Reviewed, UniProtKB/Swiss-Prot Q9SLG9 (PI5K5_ARATH)

Names and origin

Protein names

Recommended name:
    Phosphatidylinositol-4-phosphate 5-kinase 5
      Short name=AtPIP5K5
    EC=2.7.1.68
Alternative name(s):
    1-phosphatidylinositol-4-phosphate kinase 5
    PtdIns(4)P-5-kinase 5
    Diphosphoinositide kinase 5

Gene names

Name:	PIP5K5
Ordered Locus Names:	At2g41210
ORF Names:	T3K9.2

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

Protein attributes

Sequence length	772 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Sequence similarities	Contains 8 MORN repeats. Contains 1 PIPK domain.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphatidylinositol metabolic process Inferred from direct assay. Source: TAIR plant-type cell wall modification Inferred from mutant phenotype. Source: TAIR pollen germination Inferred from genetic interaction. Source: TAIR pollen tube growth Inferred from genetic interaction. Source: TAIR
Cellular component	apical plasma membrane Inferred from direct assay. Source: TAIR cytosolic part Inferred from direct assay. Source: TAIR
Molecular function	1-phosphatidylinositol-4-phosphate 5-kinase activity Inferred from direct assay. Source: TAIR ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 772	772	Phosphatidylinositol-4-phosphate 5-kinase 5		PRO_0000185477
Regions
	Repeat	75 – 97	23	MORN 1
	Repeat	98 – 120	23	MORN 2
	Repeat	121 – 143	23	MORN 3
	Repeat	144 – 166	23	MORN 4
	Repeat	167 – 189	23	MORN 5
	Repeat	190 – 212	23	MORN 6
	Repeat	213 – 235	23	MORN 7
	Repeat	236 – 257	22	MORN 8
	Domain	377 – 768	392	PIPK
	Region	728 – 749	22	Activation loop By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9SLG9-1 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D189D4B24D517152	FASTA	772	88,204
	10 20 30 40 50 60 MSKDQSYVLK AWEVTVRKTQ QAKKRANSVF GTVSVAPHTD NDTTTDDNDD ETTTNRSSLE 70 80 90 100 110 120 EFYHAERVLP NGDYYTGQWY DSFPHGHGKY LWTDGCMYIG DWYNGKTMGN GKFGWPSGAT 130 140 150 160 170 180 YEGEFKSGYM DGIGTYTGPS GDAYKGQWVM NLKHGHGVKS FANGDAYDGE WRRGLQEGQG 190 200 210 220 230 240 KYQWSDGSYY IGEWKNGTIC GKGSFVWTNG NRYDGFWDEG FPRGNGTFKW DNGSFYVGHW 250 260 270 280 290 300 SKDPEEMNGT YYPSGNEGNL EWDPKDLFNN LSEYTICSGE RVPTLPSQKK LSVWNSSKRI 310 320 330 340 350 360 EKPRRTSVDG RVSVGVDRAF EKMNMWGNEI GEGGADMRKE LDAELMRLDA EGLQSLKSSP 370 380 390 400 410 420 VPMKLPKAGR KQGETISKGH RNYELMLNLQ LGIRHSVGRQ APAASLDLKP SAFDPKDKIW 430 440 450 460 470 480 RRFPREGTKY TPPHQSTEFK WKDYCPLVFR SLRKLFKVDP ADYMLSICGN DALRELSSPG 490 500 510 520 530 540 KSGSFFYLTN DDRYMIKTMK KSETKVLLGM LAAYYNHVRA FENSLVIRFF GLHCVKLNGP 550 560 570 580 590 600 TQKKVRFVIM GNLFCSKYSV HRRFDLKGSS LGRTTDKPES EIDSNTILKD LDLNFIFRLQ 610 620 630 640 650 660 KAWYQEFIRQ IDKDCEFLEQ ERIMDYSLLV GIHFREASVA GELIPSGART PIGESEEESG 670 680 690 700 710 720 PRLSRAEVDE LLSDPSRWAS IRLGTNMPAR AERTMRKNDS ELQLVGEPTG EFYEVVMIFG 730 740 750 760 770 IIDILQDYDI SKKLEHAYKS IQYDPSSISA VDPRQYSRRF RDFIFKVFTD DN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional analysis of a novel Arabidopsis phosphatidylinositol-4-phosphate 5-kinase." Abd El-Haliem M., Elge S., Mueller-Roeber B. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	"Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C." Mueller-Roeber B., Pical C. Plant Physiol. 130:22-46(2002) [PubMed: 12226484] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF260903 mRNA. Translation: AAK49397.1. AC004261 Genomic DNA. Translation: AAM14925.1.
IPI	IPI00540063.
PIR	T02098.
RefSeq	NP_181654.1.
UniGene	At.13170
3D structure databases
HSSP	HSSP built from PDB template 1BO1 based on UniProtKB P78356.
ModBase	Search...
Protein-protein interaction databases
STRING	Q9SLG9.
Proteomic databases
PRIDE	Q9SLG9.
Genome annotation databases
GeneID	818720.
GenomeReviews	Gene locus AT2G41210 in contig CT485783_GR.
KEGG	ath:AT2G41210.
NMPDR	fig|3702.1.peg.11259.
Organism-specific databases
TAIR	At2g41210.
Enzyme and pathway databases
BRENDA	2.7.1.68. 302.
Gene expression databases
ArrayExpress	Q9SLG9.
Genevestigator	Q9SLG9.
GermOnline	AT2G41210. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR003409. MORN. IPR017163. PIno-4-P-5_kinase_pln. IPR002498. PInositol-4-P-5-kinase_core. IPR016034. PInositol-4P-5-kinase_core_sub. [Graphical view]
PANTHER	PTHR23086. PIP5K. 1 hit.
Pfam	PF02493. MORN. 8 hits. PF01504. PIP5K. 1 hit. [Graphical view]
PIRSF	PIRSF037274. PIP5K_plant_prd. 1 hit.
SMART	SM00698. MORN. 7 hits. SM00330. PIPKc. 1 hit. [Graphical view]
PROSITE	PS51455. PIPK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PI5K5_ARATH

Accession

Primary (citable) accession number: Q9SLG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	May 1, 2000
Last modified:	October 13, 2009
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)