Q9SLG9 (PI5K5_ARATH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphatidylinositol 4-phosphate 5-kinase 5
Short name=AtPIP5K5
EC=2.7.1.68

Alternative name(s):
1-phosphatidylinositol 4-phosphate kinase 5
Diphosphoinositide kinase 5
PtdIns(4)P-5-kinase 5

Gene names

Name:	PIP5K5
Ordered Locus Names:	At2g41210
ORF Names:	T3K9.2

Organism

Arabidopsis thaliana (Mouse-ear cress) [Reference proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length	772 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Catalytic activity	ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Sequence similarities	Contains 8 MORN repeats. Contains 1 PIPK domain.

Ontologies

Keywords
Domain	Repeat
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	plant-type cell wall modification Inferred from mutant phenotype PubMed 19060112. Source: TAIR pollen germination Inferred from genetic interaction PubMed 19060112. Source: TAIR pollen tube growth Inferred from genetic interaction PubMed 19060112. Source: TAIR
Cellular_component	apical plasma membrane Inferred from direct assay PubMed 19060112. Source: TAIR cytosol Inferred from direct assay PubMed 19060112. Source: TAIR pollen tube Inferred from direct assay PubMed 19060112. Source: TAIR
Molecular_function	1-phosphatidylinositol-4-phosphate 5-kinase activity Inferred from direct assay PubMed 19060112. Source: TAIR ATP binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 772	772	Phosphatidylinositol 4-phosphate 5-kinase 5		PRO_0000185477
Regions
	Repeat	75 – 97	23	MORN 1
	Repeat	98 – 120	23	MORN 2
	Repeat	121 – 143	23	MORN 3
	Repeat	144 – 166	23	MORN 4
	Repeat	167 – 189	23	MORN 5
	Repeat	190 – 212	23	MORN 6
	Repeat	213 – 235	23	MORN 7
	Repeat	236 – 257	22	MORN 8
	Domain	377 – 768	392	PIPK
	Region	728 – 749	22	Activation loop By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9SLG9 [UniParc]. Last modified May 1, 2000. Version 1. Checksum: D189D4B24D517152	FASTA	772	88,204
	10 20 30 40 50 60 MSKDQSYVLK AWEVTVRKTQ QAKKRANSVF GTVSVAPHTD NDTTTDDNDD ETTTNRSSLE 70 80 90 100 110 120 EFYHAERVLP NGDYYTGQWY DSFPHGHGKY LWTDGCMYIG DWYNGKTMGN GKFGWPSGAT 130 140 150 160 170 180 YEGEFKSGYM DGIGTYTGPS GDAYKGQWVM NLKHGHGVKS FANGDAYDGE WRRGLQEGQG 190 200 210 220 230 240 KYQWSDGSYY IGEWKNGTIC GKGSFVWTNG NRYDGFWDEG FPRGNGTFKW DNGSFYVGHW 250 260 270 280 290 300 SKDPEEMNGT YYPSGNEGNL EWDPKDLFNN LSEYTICSGE RVPTLPSQKK LSVWNSSKRI 310 320 330 340 350 360 EKPRRTSVDG RVSVGVDRAF EKMNMWGNEI GEGGADMRKE LDAELMRLDA EGLQSLKSSP 370 380 390 400 410 420 VPMKLPKAGR KQGETISKGH RNYELMLNLQ LGIRHSVGRQ APAASLDLKP SAFDPKDKIW 430 440 450 460 470 480 RRFPREGTKY TPPHQSTEFK WKDYCPLVFR SLRKLFKVDP ADYMLSICGN DALRELSSPG 490 500 510 520 530 540 KSGSFFYLTN DDRYMIKTMK KSETKVLLGM LAAYYNHVRA FENSLVIRFF GLHCVKLNGP 550 560 570 580 590 600 TQKKVRFVIM GNLFCSKYSV HRRFDLKGSS LGRTTDKPES EIDSNTILKD LDLNFIFRLQ 610 620 630 640 650 660 KAWYQEFIRQ IDKDCEFLEQ ERIMDYSLLV GIHFREASVA GELIPSGART PIGESEEESG 670 680 690 700 710 720 PRLSRAEVDE LLSDPSRWAS IRLGTNMPAR AERTMRKNDS ELQLVGEPTG EFYEVVMIFG 730 740 750 760 770 IIDILQDYDI SKKLEHAYKS IQYDPSSISA VDPRQYSRRF RDFIFKVFTD DN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and functional analysis of a novel Arabidopsis phosphatidylinositol-4-phosphate 5-kinase." Abd El-Haliem M., Elge S., Mueller-Roeber B. Submitted (APR-2000) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C. Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[3]	The Arabidopsis Information Resource (TAIR) Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases Cited for: GENOME REANNOTATION. Strain: cv. Columbia.
[4]	"Inositol phospholipid metabolism in Arabidopsis. Characterized and putative isoforms of inositol phospholipid kinase and phosphoinositide-specific phospholipase C." Mueller-Roeber B., Pical C. Plant Physiol. 130:22-46(2002) [PubMed] [Europe PMC] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF260903 mRNA. Translation: AAK49397.1. AC004261 Genomic DNA. Translation: AAM14925.1. CP002685 Genomic DNA. Translation: AEC09944.1.
IPI	IPI00540063.
PIR	T02098.
RefSeq	NP_181654.1. NM_129686.1.
UniGene	At.13170.
3D structure databases
ProteinModelPortal	Q9SLG9.
SMR	Q9SLG9. Positions 389-633.
ModBase	Search...
Protein-protein interaction databases
STRING	3702.AT2G41210.1-P.
Proteomic databases
PaxDb	Q9SLG9.
PRIDE	Q9SLG9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblPlants	AT2G41210.1; AT2G41210.1; AT2G41210.
GeneID	818720.
KEGG	ath:AT2G41210.
Organism-specific databases
TAIR	At2g41210.
Phylogenomic databases
eggNOG	COG4642.
HOGENOM	HOG000193875.
InParanoid	Q9SLG9.
KO	K00889.
OMA	WKNGTIC.
PhylomeDB	Q9SLG9.
ProtClustDB	CLSN2683759.
Gene expression databases
Genevestigator	Q9SLG9.
GermOnline	AT2G41210. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR003409. MORN. IPR017163. PIno-4-P-5_kinase_pln. IPR023610. PInositol-4-P-5-kinase. IPR002498. PInositol-4-P-5-kinase_core. IPR016034. PInositol-4P-5-kinase_core_sub. [Graphical view]
PANTHER	PTHR23086. PTHR23086. 1 hit.
Pfam	PF02493. MORN. 8 hits. PF01504. PIP5K. 1 hit. [Graphical view]
PIRSF	PIRSF037274. PIP5K_plant_prd. 1 hit.
SMART	SM00698. MORN. 7 hits. SM00330. PIPKc. 1 hit. [Graphical view]
PROSITE	PS51455. PIPK. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PI5K5_ARATH

Accession

Primary (citable) accession number: Q9SLG9

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 25, 2005
Last sequence update:	May 1, 2000
Last modified:	May 1, 2013
This is version 82 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program