Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Phosphatidylinositol 4-phosphate 5-kinase 5

Gene

PIP5K5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  • 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • phosphatidylinositol metabolic process Source: TAIR
  • plant-type cell wall modification Source: TAIR
  • pollen germination Source: TAIR
  • pollen tube growth Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G41210-MONOMER.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 5 (EC:2.7.1.68)
Short name:
AtPIP5K5
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 5
Diphosphoinositide kinase 5
PtdIns(4)P-5-kinase 5
Gene namesi
Name:PIP5K5
Ordered Locus Names:At2g41210
ORF Names:T3K9.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G41210.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: TAIR
  • cytosol Source: TAIR
  • pollen tube Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001854771 – 772Phosphatidylinositol 4-phosphate 5-kinase 5Add BLAST772

Proteomic databases

PaxDbiQ9SLG9.
PRIDEiQ9SLG9.

PTM databases

iPTMnetiQ9SLG9.

Expressioni

Gene expression databases

GenevisibleiQ9SLG9. AT.

Interactioni

Protein-protein interaction databases

BioGridi4057. 3 interactors.
MINTiMINT-8060064.
STRINGi3702.AT2G41210.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SLG9.
SMRiQ9SLG9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati75 – 97MORN 1Add BLAST23
Repeati98 – 120MORN 2Add BLAST23
Repeati121 – 143MORN 3Add BLAST23
Repeati144 – 166MORN 4Add BLAST23
Repeati167 – 189MORN 5Add BLAST23
Repeati190 – 212MORN 6Add BLAST23
Repeati213 – 235MORN 7Add BLAST23
Repeati236 – 257MORN 8Add BLAST22
Domaini377 – 768PIPKPROSITE-ProRule annotationAdd BLAST392

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni728 – 749Activation loopBy similarityAdd BLAST22

Sequence similaritiesi

Contains 8 MORN repeats.Curated
Contains 1 PIPK domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ9SLG9.
KOiK00889.
OMAiWKNGTIC.
OrthoDBiEOG093602F1.
PhylomeDBiQ9SLG9.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SLG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDQSYVLK AWEVTVRKTQ QAKKRANSVF GTVSVAPHTD NDTTTDDNDD
60 70 80 90 100
ETTTNRSSLE EFYHAERVLP NGDYYTGQWY DSFPHGHGKY LWTDGCMYIG
110 120 130 140 150
DWYNGKTMGN GKFGWPSGAT YEGEFKSGYM DGIGTYTGPS GDAYKGQWVM
160 170 180 190 200
NLKHGHGVKS FANGDAYDGE WRRGLQEGQG KYQWSDGSYY IGEWKNGTIC
210 220 230 240 250
GKGSFVWTNG NRYDGFWDEG FPRGNGTFKW DNGSFYVGHW SKDPEEMNGT
260 270 280 290 300
YYPSGNEGNL EWDPKDLFNN LSEYTICSGE RVPTLPSQKK LSVWNSSKRI
310 320 330 340 350
EKPRRTSVDG RVSVGVDRAF EKMNMWGNEI GEGGADMRKE LDAELMRLDA
360 370 380 390 400
EGLQSLKSSP VPMKLPKAGR KQGETISKGH RNYELMLNLQ LGIRHSVGRQ
410 420 430 440 450
APAASLDLKP SAFDPKDKIW RRFPREGTKY TPPHQSTEFK WKDYCPLVFR
460 470 480 490 500
SLRKLFKVDP ADYMLSICGN DALRELSSPG KSGSFFYLTN DDRYMIKTMK
510 520 530 540 550
KSETKVLLGM LAAYYNHVRA FENSLVIRFF GLHCVKLNGP TQKKVRFVIM
560 570 580 590 600
GNLFCSKYSV HRRFDLKGSS LGRTTDKPES EIDSNTILKD LDLNFIFRLQ
610 620 630 640 650
KAWYQEFIRQ IDKDCEFLEQ ERIMDYSLLV GIHFREASVA GELIPSGART
660 670 680 690 700
PIGESEEESG PRLSRAEVDE LLSDPSRWAS IRLGTNMPAR AERTMRKNDS
710 720 730 740 750
ELQLVGEPTG EFYEVVMIFG IIDILQDYDI SKKLEHAYKS IQYDPSSISA
760 770
VDPRQYSRRF RDFIFKVFTD DN
Length:772
Mass (Da):88,204
Last modified:May 1, 2000 - v1
Checksum:iD189D4B24D517152
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260903 mRNA. Translation: AAK49397.1.
AC004261 Genomic DNA. Translation: AAM14925.1.
CP002685 Genomic DNA. Translation: AEC09944.1.
PIRiT02098.
RefSeqiNP_181654.1. NM_129686.2.
UniGeneiAt.13170.

Genome annotation databases

EnsemblPlantsiAT2G41210.1; AT2G41210.1; AT2G41210.
GeneIDi818720.
GrameneiAT2G41210.1; AT2G41210.1; AT2G41210.
KEGGiath:AT2G41210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260903 mRNA. Translation: AAK49397.1.
AC004261 Genomic DNA. Translation: AAM14925.1.
CP002685 Genomic DNA. Translation: AEC09944.1.
PIRiT02098.
RefSeqiNP_181654.1. NM_129686.2.
UniGeneiAt.13170.

3D structure databases

ProteinModelPortaliQ9SLG9.
SMRiQ9SLG9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4057. 3 interactors.
MINTiMINT-8060064.
STRINGi3702.AT2G41210.1.

PTM databases

iPTMnetiQ9SLG9.

Proteomic databases

PaxDbiQ9SLG9.
PRIDEiQ9SLG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G41210.1; AT2G41210.1; AT2G41210.
GeneIDi818720.
GrameneiAT2G41210.1; AT2G41210.1; AT2G41210.
KEGGiath:AT2G41210.

Organism-specific databases

TAIRiAT2G41210.

Phylogenomic databases

eggNOGiKOG0229. Eukaryota.
COG4642. LUCA.
COG5253. LUCA.
HOGENOMiHOG000193875.
InParanoidiQ9SLG9.
KOiK00889.
OMAiWKNGTIC.
OrthoDBiEOG093602F1.
PhylomeDBiQ9SLG9.

Enzyme and pathway databases

BioCyciARA:AT2G41210-MONOMER.
ReactomeiR-ATH-1660499. Synthesis of PIPs at the plasma membrane.
R-ATH-6811558. PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
R-ATH-8856828. Clathrin-mediated endocytosis.

Miscellaneous databases

PROiQ9SLG9.

Gene expression databases

GenevisibleiQ9SLG9. AT.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPI5K5_ARATH
AccessioniPrimary (citable) accession number: Q9SLG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.