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Protein

Alcohol dehydrogenase-like 2

Gene

At1g22440

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi51Zinc 1; catalyticBy similarity1
Metal bindingi53Zinc 1By similarity1
Binding sitei53NADBy similarity1
Binding sitei53SubstrateBy similarity1
Metal bindingi74Zinc 1; catalyticBy similarity1
Binding sitei74SubstrateBy similarity1
Metal bindingi104Zinc 2By similarity1
Metal bindingi107Zinc 2By similarity1
Metal bindingi110Zinc 2By similarity1
Metal bindingi118Zinc 2By similarity1
Metal bindingi183Zinc 1; catalyticBy similarity1
Binding sitei232NADBy similarity1
Binding sitei237NADBy similarity1
Binding sitei329NAD; via amide nitrogenBy similarity1
Binding sitei379NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi208 – 213NADBy similarity6
Nucleotide bindingi302 – 304NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G22440-MONOMER.
ReactomeiR-ATH-2161541. Abacavir metabolism.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-71384. Ethanol oxidation.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-like 2 (EC:1.1.1.1By similarity)
Gene namesi
Ordered Locus Names:At1g22440
ORF Names:F12K8.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

TAIRilocus:2009512. AT1G22440.

Subcellular locationi

  • Cytoplasm By similarity

GO - Cellular componenti

  • cytosol Source: TAIR

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991841 – 386Alcohol dehydrogenase-like 2Add BLAST386

Proteomic databases

PaxDbiQ9SK87.
PRIDEiQ9SK87.

Expressioni

Gene expression databases

GenevisibleiQ9SK87. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi24089. 1 interactor.
STRINGi3702.AT1G22440.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SK87.
SMRiQ9SK87.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
InParanoidiQ9SK87.
KOiK00121.
OMAiICDLGAH.
OrthoDBiEOG09360CLU.
PhylomeDBiQ9SK87.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9SK87-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKASITEGK PIRCKAAILR KAGEPLVIEE IQVDPPQAYE VRIKILCTSL
60 70 80 90 100
CHTDVTFWKL DSGPLARFPR ILGHEAVGVV ESIGEKVDGF KQGDVVLPVF
110 120 130 140 150
HPQCEECKEC ISPKSNWCTK YTNDYLSNTR RYGMTSRFKD SRGEDIHHFI
160 170 180 190 200
FVSSFTEYTV VDIAHLVKIS PEIPVDIAAL LSCSVATGLG AAWKVADVEE
210 220 230 240 250
GSTVVIFGLG AVGLAVAEGV RLRGAAKIIG VDLNPAKFEI GKRFGITDFV
260 270 280 290 300
NPALCGEKTI SEVIREMTDV GADYSFECIG LASLMEEAFK STRPGSGKTI
310 320 330 340 350
VLGMEQKALP ISLGSYDLLR GRTVCGTLFG GLKPKLDIPI LVDRYLKKEL
360 370 380
NLEDLITHEL SFEEINKAFH LLAEGNSIRC IIWMDK
Length:386
Mass (Da):42,383
Last modified:May 1, 2000 - v1
Checksum:i53BB1BD04E88293A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006551 Genomic DNA. Translation: AAF18533.1.
CP002684 Genomic DNA. Translation: AEE30242.1.
BT015046 mRNA. Translation: AAT71918.1.
BT015637 mRNA. Translation: AAU15136.1.
PIRiE86357.
RefSeqiNP_173660.1. NM_102093.5.
UniGeneiAt.41601.

Genome annotation databases

EnsemblPlantsiAT1G22440.1; AT1G22440.1; AT1G22440.
GeneIDi838850.
GrameneiAT1G22440.1; AT1G22440.1; AT1G22440.
KEGGiath:AT1G22440.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006551 Genomic DNA. Translation: AAF18533.1.
CP002684 Genomic DNA. Translation: AEE30242.1.
BT015046 mRNA. Translation: AAT71918.1.
BT015637 mRNA. Translation: AAU15136.1.
PIRiE86357.
RefSeqiNP_173660.1. NM_102093.5.
UniGeneiAt.41601.

3D structure databases

ProteinModelPortaliQ9SK87.
SMRiQ9SK87.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi24089. 1 interactor.
STRINGi3702.AT1G22440.1.

Proteomic databases

PaxDbiQ9SK87.
PRIDEiQ9SK87.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsiAT1G22440.1; AT1G22440.1; AT1G22440.
GeneIDi838850.
GrameneiAT1G22440.1; AT1G22440.1; AT1G22440.
KEGGiath:AT1G22440.

Organism-specific databases

AraportiAT1G22440.
TAIRilocus:2009512. AT1G22440.

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
InParanoidiQ9SK87.
KOiK00121.
OMAiICDLGAH.
OrthoDBiEOG09360CLU.
PhylomeDBiQ9SK87.

Enzyme and pathway databases

BioCyciARA:AT1G22440-MONOMER.
ReactomeiR-ATH-2161541. Abacavir metabolism.
R-ATH-5365859. RA biosynthesis pathway.
R-ATH-71384. Ethanol oxidation.

Miscellaneous databases

PROiPR:Q9SK87.

Gene expression databases

GenevisibleiQ9SK87. AT.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiADHL2_ARATH
AccessioniPrimary (citable) accession number: Q9SK87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: June 7, 2017
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.