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Protein

Chalcone synthase 1

Gene

CHS1

Organism
Cicer arietinum (Chickpea) (Garbanzo)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

The primary product of this enzyme is 4,2',4',6'-tetrahydroxychalcone (also termed naringenin-chalcone or chalcone) which can under specific conditions spontaneously isomerize into naringenin.

Catalytic activityi

3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Flavonoid biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00154.

Names & Taxonomyi

Protein namesi
Recommended name:
Chalcone synthase 1 (EC:2.3.1.74)
Alternative name(s):
Naringenin-chalcone synthase 1
Gene namesi
Name:CHS1
OrganismiCicer arietinum (Chickpea) (Garbanzo)
Taxonomic identifieri3827 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsfabidsFabalesFabaceaePapilionoideaeCicereaeCicer

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 389389Chalcone synthase 1PRO_0000215967Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliQ9SML4.
SMRiQ9SML4. Positions 3-389.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the chalcone/stilbene synthases family.Curated

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SML4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVSVSEIRKA QRAEGPATIL AIGTANPSNR VEQSTYPDFY FKITNSEHKV
60 70 80 90 100
ELKQKFQRMC DKSMIKSRYM YLTEEILKEN PSVCEYMAPS LDVRQDMVVV
110 120 130 140 150
EVPRLGKEAA VKAIKEWGQP KSKITHLIFC TTSGVDMPGA DYQLTKLLGL
160 170 180 190 200
RPYVKRYMMY QQGCFAGGTV LRLAKDLAEN NKGARVLVVC SEVTAVTFRG
210 220 230 240 250
PSDTHLDSLV GQALFGDGAA ALIVGSDPIP EIEKPIFEMV WTAQTIAPDS
260 270 280 290 300
EGAIDGHLRE AGLTFHLLKD VPGIVSKNID KALIEAFQPL NISDYNSIFW
310 320 330 340 350
IAHPGGPAIL DQVEEKLALK PEKMRATREV LSEYGNMSSA CVLFILDEMR
360 370 380
RKSAKDGLKT TGEGLEWGVL FGFGPGLTIE TVVLHSVAI
Length:389
Mass (Da):42,874
Last modified:May 1, 2000 - v1
Checksum:i04CB0D50086168AC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012822 mRNA. Translation: CAA10190.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ012822 mRNA. Translation: CAA10190.1.

3D structure databases

ProteinModelPortaliQ9SML4.
SMRiQ9SML4. Positions 3-389.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayiUPA00154.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR012328. Chalcone/stilbene_synth_C.
IPR018088. Chalcone/stilbene_synthase_AS.
IPR001099. Chalcone/stilbene_synthase_N.
IPR011141. Polyketide_synthase_type-III.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF02797. Chal_sti_synt_C. 1 hit.
PF00195. Chal_sti_synt_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000451. PKS_III. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
PROSITEiPS00441. CHALCONE_SYNTH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Isolation of a full length chalcone synthase cDNA from infected chickpea plants (Cicer arietinum L.)."
    Hanselle T., Schwenger-Erger C., Barz W.
    Plant Gene Register PGR99-100
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: cv. ILC 3279.
    Tissue: Leaf.

Entry informationi

Entry nameiCHS1_CICAR
AccessioniPrimary (citable) accession number: Q9SML4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 8, 2000
Last sequence update: May 1, 2000
Last modified: October 1, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.