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Protein

Phosphatidylinositol 4-phosphate 5-kinase 5

Gene

PIP5K5

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.

GO - Molecular functioni

  • 1-phosphatidylinositol-4-phosphate 5-kinase activity Source: TAIR
  • ATP binding Source: UniProtKB-KW

GO - Biological processi

  • phosphatidylinositol metabolic process Source: TAIR
  • phosphatidylinositol phosphorylation Source: GOC
  • plant-type cell wall modification Source: TAIR
  • pollen germination Source: TAIR
  • pollen tube growth Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciARA:AT2G41210-MONOMER.
ReactomeiREACT_345128. Synthesis of PIPs at the plasma membrane.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 5 (EC:2.7.1.68)
Short name:
AtPIP5K5
Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 5
Diphosphoinositide kinase 5
PtdIns(4)P-5-kinase 5
Gene namesi
Name:PIP5K5
Ordered Locus Names:At2g41210
ORF Names:T3K9.2
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G41210.

Subcellular locationi

GO - Cellular componenti

  • apical plasma membrane Source: TAIR
  • cytosol Source: TAIR
  • pollen tube Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 772772Phosphatidylinositol 4-phosphate 5-kinase 5PRO_0000185477Add
BLAST

Proteomic databases

PaxDbiQ9SLG9.
PRIDEiQ9SLG9.

Interactioni

Protein-protein interaction databases

MINTiMINT-8060064.
STRINGi3702.AT2G41210.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SLG9.
SMRiQ9SLG9. Positions 389-633.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati75 – 9723MORN 1Add
BLAST
Repeati98 – 12023MORN 2Add
BLAST
Repeati121 – 14323MORN 3Add
BLAST
Repeati144 – 16623MORN 4Add
BLAST
Repeati167 – 18923MORN 5Add
BLAST
Repeati190 – 21223MORN 6Add
BLAST
Repeati213 – 23523MORN 7Add
BLAST
Repeati236 – 25722MORN 8Add
BLAST
Domaini377 – 768392PIPKPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni728 – 74922Activation loopBy similarityAdd
BLAST

Sequence similaritiesi

Contains 8 MORN repeats.Curated
Contains 1 PIPK domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG4642.
HOGENOMiHOG000193875.
InParanoidiQ9SLG9.
KOiK00889.
OMAiRIKLGIN.
PhylomeDBiQ9SLG9.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SLG9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKDQSYVLK AWEVTVRKTQ QAKKRANSVF GTVSVAPHTD NDTTTDDNDD
60 70 80 90 100
ETTTNRSSLE EFYHAERVLP NGDYYTGQWY DSFPHGHGKY LWTDGCMYIG
110 120 130 140 150
DWYNGKTMGN GKFGWPSGAT YEGEFKSGYM DGIGTYTGPS GDAYKGQWVM
160 170 180 190 200
NLKHGHGVKS FANGDAYDGE WRRGLQEGQG KYQWSDGSYY IGEWKNGTIC
210 220 230 240 250
GKGSFVWTNG NRYDGFWDEG FPRGNGTFKW DNGSFYVGHW SKDPEEMNGT
260 270 280 290 300
YYPSGNEGNL EWDPKDLFNN LSEYTICSGE RVPTLPSQKK LSVWNSSKRI
310 320 330 340 350
EKPRRTSVDG RVSVGVDRAF EKMNMWGNEI GEGGADMRKE LDAELMRLDA
360 370 380 390 400
EGLQSLKSSP VPMKLPKAGR KQGETISKGH RNYELMLNLQ LGIRHSVGRQ
410 420 430 440 450
APAASLDLKP SAFDPKDKIW RRFPREGTKY TPPHQSTEFK WKDYCPLVFR
460 470 480 490 500
SLRKLFKVDP ADYMLSICGN DALRELSSPG KSGSFFYLTN DDRYMIKTMK
510 520 530 540 550
KSETKVLLGM LAAYYNHVRA FENSLVIRFF GLHCVKLNGP TQKKVRFVIM
560 570 580 590 600
GNLFCSKYSV HRRFDLKGSS LGRTTDKPES EIDSNTILKD LDLNFIFRLQ
610 620 630 640 650
KAWYQEFIRQ IDKDCEFLEQ ERIMDYSLLV GIHFREASVA GELIPSGART
660 670 680 690 700
PIGESEEESG PRLSRAEVDE LLSDPSRWAS IRLGTNMPAR AERTMRKNDS
710 720 730 740 750
ELQLVGEPTG EFYEVVMIFG IIDILQDYDI SKKLEHAYKS IQYDPSSISA
760 770
VDPRQYSRRF RDFIFKVFTD DN
Length:772
Mass (Da):88,204
Last modified:May 1, 2000 - v1
Checksum:iD189D4B24D517152
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260903 mRNA. Translation: AAK49397.1.
AC004261 Genomic DNA. Translation: AAM14925.1.
CP002685 Genomic DNA. Translation: AEC09944.1.
PIRiT02098.
RefSeqiNP_181654.1. NM_129686.1.
UniGeneiAt.13170.

