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Protein

Sec-independent protein translocase protein TATC, chloroplastic

Gene

TATC

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across the thylakoid membrane. Involved in delta pH-dependent protein transport required for chloroplast development, especially thylakoid membrane formation. TATC and TATB mediate precursor recognition, whereas TATA facilitates translocation.1 Publication

Miscellaneous

According to PubMed:18930082, TATA is detectable only in minor amounts in Arabidopsis chloroplasts.

GO - Molecular functioni

  • proton motive force dependent protein transmembrane transporter activity Source: TAIR

GO - Biological processi

  • double fertilization forming a zygote and endosperm Source: TAIR
  • intracellular protein transmembrane transport Source: GO_Central
  • protein transport by the Tat complex Source: GO_Central
  • thylakoid membrane organization Source: TAIR

Keywordsi

Biological processProtein transport, Translocation, Transport

Protein family/group databases

TCDBi2.A.64.2.1 the twin arginine targeting (tat) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sec-independent protein translocase protein TATC, chloroplastic
Alternative name(s):
Protein ALBINO AND PALE GREEN 2
Protein TWIN-ARGININE TRANSLOCATION C
Protein UNFERTILIZED EMBRYO SAC 3
Gene namesi
Name:TATC
Synonyms:APG2, UNE3
Ordered Locus Names:At2g01110
ORF Names:F23H14.8
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
Proteomesi
  • UP000006548 Componenti: Chromosome 2

Organism-specific databases

AraportiAT2G01110
TAIRilocus:2045750 AT2G01110

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini61 – 127StromalSequence analysisAdd BLAST67
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 179LumenalSequence analysisAdd BLAST31
Transmembranei180 – 200HelicalSequence analysisAdd BLAST21
Topological domaini201 – 209StromalSequence analysis9
Transmembranei210 – 230HelicalSequence analysisAdd BLAST21
Topological domaini231 – 257LumenalSequence analysisAdd BLAST27
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Topological domaini279 – 289StromalSequence analysisAdd BLAST11
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Topological domaini311 – 314LumenalSequence analysis4
Transmembranei315 – 335HelicalSequence analysisAdd BLAST21
Topological domaini336 – 340StromalSequence analysis5

Keywords - Cellular componenti

Chloroplast, Membrane, Plastid, Thylakoid

Pathology & Biotechi

Disruption phenotypei

Seedling lethality when homozygous. When grown on agar medium, mutant seedlings have an albino phenotype and contain plastid lacking internal membrane structures.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 28ChloroplastSequence analysisAdd BLAST28
Transit peptidei29 – 60ThylakoidCuratedAdd BLAST32
ChainiPRO_000041991061 – 340Sec-independent protein translocase protein TATC, chloroplasticAdd BLAST280

Proteomic databases

PaxDbiQ9SJV5

Expressioni

Gene expression databases

ExpressionAtlasiQ9SJV5 baseline and differential
GenevisibleiQ9SJV5 AT

Interactioni

Subunit structurei

In thylakoid membranes, TATC and TATB form a large receptor complex, containing about eight TATC-TATB pairs, which binds the precursor protein. Twin arginine signal peptide promotes pH-triggered docking of TATA oligomers to TATC-TATB receptor complex, inducing a conformational switch of TATA that results in activation of the translocase. TATA dissociates from TATC-TATB upon completion of translocation.1 Publication

Protein-protein interaction databases

STRINGi3702.AT2G01110.1

Structurei

3D structure databases

ProteinModelPortaliQ9SJV5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TatC family.Curated

Keywords - Domaini

Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IIPA Eukaryota
COG0805 LUCA
HOGENOMiHOG000245380
InParanoidiQ9SJV5
KOiK03118
OMAiEMSFLDH
OrthoDBiEOG09360GRN
PhylomeDBiQ9SJV5

Family and domain databases

HAMAPiMF_00902 TatC, 1 hit
InterProiView protein in InterPro
IPR019820 Sec-indep_translocase_CS
IPR002033 TatC
PANTHERiPTHR30371 PTHR30371, 1 hit
PfamiView protein in Pfam
PF00902 TatC, 1 hit
PRINTSiPR01840 TATCFAMILY
TIGRFAMsiTIGR00945 tatC, 1 hit
PROSITEiView protein in PROSITE
PS01218 TATC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SJV5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSTSTSSAL IHHFRLTTRN LGSPTKQRCP YAVTFCNSWR EAGLRYSVTQ
60 70 80 90 100
RRSKGFGPVS ALNDDDSPTE TTPGVGSAVE DRPPDSSEDR SSSVYEFLYP
110 120 130 140 150
RKEELPDDKE MTIFDHLEEL RERIFVSVLA VGAAILGCFA FSKDLIVFLE
160 170 180 190 200
APVKTQGVRF LQLAPGEFFF TTLKVSGYCG LLLGSPVILY EIIAFVLPGL
210 220 230 240 250
TRAERRFLGP IVFGSSLLFY AGLAFSYWVL TPAALNFFVN YAEGVVESLW
260 270 280 290 300
SIDQYFEFVL VLMFSTGLSF QVPVIQLLLG QVGVVSGDQM LSIWRYVVVG
310 320 330 340
AVVAAAVVTP STDPVTQMLL ATPLLGLYLG GAWMVKLTGR
Length:340
Mass (Da):37,367
Last modified:June 1, 2002 - v2
Checksum:i1429C265BFEDB281
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB054096 mRNA Translation: BAB62074.1
AF145045 mRNA Translation: AAD33946.1
AC006837 Genomic DNA Translation: AAF18659.2
CP002685 Genomic DNA Translation: AEC05402.1
AF360172 mRNA Translation: AAK25882.1
AY056347 mRNA Translation: AAL07196.1
AY084784 mRNA Translation: AAM61351.1
PIRiT44583
RefSeqiNP_565252.1, NM_126173.4
UniGeneiAt.11297

Genome annotation databases

EnsemblPlantsiAT2G01110.1; AT2G01110.1; AT2G01110
GeneIDi814640
GrameneiAT2G01110.1; AT2G01110.1; AT2G01110
KEGGiath:AT2G01110

Similar proteinsi

Entry informationi

Entry nameiTATC_ARATH
AccessioniPrimary (citable) accession number: Q9SJV5
Secondary accession number(s): Q9XFI4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 31, 2012
Last sequence update: June 1, 2002
Last modified: April 25, 2018
This is version 107 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health