ID PI5K5_ARATH Reviewed; 772 AA. AC Q9SLG9; DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot. DT 01-MAY-2000, sequence version 1. DT 27-MAR-2024, entry version 141. DE RecName: Full=Phosphatidylinositol 4-phosphate 5-kinase 5; DE Short=AtPIP5K5; DE EC=2.7.1.68; DE AltName: Full=1-phosphatidylinositol 4-phosphate kinase 5; DE AltName: Full=Diphosphoinositide kinase 5; DE AltName: Full=PtdIns(4)P-5-kinase 5; GN Name=PIP5K5; OrderedLocusNames=At2g41210; ORFNames=T3K9.2; OS Arabidopsis thaliana (Mouse-ear cress). OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. OX NCBI_TaxID=3702; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RA Abd El-Haliem M., Elge S., Mueller-Roeber B.; RT "Cloning and functional analysis of a novel Arabidopsis RT phosphatidylinositol-4-phosphate 5-kinase."; RL Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases. RN [2] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=cv. Columbia; RX PubMed=10617197; DOI=10.1038/45471; RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.; RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."; RL Nature 402:761-768(1999). RN [3] RP GENOME REANNOTATION. RC STRAIN=cv. Columbia; RX PubMed=27862469; DOI=10.1111/tpj.13415; RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S., RA Town C.D.; RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference RT genome."; RL Plant J. 89:789-804(2017). RN [4] RP GENE FAMILY, AND NOMENCLATURE. RX PubMed=12226484; DOI=10.1104/pp.004770; RA Mueller-Roeber B., Pical C.; RT "Inositol phospholipid metabolism in Arabidopsis. Characterized and RT putative isoforms of inositol phospholipid kinase and phosphoinositide- RT specific phospholipase C."; RL Plant Physiol. 130:22-46(2002). CC -!- CATALYTIC ACTIVITY: CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4- CC phosphate) + ATP = a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo- CC inositol-4,5-bisphosphate) + ADP + H(+); Xref=Rhea:RHEA:14425, CC ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:58178, CC ChEBI:CHEBI:58456, ChEBI:CHEBI:456216; EC=2.7.1.68; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; AF260903; AAK49397.1; -; mRNA. DR EMBL; AC004261; AAM14925.1; -; Genomic_DNA. DR EMBL; CP002685; AEC09944.1; -; Genomic_DNA. DR PIR; T02098; T02098. DR RefSeq; NP_181654.1; NM_129686.2. DR AlphaFoldDB; Q9SLG9; -. DR SMR; Q9SLG9; -. DR BioGRID; 4057; 3. DR STRING; 3702.Q9SLG9; -. DR iPTMnet; Q9SLG9; -. DR PaxDb; 3702-AT2G41210-1; -. DR ProteomicsDB; 236754; -. DR EnsemblPlants; AT2G41210.1; AT2G41210.1; AT2G41210. DR GeneID; 818720; -. DR Gramene; AT2G41210.1; AT2G41210.1; AT2G41210. DR KEGG; ath:AT2G41210; -. DR Araport; AT2G41210; -. DR TAIR; AT2G41210; PIP5K5. DR eggNOG; KOG0229; Eukaryota. DR HOGENOM; CLU_004312_6_4_1; -. DR InParanoid; Q9SLG9; -. DR OMA; FYEVVMI; -. DR OrthoDB; 340426at2759; -. DR PhylomeDB; Q9SLG9; -. DR BioCyc; ARA:AT2G41210-MONOMER; -. DR PRO; PR:Q9SLG9; -. DR Proteomes; UP000006548; Chromosome 2. DR ExpressionAtlas; Q9SLG9; baseline and differential. DR GO; GO:0016324; C:apical plasma membrane; IDA:TAIR. DR GO; GO:0005829; C:cytosol; IDA:TAIR. DR GO; GO:0090406; C:pollen tube; IDA:TAIR. DR GO; GO:0016308; F:1-phosphatidylinositol-4-phosphate 5-kinase activity; IDA:TAIR. