Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9SKX0 (AB13C_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ABC transporter C family member 13
Short name=ABC transporter ABCC.13
Short name=AtABCC13
EC=3.6.3.44
Alternative name(s):
ATP-energized glutathione S-conjugate pump 11
Glutathione S-conjugate-transporting ATPase 11
Multidrug resistance-associated protein 11
Gene names
Name:ABCC13
Synonyms:MRP11, MRP13
Ordered Locus Names:At2g07680
ORF Names:T5E7.1
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length1410 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Pump for glutathione S-conjugates By similarity.

Catalytic activity

ATP + H2O + xenobiotic(In) = ADP + phosphate + xenobiotic(Out).

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Tissue specificity

Ubiquitous. Ref.6

Sequence similarities

Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. [View classification]

Contains 2 ABC transmembrane type-1 domains.

Contains 2 ABC transporter domains.

Sequence caution

The sequence AAD37023.1 differs from that shown. Reason: Erroneous gene model prediction.

The sequence AEC06127.1 differs from that shown. Reason: Erroneous gene model prediction.

Ontologies

Keywords
   Biological processTransport
   Cellular componentMembrane
   DomainRepeat
Transmembrane
Transmembrane helix
   LigandATP-binding
Nucleotide-binding
   Molecular functionHydrolase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

vacuolar membrane

Inferred from direct assay. Source: TAIR

   Molecular functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

xenobiotic-transporting ATPase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 14101410ABC transporter C family member 13
PRO_0000226082

Regions

Transmembrane23 – 4321Helical; Potential
Transmembrane60 – 8021Helical; Potential
Transmembrane88 – 10821Helical; Potential
Transmembrane122 – 14221Helical; Potential
Transmembrane148 – 16821Helical; Potential
Transmembrane391 – 41121Helical; Potential
Transmembrane474 – 49421Helical; Potential
Transmembrane505 – 52521Helical; Potential
Transmembrane844 – 86421Helical; Potential
Transmembrane889 – 90921Helical; Potential
Transmembrane963 – 98523Helical; Potential
Transmembrane990 – 100920Helical; Potential
Transmembrane1087 – 110721Helical; Potential
Transmembrane1111 – 113121Helical; Potential
Domain255 – 530276ABC transmembrane type-1 1
Domain564 – 791228ABC transporter 1
Domain852 – 1139288ABC transmembrane type-1 2
Domain1174 – 1407234ABC transporter 2
Nucleotide binding602 – 6098ATP 1 Potential
Nucleotide binding1208 – 12158ATP 2 Potential
Compositional bias185 – 1884Poly-Asp
Compositional bias991 – 9977Poly-Leu

Sequences

Sequence LengthMass (Da)Tools
Q9SKX0 [UniParc].

Last modified June 15, 2010. Version 3.
Checksum: AB05CE5DF255A1AE

FASTA1,410157,870
        10         20         30         40         50         60 
MAITLTNFTF LYMDANLKRL GDIVLGFGAN VVTLLLILIL TITRRNGRCN RRKSYIEKCL 

        70         80         90        100        110        120 
LYVTPALGAC LSCVDLVLLV RTNRRREVIL CFVPLSGFVM WIAVILSLKF ACCACHVFTS 

       130        140        150        160        170        180 
QILCFWWIFR FLTDALHLNM IFTLQRVQEI CLIMLDIAFG ISINVLRIKQ AHPKIIPLED 

       190        200        210        220        230        240 
PLIEDDDDQK RIVRRLFLEK NGSWWDLFTF GYIGSIMKHG SVKQLELENL LTLPPEMDPF 

       250        260        270        280        290        300 
TCCENLLRCW QLQECNNYST PSLIWSIYGV YGWPYFRLGL LKVFNDCIGF AGPLLLNRLI 

       310        320        330        340        350        360 
KSFLDTQYTF RLSKLKLKLR SSIMSVIYRK CLWVNTANRS GFSEGEIQTF MSVDADRIVN 

       370        380        390        400        410        420 
LCNSLHDLWS LPLQIGIALY LLYTQVKFAF LSGLAITILL IPVNKWISVL IASATEKMMK 

       430        440        450        460        470        480 
LKDERIRKTG ELLTNIRTLK MYGWDNWFAD WLKETRATEV THLATRKYLD AWCVFFWATT 

       490        500        510        520        530        540 
PTLFSLCTFG LFALMGHQLD AATVFTCLAL FNSLISPLNS FPWVINGLID AFISTRRVSK 

       550        560        570        580        590        600 
FLCCLEHSRD FSIDSGFTSE DLAVCVEDAS CTWSSNVEED YNLTIKQVSL RVPKGSFVAV 

       610        620        630        640        650        660 
IGEVGSGKTS LLNSLLGEMR CVHGSILLNG SVAYVPQVPW LLSGTVRENI LFGKPFDSKR 

       670        680        690        700        710        720 
YFETLSACAL DVDISLMVGG DMACIGDKGL NLSGGQRARF ALARAVYHGS DMYLLDDVLS 

