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Protein

Probable protein phosphatase 2C 22

Gene

At2g25620

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium or manganese ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi133 – 1331Manganese 1By similarity
Metal bindingi133 – 1331Manganese 2By similarity
Metal bindingi134 – 1341Manganese 1; via carbonyl oxygenBy similarity
Metal bindingi304 – 3041Manganese 2By similarity
Metal bindingi347 – 3471Manganese 2By similarity

GO - Molecular functioni

GO - Biological processi

  • protein dephosphorylation Source: InterPro
  • regulation of defense response to virus Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Keywords - Ligandi

Magnesium, Manganese, Metal-binding

Enzyme and pathway databases

BioCyciARA:AT2G25620-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable protein phosphatase 2C 22 (EC:3.1.3.16)
Short name:
AtPP2C22
Gene namesi
Ordered Locus Names:At2g25620
ORF Names:F3N11.7
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G25620.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • nucleus Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Probable protein phosphatase 2C 22PRO_0000367952Add
BLAST

Proteomic databases

PaxDbiQ9SLA1.
PRIDEiQ9SLA1.

Interactioni

Protein-protein interaction databases

BioGridi2454. 1 interaction.
STRINGi3702.AT2G25620.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SLA1.
SMRiQ9SLA1. Positions 90-354.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini89 – 356268PPM-type phosphatasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the PP2C family.Curated
Contains 1 PPM-type phosphatase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ9SLA1.
KOiK14803.
OMAiFMSQNAV.
PhylomeDBiQ9SLA1.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SLA1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEETRGISDP ENGSSSYGGK PPNPLSFSSS SAAAAVYRQT FDGERSLAPC
60 70 80 90 100
NKRSLVRHSS LVKTMVSDIS VENEFTIEKN KSEFVPATRS GAWSDIGSRS
110 120 130 140 150
SMEDAYLCVD NFMDSFGLLN SEAGPSAFYG VFDGHGGKHA AEFACHHIPR
160 170 180 190 200
YIVEDQEFPS EINKVLSSAF LQTDTAFLEA CSLDGSLASG TTALAAILFG
210 220 230 240 250
RSLVVANAGD CRAVLSRQGK AIEMSRDHKP MSSKERRRIE ASGGHVFDGY
260 270 280 290 300
LNGQLNVARA LGDFHMEGMK KKKDGSDCGP LIAEPELMTT KLTEEDEFLI
310 320 330 340 350
IGCDGVWDVF MSQNAVDFAR RRLQEHNDPV MCSKELVEEA LKRKSADNVT
360 370 380 390
AVVVCLQPQP PPNLVAPRLR VHRSFSAEGL KDLQSYLDGL GN
Length:392
Mass (Da):42,674
Last modified:May 1, 2000 - v1
Checksum:iAC09DC922197BE53
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006053 Genomic DNA. Translation: AAD31375.1.
CP002685 Genomic DNA. Translation: AEC07725.1.
AF326901 mRNA. Translation: AAG41483.1.
AF339719 mRNA. Translation: AAK00401.1.
AF436827 mRNA. Translation: AAL32009.1.
AY039595 mRNA. Translation: AAK62650.1.
AY057740 mRNA. Translation: AAL15370.1.
BT002487 mRNA. Translation: AAO00847.1.
PIRiF84650.
RefSeqiNP_180133.1. NM_128120.1.
UniGeneiAt.24605.
At.70222.
At.74045.

Genome annotation databases

EnsemblPlantsiAT2G25620.1; AT2G25620.1; AT2G25620.
GeneIDi817102.
KEGGiath:AT2G25620.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006053 Genomic DNA. Translation: AAD31375.1.
CP002685 Genomic DNA. Translation: AEC07725.1.
AF326901 mRNA. Translation: AAG41483.1.
AF339719 mRNA. Translation: AAK00401.1.
AF436827 mRNA. Translation: AAL32009.1.
AY039595 mRNA. Translation: AAK62650.1.
AY057740 mRNA. Translation: AAL15370.1.
BT002487 mRNA. Translation: AAO00847.1.
PIRiF84650.
RefSeqiNP_180133.1. NM_128120.1.
UniGeneiAt.24605.
At.70222.
At.74045.

3D structure databases

ProteinModelPortaliQ9SLA1.
SMRiQ9SLA1. Positions 90-354.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi2454. 1 interaction.
STRINGi3702.AT2G25620.1.

Proteomic databases

PaxDbiQ9SLA1.
PRIDEiQ9SLA1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G25620.1; AT2G25620.1; AT2G25620.
GeneIDi817102.
KEGGiath:AT2G25620.

Organism-specific databases

GeneFarmi3542. 320.
TAIRiAT2G25620.

Phylogenomic databases

eggNOGiCOG0631.
HOGENOMiHOG000233896.
InParanoidiQ9SLA1.
KOiK14803.
OMAiFMSQNAV.
PhylomeDBiQ9SLA1.

Enzyme and pathway databases

BioCyciARA:AT2G25620-MONOMER.

Miscellaneous databases

PROiQ9SLA1.

Family and domain databases

Gene3Di3.60.40.10. 1 hit.
InterProiIPR015655. PP2C.
IPR000222. PP2C_BS.
IPR001932. PPM-type_phosphatase_dom.
[Graphical view]
PANTHERiPTHR13832. PTHR13832. 1 hit.
PfamiPF00481. PP2C. 1 hit.
[Graphical view]
SMARTiSM00331. PP2C_SIG. 1 hit.
SM00332. PP2Cc. 1 hit.
[Graphical view]
SUPFAMiSSF81606. SSF81606. 1 hit.
PROSITEiPS01032. PPM_1. 1 hit.
PS51746. PPM_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
    Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
    BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY, NOMENCLATURE.

Entry informationi

Entry nameiP2C22_ARATH
AccessioniPrimary (citable) accession number: Q9SLA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 14, 2009
Last sequence update: May 1, 2000
Last modified: July 22, 2015
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.