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Q9SLA1

- P2C22_ARATH

UniProt

Q9SLA1 - P2C22_ARATH

Protein

Probable protein phosphatase 2C 22

Gene

At2g25620

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 May 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Cofactori

    Binds 2 magnesium or manganese ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi133 – 1331Manganese 1By similarity
    Metal bindingi133 – 1331Manganese 2By similarity
    Metal bindingi134 – 1341Manganese 1; via carbonyl oxygenBy similarity
    Metal bindingi304 – 3041Manganese 2By similarity
    Metal bindingi347 – 3471Manganese 2By similarity

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. protein serine/threonine phosphatase activity Source: InterPro

    GO - Biological processi

    1. protein dephosphorylation Source: InterPro
    2. regulation of defense response to virus Source: TAIR

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Keywords - Ligandi

    Magnesium, Manganese, Metal-binding

    Enzyme and pathway databases

    BioCyciARA:AT2G25620-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable protein phosphatase 2C 22 (EC:3.1.3.16)
    Short name:
    AtPP2C22
    Gene namesi
    Ordered Locus Names:At2g25620
    ORF Names:F3N11.7
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G25620.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: TAIR
    2. nucleus Source: TAIR

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Probable protein phosphatase 2C 22PRO_0000367952Add
    BLAST

    Proteomic databases

    PaxDbiQ9SLA1.
    PRIDEiQ9SLA1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9SLA1.

    Interactioni

    Protein-protein interaction databases

    BioGridi2454. 1 interaction.
    STRINGi3702.AT2G25620.1-P.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SLA1.
    SMRiQ9SLA1. Positions 90-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini88 – 349262PP2C-likeAdd
    BLAST

    Sequence similaritiesi

    Belongs to the PP2C family.Curated
    Contains 1 PP2C-like domain.Curated

    Phylogenomic databases

    eggNOGiCOG0631.
    HOGENOMiHOG000233896.
    InParanoidiQ9SLA1.
    KOiK14803.
    OMAiWADIGSR.
    PhylomeDBiQ9SLA1.

    Family and domain databases

    Gene3Di3.60.40.10. 1 hit.
    InterProiIPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view]
    PANTHERiPTHR13832. PTHR13832. 1 hit.
    PfamiPF00481. PP2C. 1 hit.
    [Graphical view]
    SMARTiSM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view]
    SUPFAMiSSF81606. SSF81606. 1 hit.
    PROSITEiPS01032. PP2C. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9SLA1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEETRGISDP ENGSSSYGGK PPNPLSFSSS SAAAAVYRQT FDGERSLAPC    50
    NKRSLVRHSS LVKTMVSDIS VENEFTIEKN KSEFVPATRS GAWSDIGSRS 100
    SMEDAYLCVD NFMDSFGLLN SEAGPSAFYG VFDGHGGKHA AEFACHHIPR 150
    YIVEDQEFPS EINKVLSSAF LQTDTAFLEA CSLDGSLASG TTALAAILFG 200
    RSLVVANAGD CRAVLSRQGK AIEMSRDHKP MSSKERRRIE ASGGHVFDGY 250
    LNGQLNVARA LGDFHMEGMK KKKDGSDCGP LIAEPELMTT KLTEEDEFLI 300
    IGCDGVWDVF MSQNAVDFAR RRLQEHNDPV MCSKELVEEA LKRKSADNVT 350
    AVVVCLQPQP PPNLVAPRLR VHRSFSAEGL KDLQSYLDGL GN 392
    Length:392
    Mass (Da):42,674
    Last modified:May 1, 2000 - v1
    Checksum:iAC09DC922197BE53
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006053 Genomic DNA. Translation: AAD31375.1.
    CP002685 Genomic DNA. Translation: AEC07725.1.
    AF326901 mRNA. Translation: AAG41483.1.
    AF339719 mRNA. Translation: AAK00401.1.
    AF436827 mRNA. Translation: AAL32009.1.
    AY039595 mRNA. Translation: AAK62650.1.
    AY057740 mRNA. Translation: AAL15370.1.
    BT002487 mRNA. Translation: AAO00847.1.
    PIRiF84650.
    RefSeqiNP_180133.1. NM_128120.1.
    UniGeneiAt.24605.
    At.70222.
    At.74045.

    Genome annotation databases

    EnsemblPlantsiAT2G25620.1; AT2G25620.1; AT2G25620.
    GeneIDi817102.
    KEGGiath:AT2G25620.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006053 Genomic DNA. Translation: AAD31375.1 .
    CP002685 Genomic DNA. Translation: AEC07725.1 .
    AF326901 mRNA. Translation: AAG41483.1 .
    AF339719 mRNA. Translation: AAK00401.1 .
    AF436827 mRNA. Translation: AAL32009.1 .
    AY039595 mRNA. Translation: AAK62650.1 .
    AY057740 mRNA. Translation: AAL15370.1 .
    BT002487 mRNA. Translation: AAO00847.1 .
    PIRi F84650.
    RefSeqi NP_180133.1. NM_128120.1.
    UniGenei At.24605.
    At.70222.
    At.74045.

    3D structure databases

    ProteinModelPortali Q9SLA1.
    SMRi Q9SLA1. Positions 90-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 2454. 1 interaction.
    STRINGi 3702.AT2G25620.1-P.

    Proteomic databases

    PaxDbi Q9SLA1.
    PRIDEi Q9SLA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G25620.1 ; AT2G25620.1 ; AT2G25620 .
    GeneIDi 817102.
    KEGGi ath:AT2G25620.

    Organism-specific databases

    GeneFarmi 3542. 320.
    TAIRi AT2G25620.

    Phylogenomic databases

    eggNOGi COG0631.
    HOGENOMi HOG000233896.
    InParanoidi Q9SLA1.
    KOi K14803.
    OMAi WADIGSR.
    PhylomeDBi Q9SLA1.

    Enzyme and pathway databases

    BioCyci ARA:AT2G25620-MONOMER.

    Miscellaneous databases

    PROi Q9SLA1.

    Gene expression databases

    Genevestigatori Q9SLA1.

    Family and domain databases

    Gene3Di 3.60.40.10. 1 hit.
    InterProi IPR001932. PP2C-like_dom.
    IPR000222. PP2C_Mn2_Asp60_BS.
    IPR015655. Protein_Pase_2C.
    [Graphical view ]
    PANTHERi PTHR13832. PTHR13832. 1 hit.
    Pfami PF00481. PP2C. 1 hit.
    [Graphical view ]
    SMARTi SM00331. PP2C_SIG. 1 hit.
    SM00332. PP2Cc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF81606. SSF81606. 1 hit.
    PROSITEi PS01032. PP2C. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "Genome-wide and expression analysis of protein phosphatase 2C in rice and Arabidopsis."
      Xue T., Wang D., Zhang S., Ehlting J., Ni F., Jacab S., Zheng C., Zhong Y.
      BMC Genomics 9:550-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY, NOMENCLATURE.

    Entry informationi

    Entry nameiP2C22_ARATH
    AccessioniPrimary (citable) accession number: Q9SLA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 14, 2009
    Last sequence update: May 1, 2000
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3