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Q9SK52 (PER18_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified November 16, 2011. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Peroxidase 18
Short name=Atperox P18
EC=1.11.1.7
Gene names
Name:PER18
Synonyms:P18
Ordered Locus Names:At2g24800
ORF Names:F27C12.28
OrganismArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › malvids › Brassicales › Brassicaceae › Camelineae › Arabidopsis

Protein attributes

Sequence length329 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Removal of H2O2, oxidation of toxic reductants, biosynthesis and degradation of lignin, suberization, auxin catabolism, response to environmental stresses such as wounding, pathogen attack and oxidative stress. These functions might be dependent on each isozyme/isoform in each plant tissue.

Catalytic activity

2 phenolic donor + H2O2 = 2 phenoxyl radical of the donor + 2 H2O.

Cofactor

Binds 1 heme B (iron-protoporphyrin IX) group per subunit By similarity.

Binds 2 calcium ions per subunit By similarity.

Subcellular location

Secreted By similarity.

Miscellaneous

There are 73 peroxidase genes in A.thaliana.

Sequence similarities

Belongs to the peroxidase family. Classical plant (class III) peroxidase subfamily.

Ontologies

Keywords
   Biological processHydrogen peroxide
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Heme
Iron
Metal-binding
   Molecular functionOxidoreductase
Peroxidase
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processhydrogen peroxide catabolic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionheme binding

Inferred from electronic annotation. Source: InterPro

peroxidase activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 329300Peroxidase 18
PRO_0000023684

Sites

Active site711Proton acceptor By similarity
Metal binding721Calcium 1 By similarity
Metal binding751Calcium 1; via carbonyl oxygen By similarity
Metal binding771Calcium 1; via carbonyl oxygen By similarity
Metal binding791Calcium 1 By similarity
Metal binding811Calcium 1 By similarity
Metal binding1941Iron (heme axial ligand) By similarity
Metal binding1951Calcium 2 By similarity
Metal binding2491Calcium 2 By similarity
Metal binding2521Calcium 2 By similarity
Metal binding2571Calcium 2 By similarity
Binding site1641Substrate; via carbonyl oxygen By similarity
Site671Transition state stabilizer By similarity

Amino acid modifications

Glycosylation871N-linked (GlcNAc...) Potential
Disulfide bond40 ↔ 116 By similarity
Disulfide bond73 ↔ 78 By similarity
Disulfide bond122 ↔ 325 By similarity
Disulfide bond201 ↔ 235 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9SK52 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: DF56B4DCCBD82885

FASTA32935,641
        10         20         30         40         50         60 
MALQFFSCKP KYTFLSSLLL LLLLSSSVAE LSFNFYAGSC PGAELIVRNT VRSASSSDPS 

        70         80         90        100        110        120 
VLGKLLRLIF HDCFVQGCDG SVLIRGNGTE RSDPGNASLG GFAVIESVKN ILEIFCPGTV 

       130        140        150        160        170        180 
SCADILVLAA RDAVEALGGP VVPIPTGRRD GRVSMAANVR PNIIDTDFTV DKMINIFSSK 

       190        200        210        220        230        240 
GLSVHDLVVL SGAHTIGAAH CNTFNSRFKL DPKGNLELID ASLDNSYAQT LVNKCSSSLD 

       250        260        270        280        290        300 
PTTTVVDNDP ETSSTFDNQY YKNLLAHKGL FQTDSALMED DRTRKIVEIL ANDQESFFDR 

       310        320 
WTESFLKMSL MGVRVGEEGE IRRSCSAVN

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed: 10617197] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Analysis and expression of the class III peroxidase large gene family in Arabidopsis thaliana."
Tognolli M., Penel C., Greppin H., Simon P.
Gene 288:129-138(2002) [PubMed: 12034502] [Abstract]
Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.
Strain: cv. Columbia.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AC006585 Genomic DNA. Translation: AAD23032.1.
CP002685 Genomic DNA. Translation: AEC07630.1.
IPIIPI00531914.
PIRF84640.
RefSeqNP_180053.1. NM_128039.1.
UniGeneAt.52898.

3D structure databases

ProteinModelPortalQ9SK52.
SMRQ9SK52. Positions 30-329.
ModBaseSearch...

Protein-protein interaction databases

STRINGQ9SK52.

Protein family/group databases

PeroxiBase99. AtPrx18.

Proteomic databases

PRIDEQ9SK52.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G24800.1; AT2G24800.1; AT2G24800.
GeneID817017.
GenomeReviewsGene locus AT2G24800 in contig CT485783_GR.
KEGGath:AT2G24800.
NMPDRfig|3702.1.peg.9501.

Organism-specific databases

GeneFarm1842. 61.
TAIRAt2g24800.

Phylogenomic databases

GeneTreeEPGT00050000003124.
HOGENOMHBG597790.
InParanoidQ9SK52.
OMAHCSAFSD.
PhylomeDBQ9SK52.
ProtClustDBCLSN2912945.

Gene expression databases

ArrayExpressQ9SK52.
GenevestigatorQ9SK52.
GermOnlineAT2G24800. Arabidopsis thaliana.

Family and domain databases

InterProIPR010255. Haem_peroxidase.
IPR002016. Haem_peroxidase_pln/fun/bac.
IPR000823. Peroxidase_pln.
IPR019793. Peroxidases_heam-ligand_BS.
[Graphical view]
KOK00430.
PfamPF00141. peroxidase. 1 hit.
[Graphical view]
PRINTSPR00458. PEROXIDASE.
PR00461. PLPEROXIDASE.
SUPFAMSSF48113. Peroxidase_super. 1 hit.
PROSITEPS00435. PEROXIDASE_1. 1 hit.
PS00436. PEROXIDASE_2. False negative.
PS50873. PEROXIDASE_4. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePER18_ARATH
AccessionPrimary (citable) accession number: Q9SK52
Entry history
Integrated into UniProtKB/Swiss-Prot: November 25, 2002
Last sequence update: May 1, 2000
Last modified: November 16, 2011
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

SIMILARITY comments

Index of protein domains and families

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