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Q9SJH7

- CISY3_ARATH

UniProt

Q9SJH7 - CISY3_ARATH

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Protein

Citrate synthase 3, peroxisomal

Gene
CSY3, At2g42790, F7D19.21
Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Peroxisomal citrate synthase required for the fatty acid respiration in seedlings, citrate being exported from peroxisomes into mitochondria during respiration of triacylglycerol (TAG). Indeed, complete respiration requires the transfer of carbon in the form of citrate from the peroxisome to the mitochondria.1 Publication

Catalytic activityi

Acetyl-CoA + H2O + oxaloacetate = citrate + CoA.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei319 – 3191 By similarity
Active sitei358 – 3581 By similarity
Active sitei414 – 4141 By similarity

GO - Molecular functioni

  1. citrate (Si)-synthase activity Source: TAIR

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. fatty acid beta-oxidation Source: TAIR
  3. tricarboxylic acid cycle Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Transferase

Keywords - Biological processi

Tricarboxylic acid cycle

Enzyme and pathway databases

BioCyciARA:AT2G42790-MONOMER.
UniPathwayiUPA00223; UER00717.

Names & Taxonomyi

Protein namesi
Recommended name:
Citrate synthase 3, peroxisomal (EC:2.3.3.16)
Gene namesi
Name:CSY3
Ordered Locus Names:At2g42790
ORF Names:F7D19.21
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G42790.

Subcellular locationi

Peroxisome 1 Publication

GO - Cellular componenti

  1. peroxisome Source: TAIR
Complete GO annotation...

Keywords - Cellular componenti

Peroxisome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 509Citrate synthase 3, peroxisomalPRO_0000005483
Transit peptidei1 – ?Peroxisome Reviewed prediction

Proteomic databases

PaxDbiQ9SJH7.
PRIDEiQ9SJH7.

Expressioni

Tissue specificityi

Widely expressed. Expressed throughout the shoot. Expressed in flower, silique, stem, cauline leaf, young leaf, mature leaf and senescent leaf.1 Publication

Developmental stagei

Expressed throughout seedling growth.1 Publication

Gene expression databases

ArrayExpressiQ9SJH7.
GenevestigatoriQ9SJH7.

Interactioni

Protein-protein interaction databases

BioGridi4216. 13 interactions.
IntActiQ9SJH7. 17 interactions.
STRINGi3702.AT2G42790.1-P.

Structurei

3D structure databases

ProteinModelPortaliQ9SJH7.
SMRiQ9SJH7. Positions 57-479.

Family & Domainsi

Sequence similaritiesi

Belongs to the citrate synthase family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0372.
HOGENOMiHOG000021224.
InParanoidiQ9SJH7.
KOiK01647.
PhylomeDBiQ9SJH7.

Family and domain databases

Gene3Di1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProiIPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view]
PANTHERiPTHR11739. PTHR11739. 1 hit.
PfamiPF00285. Citrate_synt. 1 hit.
[Graphical view]
PIRSFiPIRSF001369. Citrate_synth. 1 hit.
PRINTSiPR00143. CITRTSNTHASE.
SUPFAMiSSF48256. SSF48256. 1 hit.
PROSITEiPS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9SJH7-1 [UniParc]FASTAAdd to Basket