Genome annotation databases

EnsemblPlantsiAT2G41210.1; AT2G41210.1; AT2G41210.
GeneIDi818720.
KEGGiath:AT2G41210.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF260903 mRNA. Translation: AAK49397.1.
AC004261 Genomic DNA. Translation: AAM14925.1.
CP002685 Genomic DNA. Translation: AEC09944.1.
PIRiT02098.
RefSeqiNP_181654.1. NM_129686.1.
UniGeneiAt.13170.

3D structure databases

ProteinModelPortaliQ9SLG9.
SMRiQ9SLG9. Positions 389-633.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-8060064.
STRINGi3702.AT2G41210.1.

Proteomic databases

PaxDbiQ9SLG9.
PRIDEiQ9SLG9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G41210.1; AT2G41210.1; AT2G41210.
GeneIDi818720.
KEGGiath:AT2G41210.

Organism-specific databases

TAIRiAT2G41210.

Phylogenomic databases

eggNOGiCOG4642.
HOGENOMiHOG000193875.
InParanoidiQ9SLG9.
KOiK00889.
OMAiRIKLGIN.
PhylomeDBiQ9SLG9.

Enzyme and pathway databases

BioCyciARA:AT2G41210-MONOMER.
ReactomeiREACT_345128. Synthesis of PIPs at the plasma membrane.

Miscellaneous databases

PROiQ9SLG9.

Family and domain databases

Gene3Di3.30.800.10. 1 hit.
3.30.810.10. 2 hits.
InterProiIPR003409. MORN.
IPR017163. PIno-4-P-5_kinase_pln.
IPR023610. PInositol-4-P-5-kinase.
IPR027483. PInositol-4-P-5-kinase_C.
IPR002498. PInositol-4-P-5-kinase_core.
IPR027484. PInositol-4-P-5-kinase_N.
IPR016034. PInositol-4P-5-kinase_core_sub.
[Graphical view]
PANTHERiPTHR23086. PTHR23086. 1 hit.
PfamiPF02493. MORN. 8 hits.
PF01504. PIP5K. 1 hit.
[Graphical view]
PIRSFiPIRSF037274. PIP5K_plant_prd. 1 hit.
SMARTiSM00698. MORN. 7 hits.
SM00330. PIPKc. 1 hit.
[Graphical view]
PROSITEiPS51455. PIPK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and functional analysis of a novel Arabidopsis phosphatidylinositol-4-phosphate 5-kinase."
    Abd El-Haliem M., Elge S., Mueller-Roeber B.
    Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C."
    Mueller-Roeber B., Pical C.
    Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiPI5K5_ARATH
AccessioniPrimary (citable) accession number: Q9SLG9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 1, 2000
Last modified: June 24, 2015
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.