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Protein

Peptidyl-prolyl cis-trans isomerase Pin1

Gene

PIN1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Prolyl cis/trans isomerase with specificity for phospho-Ser-Pro bonds.1 Publication

Miscellaneous

Like all plant Pin1-type PPIases, do not contain the N-terminal WW domain found in other eukaryotic parvulins, but contains a four-amino acid insertion next to the phospho-specific recognition site of the active site. These extra amino acids may be important for mediating the substrate interaction of plant enzymes.

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).

GO - Molecular functioni

  • peptidyl-prolyl cis-trans isomerase activity Source: TAIR

GO - Biological processi

  • gravitropism Source: TAIR
  • regulation of cell cycle Source: TAIR
  • regulation of flower development Source: TAIR
  • regulation of protein localization Source: TAIR

Keywordsi

Molecular functionIsomerase, Rotamase

Enzyme and pathway databases

BioCyciARA:AT2G18040-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomerase Pin1 (EC:5.2.1.8)
Short name:
PPIase Pin1
Alternative name(s):
PIN1At
Rotamase Pin1
Gene namesi
Name:PIN1
Ordered Locus Names:At2g18040
ORF Names:T27K22.9
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

TAIRilocus:2060922. AT2G18040.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: TAIR
  • endoplasmic reticulum Source: TAIR
  • plasma membrane Source: TAIR
  • plasmodesma Source: TAIR

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001934401 – 119Peptidyl-prolyl cis-trans isomerase Pin1Add BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei103PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ9SL42.
PRIDEiQ9SL42.

PTM databases

iPTMnetiQ9SL42.

Expressioni

Tissue specificityi

Expressed in roots, leaves, stems and flowers.1 Publication

Gene expression databases

GenevisibleiQ9SL42. AT.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

IntActiQ9SL42. 2 interactors.
STRINGi3702.AT2G18040.1.

Structurei

Secondary structure

1119
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi8 – 10Combined sources3
Beta strandi20 – 24Combined sources5
Helixi38 – 53Combined sources16
Helixi60 – 65Combined sources6
Helixi69 – 73Combined sources5
Beta strandi76 – 80Combined sources5
Beta strandi82 – 86Combined sources5
Helixi89 – 96Combined sources8
Beta strandi99 – 101Combined sources3
Beta strandi106 – 108Combined sources3
Beta strandi111 – 113Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J6YNMR-A1-119[»]
ProteinModelPortaliQ9SL42.
SMRiQ9SL42.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9SL42.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 119PpiCPROSITE-ProRule annotationAdd BLAST116

Sequence similaritiesi

Belongs to the PpiC/parvulin rotamase family.Curated

Phylogenomic databases

eggNOGiKOG3259. Eukaryota.
COG0760. LUCA.
HOGENOMiHOG000275331.
KOiK09578.
OMAiVHIIKRI.
OrthoDBiEOG09360TTC.
PhylomeDBiQ9SL42.

Family and domain databases

InterProiView protein in InterPro
IPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
PfamiView protein in Pfam
PF00639. Rotamase. 1 hit.
PROSITEiView protein in PROSITE
PS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9SL42-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASRDQVKAS HILIKHQGSR RKASWKDPEG KIILTTTREA AVEQLKSIRE
60 70 80 90 100
DIVSGKANFE EVATRVSDCS SAKRGGDLGS FGRGQMQKPF EEATYALKVG
110
DISDIVDTDS GVHIIKRTA
Length:119
Mass (Da):13,015
Last modified:May 1, 2000 - v1
Checksum:iE926CB566E76A0A3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006201 Genomic DNA. Translation: AAD20122.1.
CP002685 Genomic DNA. Translation: AEC06719.1.
AF360318 mRNA. Translation: AAK26028.1.
AY057514 mRNA. Translation: AAL09755.1.
AY056314 mRNA. Translation: AAL07163.1.
AY085059 mRNA. Translation: AAM61615.1.
F13919 mRNA. Translation: CAA23077.1.
PIRiE84559.
RefSeqiNP_179395.1. NM_127360.4.
UniGeneiAt.20592.

Genome annotation databases

EnsemblPlantsiAT2G18040.1; AT2G18040.1; AT2G18040.
GeneIDi816316.
GrameneiAT2G18040.1; AT2G18040.1; AT2G18040.
KEGGiath:AT2G18040.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006201 Genomic DNA. Translation: AAD20122.1.
CP002685 Genomic DNA. Translation: AEC06719.1.
AF360318 mRNA. Translation: AAK26028.1.
AY057514 mRNA. Translation: AAL09755.1.
AY056314 mRNA. Translation: AAL07163.1.
AY085059 mRNA. Translation: AAM61615.1.
F13919 mRNA. Translation: CAA23077.1.
PIRiE84559.
RefSeqiNP_179395.1. NM_127360.4.
UniGeneiAt.20592.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J6YNMR-A1-119[»]
ProteinModelPortaliQ9SL42.
SMRiQ9SL42.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ9SL42. 2 interactors.
STRINGi3702.AT2G18040.1.

PTM databases

iPTMnetiQ9SL42.

Proteomic databases

PaxDbiQ9SL42.
PRIDEiQ9SL42.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT2G18040.1; AT2G18040.1; AT2G18040.
GeneIDi816316.
GrameneiAT2G18040.1; AT2G18040.1; AT2G18040.
KEGGiath:AT2G18040.

Organism-specific databases

AraportiAT2G18040.
TAIRilocus:2060922. AT2G18040.

Phylogenomic databases

eggNOGiKOG3259. Eukaryota.
COG0760. LUCA.
HOGENOMiHOG000275331.
KOiK09578.
OMAiVHIIKRI.
OrthoDBiEOG09360TTC.
PhylomeDBiQ9SL42.

Enzyme and pathway databases

BioCyciARA:AT2G18040-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9SL42.
PROiPR:Q9SL42.

Gene expression databases

GenevisibleiQ9SL42. AT.

Family and domain databases

InterProiView protein in InterPro
IPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
PfamiView protein in Pfam
PF00639. Rotamase. 1 hit.
PROSITEiView protein in PROSITE
PS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPIN1_ARATH
AccessioniPrimary (citable) accession number: Q9SL42
Secondary accession number(s): Q42334
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: May 1, 2000
Last modified: April 12, 2017
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.