Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q9SJA1 (UBP19_ARATH) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ubiquitin carboxyl-terminal hydrolase 19

EC=3.4.19.12
Alternative name(s):
Deubiquitinating enzyme 19
Short name=AtUBP19
Ubiquitin thioesterase 19
Ubiquitin-specific-processing protease 19
Gene names
Name:UBP19
Ordered Locus Names:At2g24640
ORF Names:F25P17.6
OrganismArabidopsis thaliana (Mouse-ear cress) [Reference proteome]
Taxonomic identifier3702 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis

Protein attributes

Sequence length672 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins By similarity.

Catalytic activity

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Subcellular location

Membrane; Single-pass membrane protein Potential.

Sequence similarities

Belongs to the peptidase C19 family.

Contains 1 MYND-type zinc finger.

Contains 1 USP domain.

Ontologies

Alternative products

This entry describes 1 isoform produced by alternative splicing. [Select]

Note: A number of isoforms are produced. According to EST sequences.
Isoform 1 (identifier: Q9SJA1-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 672672Ubiquitin carboxyl-terminal hydrolase 19
PRO_0000313045

Regions

Transmembrane11 – 3121Helical; Potential
Domain174 – 480307USP
Zinc finger64 – 10138MYND-type

Sites

Active site1831Nucleophile By similarity
Active site4391Proton acceptor By similarity

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified June 1, 2002. Version 2.
Checksum: 0A3B1BDA29F3FB30

FASTA67275,720
        10         20         30         40         50         60 
MHEVGLFVDL NSFTQLILTL FFVSIGLLYF VKRTAAKYFE VGGGSGGFDR DHRRDFMVSD 

        70         80         90        100        110        120 
TAECSVCGKA TTKKCSRCKS VRYCSAACQT SDWKSGHKLK CKGFRSTDSS PVRRDDIDFE 

       130        140        150        160        170        180 
ASLFGNRSAS KKTRIALVPQ QSQSKATLKP TDVLFPYESF VRYYNWDRPI MAPCGLTNCG 

       190        200        210        220        230        240 
NSCFANVVLQ CLSWTRPLVA YLLERGHKRE CRRNDWCFLC EFENHLDRAN YSRFPFSPMN 

       250        260        270        280        290        300 
IISRLPNIGG NLGYGRQEDA HELMRFAIDM MQSVCLDEFG GEKVVPPRAQ ETTLIQYIFG 

       310        320        330        340        350        360 
GLLQSQVQCT ACSNVSDQYE NMMDLTVEIH GDAVSLEECL DQFTAKEWLQ GDNLYKCDRC 

       370        380        390        400        410        420 
DDYVKACKRL SIRCAPNILT IALKRFQGGR FGKLNKRISF PETFDLGPYM SGGGEGSDVY 

       430        440        450        460        470        480 
KLYAVIVHLD MLNASFFGHY ICYVKDFRGN WYRIDDSEVE KVELEDVLSQ RAYMLLYSRV 

       490        500        510        520        530        540 
QPRPSNLRSE ESQDEKKTDT LNTESNQDGS VESSGVGTND TSVSSLCNGI ISHSEDPEYE 

       550        560        570        580        590        600 
KESSLSASVP VSEEGKEVDV KVDTVDSESN RSIDMEHDSG TDHQEEEANG KEDPTVENLA 

       610        620        630        640        650        660 
VDSSCLDITT PSPSAATEFI PQENERSDTE SKPLEKEHSD TESNKPLEKE HLDSESKPLE 

       670 
KEHSDTEMID AQ 

« Hide

References

« Hide 'large scale' references
[1]"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana."
Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. expand/collapse author list , Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J., Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M., Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O., Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.
Nature 402:761-768(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: cv. Columbia.
[2]The Arabidopsis Information Resource (TAIR)
Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: cv. Columbia.
[3]"Empirical analysis of transcriptional activity in the Arabidopsis genome."
Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G. expand/collapse author list , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: cv. Columbia.
[4]"The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC006954 Genomic DNA. Translation: AAD23896.2.
CP002685 Genomic DNA. Translation: AEC07607.1.
AF360315 mRNA. Translation: AAK26025.1.
AY056366 mRNA. Translation: AAL07252.1.
PIRB84639.
RefSeqNP_565576.1. NM_128025.3.
UniGeneAt.14198.

3D structure databases

ProteinModelPortalQ9SJA1.
SMRQ9SJA1. Positions 61-481.
ModBaseSearch...
MobiDBSearch...

Protein family/group databases

MEROPSC19.A09.

Proteomic databases

PRIDEQ9SJA1.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblPlantsAT2G24640.1; AT2G24640.1; AT2G24640.
GeneID817000.
KEGGath:AT2G24640.

Organism-specific databases

TAIRAT2G24640.

Phylogenomic databases

eggNOGCOG5533.
HOGENOMHOG000097839.
InParanoidQ9SJA1.
KOK11855.
OMAPLEKEHS.
PhylomeDBQ9SJA1.
ProtClustDBCLSN2685876.

Enzyme and pathway databases

BioCycARA:AT2G24640-MONOMER.
ARA:GQT-651-MONOMER.

Gene expression databases

ArrayExpressQ9SJA1.
GenevestigatorQ9SJA1.

Family and domain databases

InterProIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view]
PfamPF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEPS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUBP19_ARATH
AccessionPrimary (citable) accession number: Q9SJA1
Secondary accession number(s): Q9C5D8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: March 19, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names