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Protein

Probable carboxylesterase 12

Gene

CXE12

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carboxylesterase acting on esters with varying acyl chain length.By similarity

Catalytic activityi

A carboxylic ester + H2O = an alcohol + a carboxylate.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei162PROSITE-ProRule annotation1
Active sitei265PROSITE-ProRule annotation1
Active sitei297PROSITE-ProRule annotation1

GO - Molecular functioni

  • carboxylic ester hydrolase activity Source: TAIR

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Serine esterase

Enzyme and pathway databases

BioCyciARA:AT3G48690-MONOMER

Protein family/group databases

ESTHERiarath-CXE12 Plant_carboxylesterase
MEROPSiS09.A09

Names & Taxonomyi

Protein namesi
Recommended name:
Probable carboxylesterase 12
Alternative name(s):
AtCXE12 (EC:3.1.1.1)
Gene namesi
Name:CXE12
Ordered Locus Names:At3g48690
ORF Names:T8P19.200
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 3

Organism-specific databases

AraportiAT3G48690
TAIRilocus:2114450 AT3G48690

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1932906

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004025571 – 324Probable carboxylesterase 12Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ9SMN0
PRIDEiQ9SMN0

PTM databases

iPTMnetiQ9SMN0

Expressioni

Tissue specificityi

Expressed in leaves, stems, flowers and siliques.1 Publication

Gene expression databases

ExpressionAtlasiQ9SMN0 baseline and differential
GenevisibleiQ9SMN0 AT

Interactioni

Protein-protein interaction databases

BioGridi9348, 3 interactors
IntActiQ9SMN0, 3 interactors
STRINGi3702.AT3G48690.1

Structurei

3D structure databases

ProteinModelPortaliQ9SMN0
SMRiQ9SMN0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi78 – 80Involved in the stabilization of the negatively charged intermediate by the formation of the oxyanion holeBy similarity3

Sequence similaritiesi

Belongs to the 'GDXG' lipolytic enzyme family.Curated

Phylogenomic databases

eggNOGiKOG1515 Eukaryota
COG0657 LUCA
HOGENOMiHOG000152317
InParanoidiQ9SMN0
OMAiYEDSWIA
OrthoDBiEOG09360JK5
PhylomeDBiQ9SMN0

Family and domain databases

Gene3Di3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR029058 AB_hydrolase
IPR013094 AB_hydrolase_3
IPR033140 Lipase_GDXG_put_SER_AS
PfamiView protein in Pfam
PF07859 Abhydrolase_3, 1 hit
SUPFAMiSSF53474 SSF53474, 1 hit
PROSITEiView protein in PROSITE
PS01174 LIPASE_GDXG_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9SMN0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDSEIAVDCS PLLKIYKSGR IERLMGEATV PPSSEPQNGV VSKDVVYSAD
60 70 80 90 100
NNLSVRIYLP EKAAAETDSK LPLLVYFHGG GFIIETAFSP TYHTFLTTSV
110 120 130 140 150
SASNCVAVSV DYRRAPEHPI SVPFDDSWTA LKWVFTHITG SGQEDWLNKH
160 170 180 190 200
ADFSRVFLSG DSAGANIVHH MAMRAAKEKL SPGLNDTGIS GIILLHPYFW
210 220 230 240 250
SKTPIDEKDT KDETLRMKIE AFWMMASPNS KDGTDDPLLN VVQSESVDLS
260 270 280 290 300
GLGCGKVLVM VAEKDALVRQ GWGYAAKLEK SGWKGEVEVV ESEGEDHVFH
310 320
LLKPECDNAI EVMHKFSGFI KGGN
Length:324
Mass (Da):35,567
Last modified:May 1, 2000 - v1
Checksum:iF47FC29B48B7888C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95F → L in BAE98942 (Ref. 5) Curated1
Sequence conflicti144E → D in AAL57633 (PubMed:14593172).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL133315 Genomic DNA Translation: CAB62358.1
CP002686 Genomic DNA Translation: AEE78446.1
AY064980 mRNA Translation: AAL57633.1
BT015037 mRNA Translation: AAT70488.1
AK226849 mRNA Translation: BAE98942.1
PIRiT46213
RefSeqiNP_190438.1, NM_114728.5
UniGeneiAt.24698
At.75571

Genome annotation databases

EnsemblPlantsiAT3G48690.1; AT3G48690.1; AT3G48690
GeneIDi824030
GrameneiAT3G48690.1; AT3G48690.1; AT3G48690
KEGGiath:AT3G48690

Similar proteinsi

Entry informationi

Entry nameiCXE12_ARATH
AccessioniPrimary (citable) accession number: Q9SMN0
Secondary accession number(s): Q0WVA6, Q8VZG3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2011
Last sequence update: May 1, 2000
Last modified: May 23, 2018
This is version 111 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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