Probable cellulose synthase A catalytic subunit 9 [UDP-forming]

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Reviewed, UniProtKB/Swiss-Prot Q9SJ22 (CESA9_ARATH)

Last modified June 16, 2009. Version 56. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    Probable cellulose synthase A catalytic subunit 9 [UDP-forming]
      Short name=AtCesA9
    EC=2.4.1.12

Gene names

Name:	CESA9
Synonyms:	CESA09
Ordered Locus Names:	At2g21770
ORF Names:	F7D8.9

Organism

Arabidopsis thaliana (Mouse-ear cress) [Complete proteome]

Taxonomic identifier

3702 [NCBI]

Taxonomic lineage

Eukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › rosids › eurosids II › Brassicales › Brassicaceae › Arabidopsis

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Protein attributes

Sequence length	1088 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

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General annotation (Comments)

Function	Probable catalytic subunit of cellulose synthase terminal complexes ('rosettes'), required for beta-1,4-glucan microfibril crystallization, a major mechanism of the cell wall formation By similarity.
Catalytic activity	UDP-glucose + (1,4-beta-D-glucosyl)(n) = UDP + (1,4-beta-D-glucosyl)(n+1).
Cofactor	Binds 2 zinc ions per subunit By similarity.
Pathway	Glycan metabolism; plant cellulose biosynthesis.
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Tissue specificity	Expressed in young plants, stems and flowers. Ref.3
Developmental stage	Mostly expressed in cotyledons during all steps of embryogenesis, and decrease toward the bent-cotyledon stage. Ref.3
Sequence similarities	Belongs to the glycosyltransferase 2 family. Plant cellulose synthase subfamily. Contains 1 RING-type zinc finger.

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Ontologies

Keywords
Biological process	Cell wall biogenesis/degradation Cellulose biosynthesis
Cellular component	Cell membrane Membrane
Domain	Transmembrane Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	Glycosyltransferase Transferase
PTM	Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW cellulose biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from direct assay. Source: TAIR
Molecular function	cellulose synthase (UDP-forming) activity Inferred from electronic annotation. Source: EC protein binding Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 1088

1088

Probable cellulose synthase A catalytic subunit 9 [UDP-forming]

PRO_0000166375

Regions

Topological domain

1 – 283

283

Cytoplasmic Potential

Transmembrane

284 – 304

Potential

Topological domain

305 – 306

Extracellular Potential

Transmembrane

307 – 327

Potential

Topological domain

328 – 871

544

Cytoplasmic Potential

Transmembrane

872 – 892

Potential

Topological domain

893 – 897

Extracellular Potential

Transmembrane

898 – 918

Potential

Topological domain

919 – 933

Cytoplasmic Potential

Transmembrane

934 – 954

Potential

Topological domain

955 – 983

Extracellular Potential

Transmembrane

984 – 1004

Potential

Topological domain

1005 – 1015

Cytoplasmic Potential

Transmembrane

1016 – 1036

Potential

Topological domain

1037 – 1045

Extracellular Potential

Transmembrane

1046 – 1066

Potential

Topological domain

1067 – 1088

Cytoplasmic Potential

Zinc finger

39 – 85

RING-type; degenerate

Compositional bias

664 – 675

Cys-rich

Sites

Active site

402

Potential

Active site

788

Potential

Metal binding

Zinc 1 By similarity

Metal binding

Zinc 1 By similarity

Metal binding

Zinc 2 By similarity

Metal binding

Zinc 2 By similarity

Metal binding

Zinc 1 By similarity

Metal binding

Zinc 1 By similarity

Metal binding

Zinc 2 By similarity

Metal binding

Zinc 2 By similarity

Binding site

568

Substrate Potential

Binding site

570

Substrate Potential

Amino acid modifications

Glycosylation

961

N-linked (GlcNAc...) Potential

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9SJ22-1 [UniParc].

Last modified May 1, 2000. Version 1.
Checksum: 060571118600DC9F
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FASTA

1,088

123,447

        10         20         30         40         50         60 
MNTGGRLIAG SHNRNEFVLI NADDTARIRS AEELSGQTCK ICRDEIELTD NGEPFIACNE 

        70         80         90        100        110        120 
CAFPTCRPCY EYERREGNQA CPQCGTRYKR IKGSPRVEGD EEDDDIDDLE HEFYGMDPEH 

       130        140        150        160        170        180 
VTEAALYYMR LNTGRGTDEV SHLYSASPGS EVPLLTYCDE DSDMYSDRHA LIVPPSTGLG 

       190        200        210        220        230        240 
NRVHHVPFTD SFASIHTRPM VPQKDLTVYG YGSVAWKDRM EVWKKQQIEK LQVVKNERVN 

       250        260        270        280        290        300 
DGDGDGFIVD ELDDPGLPMM DEGRQPLSRK LPIRSSRINP YRMLIFCRLA ILGLFFHYRI 

