446.1.
AY064980 mRNA. Translation: AAL57633.1.
BT015037 mRNA. Translation: AAT70488.1.
AK226849 mRNA. Translation: BAE98942.1.
PIRiT46213.
RefSeqiNP_190438.1. NM_114728.5.
UniGeneiAt.24698.
At.75571.

Genome annotation databases

EnsemblPlantsiAT3G48690.1; AT3G48690.1; AT3G48690.
GeneIDi824030.
GrameneiAT3G48690.1; AT3G48690.1; AT3G48690.
KEGGiath:AT3G48690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133315 Genomic DNA. Translation: CAB62358.1.
CP002686 Genomic DNA. Translation: AEE78446.1.
AY064980 mRNA. Translation: AAL57633.1.
BT015037 mRNA. Translation: AAT70488.1.
AK226849 mRNA. Translation: BAE98942.1.
PIRiT46213.
RefSeqiNP_190438.1. NM_114728.5.
UniGeneiAt.24698.
At.75571.

3D structure databases

ProteinModelPortaliQ9SMN0.
SMRiQ9SMN0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi9348. 3 interactors.
IntActiQ9SMN0. 3 interactors.
STRINGi3702.AT3G48690.1.

Chemistry databases

ChEMBLiCHEMBL1932906.

Protein family/group databases

ESTHERiarath-CXE12. Plant_carboxylesterase.
MEROPSiS09.A09.

Proteomic databases

PaxDbiQ9SMN0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT3G48690.1; AT3G48690.1; AT3G48690.
GeneIDi824030.
GrameneiAT3G48690.1; AT3G48690.1; AT3G48690.
KEGGiath:AT3G48690.

Organism-specific databases

TAIRiAT3G48690.

Phylogenomic databases

eggNOGiKOG1515. Eukaryota.
COG0657. LUCA.
HOGENOMiHOG000152317.
InParanoidiQ9SMN0.
OMAiWMMASPN.
OrthoDBiEOG09360JK5.
PhylomeDBiQ9SMN0.

Enzyme and pathway databases

BioCyciARA:AT3G48690-MONOMER.

Miscellaneous databases

PROiQ9SMN0.

Gene expression databases

GenevisibleiQ9SMN0. AT.

Family and domain databases

Gene3Di3.40.50.1820. 1 hit.
InterProiIPR029058. AB_hydrolase.
IPR013094. AB_hydrolase_3.
IPR033140. Lipase_GDXG_put_SER_AS.
[Graphical view]
PfamiPF07859. Abhydrolase_3. 1 hit.
[Graphical view]
SUPFAMiSSF53474. SSF53474. 1 hit.
PROSITEiPS01174. LIPASE_GDXG_SER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXE12_ARATH
AccessioniPrimary (citable) accession number: Q9SMN0
Secondary accession number(s): Q0WVA6, Q8VZG3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 102 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.