UniProtKB - Q9SLY8 (CALR_ORYSJ)
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Protein
Calreticulin
Gene
Os07g0246200
Organism
Oryza sativa subsp. japonica (Rice)
Status
Functioni
Molecular calcium-binding chaperone promoting folding, oligomeric assembly and quality control in the ER via the calreticulin/calnexin cycle. This lectin may interact transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER (By similarity).By similarity
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 119 | CarbohydrateBy similarity | 1 | |
Binding sitei | 121 | CarbohydrateBy similarity | 1 | |
Binding sitei | 138 | CarbohydrateBy similarity | 1 | |
Binding sitei | 145 | CarbohydrateBy similarity | 1 | |
Binding sitei | 328 | CarbohydrateBy similarity | 1 |
GO - Molecular functioni
- calcium ion binding Source: Gramene
- carbohydrate binding Source: UniProtKB-KW
- unfolded protein binding Source: Gramene
GO - Biological processi
- multicellular organism development Source: Gramene
- protein folding Source: InterPro
Keywordsi
Molecular function | Chaperone |
Ligand | Calcium, Lectin, Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-OSA-901042. Calnexin/calreticulin cycle. |
Names & Taxonomyi
Protein namesi | Recommended name: Calreticulin |
Gene namesi | Ordered Locus Names:Os07g0246200, LOC_Os07g14270 ORF Names:OJ1058_C08.34-1, OJ1058_C08.34-2, OSJNBa0003K21.18-1, OSJNBa0003K21.18-2 |
Organismi | Oryza sativa subsp. japonica (Rice) |
Taxonomic identifieri | 39947 [NCBI] |
Taxonomic lineagei | Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › Liliopsida › Poales › Poaceae › BOP clade › Oryzoideae › Oryzeae › Oryzinae › Oryza › Oryza sativa |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 29 | 1 PublicationAdd BLAST | 29 | |
ChainiPRO_0000004193 | 30 – 424 | CalreticulinAdd BLAST | 395 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 61 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 115 ↔ 147 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q9SLY8. |
PRIDEi | Q9SLY8. |
Expressioni
Gene expression databases
ExpressionAtlasi | Q9SLY8. baseline and differential. |
Genevisiblei | Q9SLY8. OS. |
Interactioni
GO - Molecular functioni
- unfolded protein binding Source: Gramene
Protein-protein interaction databases
STRINGi | 39947.LOC_Os07g14270.1. |
Structurei
3D structure databases
ProteinModelPortali | Q9SLY8. |
SMRi | Q9SLY8. |
ModBasei | Search... |
MobiDBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Repeati | 201 – 212 | 1-1Add BLAST | 12 | |
Repeati | 220 – 231 | 1-2Add BLAST | 12 | |
Repeati | 237 – 248 | 1-3Add BLAST | 12 | |
Repeati | 255 – 266 | 1-4Add BLAST | 12 | |
Repeati | 270 – 280 | 2-1Add BLAST | 11 | |
Repeati | 284 – 294 | 2-2Add BLAST | 11 | |
Repeati | 298 – 308 | 2-3Add BLAST | 11 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 201 – 266 | 4 X approximate repeatsAdd BLAST | 66 | |
Regioni | 270 – 308 | 3 X approximate repeatsAdd BLAST | 39 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 421 – 424 | Prevents secretion from ERPROSITE-ProRule annotation | 4 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 362 – 420 | Asp/Glu/Lys-richAdd BLAST | 59 |
Domaini
Can be divided into a N-terminal globular domain, a proline-rich P-domain forming an elongated arm-like structure and a C-terminal acidic domain. The P-domain binds one molecule of calcium with high affinity, whereas the acidic C-domain binds multiple calcium ions with low affinity (By similarity).By similarity
The interaction with glycans occurs through a binding site in the globular lectin domain.By similarity
The zinc binding sites are localized to the N-domain.By similarity
Sequence similaritiesi
Belongs to the calreticulin family.Curated
Keywords - Domaini
Repeat, SignalPhylogenomic databases
eggNOGi | KOG0674. Eukaryota. ENOG410XRR7. LUCA. |
HOGENOMi | HOG000192435. |
InParanoidi | Q9SLY8. |