       310        320        330        340        350        360 
LHPVNDAFGL WLTSVICEIW FAVSWILDQF PKWYPIERET YLDRLSLRYE KEGKPSELAP 

       370        380        390        400        410        420 
VDVFVSTVDP LKEPPLITAN TVLSILAVDY PVEKVACYVS DDGAAMLTFE ALSYTAEFAR 

       430        440        450        460        470        480 
KWVPFCKKFS IEPRAPEWYF SQKMDYLKHK VDPAFVMERR AMKRDYEEFK VKINALVSVS 

       490        500        510        520        530        540 
QKVPEDGWTM QDGTPWPGNN VRDHPGMIQV FLGHSGVCDM DGNELPRLVY VSREKRPGFD 

       550        560        570        580        590        600 
HHKKAGAMNS LIRVSAVLSN APYLLNVDCD HYINNSKAIR EAMCFMMDPQ SGKKICYVQF 

       610        620        630        640        650        660 
PQRFDGIDRH DRYSNRNVVF FDINMKGLDG IQGPIYVGTG CVFRRQALYG FDAPKKKQPP 

       670        680        690        700        710        720 
GRTCNCWPKW CCLCCGMRKK KTGKVKDNQR KKPKETSKQI HALEHIEEGL QVTNAENNSE 

       730        740        750        760        770        780 
TAQLKLEKKF GQSPVLVAST LLLNGGVPSN VNPASLLRES IQVISCGYEE KTEWGKEIGW 

       790        800        810        820        830        840 
IYGSVTEDIL TGFKMHCHGW RSVYCMPKRA AFKGSAPINL SDRLHQVLRW ALGSVEIFLS 

       850        860        870        880        890        900 
RHCPIWYGYG GGLKWLERFS YINSVVYPWT SLPLLVYCSL PAICLLTGKF IVPEISNYAG 

       910        920        930        940        950        960 
ILFLLMFMSI AVTGILEMQW GKIGIDDWWR NEQFWVIGGV SSHLFALFQG LLKVLAGVST 

       970        980        990       1000       1010       1020 
NFTVTSKAAD DGEFSELYIF KWTSLLIPPT TLLIINIVGV IVGVSDAINN GYDSWGPLFG 

      1030       1040       1050       1060       1070       1080 
RLFFALWVIV HLYPFLKGLL GKQDRVPTII LVWSILLASI LTLLWVRVNP FVSKDGPVLE 


ICGLDCLK

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana." Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D., Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V., Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S., Cronin L.A. Venter J.C. Nature 402:761-768(1999) [PubMed: 10617197] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: cv. Columbia.
[2]	"Higher plant cellulose synthases." Richmond T. Genome Biol. 1:REVIEWS3001.1-REVIEWS3001.6(2000) [PubMed: 11178255] [Abstract] Cited for: GENE FAMILY, NOMENCLATURE.
[3]	"Genetic complexity of cellulose synthase A gene function in Arabidopsis embryogenesis." Beeckman T., Przemeck G.K.H., Stamatiou G., Lau R., Terryn N., De Rycke R., Inze D., Berleth T. Plant Physiol. 130:1883-1893(2002) [PubMed: 12481071] [Abstract] Cited for: TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.

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Cross-references

Sequence databases
	AC007019 Genomic DNA. Translation: AAD20396.1.
IPI	IPI00544550.
PIR	H84604.
RefSeq	NP_179768.1.
UniGene	At.39527
3D structure databases
SMR	Q9SJ22. Positions 32-97.
ModBase	Search...
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
Proteomic databases
PRIDE	Q9SJ22.
Genome annotation databases
GeneID	816713.
GenomeReviews	Gene locus AT2G21770 in contig CT485783_GR.
KEGG	ath:AT2G21770.
NMPDR	fig\|3702.1.peg.9200.
Organism-specific databases
GeneFarm	5092. 484.
TAIR	At2g21770.
Enzyme and pathway databases
BRENDA	2.4.1.12. 302.
Gene expression databases
ArrayExpress	Q9SJ22.
GermOnline	AT2G21770. Arabidopsis thaliana.
Family and domain databases
InterPro	IPR005150. Cellulose_synth. IPR001841. Znf_RING. IPR017907. Znf_RING_CS. [Graphical view]
Pfam	PF03552. Cellulose_synt. 1 hit. [Graphical view]
SMART	SM00184. RING. 1 hit. [Graphical view]
PROSITE	PS00518. ZF_RING_1. False negative. PS50089. ZF_RING_2. False negative. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

CESA9_ARATH

Accession

Primary (citable) accession number: Q9SJ22

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	May 1, 2000
Last modified:	June 16, 2009
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

PPAP (Plant Proteome Annotation Project)

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Relevant documents

Arabidopsis thaliana

Arabidopsis thaliana: entries and gene names

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein family/group databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Entry information

Relevant documents