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Q9SL42

- PIN1_ARATH

UniProt

Q9SL42 - PIN1_ARATH

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Protein

Peptidyl-prolyl cis-trans isomerase Pin1

Gene
PIN1, At2g18040, T27K22.9
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Prolyl cis/trans isomerase with specificity for phospho-Ser-Pro bonds.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  1. peptidyl-prolyl cis-trans isomerase activity Source: TAIR
  2. protein binding Source: IntAct

GO - Biological processi

  1. protein folding Source: UniProtKB-KW
  2. protein peptidyl-prolyl isomerization Source: GOC
  3. regulation of cell cycle Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciARA:AT2G18040-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase Pin1 (EC:5.2.1.8)
Short name:
PPIase Pin1
Alternative name(s):
PIN1At
Rotamase Pin1
Gene namesi
Name:PIN1
Ordered Locus Names:At2g18040
ORF Names:T27K22.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G18040.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: TAIR
  2. endoplasmic reticulum Source: TAIR
  3. plasma membrane Source: TAIR
  4. plasmodesma Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 119119Peptidyl-prolyl cis-trans isomerase Pin1PRO_0000193440Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei103 – 1031Phosphoserine1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SL42.
PRIDEiQ9SL42.

Expressioni

Tissue specificityi

Expressed in roots, leaves, stems and flowers.1 Publication

Gene expression databases

GenevestigatoriQ9SL42.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGL24O827944EBI-2618990,EBI-592083
SOC1O646453EBI-2618990,EBI-592041

Protein-protein interaction databases

IntActiQ9SL42. 2 interactions.

Structurei

Secondary structure

1
119
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi8 – 103
Beta strandi20 – 245
Helixi38 – 5316
Helixi60 – 656
Helixi69 – 735
Beta strandi76 – 805
Beta strandi82 – 865
Helixi89 – 968
Beta strandi99 – 1013
Beta strandi106 – 1083
Beta strandi111 – 1133

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1J6YNMR-A1-119[»]
ProteinModelPortaliQ9SL42.
SMRiQ9SL42. Positions 1-119.

Miscellaneous databases

EvolutionaryTraceiQ9SL42.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 119116PpiCAdd
BLAST

Sequence similaritiesi

Contains 1 PpiC domain.

Phylogenomic databases

eggNOGiCOG0760.
HOGENOMiHOG000275331.
InParanoidiQ9SL42.
KOiK09578.
OMAiETVRASH.
PhylomeDBiQ9SL42.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
[Graphical view]
PROSITEiPS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SL42-1 [UniParc]FASTAAdd to Basket

« Hide

MASRDQVKAS HILIKHQGSR RKASWKDPEG KIILTTTREA AVEQLKSIRE    50
DIVSGKANFE EVATRVSDCS SAKRGGDLGS FGRGQMQKPF EEATYALKVG 100
DISDIVDTDS GVHIIKRTA 119
Length:119
Mass (Da):13,015
Last modified:May 1, 2000 - v1
Checksum:iE926CB566E76A0A3
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006201 Genomic DNA. Translation: AAD20122.1.
CP002685 Genomic DNA. Translation: AEC06719.1.
AF360318 mRNA. Translation: AAK26028.1.
AY057514 mRNA. Translation: AAL09755.1.
AY056314 mRNA. Translation: AAL07163.1.
AY085059 mRNA. Translation: AAM61615.1.
F13919 mRNA. Translation: CAA23077.1.
PIRiE84559.
RefSeqiNP_179395.1. NM_127360.3.
UniGeneiAt.20592.

Genome annotation databases

EnsemblPlantsiAT2G18040.1; AT2G18040.1; AT2G18040.
GeneIDi816316.
KEGGiath:AT2G18040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006201 Genomic DNA. Translation: AAD20122.1 .
CP002685 Genomic DNA. Translation: AEC06719.1 .
AF360318 mRNA. Translation: AAK26028.1 .
AY057514 mRNA. Translation: AAL09755.1 .
AY056314 mRNA. Translation: AAL07163.1 .
AY085059 mRNA. Translation: AAM61615.1 .
F13919 mRNA. Translation: CAA23077.1 .
PIRi E84559.
RefSeqi NP_179395.1. NM_127360.3.
UniGenei At.20592.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1J6Y NMR - A 1-119 [» ]
ProteinModelPortali Q9SL42.
SMRi Q9SL42. Positions 1-119.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q9SL42. 2 interactions.

Proteomic databases

PaxDbi Q9SL42.
PRIDEi Q9SL42.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G18040.1 ; AT2G18040.1 ; AT2G18040 .
GeneIDi 816316.
KEGGi ath:AT2G18040.

Organism-specific databases

TAIRi AT2G18040.

Phylogenomic databases

eggNOGi COG0760.
HOGENOMi HOG000275331.
InParanoidi Q9SL42.
KOi K09578.
OMAi ETVRASH.
PhylomeDBi Q9SL42.

Enzyme and pathway databases

BioCyci ARA:AT2G18040-MONOMER.

Miscellaneous databases

EvolutionaryTracei Q9SL42.
PROi Q9SL42.

Gene expression databases

Genevestigatori Q9SL42.

Family and domain databases

InterProi IPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
[Graphical view ]
Pfami PF00639. Rotamase. 1 hit.
[Graphical view ]
PROSITEi PS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Arabidopsis thaliana PIN1At gene encodes a single-domain phosphorylation-dependent peptidyl prolyl cis/trans isomerase."
    Landrieu I., de Veylder L., Fruchart J.-S., Odaert B., Casteels P., Portetelle D., Van Montagu M., Inze D., Lippens G.
    J. Biol. Chem. 275:10577-10581(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  3. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  4. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  5. "Full-length cDNA from Arabidopsis thaliana."
    Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B., Feldmann K.A.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 51-119.
    Strain: cv. Columbia.
    Tissue: Dry seed.
  7. "Identification of phosphoproteins in Arabidopsis thaliana leaves using polyethylene glycol fractionation, immobilized metal-ion affinity chromatography, two-dimensional gel electrophoresis and mass spectrometry."
    Aryal U.K., Krochko J.E., Ross A.R.
    J. Proteome Res. 11:425-437(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-103, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  8. "Sequence-specific 1H, 13C and 15N chemical shift backbone NMR assignment and secondary structure of the Arabidopsis thaliana PIN1At protein."
    Landrieu I., Wieruszeski J.-M., Odaert B., Inze D., Grzesiek S., Lippen G.
    J. Biomol. NMR 17:271-272(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-18 AND 36-119.
  9. "Solution structure of the single-domain prolyl cis/trans isomerase PIN1At from Arabidopsis thaliana."
    Landrieu I., Wieruszeski J.-M., Wintjens R., Inze D., Lippens G.
    J. Mol. Biol. 320:321-332(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR.

Entry informationi

Entry nameiPIN1_ARATH
AccessioniPrimary (citable) accession number: Q9SL42
Secondary accession number(s): Q42334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 1, 2000
Last modified: June 11, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Like all plant Pin1-type PPIases, do not contain the N-terminal WW domain found in other eukaryotic parvulins, but contains a four-amino acid insertion next to the phospho-specific recognition site of the active site. These extra amino acids may be important for mediating the substrate interaction of plant enzymes.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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