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Protein

Alcohol dehydrogenase-like 1

Gene

At1g22430

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

An alcohol + NAD+ = an aldehyde or ketone + NADH.By similarity

Cofactori

Zn2+By similarityNote: Binds 2 Zn2+ ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Zinc 1; catalyticBy similarity1
Metal bindingi55Zinc 1By similarity1
Binding sitei55NADBy similarity1
Binding sitei55SubstrateBy similarity1
Metal bindingi76Zinc 1; catalyticBy similarity1
Binding sitei76SubstrateBy similarity1
Metal bindingi106Zinc 2By similarity1
Metal bindingi109Zinc 2By similarity1
Metal bindingi112Zinc 2By similarity1
Metal bindingi120Zinc 2By similarity1
Metal bindingi185Zinc 1; catalyticBy similarity1
Binding sitei234NADBy similarity1
Binding sitei239NADBy similarity1
Binding sitei331NAD; via amide nitrogenBy similarity1
Binding sitei381NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi210 – 215NADBy similarity6
Nucleotide bindingi304 – 306NADBy similarity3

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciARA:AT1G22430-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase-like 1 (EC:1.1.1.1By similarity)
Gene namesi
Ordered Locus Names:At1g22430
ORF Names:F12K8.22
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 1

Organism-specific databases

AraportiAT1G22430.
TAIRilocus:2009522. AT1G22430.

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002991831 – 388Alcohol dehydrogenase-like 1Add BLAST388

Proteomic databases

PaxDbiQ9SK86.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SK86. baseline and differential.
GenevisibleiQ9SK86. AT.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi24088. 1 interactor.
STRINGi3702.AT1G22430.1.

Structurei

3D structure databases

ProteinModelPortaliQ9SK86.
SMRiQ9SK86.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0022. Eukaryota.
COG1062. LUCA.
HOGENOMiHOG000294674.
InParanoidiQ9SK86.
KOiK00121.
OMAiICGASTI.
OrthoDBiEOG09360CLU.
PhylomeDBiQ9SK86.

Family and domain databases

InterProiView protein in InterPro
IPR013149. ADH_C.
IPR013154. ADH_N.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
PfamiView protein in Pfam
PF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
SUPFAMiSSF50129. SSF50129. 2 hits.
SSF51735. SSF51735. 1 hit.
PROSITEiView protein in PROSITE
PS00059. ADH_ZINC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9SK86-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDKTFFSSNE GKPITCKAAI CRKAGEALVI EDIHVDPPQA YEVRIKILCT
60 70 80 90 100
SLCHTDLTFW KLSFGPISRF PRILGHEAVG VVESIGENVD GFKQGDVVLP
110 120 130 140 150
VFHPYCEECK DCKSSKTNWC DRYAEDFISN TRRYGMASRF KDSSGEVIHH
160 170 180 190 200
FLFVSSFSEY TVVDIAHLVK ISPEIPVDKA ALLSCGVSTG IGAAWKVANV
210 220 230 240 250
EEGSTIAIFG LGAVGLAVAE GARLRGAAKI IGIDTNSDKF ELGKKFGFTD
260 270 280 290 300
FINPTLCGEK KISEVIKEMT EGGVDYSFEC VGLASLLNEA FISTRTGTGK
310 320 330 340 350
TVMLGMEKHA APISLGSFDL LRGRVICGSL FGGLKSKLDI PILVDHYLKK
360 370 380
ELNLDSFITH ELNFKEINKA FALLEEGKSL RCILWMDK
Length:388
Mass (Da):42,529
Last modified:May 1, 2000 - v1
Checksum:i6B604C871850B421
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC006551 Genomic DNA. Translation: AAF18534.1.
CP002684 Genomic DNA. Translation: AEE30240.1.
CP002684 Genomic DNA. Translation: AEE30241.1.
AY093114 mRNA. Translation: AAM13113.1.
AY128821 mRNA. Translation: AAM91221.1.
PIRiD86357.
RefSeqiNP_001031079.1. NM_001036002.1.
NP_173659.1. NM_102092.6.
UniGeneiAt.41602.

Genome annotation databases

EnsemblPlantsiAT1G22430.1; AT1G22430.1; AT1G22430.
AT1G22430.2; AT1G22430.2; AT1G22430.
GeneIDi838849.
GrameneiAT1G22430.1; AT1G22430.1; AT1G22430.
AT1G22430.2; AT1G22430.2; AT1G22430.
KEGGiath:AT1G22430.

Similar proteinsi

Entry informationi

Entry nameiADHL1_ARATH
AccessioniPrimary (citable) accession number: Q9SK86
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: May 1, 2000
Last modified: September 27, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families