       730        740        750        760        770        780 
AVDSQVGCWI LQRALLGPLL NKKTRVMCTH NIQAISCADM IVVMDKGKVN WSGSVTDMPK 

       790        800        810        820        830        840 
SISPTFSLTN EFDMSSPNHL TKRKETLSIK EDGVDEISEA AADIVKLEER KEGRVEMMVY 

       850        860        870        880        890        900 
RNYAVFSGWF ITIVILVSAV LMQGSRNGND LWLSYWVDKT GKGVSHYSTS FYLMVLCIFC 

       910        920        930        940        950        960 
IINSILTLVR AFSFAFGGLK AAVHVHNALI SKLINAPTQF FDQTPSGRIL NRFSSDLYTI 

       970        980        990       1000       1010       1020 
DDSLPFILNI LLANFVGLLG IIVVLSYVQV LFLLLLLPFW YIYSKLQVFY RSTSRELRRL 

      1030       1040       1050       1060       1070       1080 
DSVSRSPIYA SFTETLDGSS TIRAFKSEEH FVGRFIEHLT LYQRTSYSEI IASLWLSLRL 

      1090       1100       1110       1120       1130       1140 
QLLGSMIVLF VAVMAVLGSG GNFPISFGTP GLVGLALSYA APLVSLLGSL LTSFTETEKE 

      1150       1160       1170       1180       1190       1200 
MVSVERVLQY MDVPQEEVSG PQSLSDKWPV HGLVEFHNVT MRYISTLPPA LTQISFTIQG 

      1210       1220       1230       1240       1250       1260 
GMHVGVIGRT GAGKSSILNA LFRLTPVCSG EILVDGKNIS HLPIRELRSC LAVVPQSPFL 

      1270       1280       1290       1300       1310       1320 
FQGSLRDNLD PLGLSEDWRI WEILDKCKVK AAVESVGGLD SYVKESGCSF SVGQRQLLCL 

      1330       1340       1350       1360       1370       1380 
ARALLKSSKI LCLDECTANI DVHTASLLHN TISSECKGVT VITIAHRIST VVDLDSILIL 

      1390       1400       1410 
DRGILVEQGK PQHLLQDDSS TFSSFVRASQ

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed: 10617197] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]Ducos E.
Unpublished observations (MAY-2010)
Cited for: GENE REANNOTATION.
[3]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[4]"The Arabidopsis thaliana ABC protein superfamily, a complete inventory."
Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.
J. Biol. Chem. 276:30231-30244(2001) [PubMed: 11346655] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
[5]"Multifunctionality of plant ABC transporters -- more than just detoxifiers."
Martinoia E., Klein M., Geisler M., Bovet L., Forestier C., Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.
Planta 214:345-355(2002) [PubMed: 11855639] [Abstract]
Cited for: GENE FAMILY.
[6]"Family business: the multidrug-resistance related protein (MRP) ABC transporter genes in Arabidopsis thaliana."
Kolukisaoglu U.H., Bovet L., Klein M., Eggmann T., Geisler M., Wanke D., Martinoia E., Schulz B.
Planta 216:107-119(2002) [PubMed: 12430019] [Abstract]
Cited for: TISSUE SPECIFICITY.
[7]"Plant ABC proteins - a unified nomenclature and updated inventory."
Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M., Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A., Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.
Trends Plant Sci. 13:151-159(2008) [PubMed: 18299247] [Abstract]
Cited for: GENE FAMILY, NOMENCLATURE.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC006225 Genomic DNA. Translation: AAD37023.1. Sequence problems.
CP002685 Genomic DNA. Translation: AEC06127.1. Sequence problems.
IPIIPI00519532.
IPI01020204.
PIRF84487.

3D structure databases

ProteinModelPortalQ9SKX0.
SMRQ9SKX0. Positions 532-792, 838-1410.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9SKX0.

Proteomic databases

PRIDEQ9SKX0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G07680.1; AT2G07680.1; AT2G07680.
GenomeReviewsGene locus AT2G07680 in contig CT485783_GR.
NMPDRfig|3702.1.peg.8279.

Organism-specific databases

TAIRAt2g07680.

Phylogenomic databases

eggNOGKOG0054.
GeneTreeEPGT00070000030499.
HOGENOMHBG758042.
InParanoidQ9SKX0.

Gene expression databases

ArrayExpressQ9SKX0.
GenevestigatorQ9SKX0.
GermOnlineAT2G07680. Arabidopsis thaliana.

Family and domain databases

InterProIPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR017940. ABC_transporter_type1.
IPR001140. ABC_transptr_TM_dom.
IPR011527. ABC_transptrTM_dom_typ1.
IPR003593. ATPase_AAA+_core.
[Graphical view]
PfamPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMSSF90123. ABC_TM_1. 2 hits.
PROSITEPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAB13C_ARATH
AccessionPrimary (citable) accession number: Q9SKX0
Secondary accession number(s): F4INF8
Entry history
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: June 15, 2010
Last modified: January 25, 2012
This is version 86 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents