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Q9SLA1

- P2C22_ARATH

UniProt

Q9SLA1 - P2C22_ARATH

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Protein

Probable protein phosphatase 2C 22

Gene

At2g25620

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi133 – 1331Manganese 1By similarity
Metal bindingi133 – 1331Manganese 2By similarity
Metal bindingi134 – 1341Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi304 – 3041Manganese 2By similarity
Metal bindingi347 – 3471Manganese 2By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. protein serine/threonine phosphatase activity Source: InterPro

GO - Biological processi

  1. protein dephosphorylation Source: InterPro
  2. regulation of defense response to virus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G25620-MONOMER.
ReactomeiREACT_247278. ISG15 antiviral mechanism.
REACT_259981. Regulation of AMPK activity via LKB1.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 22 (EC:3.1.3.16)
Short name:
AtPP2C22
Gene namesi
Ordered Locus Names:At2g25620
ORF Names:F3N11.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G25620.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: TAIR
  2. nucleus Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Probable protein phosphatase 2C 22PRO_0000367952Add
BLAST

Proteomic databases

PaxDbiQ9SLA1.
PRIDEiQ9SLA1.

Expressioni

Gene expression databases

GenevestigatoriQ9SLA1.

Interactioni

Protein-protein interaction databases

BioGridi2454. 1 interaction.
STRINGi3702.AT2G25620.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9SLA1.
SMRiQ9SLA1. Positions 90-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini88 – 349262PP2C-likeAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PP2C-like domain.Curated

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ9SLA1.
KOiK14803.
OMAiWADIGSR.
PhylomeDBiQ9SLA1.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PP2C. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SLA1-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEETRGISDP ENGSSSYGGK PPNPLSFSSS SAAAAVYRQT FDGERSLAPC
60 70 80 90 100
NKRSLVRHSS LVKTMVSDIS VENEFTIEKN KSEFVPATRS GAWSDIGSRS
110 120 130 140 150
SMEDAYLCVD NFMDSFGLLN SEAGPSAFYG VFDGHGGKHA AEFACHHIPR
160 170 180 190 200
YIVEDQEFPS EINKVLSSAF LQTDTAFLEA CSLDGSLASG TTALAAILFG
210 220 230 240 250
RSLVVANAGD CRAVLSRQGK AIEMSRDHKP MSSKERRRIE ASGGHVFDGY
260 270 280 290 300
LNGQLNVARA LGDFHMEGMK KKKDGSDCGP LIAEPELMTT KLTEEDEFLI
310 320 330 340 350
IGCDGVWDVF MSQNAVDFAR RRLQEHNDPV MCSKELVEEA LKRKSADNVT
360 370 380 390
AVVVCLQPQP PPNLVAPRLR VHRSFSAEGL KDLQSYLDGL GN
Length:392
Mass (Da):42,674
Last modified:May 1, 2000 - v1
Checksum:iAC09DC922197BE53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006053 Genomic DNA. Translation: AAD31375.1.
CP002685 Genomic DNA. Translation: AEC07725.1.
AF326901 mRNA. Translation: AAG41483.1.
AF339719 mRNA. Translation: AAK00401.1.
AF436827 mRNA. Translation: AAL32009.1.
AY039595 mRNA. Translation: AAK62650.1.
AY057740 mRNA. Translation: AAL15370.1.
BT002487 mRNA. Translation: AAO00847.1.
PIRiF84650.
RefSeqiNP_180133.1. NM_128120.1.
UniGeneiAt.24605.
At.70222.
At.74045.

Genome annotation databases

EnsemblPlantsiAT2G25620.1; AT2G25620.1; AT2G25620.
GeneIDi817102.
KEGGiath:AT2G25620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006053 Genomic DNA. Translation: AAD31375.1 .
CP002685 Genomic DNA. Translation: AEC07725.1 .
AF326901 mRNA. Translation: AAG41483.1 .
AF339719 mRNA. Translation: AAK00401.1 .
AF436827 mRNA. Translation: AAL32009.1 .
AY039595 mRNA. Translation: AAK62650.1 .
AY057740 mRNA. Translation: AAL15370.1 .
BT002487 mRNA. Translation: AAO00847.1 .
PIRi F84650.
RefSeqi NP_180133.1. NM_128120.1.
UniGenei At.24605.
At.70222.
At.74045.

3D structure databases

ProteinModelPortali Q9SLA1.
SMRi Q9SLA1. Positions 90-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 2454. 1 interaction.
STRINGi 3702.AT2G25620.1-P.

Proteomic databases

PaxDbi Q9SLA1.
PRIDEi Q9SLA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G25620.1 ; AT2G25620.1 ; AT2G25620 .
GeneIDi 817102.
KEGGi ath:AT2G25620.

Organism-specific databases

GeneFarmi 3542. 320.
TAIRi AT2G25620.

Phylogenomic databases

eggNOGi COG0631.
HOGENOMi HOG000233896.
InParanoidi Q9SLA1.
KOi K14803.
OMAi WADIGSR.
PhylomeDBi Q9SLA1.

Enzyme and pathway databases

BioCyci ARA:AT2G25620-MONOMER.
Reactomei REACT_247278. ISG15 antiviral mechanism.
REACT_259981. Regulation of AMPK activity via LKB1.

Miscellaneous databases

PROi Q9SLA1.

Gene expression databases

Genevestigatori Q9SLA1.

Family and domain databases

Gene3Di 3.60.40.10. 1 hit.
InterProi IPR001932. PP2C-like_dom.
IPR000222. PP2C_Mn2_Asp60_BS.
IPR015655. Protein_Pase_2C.
[Graphical view ]
PANTHERi PTHR13832. PTHR13832. 1 hit.
Pfami PF00481. PP2C. 1 hit.
[Graphical view ]
SMARTi SM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view ]
SUPFAMi SSF81606. SSF81606. 1 hit.
PROSITEi PS01032. PP2C. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C22_ARATH
AccessioniPrimary (citable) accession number: Q9SLA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2000
Last modified: November 26, 2014
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3