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Q9SLK6 (ALA6_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phospholipid-transporting ATPase 6
Short name=AtALA6
EC=3.6.3.1
Alternative name(s):
Aminophospholipid flippase 6
Gene names
Name:ALA6
Ordered Locus Names:At1g54280
ORF Names:F20D21.10
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length1240 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Involved in transport of phospholipids Potential.

Catalytic activity

ATP + H2O + phospholipid(In) = ADP + phosphate + phospholipid(Out).

Subcellular location

Membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. [View classification]

Sequence caution

The sequence AAD25608.2 differs from that shown. Reason: Erroneous gene model prediction.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12401240Phospholipid-transporting ATPase 6
PRO_0000046390

Regions

Topological domain1 – 7575Cytoplasmic Potential
Transmembrane76 – 9722Helical; Potential
Topological domain98 – 1014Extracellular Potential
Transmembrane102 – 12423Helical; Potential
Topological domain125 – 306182Cytoplasmic Potential
Transmembrane307 – 32822Helical; Potential
Topological domain329 – 36032Extracellular Potential
Transmembrane361 – 37818Helical; Potential
Topological domain379 – 943565Cytoplasmic Potential
Transmembrane944 – 96320Helical; Potential
Topological domain964 – 97714Extracellular Potential
Transmembrane978 – 99720Helical; Potential
Topological domain998 – 102730Cytoplasmic Potential
Transmembrane1028 – 105023Helical; Potential
Topological domain1051 – 106313Extracellular Potential
Transmembrane1064 – 108623Helical; Potential
Topological domain1087 – 10926Cytoplasmic Potential
Transmembrane1093 – 111321Helical; Potential
Topological domain1114 – 113017Extracellular Potential
Transmembrane1131 – 115525Helical; Potential
Topological domain1156 – 124085Cytoplasmic Potential

Sites

Active site42614-aspartylphosphate intermediate By similarity
Metal binding8881Magnesium By similarity
Metal binding8921Magnesium By similarity

Amino acid modifications

Cross-link625Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.3
Cross-link717Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q9SLK6 [UniParc].

Last modified September 22, 2009. Version 2.
Checksum: 63866920588AFB9C

FASTA1,240140,102
        10         20         30         40         50         60 
MARRRIRSRI RKSHFYTFRC LRPKTLDDQG PHVINGPGYT RIVHCNQPHL HLATKLIRYR 

        70         80         90        100        110        120 
SNYVSTTRYN LLTFLPKCLY EQFHRVANFY FLVAAILSVF PLSPFNKWSM IAPLVFVVGL 

       130        140        150        160        170        180 
SMGKEALEDW RRFMQDVEVN SRKASVHKGS GDFGRRTWKR IRVGDIVRVE KDEFFPADLL 

       190        200        210        220        230        240 
LLSSSYEDGI CYVETMNLDG ETNLKVKRCL DATLALEKDE SFQNFSGTIK CEDPNPNLYT 

       250        260        270        280        290        300 
FVGNLECDGQ VYPLDPNQIL LRDSKLRNTA YVYGVVVFTG HDTKVMQNST KSPSKRSRIE 

       310        320        330        340        350        360 
KRMDYIIYTL FALLLTVSFI SSLGFAVMTK LLMAEWWYLR PDKPESLTNP TNPLYAWVVH 

       370        380        390        400        410        420 
LITALLLYGY LIPISLYVSI EVVKVLQAHF INQDLQLYDS ESGTPAQART SNLNEELGQV 

       430        440        450        460        470        480 
DTILSDKTGT LTCNQMDFLK CSIAGTSYGV RASEVELAAA KQMAMDLEEK GEEVANLSMN 

       490        500        510        520        530        540 
KGRTQRYAKL ASKTSSDFEL ETVVTASDEK DQKQNTGVKG FSFEDNRLMN ENWLNEPNSD 

       550        560        570        580        590        600 
DILMFFRILA VCHTAIPEVD EDTGMCTYEA ESPDEVAFLV ASREFGFEFT KRTQSSVFIA 

       610        620        630        640        650        660 
ERFSSSGQPV DREYKILNLL DFTSKRKRMS AIVRDEEGQI LLLCKGADSI IFERLSKSGK 

       670        680        690        700        710        720 
EYLGATSKHL NVYGEAGLRT LALGYRKLDE TEYAAWNSEF HKAKTSVGAD RDEMLEKVSD 

       730        740        750        760        770        780 
MMEKELILVG ATAVEDKLQK GVPQCIDNLA QAGLKIWVLT GDKMETAINI GYACSLLRQG 

