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Q9SJA1

- UBP19_ARATH

UniProt

Q9SJA1 - UBP19_ARATH

Protein

Ubiquitin carboxyl-terminal hydrolase 19

Gene

UBP19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 2 (01 Jun 2002)
      Previous versions | rss
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    Functioni

    Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.By similarity

    Catalytic activityi

    Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei183 – 1831NucleophilePROSITE-ProRule annotation
    Active sitei439 – 4391Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri64 – 10138MYND-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. cysteine-type peptidase activity Source: UniProtKB-KW
    2. metal ion binding Source: UniProtKB-KW
    3. ubiquitinyl hydrolase activity Source: InterPro

    GO - Biological processi

    1. ubiquitin-dependent protein catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Protease, Thiol protease

    Keywords - Biological processi

    Ubl conjugation pathway

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciARA:AT2G24640-MONOMER.
    ARA:GQT-651-MONOMER.

    Protein family/group databases

    MEROPSiC19.A09.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ubiquitin carboxyl-terminal hydrolase 19 (EC:3.4.19.12)
    Alternative name(s):
    Deubiquitinating enzyme 19
    Short name:
    AtUBP19
    Ubiquitin thioesterase 19
    Ubiquitin-specific-processing protease 19
    Gene namesi
    Name:UBP19
    Ordered Locus Names:At2g24640
    ORF Names:F25P17.6
    OrganismiArabidopsis thaliana (Mouse-ear cress)
    Taxonomic identifieri3702 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
    ProteomesiUP000006548: Chromosome 2

    Organism-specific databases

    TAIRiAT2G24640.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 672672Ubiquitin carboxyl-terminal hydrolase 19PRO_0000313045Add
    BLAST

    Proteomic databases

    PRIDEiQ9SJA1.

    Expressioni

    Gene expression databases

    GenevestigatoriQ9SJA1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9SJA1.
    SMRiQ9SJA1. Positions 175-478.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei11 – 3121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini174 – 480307USPAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase C19 family.Curated
    Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
    Contains 1 USP domain.Curated

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri64 – 10138MYND-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Transmembrane, Transmembrane helix, Zinc-finger

    Phylogenomic databases

    eggNOGiCOG5533.
    HOGENOMiHOG000097839.
    InParanoidiQ9SJA1.
    KOiK11855.
    OMAiPLEKEHS.
    PhylomeDBiQ9SJA1.

    Family and domain databases

    InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR002893. Znf_MYND.
    [Graphical view]
    PfamiPF00443. UCH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view]
    PROSITEiPS00972. USP_1. 1 hit.
    PS50235. USP_3. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    This entry describes 1 isoform i produced by alternative splicing. Align

    Note: A number of isoforms are produced. According to EST sequences.

    Isoform 1 (identifier: Q9SJA1-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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    MHEVGLFVDL NSFTQLILTL FFVSIGLLYF VKRTAAKYFE VGGGSGGFDR    50
    DHRRDFMVSD TAECSVCGKA TTKKCSRCKS VRYCSAACQT SDWKSGHKLK 100
    CKGFRSTDSS PVRRDDIDFE ASLFGNRSAS KKTRIALVPQ QSQSKATLKP 150
    TDVLFPYESF VRYYNWDRPI MAPCGLTNCG NSCFANVVLQ CLSWTRPLVA 200
    YLLERGHKRE CRRNDWCFLC EFENHLDRAN YSRFPFSPMN IISRLPNIGG 250
    NLGYGRQEDA HELMRFAIDM MQSVCLDEFG GEKVVPPRAQ ETTLIQYIFG 300
    GLLQSQVQCT ACSNVSDQYE NMMDLTVEIH GDAVSLEECL DQFTAKEWLQ 350
    GDNLYKCDRC DDYVKACKRL SIRCAPNILT IALKRFQGGR FGKLNKRISF 400
    PETFDLGPYM SGGGEGSDVY KLYAVIVHLD MLNASFFGHY ICYVKDFRGN 450
    WYRIDDSEVE KVELEDVLSQ RAYMLLYSRV QPRPSNLRSE ESQDEKKTDT 500
    LNTESNQDGS VESSGVGTND TSVSSLCNGI ISHSEDPEYE KESSLSASVP 550
    VSEEGKEVDV KVDTVDSESN RSIDMEHDSG TDHQEEEANG KEDPTVENLA 600
    VDSSCLDITT PSPSAATEFI PQENERSDTE SKPLEKEHSD TESNKPLEKE 650
    HLDSESKPLE KEHSDTEMID AQ 672
    Length:672
    Mass (Da):75,720
    Last modified:June 1, 2002 - v2
    Checksum:i0A3B1BDA29F3FB30
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006954 Genomic DNA. Translation: AAD23896.2.
    CP002685 Genomic DNA. Translation: AEC07607.1.
    AF360315 mRNA. Translation: AAK26025.1.
    AY056366 mRNA. Translation: AAL07252.1.
    PIRiB84639.
    RefSeqiNP_565576.1. NM_128025.3. [Q9SJA1-1]
    UniGeneiAt.14198.

    Genome annotation databases

    EnsemblPlantsiAT2G24640.1; AT2G24640.1; AT2G24640. [Q9SJA1-1]
    GeneIDi817000.
    KEGGiath:AT2G24640.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC006954 Genomic DNA. Translation: AAD23896.2 .
    CP002685 Genomic DNA. Translation: AEC07607.1 .
    AF360315 mRNA. Translation: AAK26025.1 .
    AY056366 mRNA. Translation: AAL07252.1 .
    PIRi B84639.
    RefSeqi NP_565576.1. NM_128025.3. [Q9SJA1-1 ]
    UniGenei At.14198.

    3D structure databases

    ProteinModelPortali Q9SJA1.
    SMRi Q9SJA1. Positions 175-478.
    ModBasei Search...
    MobiDBi Search...

    Protein family/group databases

    MEROPSi C19.A09.

    Proteomic databases

    PRIDEi Q9SJA1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblPlantsi AT2G24640.1 ; AT2G24640.1 ; AT2G24640 . [Q9SJA1-1 ]
    GeneIDi 817000.
    KEGGi ath:AT2G24640.

    Organism-specific databases

    TAIRi AT2G24640.

    Phylogenomic databases

    eggNOGi COG5533.
    HOGENOMi HOG000097839.
    InParanoidi Q9SJA1.
    KOi K11855.
    OMAi PLEKEHS.
    PhylomeDBi Q9SJA1.

    Enzyme and pathway databases

    BioCyci ARA:AT2G24640-MONOMER.
    ARA:GQT-651-MONOMER.

    Gene expression databases

    Genevestigatori Q9SJA1.

    Family and domain databases

    InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
    IPR001394. Peptidase_C19_UCH.
    IPR028889. UCH/PAN2.
    IPR002893. Znf_MYND.
    [Graphical view ]
    Pfami PF00443. UCH. 1 hit.
    PF01753. zf-MYND. 1 hit.
    [Graphical view ]
    PROSITEi PS00972. USP_1. 1 hit.
    PS50235. USP_3. 1 hit.
    PS01360. ZF_MYND_1. 1 hit.
    PS50865. ZF_MYND_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: cv. Columbia.
    2. The Arabidopsis Information Resource (TAIR)
      Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
      Cited for: GENOME REANNOTATION.
      Strain: cv. Columbia.
    3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
      Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
      , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
      Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: cv. Columbia.
    4. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
      Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
      Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.

    Entry informationi

    Entry nameiUBP19_ARATH
    AccessioniPrimary (citable) accession number: Q9SJA1
    Secondary accession number(s): Q9C5D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 15, 2008
    Last sequence update: June 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Arabidopsis thaliana
      Arabidopsis thaliana: entries and gene names
    2. Peptidase families
      Classification of peptidase families and list of entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3