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Protein

Peptidyl-prolyl cis-trans isomerase Pin1

Gene

PIN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Prolyl cis/trans isomerase with specificity for phospho-Ser-Pro bonds.1 Publication

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

GO - Biological processi

  • regulation of cell cycle Source: TAIR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase, Rotamase

Enzyme and pathway databases

BioCyciARA:AT2G18040-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase Pin1 (EC:5.2.1.8)
Short name:
PPIase Pin1
Alternative name(s):
PIN1At
Rotamase Pin1
Gene namesi
Name:PIN1
Ordered Locus Names:At2g18040
ORF Names:T27K22.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRiAT2G18040.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • endoplasmic reticulum Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001934401 – 119Peptidyl-prolyl cis-trans isomerase Pin1Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SL42.
PRIDEiQ9SL42.

PTM databases

iPTMnetiQ9SL42.

Expressioni

Tissue specificityi

Expressed in roots, leaves, stems and flowers.1 Publication

Gene expression databases

GenevisibleiQ9SL42. AT.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
AGL24O827944EBI-2618990,EBI-592083
SOC1O646453EBI-2618990,EBI-592041

Protein-protein interaction databases

IntActiQ9SL42. 2 interactors.
STRINGi3702.AT2G18040.1.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 10Combined sources3
Beta strandi20 – 24Combined sources5
Helixi38 – 53Combined sources16
Helixi60 – 65Combined sources6
Helixi69 – 73Combined sources5
Beta strandi76 – 80Combined sources5
Beta strandi82 – 86Combined sources5
Helixi89 – 96Combined sources8
Beta strandi99 – 101Combined sources3
Beta strandi106 – 108Combined sources3
Beta strandi111 – 113Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J6YNMR-A1-119[»]
ProteinModelPortaliQ9SL42.
SMRiQ9SL42.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9SL42.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 119PpiCPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Belongs to the PpiC/parvulin rotamase family.Curated
Contains 1 PpiC domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3259. Eukaryota.
COG0760. LUCA.
HOGENOMiHOG000275331.
KOiK09578.
OMAiVHIIKRI.
OrthoDBiEOG09360TTC.
PhylomeDBiQ9SL42.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
[Graphical view]
PROSITEiPS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9SL42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRDQVKAS HILIKHQGSR RKASWKDPEG KIILTTTREA AVEQLKSIRE
60 70 80 90 100
DIVSGKANFE EVATRVSDCS SAKRGGDLGS FGRGQMQKPF EEATYALKVG
110
DISDIVDTDS GVHIIKRTA
Length:119
Mass (Da):13,015
Last modified:May 1, 2000 - v1
Checksum:iE926CB566E76A0A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006201 Genomic DNA. Translation: AAD20122.1.
CP002685 Genomic DNA. Translation: AEC06719.1.
AF360318 mRNA. Translation: AAK26028.1.
AY057514 mRNA. Translation: AAL09755.1.
AY056314 mRNA. Translation: AAL07163.1.
AY085059 mRNA. Translation: AAM61615.1.
F13919 mRNA. Translation: CAA23077.1.
PIRiE84559.
RefSeqiNP_179395.1. NM_127360.4.
UniGeneiAt.20592.

Genome annotation databases

EnsemblPlantsiAT2G18040.1; AT2G18040.1; AT2G18040.
GeneIDi816316.
GrameneiAT2G18040.1; AT2G18040.1; AT2G18040.
KEGGiath:AT2G18040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006201 Genomic DNA. Translation: AAD20122.1.
CP002685 Genomic DNA. Translation: AEC06719.1.
AF360318 mRNA. Translation: AAK26028.1.
AY057514 mRNA. Translation: AAL09755.1.
AY056314 mRNA. Translation: AAL07163.1.
AY085059 mRNA. Translation: AAM61615.1.
F13919 mRNA. Translation: CAA23077.1.
PIRiE84559.
RefSeqiNP_179395.1. NM_127360.4.
UniGeneiAt.20592.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J6YNMR-A1-119[»]
ProteinModelPortaliQ9SL42.
SMRiQ9SL42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9SL42. 2 interactors.
STRINGi3702.AT2G18040.1.

PTM databases

iPTMnetiQ9SL42.

Proteomic databases

PaxDbiQ9SL42.
PRIDEiQ9SL42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G18040.1; AT2G18040.1; AT2G18040.
GeneIDi816316.
GrameneiAT2G18040.1; AT2G18040.1; AT2G18040.
KEGGiath:AT2G18040.

Organism-specific databases

TAIRiAT2G18040.

Phylogenomic databases

eggNOGiKOG3259. Eukaryota.
COG0760. LUCA.
HOGENOMiHOG000275331.
KOiK09578.
OMAiVHIIKRI.
OrthoDBiEOG09360TTC.
PhylomeDBiQ9SL42.

Enzyme and pathway databases

BioCyciARA:AT2G18040-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9SL42.
PROiQ9SL42.

Gene expression databases

GenevisibleiQ9SL42. AT.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
[Graphical view]
PROSITEiPS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPIN1_ARATH
AccessioniPrimary (citable) accession number: Q9SL42
Secondary accession number(s): Q42334
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 1, 2000
Last modified: November 30, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Like all plant Pin1-type PPIases, do not contain the N-terminal WW domain found in other eukaryotic parvulins, but contains a four-amino acid insertion next to the phospho-specific recognition site of the active site. These extra amino acids may be important for mediating the substrate interaction of plant enzymes.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.