       790        800        810        820        830        840 
MKQISISLTN VEESSQNSEA AAKESILMQI TNASQMIKIE KDPHAAFALI IDGKTLTYAL 

       850        860        870        880        890        900 
KDDVKYQFLA LAVDCASVIC CRVSPKQKAL VTRLAKEGTG KTTLAIGDGA NDVGMIQEAD 

       910        920        930        940        950        960 
IGVGISGVEG MQAVMASDFS IAQFRFLERL LVVHGHWCYK RIAQMICYFF YKNITFGLTL 

       970        980        990       1000       1010       1020 
FYFECFTGFS GQSIYNDSYL LLFNVVLTSL PVISLGVFEQ DVPSDVCLQF PALYQQGPKN 

      1030       1040       1050       1060       1070       1080 
LFFDWYRILG WMGNGVYASI VIFTLNLGIF HVQSFRSDGQ TADMNAMGTA MFTCIIWAVN 

      1090       1100       1110       1120       1130       1140 
VQIALTMSHF TWIQHVMIWG SIGAWYVFLA LYGMLPVKLS GNIFHMLVEI LAPAPIFWLT 

      1150       1160       1170       1180       1190       1200 
SLLVIAATTL PYLFHISYQR SVNPLDHHII QEIKHFRIDV EDERMWKREK SKAREKTKIG 

      1210       1220       1230       1240 
FTARVDAKIR QLRGRLQRKH SVLSVMSGTS SNDTPSSNSQ

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana."
Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O., Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E., Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K. expand/collapse author list , Conn L., Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P., Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D., Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J., Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L., Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A., Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A., Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M., Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M., Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P., Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D., Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D., Yu G., Fraser C.M., Venter J.C., Davis R.W.
Nature 408:816-820(2000) [PubMed: 11130712] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Multidimensional protein identification technology (MudPIT) analysis of ubiquitinated proteins in plants."
Maor R., Jones A., Nuehse T.S., Studholme D.J., Peck S.C., Shirasu K.
Mol. Cell. Proteomics 6:601-610(2007) [PubMed: 17272265] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-625 AND LYS-717, MASS SPECTROMETRY.
Strain: cv. Landsberg erecta.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC005287 Genomic DNA. Translation: AAD25608.2. Sequence problems.
CP002684 Genomic DNA. Translation: AEE33075.1.
IPIIPI00546745.
PIRC96584.
RefSeqNP_175830.1. NM_104306.2.

3D structure databases

ProteinModelPortalQ9SLK6.
SMRQ9SLK6. Positions 860-923.
ModBaseSearch...

Proteomic databases

PRIDEQ9SLK6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT1G54280.1; AT1G54280.1; AT1G54280.
GeneID841869.
GenomeReviewsGene locus AT1G54280 in contig CT485782_GR.
KEGGath:AT1G54280.

Organism-specific databases

TAIRAt1g54280.

Phylogenomic databases

eggNOGKOG0206.
GeneTreeEPGT00070000028188.
HOGENOMHBG745019.
InParanoidQ9SLK6.
OMAKLRNTAY.
PhylomeDBQ9SLK6.
ProtClustDBCLSN2679593.

Gene expression databases

ArrayExpressQ9SLK6.
GenevestigatorQ9SLK6.
GermOnlineAT1G54280. Arabidopsis thaliana.

Family and domain databases

InterProIPR023306. ATPase_cation_domN.
IPR008250. ATPase_P-typ_ATPase-assoc-dom.
IPR023300. ATPase_P-typ_cyto_domA.
IPR023299. ATPase_P-typ_cyto_domN.
IPR001757. ATPase_P-typ_ion-transptr.
IPR018303. ATPase_P-typ_P_site.
IPR006539. ATPase_P-typ_Plipid-transl.
IPR023214. HAD-like_dom.
[Graphical view]
Gene3DG3DSA:2.70.150.10. ATPase_P-typ_cyto_domA. 2 hits.
G3DSA:3.40.1110.10. ATPase_P-typ_cyto_domN. 2 hits.
G3DSA:3.40.50.1000. HAD-like_dom. 2 hits.
KOK01530.
PfamPF00122. E1-E2_ATPase. 1 hit.
[Graphical view]
PRINTSPR00119. CATATPASE.
SUPFAMSSF81660. ATPase_cation_domN. 1 hit.
SSF56784. HAD-like_dom. 1 hit.
TIGRFAMsTIGR01652. ATPase-Plipid. 1 hit.
TIGR01494. ATPase_P-type. 2 hits.
PROSITEPS00154. ATPASE_E1_E2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALA6_ARATH
AccessionPrimary (citable) accession number: Q9SLK6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: September 22, 2009
Last modified: December 14, 2011
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents