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Q9SJA1

- UBP19_ARATH

UniProt

Q9SJA1 - UBP19_ARATH

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Protein

Ubiquitin carboxyl-terminal hydrolase 19

Gene

UBP19

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).By similarity

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei183 – 1831NucleophilePROSITE-ProRule annotation
Active sitei439 – 4391Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri64 – 10138MYND-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. cysteine-type peptidase activity Source: UniProtKB-KW
  2. metal ion binding Source: UniProtKB-KW
  3. ubiquitinyl hydrolase activity Source: InterPro

GO - Biological processi

  1. ubiquitin-dependent protein catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Ubl conjugation pathway

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

BioCyciARA:AT2G24640-MONOMER.
ARA:GQT-651-MONOMER.

Protein family/group databases

MEROPSiC19.A09.

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 19 (EC:3.4.19.12)
Alternative name(s):
Deubiquitinating enzyme 19
Short name:
AtUBP19
Ubiquitin thioesterase 19
Ubiquitin-specific-processing protease 19
Gene namesi
Name:UBP19
Ordered Locus Names:At2g24640
ORF Names:F25P17.6
OrganismiArabidopsis thaliana (Mouse-ear cress)
Taxonomic identifieri3702 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
ProteomesiUP000006548: Chromosome 2

Organism-specific databases

TAIRiAT2G24640.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 672672Ubiquitin carboxyl-terminal hydrolase 19PRO_0000313045Add
BLAST

Proteomic databases

PRIDEiQ9SJA1.

Expressioni

Gene expression databases

ExpressionAtlasiQ9SJA1. baseline and differential.
GenevestigatoriQ9SJA1.

Structurei

3D structure databases

ProteinModelPortaliQ9SJA1.
SMRiQ9SJA1. Positions 175-478.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei11 – 3121HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini174 – 480307USPAdd
BLAST

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated
Contains 1 MYND-type zinc finger.PROSITE-ProRule annotation
Contains 1 USP domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri64 – 10138MYND-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Transmembrane, Transmembrane helix, Zinc-finger

Phylogenomic databases

eggNOGiCOG5533.
HOGENOMiHOG000097839.
InParanoidiQ9SJA1.
KOiK11855.
OMAiPLEKEHS.
PhylomeDBiQ9SJA1.

Family and domain databases

InterProiIPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view]
PfamiPF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view]
PROSITEiPS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

This entry describes 1 isoform i produced by alternative splicing. Align

Note: A number of isoforms are produced. According to EST sequences.

Isoform 1 (identifier: Q9SJA1-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MHEVGLFVDL NSFTQLILTL FFVSIGLLYF VKRTAAKYFE VGGGSGGFDR
60 70 80 90 100
DHRRDFMVSD TAECSVCGKA TTKKCSRCKS VRYCSAACQT SDWKSGHKLK
110 120 130 140 150
CKGFRSTDSS PVRRDDIDFE ASLFGNRSAS KKTRIALVPQ QSQSKATLKP
160 170 180 190 200
TDVLFPYESF VRYYNWDRPI MAPCGLTNCG NSCFANVVLQ CLSWTRPLVA
210 220 230 240 250
YLLERGHKRE CRRNDWCFLC EFENHLDRAN YSRFPFSPMN IISRLPNIGG
260 270 280 290 300
NLGYGRQEDA HELMRFAIDM MQSVCLDEFG GEKVVPPRAQ ETTLIQYIFG
310 320 330 340 350
GLLQSQVQCT ACSNVSDQYE NMMDLTVEIH GDAVSLEECL DQFTAKEWLQ
360 370 380 390 400
GDNLYKCDRC DDYVKACKRL SIRCAPNILT IALKRFQGGR FGKLNKRISF
410 420 430 440 450
PETFDLGPYM SGGGEGSDVY KLYAVIVHLD MLNASFFGHY ICYVKDFRGN
460 470 480 490 500
WYRIDDSEVE KVELEDVLSQ RAYMLLYSRV QPRPSNLRSE ESQDEKKTDT
510 520 530 540 550
LNTESNQDGS VESSGVGTND TSVSSLCNGI ISHSEDPEYE KESSLSASVP
560 570 580 590 600
VSEEGKEVDV KVDTVDSESN RSIDMEHDSG TDHQEEEANG KEDPTVENLA
610 620 630 640 650
VDSSCLDITT PSPSAATEFI PQENERSDTE SKPLEKEHSD TESNKPLEKE
660 670
HLDSESKPLE KEHSDTEMID AQ
Length:672
Mass (Da):75,720
Last modified:June 1, 2002 - v2
Checksum:i0A3B1BDA29F3FB30
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006954 Genomic DNA. Translation: AAD23896.2.
CP002685 Genomic DNA. Translation: AEC07607.1.
AF360315 mRNA. Translation: AAK26025.1.
AY056366 mRNA. Translation: AAL07252.1.
PIRiB84639.
RefSeqiNP_565576.1. NM_128025.3. [Q9SJA1-1]
UniGeneiAt.14198.

Genome annotation databases

EnsemblPlantsiAT2G24640.1; AT2G24640.1; AT2G24640. [Q9SJA1-1]
GeneIDi817000.
KEGGiath:AT2G24640.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AC006954 Genomic DNA. Translation: AAD23896.2 .
CP002685 Genomic DNA. Translation: AEC07607.1 .
AF360315 mRNA. Translation: AAK26025.1 .
AY056366 mRNA. Translation: AAL07252.1 .
PIRi B84639.
RefSeqi NP_565576.1. NM_128025.3. [Q9SJA1-1 ]
UniGenei At.14198.

3D structure databases

ProteinModelPortali Q9SJA1.
SMRi Q9SJA1. Positions 175-478.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

MEROPSi C19.A09.

Proteomic databases

PRIDEi Q9SJA1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblPlantsi AT2G24640.1 ; AT2G24640.1 ; AT2G24640 . [Q9SJA1-1 ]
GeneIDi 817000.
KEGGi ath:AT2G24640.

Organism-specific databases

TAIRi AT2G24640.

Phylogenomic databases

eggNOGi COG5533.
HOGENOMi HOG000097839.
InParanoidi Q9SJA1.
KOi K11855.
OMAi PLEKEHS.
PhylomeDBi Q9SJA1.

Enzyme and pathway databases

BioCyci ARA:AT2G24640-MONOMER.
ARA:GQT-651-MONOMER.

Gene expression databases

ExpressionAtlasi Q9SJA1. baseline and differential.
Genevestigatori Q9SJA1.

Family and domain databases

InterProi IPR018200. Pept_C19ubi-hydrolase_C_CS.
IPR001394. Peptidase_C19_UCH.
IPR028889. UCH/PAN2.
IPR002893. Znf_MYND.
[Graphical view ]
Pfami PF00443. UCH. 1 hit.
PF01753. zf-MYND. 1 hit.
[Graphical view ]
PROSITEi PS00972. USP_1. 1 hit.
PS50235. USP_3. 1 hit.
PS01360. ZF_MYND_1. 1 hit.
PS50865. ZF_MYND_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: cv. Columbia.
  2. The Arabidopsis Information Resource (TAIR)
    Submitted (APR-2011) to the EMBL/GenBank/DDBJ databases
    Cited for: GENOME REANNOTATION.
    Strain: cv. Columbia.
  3. "Empirical analysis of transcriptional activity in the Arabidopsis genome."
    Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M., Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G., Liu S.X., Lam B., Sakano H., Wu T., Yu G.
    , Miranda M., Quach H.L., Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C., Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J., Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A., Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C., Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X., Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M., Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K., Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A., Ecker J.R.
    Science 302:842-846(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: cv. Columbia.
  4. "The ubiquitin-specific protease family from Arabidopsis. AtUBP1 and 2 are required for the resistance to the amino acid analog canavanine."
    Yan N., Doelling J.H., Falbel T.G., Durski A.M., Vierstra R.D.
    Plant Physiol. 124:1828-1843(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: GENE FAMILY ORGANIZATION, NOMENCLATURE.

Entry informationi

Entry nameiUBP19_ARATH
AccessioniPrimary (citable) accession number: Q9SJA1
Secondary accession number(s): Q9C5D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3