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0046488; P:phosphatidylinositol metabolic process; IDA:TAIR. DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW. DR GO; GO:0009827; P:plant-type cell wall modification; IMP:TAIR. DR GO; GO:0009846; P:pollen germination; IGI:TAIR. DR GO; GO:0009860; P:pollen tube growth; IGI:TAIR. DR CDD; cd17302; PIPKc_AtPIP5K_like; 1. DR Gene3D; 3.30.810.10; 2-Layer Sandwich; 2. DR Gene3D; 2.20.110.10; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 3. DR Gene3D; 3.30.800.10; Phosphatidylinositol Phosphate Kinase II Beta; 1. DR InterPro; IPR003409; MORN. DR InterPro; IPR017163; PIno-4-P-5_kinase_pln. DR InterPro; IPR027483; PInositol-4-P-4/5-kinase_C_sf. DR InterPro; IPR002498; PInositol-4-P-4/5-kinase_core. DR InterPro; IPR027484; PInositol-4-P-5-kinase_N. DR InterPro; IPR023610; PInositol-4/5-P-5/4-kinase. DR PANTHER; PTHR23086:SF94; PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE 5; 1. DR PANTHER; PTHR23086; PHOSPHATIDYLINOSITOL-4-PHOSPHATE 5-KINASE; 1. DR Pfam; PF02493; MORN; 8. DR Pfam; PF01504; PIP5K; 1. DR PIRSF; PIRSF037274; PIP5K_plant_prd; 1. DR SMART; SM00698; MORN; 7. DR SMART; SM00330; PIPKc; 1. DR SUPFAM; SSF82185; Histone H3 K4-specific methyltransferase SET7/9 N-terminal domain; 1. DR SUPFAM; SSF56104; SAICAR synthase-like; 1. DR PROSITE; PS51455; PIPK; 1. DR Genevisible; Q9SLG9; AT. PE 2: Evidence at transcript level; KW ATP-binding; Kinase; Nucleotide-binding; Reference proteome; Repeat; KW Transferase. FT CHAIN 1..772 FT /note="Phosphatidylinositol 4-phosphate 5-kinase 5" FT /id="PRO_0000185477" FT REPEAT 75..97 FT /note="MORN 1" FT REPEAT 98..120 FT /note="MORN 2" FT REPEAT 121..143 FT /note="MORN 3" FT REPEAT 144..166 FT /note="MORN 4" FT REPEAT 167..189 FT /note="MORN 5" FT REPEAT 190..212 FT /note="MORN 6" FT REPEAT 213..235 FT /note="MORN 7" FT REPEAT 236..257 FT /note="MORN 8" FT DOMAIN 377..768 FT /note="PIPK" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00781" FT REGION 22..56 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 646..665 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 728..749 FT /note="Activation loop" FT /evidence="ECO:0000250" FT COMPBIAS 22..41 FT /note="Polar residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 772 AA; 88204 MW; D189D4B24D517152 CRC64; MSKDQSYVLK AWEVTVRKTQ QAKKRANSVF GTVSVAPHTD NDTTTDDNDD ETTTNRSSLE EFYHAERVLP NGDYYTGQWY DSFPHGHGKY LWTDGCMYIG DWYNGKTMGN GKFGWPSGAT YEGEFKSGYM DGIGTYTGPS GDAYKGQWVM NLKHGHGVKS FANGDAYDGE WRRGLQEGQG KYQWSDGSYY IGEWKNGTIC GKGSFVWTNG NRYDGFWDEG FPRGNGTFKW DNGSFYVGHW SKDPEEMNGT YYPSGNEGNL EWDPKDLFNN LSEYTICSGE RVPTLPSQKK LSVWNSSKRI EKPRRTSVDG RVSVGVDRAF EKMNMWGNEI GEGGADMRKE LDAELMRLDA EGLQSLKSSP VPMKLPKAGR KQGETISKGH RNYELMLNLQ LGIRHSVGRQ APAASLDLKP SAFDPKDKIW RRFPREGTKY TPPHQSTEFK WKDYCPLVFR SLRKLFKVDP ADYMLSICGN DALRELSSPG KSGSFFYLTN DDRYMIKTMK KSETKVLLGM LAAYYNHVRA FENSLVIRFF GLHCVKLNGP TQKKVRFVIM GNLFCSKYSV HRRFDLKGSS LGRTTDKPES EIDSNTILKD LDLNFIFRLQ KAWYQEFIRQ IDKDCEFLEQ ERIMDYSLLV GIHFREASVA GELIPSGART PIGESEEESG PRLSRAEVDE LLSDPSRWAS IRLGTNMPAR AERTMRKNDS ELQLVGEPTG EFYEVVMIFG IIDILQDYDI SKKLEHAYKS IQYDPSSISA VDPRQYSRRF RDFIFKVFTD DN //