KOi | K08057. |
OMAi | NSKHKSD. |
Family and domain databases
Gene3Di | 2.10.250.10. 2 hits. |
InterProi | View protein in InterPro IPR001580. Calret/calnex. IPR018124. Calret/calnex_CS. IPR009169. Calreticulin. IPR009033. Calreticulin/calnexin_P_dom_sf. IPR013320. ConA-like_dom_sf. |
PANTHERi | PTHR11073. PTHR11073. 1 hit. |
Pfami | View protein in Pfam PF00262. Calreticulin. 2 hits. |
PIRSFi | PIRSF002356. Calreticulin. 1 hit. |
PRINTSi | PR00626. CALRETICULIN. |
SUPFAMi | SSF49899. SSF49899. 1 hit. SSF63887. SSF63887. 1 hit. |
PROSITEi | View protein in PROSITE PS00803. CALRETICULIN_1. 1 hit. PS00804. CALRETICULIN_2. 1 hit. PS00805. CALRETICULIN_REPEAT. 2 hits. PS00014. ER_TARGET. 1 hit. |
s (2)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q9SLY8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MAIRARSSSY AAAAVALALA LASVAAVAGE VFFQEKFEDG WESRWVKSEW
60 70 80 90 100
KKDENMAGEW NHTSGKWNGD PEDKGIQTSE DYRFYAISAE YPEFSNKDKT
110 120 130 140 150
LVLQFSVKHE QKLDCGGGYV KLLGGDVDQK KFGGDTPYSI MFGPDICGYS
160 170 180 190 200
TKKVHTIFTK NDKNHLIKKD VPCETDQLSH VYTLIIHPDA TYTILIDNVE
210 220 230 240 250
KQSGSIYEHW DILPPKQIKD PEAKKPEDWD DKEYIPDPED KKPEGYDDIP
260 270 280 290 300
KEIPDPDAKK PEDWDDEEDG EWTAPTIPNP EYKGPWKQKK IKNPNYQGKW
310 320 330 340 350
KAPMIDNPDF KDDPYIYAFD SLKYIGIELW QVKSGTLFDN FLITDDPELA
360 370 380 390 400
KTFAEETWGK HKDAEKAAFD EAEKKKEEEE AAKAGEDDDD LDDEDAEDED
410 420
KADEKADSDA EDGKDSDDEK HDEL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 193 | T → S in BAA88900 (PubMed:10651810).Curated | 1 | |
Sequence conflicti | 263 – 265 | DWD → AGA in BAA88900 (PubMed:10651810).Curated | 3 | |
Sequence conflicti | 278 | P → R in BAA88900 (PubMed:10651810).Curated | 1 | |
Sequence conflicti | 302 | A → P in BAA88900 (PubMed:10651810).Curated | 1 | |
Sequence conflicti | 306 – 307 | DN → AT in BAA88900 (PubMed:10651810).Curated | 2 | |
Sequence conflicti | 311 | K → Q in BAA88900 (PubMed:10651810).Curated | 1 | |
Sequence conflicti | 324 | Y → S in BAA88900 (PubMed:10651810).Curated | 1 | |
Sequence conflicti | 341 | F → I in BAA88900 (PubMed:10651810).Curated | 1 | |
Sequence conflicti | 347 – 348 | PE → AA in BAA88900 (PubMed:10651810).Curated | 2 | |
Sequence conflicti | 359 | G → A in BAA88900 (PubMed:10651810).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016726 | 422 – 424 | DEL → VCNTPAFS in isoform 2. 1 Publication | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB021259 mRNA. Translation: BAA88900.1. AP003738 Genomic DNA. Translation: BAC82932.1. AP003738 Genomic DNA. Translation: BAC82933.1. AP006266 Genomic DNA. Translation: BAD31961.1. AP006266 Genomic DNA. Translation: BAD31962.1. AP014963 Genomic DNA. Translation: BAT00809.1. AP014963 Genomic DNA. Translation: BAT00810.1. AK065341 mRNA. No translation available. AK104328 mRNA. No translation available. |
RefSeqi | XP_015647166.1. XM_015791680.1. [Q9SLY8-2] XP_015647167.1. XM_015791681.1. [Q9SLY8-1] |
UniGenei | Os.60530. |
Genome annotation databases
EnsemblPlantsi | Os07t0246200-01; Os07t0246200-01; Os07g0246200. [Q9SLY8-1] Os07t0246200-02; Os07t0246200-02; Os07g0246200. [Q9SLY8-1] Os07t0246200-03; Os07t0246200-03; Os07g0246200. [Q9SLY8-2] |
GeneIDi | 4342826. |
Gramenei | Os07t0246200-01; Os07t0246200-01; Os07g0246200. [Q9SLY8-1] Os07t0246200-02; Os07t0246200-02; Os07g0246200. [Q9SLY8-1] Os07t0246200-03; Os07t0246200-03; Os07g0246200. [Q9SLY8-2] |
KEGGi | osa:4342826. |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Entry informationi
Entry namei | CALR_ORYSJ | |
Accessioni | Q9SLY8Primary (citable) accession number: Q9SLY8 Secondary accession number(s): Q6ZLM7, Q6ZLM8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 1, 2000 |
Last sequence update: | December 20, 2005 | |
Last modified: | March 28, 2018 | |
This is version 121 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Plant Protein Annotation Program |