« Hide

MEISERVRAR LAVLSGHLSE GKQDSPAIER WCTSADTSVA PLGSLKGTLT    50
IVDERTGKNY KVPVSDDGTV KAVDFKKIVT GKEDKGLKLY DPGYLNTAPV 100
RSSISYIDGD EGILRYRGYP IEEMAENSTF LEVAYLLMYG NLPSESQLSD 150
WEFAVSQHSA VPQGVLDIIQ SMPHDAHPMG VLVSAMSALS IFHPDANPAL 200
RGQDIYDSKQ VRDKQIIRII GKAPTIAAAA YLRMAGRPPV LPSGNLPYAD 250
NFLYMLDSLG NRSYKPNPRL ARVLDILFIL HAEHEMNCST AAARHLASSG 300
VDVYTAVAGA VGALYGPLHG GANEAVLKML SEIGTVENIP EFIEGVKNRK 350
RKMSGFGHRV YKNYDPRAKV IKNLADEVFS IVGKDPLIEV AVALEKAALS 400
DDYFVKRKLY PNVDFYSGLI YRAMGFPPEF FTVLFAIPRM AGYLSHWKES 450
LDDPDTKIMR PQQVYTGVWL RHYTPVRERI VTDDSKESDK LGQVATSNAS 500
RRRLAGSSV 509
Length:509
Mass (Da):56,175
Last modified:May 1, 2000 - v1
Checksum:i5ADF4A63F1DDFE38
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti430 – 4301F → L in BAD93930. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006931 Genomic DNA. Translation: AAD21729.1.
CP002685 Genomic DNA. Translation: AEC10169.1.
AY048214 mRNA. Translation: AAK82477.1.
AY124841 mRNA. Translation: AAM70550.1.
AK221264 mRNA. Translation: BAD93930.1.
PIRiC84858.
RefSeqiNP_181807.1. NM_129840.4.
UniGeneiAt.19848.
At.75577.

Genome annotation databases

EnsemblPlantsiAT2G42790.1; AT2G42790.1; AT2G42790.
GeneIDi818879.
KEGGiath:AT2G42790.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006931 Genomic DNA. Translation: AAD21729.1 .
CP002685 Genomic DNA. Translation: AEC10169.1 .
AY048214 mRNA. Translation: AAK82477.1 .
AY124841 mRNA. Translation: AAM70550.1 .
AK221264 mRNA. Translation: BAD93930.1 .
PIRi C84858.
RefSeqi NP_181807.1. NM_129840.4.
UniGenei At.19848.
At.75577.

3D structure databases

ProteinModelPortali Q9SJH7.
SMRi Q9SJH7. Positions 57-479.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 4216. 13 interactions.
IntActi Q9SJH7. 17 interactions.
STRINGi 3702.AT2G42790.1-P.

Proteomic databases

PaxDbi Q9SJH7.
PRIDEi Q9SJH7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G42790.1 ; AT2G42790.1 ; AT2G42790 .
GeneIDi 818879.
KEGGi ath:AT2G42790.

Organism-specific databases

TAIRi AT2G42790.

Phylogenomic databases

eggNOGi COG0372.
HOGENOMi HOG000021224.
InParanoidi Q9SJH7.
KOi K01647.
PhylomeDBi Q9SJH7.

Enzyme and pathway databases

UniPathwayi UPA00223 ; UER00717 .
BioCyci ARA:AT2G42790-MONOMER.

Gene expression databases

ArrayExpressi Q9SJH7.
Genevestigatori Q9SJH7.

Family and domain databases

Gene3Di 1.10.230.10. 1 hit.
1.10.580.10. 1 hit.
InterProi IPR016142. Citrate_synth-like_lrg_a-sub.
IPR016143. Citrate_synth-like_sm_a-sub.
IPR002020. Citrate_synthase-like.
IPR016141. Citrate_synthase-like_core.
IPR019810. Citrate_synthase_AS.
IPR024176. Citrate_synthase_bac-typ.
[Graphical view ]
PANTHERi PTHR11739. PTHR11739. 1 hit.
Pfami PF00285. Citrate_synt. 1 hit.
[Graphical view ]
PIRSFi PIRSF001369. Citrate_synth. 1 hit.
PRINTSi PR00143. CITRTSNTHASE.
SUPFAMi SSF48256. SSF48256. 1 hit.
PROSITEi PS00480. CITRATE_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs."
    Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A., Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y., Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.
    , Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y., Shinozaki K.
    Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 369-509.
    Strain: cv. Columbia.
  5. "Arabidopsis peroxisomal citrate synthase is required for fatty acid respiration and seed germination."
    Pracharoenwattana I., Cornah J.E., Smith S.M.
    Plant Cell 17:2037-2048(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

Entry informationi

Entry nameiCISY3_ARATH
AccessioniPrimary (citable) accession number: Q9SJH7
Secondary accession number(s): Q56YQ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: May 1, 2000
Last modified: May 14, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Miscellaneous

Citrate synthase is found in nearly all cells capable of oxidative metabolism.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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